CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Xu Jia,Yu Han,Mingliang Pei,Xubo Zhao,Kun Tian,Tingting Zhou,Peng Liu
Hyaluronic acid (HA)-based theranostic nanogels were designed for the tumor diagnosis and chemotherapy, by crosslinking the folate-terminated poly(ethylene glycol) modified hyaluronic acid (FA-PEG-HA) with carbon dots (CDs) for the first time. Due to the extraordinary fluorescence property of the integrated CDs, the theranostic nanogels could be used for the real-time and noninvasive location tracking to cancer cells. HA could load Doxorubicin (DOX) via electrostatic interaction with a drug-loading capacity (DLC) of 32.5%. The nanogels possessed an ideal release of DOX in the weak acid environment, while it was restrained in the neutral media, demonstrating the pH-responsive controlled release behavior. The cytotoxicity and cellular uptake results clearly illustrated that most DOX was released and accumulated in the cell nuclei and killed the cancer cells efficaciously, due to their dual receptor-mediated targeting characteristics.
研究领域:
生物材料学
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肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 9
·2328
·
IF 5.076
Zhao Wang,Xinhua Li,Xiaojuan Zhang,Ruilong Sheng,Qing Lin,Wenli Song,Lingyun Hao
Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.Keywords:contact lenses;nanogels;ophthalmic drug delivery;sustained release
研究领域:
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Fang Yuan,Shasha Wang,Gaojian Chen,Kehua Tu,Hongliang Jiang,Li-Qun Wang
A novel approach to design pH-sensitive and disintegrable polyelectrolyte nanogels composed of citraconic-based N -(carboxyacyl) chitosan (polyanion) and quaternary chitosan (polycation) was reported. Firstly, the hydrolysis of citraconic-modified chitosan was monitored using fluorescamine assay and it could selectively dissociate in acidic media (e.g., pH ∼5.0) due to the isomerization during the addition of citraconic anhydride to chitosan. Secondly, the self-assembly behaviors of different polyelectrolyte pairs between citraconic-based chitosan and quaternary chitosan were investigated via colloidal titration assay. It was indicated that the difference in molecular weight (MW) of opposite charged polyelectrolytes played an important role on the formation of polyelectrolyte nanogels. Results showed that polyelectrolyte nanogels (ca. 300 nm in size) only formed when polyanion and polycation had a very large difference in MW. The pH-sensitive behavior of polyelectrolyte nanogels was comprehensively investigated by dynamic light scattering (DLS) and transmission electron microscope (TEM). The incorporation of charge-conversional citraconic-based chitosan into polyelectrolyte complexes has provided an effective approach to prepare polyelectrolyte nanogels which were very stable at neutral pH but disintegrated quickly in acidic media.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2016
·
IF 3.586
Yong Zuo,Zhenqian Jiao,Li Ma,Pengfei Song,Rongmin Wang,Yubing Xiong
In this study, novel thermo-responsive nanogels were facilely fabricated via ternary cross-linking copolymerization of ionic liquid (IL)-based monomers and cross-linker in methanol. To achieve the thermo-responsive performance of nanogels, monomers with hydroxyl or carboxyl group which can contribute to hydrogen (H)-bonding interaction is the key point of this strategy. The thermo-responsive behavior of poly(ionic liquid)s (PIL)-based nanogels were testified using dynamic light scattering (DLS), turbidimetric method, and differential scanning calorimetry (DSC) measurements. The results demonstrated that these novel nanogels presented reversible upper critical solution temperature (UCST) phase transition with the temperature changing. And their UCSTs could be tuned via the feed ratio of IL-based monomers and cross-linker. The nanogels were also measured using scanning electronic microscopy (SEM), thermo-gravimetric analyses (TGA) and Fourier transform infrared spectroscopy (FT-IR) techniques. In addition, a possible mechanism of thermo-responsive performance was suggested based on the above results. As a result, our findings provide an efficient and applicable platform for the fabrication of thermo-responsive polymeric nanomaterials .
