EUROPEAN POLYMER JOURNAL
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2018
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IF 3.741
Xia Xia,Haojie Yu,Li Wang,Zheng Deng,Kenneth J. Shea,Zain-ul-Abdin
A series of redox- and photo-responsive copolymers, poly(2-(methacryloyloxy)ethyl ferrocenecarboxylate- co -4-methacryloylamino-4′-nitroazobenzene) (P(FcEMA- co -MAAzo)s) were synthesized using free radical polymerization. The synthesized copolymers were characterized by 1 H NMR, FT-IR, gel permeation chromatography (GPC) and thermogravimetric analysis (TGA). Cyclic voltammetry (CV) and Ultraviolet–visible (UV–vis) absorption studies showed redox- and photo-responsive properties of the synthesized copolymers in the solution. P(FcEMA- co -MAAzo)s films were prepared by spin-coating or drop-coating method and these films were found to be redox- and photo-responsive. The color of the prepared films could be adjusted by the redox stimulus, while UV–vis absorption properties of the prepared films could be adjusted by changing wavelength of light. It was found that these synthesized films show potential application for high density information storage.
研究领域:
材料科学
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化学
✓ 已验证
DOI
高影响因子
MACROMOLECULES
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2025
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IF 5.2
Chen Lin,Han Hu,Hanxu Zhu,Qingyang Luan,Zhenzhong Li,Jinggang Wang,Jin Zhu
Common biodegradable polyesters are degraded under favorable conditions, such as industrial compost. Poly(butylene adipate-co-terephthalate) (PBAT) is one of the most prospective and prevalent biodegradable polymer, while its degradation in natural environment is slow. Herein, we introduce a stimulus group with disulfide bonds to obtain a poly(butylene adipate-co-dithiodipropionate-co-terephthalate) (PBADiT) copolyester. Their melting temperature is higher than 120 °C and the thermal stability is sufficient for melt processing. They show high modulus (>110 MPa) and high toughness when ≤30% of disulfide bonds are introduced. BDi (butylene dithiodipropionate) units show slightly lower hydrolysis and enzymatic degradation ability, and PBADiT copolymers show acceptable storage stability in a damp environment. The redox response of PBADiT helps realize on-demand degradation after use. From 0.01 to 1 mol/L H2O2 solutions, the hydrolysis of PBADiT can be regulated or accelerated by 15 days of fast hydrolysis with weight loss exceeding 40%. Reductive conditions, represented by 0.2 mol/L dithiothreitol (DTT) solutions, are also an efficient stimulus source for achieving rapid breakage of PBADiT. Hence, PBADiT copolymers provide a new approach for sustainable and degradable materials with required usage time and impart the polymer with accelerated degradation in redox environments.
研究领域:
材料科学
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环境科学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2019
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IF 2.066
Amin Khan,Haojie Yu,Li Wang,Pavel A. Zhizhko,Dmitry N. Zarubin,Dmitry A. Lemenovskiy,Fazal Haq,Muhammad Usman,Ahsan Nazir,Kaleem-ur-Rehman Naveed
Herein, poly(2-(methacryloyloxy) ethyl ferrocene carboxylate- co -(methacrylohydroxyhexane azobenzene)s) (P(FHEMA- co -MAZOHE)s) were prepared by random copolymerization and were characterized by proton nuclear magnetic resonance ( 1 H NMR) and gel permeation chromatography (GPC) to confirm the structures and molecular weights respectively. Thermal variations were analyzed by thermogravimetric (TG), differential thermogravimetric (DTG) and differential scanning calorimetry (DSC) techniques. Finally, redox and photo stimuli-responsive properties were confirmed by cyclic voltammetry (CV) and ultraviolet–visible spectroscopy (UV–vis) respectively. The results revealed that (P(FHEMA- co -MAZOHE)s) can be useful as information storage materials.
研究领域:
高分子化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2018
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IF 3.741
Yudong Xue,Jia Tian,Lei Xu,Zhiyong Liu,Yongjia Shen,Weian Zhang
Stimulus-sensitive nanoparticles (NPs) have been established to widely adapt to remarkable abnormalities under the tumor microenvironment, which can observably enhance the therapeutic efficiency, improve the specific targeting ability and reduce the side effects. Photodynamic therapy (PDT) as a promising non-invasive and selective treatment for cancers through photodynamic reaction can profit from stimulus-sensitive NPs. Herein, a harmonious amphiphilic polymer (PEG- b -PTPPDS- b -PEG) with an extremely sensitive redox response is constructed via click chemistry between N 3 -TPPC6-N 3 , PEG-N 3 and alkynyl-containing disulfide ester for PDT. This polymer can be self-assembled into micelles with excellent stability, ultra-fast sensitivity of redox-triggered porphyrin release, and significant photodynamic anticancer performance. The redox-triggered dissociation of micelles and the release of porphyrin are much faster than common porphyrin-containing polymer. The bio-distribution and phototoxicity of micelles against A549 cells are measured and evaluated in vitro by flow cytometry, confocal scanning laser microscopy (CLSM) and MTT assay, respectively. The results reveal that PEG- b -PTPPDS- b -PEG micelles can effectively enhance the cellular uptake and cellular internalization of porphyrin and have an extremely low dark toxicity with efficient PDT towards A549 cells. This intracellular responsive nanoparticle provides a potential strategy for anticancer therapeutic application.
