JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Yi-bo Zhang,Ji-Sheng Liang,Chengyan Liu,Qi Zhou,Zhe Xu,Hong-bo Chen,Fu-cong Li,Ying Peng,Lei Miao
P-type Mg 3 Sb 2 -based Zintls have attracted considerable interest in the thermoelectric (TE) field due to their environmental friendliness and low cost. However, compared to their n-type counterparts, they show relatively low TE performance, limiting their application in TE devices. In this work, we simultaneously introduce Bi alloying at Sb sites and Ag doping at Mg sites into the Mg 3 Sb 2 to cooperatively optimize the electrical and thermal properties for the first time, acquiring the highest ZT value of ∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323–723 K in sample Mg 2.94 Ag 0.06 Sb 1.9 Bi 0.1 . The first-principle calculations show that the co-doping of Ag and Bi can shift the Fermi level into the valence band and narrow the band gap, resulting in the increased carrier concentration from 3.50 × 10 17 cm −3 in the reference Mg 3 Sb 0.9 Bi 0.1 to ∼7.88 × 10 19 cm −3 in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1 . As a result, a remarkable power factor of ∼778.9 µW m − 1 K − 2 at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1 . Meanwhile, a low lattice thermal conductivity of ∼0.48 W m − 1 K − 1 at 723 K is also obtained with the help of phonon scattering at the distorted lattice, point defects, and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1 . The synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg 3 Sb 2 holds promise for further improving the TE performance of Zintl phase materials or even others.
研究领域:
材料科学
·
能源科学
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DOI
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Jiajing Zhu,Hui Wang,Liangjun Huang,Liuzhang Ouyang,Lan Zhang,Min Zhu
Nanosized SrTiO3, a common photocatalyst that enhances water splitting for hydrogen production, has been synthesized to catalyze the reversible hydrogen gas–solid reaction of MgH2. Compared to the pure MgH2, the milled MgH2-SrTiO3 composite shows significantly enhanced hydrogen storage properties, absorbing 3.5 wt % H2 within 1 min at room temperature and releasing 6.1 wt % H2 within 9 min at 250 °C. The activation energy for dehydrogenation is 82.91 kJ/mol, which is 52.09 kJ/mol lower than that of as-milled MgH2. The composite retains a capacity of 5.47 wt % after 40 cycles of dehydrogenation at 250 °C. The catalytic mechanism of nanosized SrTiO3 was discussed. Therefore, like anatase TiO2 photocatalysts, SrTiO3 shows an excellent catalytic effect to enhance the hydrogen sorption of MgH2 at significantly lower temperatures. A significant number of photocatalytsts have great potential to enhance the hydrogen sorption of Mg, making them promising candidates for solid-state hydrogen storage materials.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2017
·
IF 2.991
Biao-Qi Chen,Ranjith Kumar Kankala,Shi-Bin Wang,Ai-Zheng Chen
Despite the significant advancements in the pharmaceutical manufacturing process, the aqueous solubility of most of the potent drugs has remained as an unresolved problem during the formulation development and drug delivery processes. To address this critical issue, we modified the continuous-rapid expansion of supercritical solution (RESS-C) process, which is incessant, stable and well-regulated. Initially, the solubility of lonidamine (LND) in supercritical carbon dioxide (SC-CO 2 ) was tested using a static analytical method at altered critical conditions ( T : 308.15-328.15 K, P : 10.0-30.0 MPa). Under optimized conditions (LND conc.- 0.5% (w/v), flow rate- 1.0 mL/min, T - 328.15 K, P - 20.0 MPa and CO 2 flow rate- 30.0 g/min), the modified RESS-C process resulted in nano-sized spheres with a smooth surface and a narrow particle size distribution. Further, the crystal properties of the samples and their molecular interactions were elucidated. The altered physical state of RESS-C processed LND from crystalline to amorphous resulted in the solubility improvement and also enhanced the in vitro antiproliferative effects compared to the unprocessed LND, demonstrating the potential of the modified RESS-C process in improving the bioavailability of poorly water-soluble drugs.