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Gels
·
2022
·Vol. 9
·期 1
·23
·
IF 4.432
Hongyan Du,Kaihe Lv,Jinsheng Sun,Xianbin Huang,Haokun Shen
With the exploration and development of unconventional oil and gas, the use frequency of oil-based drilling fluid (ODF) is increasing gradually. During the use of ODFs, wellbore instability caused by invasion of drilling fluid into formation is a major challenge. To improve the plugging property of ODFs, nano-sized poly(styrene-lauryl acrylate) (PSL) rubber nanogels were synthesized using styrene and lauryl acrylate through soap-free emulsion polymerization method and were characterized using FTIR, NMR, SEM, TEM, particle size analysis and TGA. The results show that, due to good dispersion stability and oil-absorbing expansion ability, the PSL rubber nanogels have a wide range of adaptations for nano-scale pores to deposit a layer of dense filter cake on the surface of filter paper with various pore diameters, reducing the filtration of mineral oil and W/O emulsion significantly. Due to the unique wettability, the PSL rubber nanogels can be adsorbed stably at the oil–water interface and form a dense granular film to prevent droplets coalescing, which improves the emulsification stability of W/O emulsion. Furthermore, the PSL rubber nanogels are soap-free and compatible with ODFs without foaming problems. The PSL rubber nanogels can increase the hole-cleaning performance of ODFs by raising viscosity and yield point. The PSL rubber nanogels outperformed hydrophobic modified nano silica and polystyrene nanospheres in plugging and filtration reduction. Therefore, the PSL rubber nanogels are expected to be used as a new plugging agent in oil-based drilling fluid. This research provide important insights for the use of organic nanogels in ODFs and the optimization of plugging conditions.Keywords:oil-based drilling fluid;nanogels;plugging agent;emulsion stability
研究领域:
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2019
·Vol. 34
·期 4
·960-967
·
IF 0.605
Yin Meizhen,Su Zhenhong,Cui Bingcun,Han Yingchao,Dai Honglian,Yu Xin
To design a new type of antitumor nanodrug carrier with good biocompatibility, a drug delivery system with a 2.19% drug-loading rate, measured by high-performance liquid chromatography (HPLC), was prepared by membrane hydration using a mixed polymer: Pluronic® F-127, which binds folic acid (FA), Pluronic® F-68 and triptolide (TPL) (FA-F-127/F-68-TPL). As a control, another drug delivery system based on a single polymer (FA-F-127-TPL) with a 1.90% drug-loading rate was prepared by substituting F-68 with F-127. The average particle sizes of FA-F-127/F-68-TPL and FA-F-127-TPL measured by a particle size analyzer were 30.7 nm and 31.6 nm, respectively. Their morphology was observed by atomic force microscopy (AFM). The results showed that FA-F-127-TPL self-assembled into nanomicelles, whereas FA-F-127/F-68-TPL self-assembled into nanogels. An MTT assay showed that a very low concentration of FA-F-127/F-68-TPL or FA-F-127-TPL could significantly inhibit the proliferation of multidrug-resistant (MDR) breast cancer cells (MCF-7/ADR cells) and induce cell death. The effects were signifcantly different from those of free TPL ( P < 0.01). Using the fuorescent probe Nile red (Nr) as the drug model, FA-F-127/F-68-Nr nanogels and FA-F-127-Nr nanomicelles were prepared and then incubated with human hepatocarcinoma (HepG2) and MCF-7/ADR cells, and the fluorescence intensity in the cells was measured by a multifunctional microplate reader. The results indicated that both FA-F-127/F-68-Nr and FA-F-127-Nr had sustained release in the cells, but HepG2 and MCF-7/ADR cells exhibited significantly higher endocytosis of FA-F-127/F-68-Nr than that of FA-F-127-Nr ( P < 0.01). A nude mice transplanted tumor model was prepared to monitor FA-F-127/F-68-Nr in the tumor tissue and organs by whole-body fluorescent imaging. The results showed that FA-F-127/F-68-Nr targeted tumor tissues. The prepared nanogels had small particle size, were easy to swallow, exhibited slow release property, targeted tumor cells, and could improve the antitumor effects of TPL; hence, they are ideal carriers for low-dose antineoplastic drugs.