研究领域:
生物医学工程
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肿瘤学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Lidong Gong,Changrong Wang,Pengcheng Xu,Jingjing Gong,Chuanda Zhu,Shiming Di,Yanglonghao Li,Yongxu Mu,Hongbin Han,Qiang Zhang,Zhiqiang Lin
Bioresponsive nanomaterials are increasingly important in a variety of applications such as disease imaging, drug delivery, and tissue engineering. However, it remains a big challenge to manipulate response efficacy of such materials for performance optimization in a highly complex milieu in vivo. Here, we developed chemically adjustable nanoreactors (CANs) with the structure of polymeric cores and albumin shells to achieve tunable redox responsivity. In vitro characterization demonstrates stable, spherical nanoparticles of the CANs with a particle size of about 50 nm. The fluorescence activation ratios of the CANs are determined by various albumin modification densities on the shell. Meanwhile, the response sensitivity of the CANs to GSH levels (0.6–4 mM) can be tuned by acid–base properties of polymeric blocks in the core. This unique tunable redox responsivity enables the CANs suitable for probe optimization in cancer imaging both in vivo and at histological levels. Overall, this study offers a new design strategy for manipulation on performance of core/shell nanoreactors or bioresponsive nanomaterials.
研究领域:
生物材料学
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医学工程
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分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
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2025
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IF 4.9
Jin Rui,Gong Weijian,Wang Dongzhao,Du Yangyang,Nie Guoyan,Zhu Mingting,Yu Yong
Regulating the release of drugs and limiting their accumulation in healthy tissues is highly beneficial. This study employed core mesoporous silica (MS) nanoparticles, encapsulated with Vincristine sulphate (VC) and cloaked with non-porous shell silica modified with the disulfide bonds (SS). The MS was cloaked with polyethylene glycol (PEG) through disulfide bonds (PEG/NH 2 -MS@VC-SS). We examined the physicochemical characteristics of MS, encompassing XRD patterns, FTIR spectra, SEM, TEM, DLS, and zeta potential. The drug release pattern was assessed using different glutathione (GSH) levels. The nanoparticle cell uptake of the cell lines was evaluated. Additionally, the nanoparticle’s cell survival and ability to trigger apoptosis in the PC3 cell lines was assessed by MTT assay. The NPs-treated PC3 cell lines were imagined through fluorescent microscopy using acridine orange/propidium iodide (AO/PI) staining, 4′,6-diamidino-2-phenylindole (DAPI), and propidium iodide (PI) staining. Our study demonstrated that the release of VC from the PEG/NH 2 -MS@VC-SS was responsive to redox conditions. Outcomes showed increased cellular absorption and effective apoptosis induction, highlighting the promising capability of these redox-response DDSs for prostate cancer treatment.
研究领域:
药剂学
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肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Exploration
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2025
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IF 22.5
Tongyao Zhao,Yao Chen,Haimeng Yuan,Shuqian Yang,Hongyuan Zhang,Yuequan Wang,Shenwu Zhang,Qin Chen,Jin Sun,Zhonggui He,Cong Luo
Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non-stem cancer cells. Herein, we propose a cancer cells/CSCs double-killing modality for breast cancer treatment. Specifically, a carrier-free nano-cocktail is developed through the precise co-assembly of a redox-responsive docetaxel (DTX) dimeric prodrug and salinomycin (SAL, an anti-CSCs drug). Precision combination of DTX and SAL not only shows synergistic tumor-killing activity, but also sharply reduces the proportion of CSCs in tumors. More importantly, tumor-specific prodrug activation-initiated drug release from the nano-cocktail confers high drug co-delivery efficiency and low off-target toxicity risk. As expected, such a one-stone-two-birds nanomedicine presents satisfactory performance on tumor stemness eradication, antitumor responses, and safety in both xenograft and orthotopic 4T1 breast cancer mouse models. This study advances cancer cells/CSCs double-killing nanotherapeutics towards clinical breast cancer therapy.
研究领域:
肿瘤学
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纳米医学
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转化医学
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药物递送
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分子肿瘤学
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抗肿瘤药理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2015
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IF 1.648
Zhifei Xie,Huameng Gong,Mingxing Liu,Hongda Zhu,Honghao Sun
In this paper, a novel drug-loaded material (MSNs-SS-PEG) was obtained by grafting the thiol-linked methoxy polyethylene glycol (MeOPEG-SH) onto the thiol-functionalized mesoporous silica nanoparticles (MSNs-SH) via the disulfide bond linker. In our designed experiment, three different chain lengths of PEG (PEG1000, PEG5000, and PEG1000-PEG5000) were used. The silica materials were characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering, field emission scanning electron microscopy, transmission electron microscopy, nitrogen adsorption–desorption measurements, and X-ray diffraction. The morphology of the MSNs-SS-PEG was spherical with an average diameter of about 150 nm. Due to the covalent modification of hydrophilic MeOPEG, the MSNs-SS-PEG was coated by a thin polymer shell, showing stable and inerratic MCM-41 type mesoporous structure as well as high specific surface areas and large pore volumes. Moreover, the releases of doxorubicin hydrochloride (DOX) from these materials at 10 mM of glutathione were investigated. The PEG functionalization could effectively cap drugs in the mesoporous channels. The release of DOX from the MSNs-SS-PEGn revealed redox-responsive characteristic. The obtained results showed that the MSNs-SS-PEG might be promising drug delivery carrier materials, which could play an important role in the development of drug delivery.
研究领域:
纳米医学
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药剂学
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生物材料
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药物递送
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分子影像
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肿瘤治疗
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转化医学
✓ 已验证
DOI
高影响因子
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