研究领域:
药剂学
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制药工程
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药物递送
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产品关联
DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 33
·23606-23620
·
IF 3.9
Xinyi Yang,Jingjing Liu,Xuejin Huang,Hemin Cui,Ligang Wei,Guolin Shao,Xu Fu,Na Liu,Qingda An,Shangru Zhai
The cost-effective and green separation of dye pollutants from wastewater is of great importance in environmental remediation. Industrial seaweed residue (SR), as a low-cost cellulose source, was used to produce carboxylated nanorized-SR (NSR) via oxalic acid (OA)–water pretreatments followed by ultrasonic disintegration. Fourier transform infrared spectroscopy, X-ray polycrystalline diffraction, nitrogen isotherms, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, X-ray photoelectron spectrometry, particle charge detection, zeta potential and retro titration experiments were utilized to explore the physiochemical properties of samples. The NSRs with carboxyl content of 4.58–6.73 mmol g−1 were prepared using 10–60% OA–water pretreatment. In the case of 20% OA–water pretreatment, the highest NSR yield (73.9%) and nanocellulose content (80.2%) were obtained. Through self-assembly induced by the electrostatic interaction, magnetic NSR composite adsorbents (MNSRs) were prepared with the combination of NSR and Fe3O4 nanoparticles (NPs). The carboxylated NSR with negative charge demonstrated good affinity for Fe3O4 NPs. The Fe3O4 NPs were perfectly microencapsulated with the NSR when the NSR/Fe3O4 mass ratio was higher than 1/1. The adsorption properties of the MNSR for methylene blue (MB) removal from aqueous solution were investigated. The adsorbent with NSR/Fe3O4 mass ratio of 1/1 (MNSR1/1) exhibited optimum performance in terms of the magnetic properties and adsorption capacity. The MNSR1/1 showed high adsorption ability in a pH ≥7 environment. According to the Langmuir fitting, the maximum adsorption capacity of MNSR1/1 for MB reached 184.25 mg g−1. The adsorption of MB complies with the pseudo-second-order kinetic model. MNSR1/1 still maintained good adsorption properties after the fifth cycle of adsorption–desorption. MNSR1/1 could selectively adsorb cationic dye (i.e., MB and methyl violet) from wastewater, with hydrogen bonding and electrostatic interaction as the main force.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Chunli Qi,Huijie Xing,Ning Ding,Weifeng Feng,Yongyi Wu,Xingwang Zhang,Yigang Yu
Purpose: Diabetes mellitus (DM) remains a significant health challenge, with traditional treatments often failing to provide lasting solutions. Taxifolin (Tax), a potential phytomedicine with antioxidant and anti-hyperglycemic properties, suffers from low water solubility and poor bioavailability, necessitating advanced delivery systems. This study aims to nanometerize taxifolin (Tax) into selenized liposomes (Tax-Se@LPs) for enhanced oral delivery and hypoglycemic effect.Methods: Tax-Se@LPs were fabricated through a thin-film hydration/in situ reduction technique. The resulting nanomedicine was characterized through in vitro release studies, pharmacokinetic and pharmacodynamic evaluations, cellular uptake assays, and formulation stability tests.Results: The optimized Tax-Se@LPs demonstrated an average particle size of 185.3 nm and an entrapment efficiency of 95.25% after optimization. In vitro release studies revealed that Tax-Se@LPs exhibited a slower and more sustained release profile compared to conventional liposomes, favoring gastrointestinal drug absorption. Pharmacokinetic evaluations in normal rats indicated that Tax-Se@LPs achieved a relative bioavailability of 216.65%, significantly higher than Tax suspensions and unmodified liposomes. Furthermore, in diabetic GK rats, Tax-Se@LPs resulted in a maximal blood glucose reduction of 46.8% and exhibited a more sustained therapeutic duration compared to other formulations. Cellular uptake tests manifested that selenization altered the internalization mechanisms of liposomes while preserving their absorption aptness by intestinal epithelial cells. The physiological and in vitro stability of Tax-Se@LPs was also reinforced by selenization.Conclusion: Overall, Tax-Se@LPs not only improve the oral bioavailability of Tax but also enhance its therapeutic efficacy. These findings underscore the potential of Tax-Se@LPs as a promising therapeutic strategy for DM management.
研究领域:
药剂学
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糖尿病研究
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纳米医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Yue-Ming Yu,Fan-Zhi Bu,Su-Su Meng,Cui-Wei Yan,Zhi-Yong Wu,Yan-Tuan Li
To emphasize the superiority of uracil (UR) in ameliorating biopharmaceutical characteristics of marine antitumor medicine cytarabine (ARA), thus gaining some innovative opinions for the exploitation of nanococrystal formulation, a cocrystal nanonization strategy is proposed by integrating cocrystallization and nanosize preparation techniques. For one thing, based on UR's unique structural features and natures together with advantages of preferential uptake by tumor cells, cocrystallizing ARA with UR is expected to improve the in vitro / vivo performances. For another, the nanonization procedure is oriented towards maintaining the long-term effective drug level. Along this route, a cocrystal of ARA with UR, viz ., ARA-UR, is successfully synthesized and then transformed into nano-cocrystal. The cocrystal structure is precisely confirmed by various methods, demonstrating that a 1:1 ARA and UR in the crystal forms cytosine-UR hydrogen-bonding interactions, thus constructing supramolecular frameworks by strong π-π stacking interplays; while the nano-cocrystal is block-shaped particles of 562.70 nm with zeta potential −33.40 mV. The properties of cocrystal ARA-UR and its nano-cocrystal in vitro / vivo are comparatively explored by theoretical calculations and experimental analyses, revealing that permeability of both is significantly increased than ARA per se . Notably, the meliorative natures of both the cocrystal and nano-cocrystal in vitro bring excellent antitumor activity , but the latter has greater strengths over the former. More notably, the nano-cocrystal can sustain effective concentration for a relatively longer time, causing lengthened retention time and better absorption in vivo . The contribution offers a fire-new dosage form of ARA for long-lasting delivery, thus filling the vacancy in nanococrystal studies about marine drugs.