研究领域:
药剂学
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肿瘤学
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生物材料学
✓ 已验证
DOI
高影响因子
ACS Nano
·
2021
·
IF 15.881
Jian Luo,Yue Gao,Yukun Liu,Xueping Huang,Da-xia Zhang,Haichao Cao,Tongfang Jing,Feng Liu,Beixing Li
At present, it is highly important to develop a simple and compatible nano delivery system for pesticides for foliar application, which can improve their insecticidal efficacy and resistance to adverse climates while reducing the environmental risks. Polyethylene glycol and 4,4-methylenediphenyl diisocyanate are used as hydrophilic soft and hydrophobic hard segments, respectively, for polymer self-assembly and polyurethane gelation in a nanoreactor. The nanocarrier synthesis and the pesticide loading are realized by a one-step integration procedure and suited well for hydrophobic active compounds. Modifying the molecular structure of the soft segment can adjust the flexibility of the nanocarriers and result in viscosity and deformation characteristics. After foliar spray application, the foliar flattening state of the nanogels increases the foliar protection area by 2.21 times and improves both pesticide exposure area and target contact efficiency. Concurrently, the flexibility and viscosity of the nanogels increase the washing resistance and the retention rate of the pesticide by approximately 80 times under continuous washing. The encapsulation of the nanogels reduces the foliar ultraviolet (UV) degradation and aquatic pesticide exposure, which increase the security of λ-cyhalothrine by 9.33 times. Moreover, the degradability of nanogels is beneficial for pesticide exposure and reducing pollution. This system has simple preparation, good properties, and environmental friendliness, making the nanocarriers promising for delivering pesticides.
研究领域:
农业科学
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材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Bin Zhou,Mengchen Li,Jingyun Zhao,Yujuan Rong,Hongshan Liang,Bin Li
Heat-induced gel-assisted desalination could efficiently and inexpensively remove salt from salted egg whites . However, it was at the expense of the excellent foaming properties of egg whites, caused by the denaturation and aggregation of proteins during heating treatment. Hence, in this current work, the enzymatic treatment was used to re-endow duck egg white nanogels (DEWN) with outstanding foaming properties. We found that low levels of hydrolysis (DH = 2.27 %) could dramatically improve the foaming capability (FC), reaching >200 %, which also enhanced the foaming stability (FS). As the hydrolysis time extended, the adsorption and diffusion rate of the supernatant on the interface increased and performed high elasticity. The dilatational rheology and Lissajous plots were explored to investigate the nonlinear dilatational rheological behaviors of the air/water interface stabilized by the hydrolysed samples. Finally, we evaluated the effect of pH on foaming properties and found that the FC could exceed 250 %, and the FS was close to 80 % at pH = 5. These encouraging results showed that simple enzymatic treatment could revive nanogels from their dissatisfied foaming properties. In this work, gel-assisted desalination combined with enzyme treatment significantly promotes the high-quality and high-value utilization of salted egg white.
研究领域:
食品科学
·
蛋白质化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Daqi Li,Dujie Zhang,Fan Li,Qiaoling Xiang,Yuan Dong,Lizhu Wang
Traditional granular hydrogels showed excellent injectivity, thermal integrity, and efficient remediation of heterogeneous reservoirs. However, granular hydrogels have demonstrated their inability to adapt to fractures due to the lack of sufficient interactions. Herein, we present new nanocomposite hydrogels consisting of cationic nanogelators and anionic granular hydrogels that can chemically in situ reform bulk hydrogels in the fractures. Interestingly, our granular hydrogels showed recross-linking independence on carrying fluids, contrary to prior reported fluid-dependent recross-linking granular hydrogels. The recross-linking of nanogelators and granular hydrogels can be accomplished from room temperature to 130 °C. The nanocomposite hydrogels displayed increased shear elastic moduli compared to pristine anionic granular hydrogels, probably due to the increased covalent cross-links formed by the homogeneous regenerative approach. We found that the granular hydrogels had high salinity tolerance even in the presence of 1000 ppm divalent ions of calcium (Ca2+) since Ca2+ ions often act as the cross-linker for partially hydrolyzed acrylamide-based hydrogels. Overall, we obtained new regenerative nanocomposite hydrogels based on cationic nanogelators and anionic granular hydrogels for fracture treatments.
研究领域:
材料科学
·
生物医学工程
·
石油工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Kai Dong,Qiuya Lei,Runhao Guo,Xianglong Wu,Yanni Zhang,Ning Cui,Jian-Yu Shi,Tingli Lu
Purpose: The levels of reactive oxygen species (ROS) in tumor cells are much higher than that in normal cells, and rise rapidly under the influence of exogenous or endogenous inducing factors, eventually leading to the apoptosis of tumor cells. Therefore, this study prepared a dual pH/reducing-responsive poly (N-isopropylacrylamide-co-Cinnamaldehyde-co-D-α-tocopheryl polyethylene glycol 1000 succinate, PssNCT) nanogels, which employed two exogenous ROS inducers, cinnamaldehyde (CA) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), to selectively induce apoptosis by regulating ROS levels in tumor cells.Methods: The PssNCT nanogels were prepared by the free radical precipitation polymerization under the crosslink between pH-sensitive hydrazone and reducing-sensitive disulfide bonds, followed by the physicochemical and morphological characteristics investigations. Plasma stability, dual pH/reducing responsive degradation and in vitro release were also assessed. In cell experiments, cytotoxicity in different cells were first detected. The intracellular ROS levels and mitochondrial functions of tumor cells were then evaluated. Moreover, the apoptosis and western-blot assays were employed to verify the association between ROS levels elevation and apoptosis in tumor cells.Results: The nanogels exhibited a round-like hollow structure with the diameter smaller than 200nm. The nanogels were stable in plasma, while showed rapid degradation in acidic and reducing environments, thus achieving significant release of CA and TPGS in these media. Furthermore, the sufficient amplification of ROS signals was induced by the synergistically function of CA and TPGS on mitochondria, which resulted in the opening of the mitochondrial apoptotic pathway and enhanced cytotoxicity on MCF-7 cells. However, nanogels barely affected L929 cells owing to their lower intracellular ROS basal levels.Conclusion: The specific ROS regulation method achieved by these nanogels could be explored to selectively kill tumor cells according to the difference of ROS signals in different kinds of cells.
研究领域:
肿瘤学
·
药剂学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Yi Meng,Tanglong Liu,Shanshan Yu,Yi Cheng,Jie Lu,Xianzheng Yuan,Haisong Wang
A recyclable and high-efficiency nanoscale adsorbent is prepared from sustainable resources in this study. Inspired by the amino acid and phenolic hydroxyl group in reed root acting as active sites for adsorption, a chemically modified method is employed, where lignin is improved with glycine to prepare a biomimic adsorbent with a synergistic effect of amino acid and phenolic hydroxyl. By blending with nano-Fe3O4, the modified lignin is applied to synthesize lignin derivate magnetic nanogels that adsorb inorganic ions and organic dyes. The maximum capacities of the adsorption are highly improved, whereas unmodified lignin-based adsorbents reveal a low adsorption capacity under the same conditions. The used nanogels are recycled by magnetic separation and regenerated in hydrochloric acid, and the tests are repeated three times. All the regeneration ratios are over 90%, thus ensuring reusability. Finally, the as-prepared nanogels are applied to treat pulp bleaching effluents, revealing one potential application in industry. The designing concept of the recyclable nanogel in this study provides a biomimic strategy of using sustainable resources to treat contamination.
研究领域:
环境科学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Yuan Wang,Zhuang Liu,Feng Luo,Han-Yu Peng,Shu-Gui Zhang,Rui Xie,Xiao-Jie Ju,Wei Wang,Yousef Faraj,Liang-Yin Chu
A novel smart membrane with ion-recognizable nanogels as gates on interconnected pores is developed for simple and rapid detection of trace lead(II) ions in water. The membrane is prepared via one-step vapor-induced phase separation (VIPS) method, and featured with interconnected porous structure and Pb 2+ -responsive poly( N -isopropylacrylamide- co -benzo-18-crown-6-acrylamide) (PNB) nanogels on polyethersulfone (PES) membrane pore surfaces as gates. Afforded by such a unique architecture, both high flux and significant responsive characteristics are achieved. With the proposed strategy, the nanogels are fixed onto the membrane pore surfaces during the formation of interconnected porous structure; thus, the immobilization of nanogels onto the membrane pore surfaces does not result in the decrease of pore sizes. The water fluxes of fabricated membranes could be even higher than 6000 kg m −2 h −1 driven by the static pressure of 20 cm water column under gravity at 34 °C, because of the three-dimensionally interconnected porous structures. Due to high sensitivity and selectivity of PNB nanogels on the membrane pore surfaces in response to Pb 2+ ions, the fabricated membranes can efficiently detect Pb 2+ ions with a limit of detection as low as 10 −9 mol/L. With the proposed novel membrane, rapid detection of trace lead(II) ions in water can be easily achieved by simply monitoring the trans-membrane flux change in a gravity-driven membrane module device, which is highly potential and promising in real-time and easy-to-popularize monitoring of drinking water safety and may expand the scope of applications of facile detection techniques.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）