研究领域:
药剂学
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纳米技术
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药物递送系统
·
癌症治疗
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2019
·
IF 3.481
Shu-Ting Xiang,Biao-Qi Chen,Ranjith Kumar Kankala,Shi-Bin Wang,Ai-Zheng Chen
Despite the captivating interest for its potential anticancer efficacy against multiple types of cancer and ability to overcome multidrug resistance, the practical application of gambogic acid (GA) has been hampered by its poor water solubility. Herein, the fabrication of nanosized GA particles (251.2 nm ± 85.6 nm) using eco-friendly supercritical fluid (SCF)-assisted rapid expansion of a supercritical solution into a liquid solvent (RESOLV) process was demonstrated. The equilibrium solubility of GA in supercritical carbon dioxide (SC−CO 2 ) was initially determined at altered supercritical conditions (P: 10.0 MPa to 30.0 MPa, T: 308.15 K–328.15 K) and the obtained data points were then correlated using various density-based models including Méndez-Santiago and Teja, Bartle as well as Chrastil models. The solubility of GA in SC−CO 2 was found to be between 1.63 × 10 −6 and 22.62 × 10 −6 in terms of GA mole fraction, and considerably good correlation agreement was obtained with all the applied models and being the lowest deviations obtained with the Méndez-Santiago and Teja model. Furthermore, the fabricated GA nanoparticles (NPs) through benign RESOLV technique, were systematically characterized. Subsequently, in vitro antiproliferation tests resulted in its augmented antitumor efficacy due to enhanced solubility of GA. Together, the results have suggested that the benign RESOLV process has successfully fabricated nanosuspensions of GA with enhanced bioavailability and antineoplastic efficacy and may have great potential in pharmaceutics.
研究领域:
药学
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纳米技术
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癌症研究
·
超临界流体技术
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产品关联
DOI
高影响因子
ACTA MATERIALIA
·
2025
·
IF 9.3
Hongyao Zhang,Haotian Gao,Tianxiang Jiang,Qiang Feng,Huili Liu,Tongsuo Lu,Beibei Xu,Wujie Qiu,He Lin,Kunpeng Zhao
Understanding and engineering thermal transport in complex structures is essential for the development of materials with ultralow lattice thermal conductivity . In this study, we examine the unusual thermal transport behavior of Mg 2 Sn-based high-entropy materials, using a combination of pair distribution function (PDF) analysis, first-principles calculations, and theoretical modeling. Our findings demonstrate that the crystalline high-entropy materials exhibit glass-like thermal transports, characterized by an exceptionally low lattice thermal conductivity that increases monotonically with increasing temperature across the entire measured range, devoid of the characteristic peaks typical of crystalline materials. This unique behavior is attributed to the large atomic displacement parameter (ADP) of Mg atoms, which causes the Einstein oscillators to significantly reduce lattice thermal conductivity , complemented by the strong scattering of phonons by the nanoscale chemical fluctuations and a dense concentration of point defects within the high-entropy structure. These insights deepen our understanding of thermal transport in complex-structured materials, such as Mg 2 Sn-related compounds, and offer a foundation for designing new materials with tailored thermal conductivities for advanced thermal management and thermoelectric applications.
研究领域:
材料科学
·
凝聚态物理
·
热电材料
·
固体化学
·
热输运
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Sihang Liu,Liangbo Xu,Zhefan Yuan,Mei Huang,Tian Yang,Shengfu Chen
The design of three-dimensional crosslinked units with a spatial structure is of great significance for improving the mechanical properties of hydrogels. However, almost all the nanocomposites incorporated in hydrogels were defined as rigid nanofillers without further discussion on the potential contribution from the spatial structure change. In this work, the 3D nano chemical crosslinker multilayer graphene oxide acrylate (mGOa) was developed as a pressure-responsive crosslinker to achieve both low elastic modulus and high compression stress by synergizing more polymer chains against the loading force through interlayer sliding. Results showed that the hydrogel crosslinked by only 2 mg/mL mGOa nano chemical crosslinker in the poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogel (molar ratio: 1:1) can effectively enhance the mechanical strength up to 14.1 ± 2.1 MPa at a high compressive strain (90.6%) with an elastic modulus of less than 0.03 MPa at the initial 5% compression, whereas the hydrogel crosslinked by methacrylated single-layer graphene oxide (sGOa) or a small-molecule chemical crosslinker, N,N′-methylene bisacrylamide, can only reach 2.3 ± 0.8 MPa and 1.4 ± 0.4 MPa, respectively. In addition, the instantaneous modulus of the mGOa crosslinked hydrogel rapidly increased to the peak value with the increase of strain. The repeated compression test of HcA-mGOa hydrogels showed the responsive increase of the modulus, which was promoted by the synergism of polymer chains under compression. This indicated that the interlayer sliding of mGOa is the key contributor to mechanical strength enhancement, which provides a new rationale to design tough hydrogels.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Tianrui Chen,Ruhong Li,Jianchao Liu,Deying Mu,Shuting Sun,Li Zhao,Shuang Tian,Weimin Zhu,Xiuli Wang,Changsong Dai
Nanometerization of tin-based materials is beneficial to alleviate the volume effect, and thus improving the cycle stability of tin-based materials. Meanwhile, the smaller size can enhance the reversibility of the conversion reaction, which is crucial for increasing the capacity of tin-based materials. Therefore, reducing the size of tin-based materials may bring the advantages of cycle stability and specific capacity. In this work, we tried to disperse tin ions with organic skeleton to maximize the dispersion of active materials. Tin-based anode material based on polyethyleneimine‑sodium xanthogenate is synthesized by in-situ method at room temperature , and the thiocarboxyl group of polyethyleneimine‑sodium xanthogenate greatly increases the dispersion of metal ions . Carbon nanotubes (CNTs) are further introduced to improve the conductibility of tin-based materials owing to the existence of non-conductive organic groups. The anode material exhibits a long cycle life which delivers a specific capacity of 560 mAh g −1 after 1000 cycles. By analyzing the differential charge capacity (dQ/dV) curves, we find that the conversion reaction of tin-based materials is highly reversible.
研究领域:
材料科学
·
电化学
·
电池技术
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2023
·
IF 3.8
Jingzhou Guo,Yuanzuo Zou,Bo Shi,Yuan Pu,Jiexin Wang,Dan Wang,Jianfeng Chen
Solubility enhancement has been a priority to overcome poor solubility with optoelectronic molecules for solution-processable devices. This study aims to obtain experimental data on the effect of particle sizes on the solubility properties of several typical optoelectronic molecules in organic solvents, including the solubility results of 1,3-bis(9-carbazolyl)benzene (mCP), 1,3,5-tris(1-phenyl-1H-benzimidazol-2-yl)benzene (TPBi) and 2-(4- tert -butylphenyl)-5-(4-biphenyl)-1,3,4-oxadiazole (PBD) in ethanol and acetonitrile , respectively. Nanoparticles of mCP, TPBi and PBD with sizes from dozens to several hundred nanometers were prepared by solvent antisolvent precipitation method and their solubility were determined by using isothermal saturation method. The saturation solubility of nanoparticles of three kinds of optoelectronic molecules exhibited increase of 12.9%−25.7% in comparison to the same raw materials in the form of microparticles. The experimental evidence indicates that nanonization technology is a feasible way to make optoelectronic molecules dissolve in liquids with enhanced solubility.
研究领域:
材料科学
·
光电子学
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2020
·
IF 3.744
Pei-Yao Xu,Chao-Ping Fu,Ranjith Kumar Kankala,Shi-Bin Wang,Ai-Zheng Chen
Owing to its poor solubility, the applicability of dihydromyricetin (DMY) is limited in various biomedical applications. To overcome this issue, nano-sized DMY particles (DMY NPs) were fabricated using the supercritical antisolvent (SAS) approach for improving the bioavailability of DMY. Initially, the experimental conditions were optimized such as temperature of 45 °C, pressure of 8 MPa, and DMY solution flow rate of 0.5 mL/min, resulting in the DMY particles at a mean particle size of 169.1 ± 23.7 nm. Further, the physicochemical characteristics of the resultant DMY NPs were evaluated using various characterization techniques. The DMY NPs with reduced particle size and improved dissolution rate resulted in improved anticancer, antibacterial, and biofilm inhibition efficacies, comparable to that of unprocessed DMY. Together, the designed DMY NPs using the SAS process have great potential in food and pharmaceutical industries.
研究领域:
药学
·
纳米技术
·
生物医学工程
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）