Arabian Journal of Chemistry
·
2021
·Vol. 14
·期 10
·103351
·
IF 5.165
Deqiang Wang,Xin Zhou,Chong Ma,Meiying Liu,Hongye Huang,Xiaoyong Zhang,Yen Wei
Fluorescent sensor has demonstrated to be a facile and effective method to detect heavy metal ions owing to its unique characteristics such as simplicity, ease of operation and cost-effectiveness. In this work, a novel fluorescent probe with aggregation-induced emission (AIE) feature that contains an amide ligand base on the tetraphenylethylene (TPE) dye was designed and successfully synthesized. The utilization of the AIE-active fluorescent probe (named as FDPA) for detection of Cu 2+ in aqueous solution has also been examined. We demonstrated that the resultant AIE-active molecule displays amphiphilic property and can self-assemble in aqueous solution with remarkable enhancement of fluorescent intensity owing to its AIE feature. The detection limit of probe for Cu 2+ determination is 6.11 × 10 −9 M and shows excellent selectivity in the presence of competitive ions. This work provides a useful route to overcome the fluorescence quenching of conventional fluorescent probes in aqueous solution and an elegant way to prepare fluorescent probes with better fluorescence properties.
研究领域:
分析化学
·
生物医学工程
·
分子影像
·
环境毒理学
·
化学生物学
·
药物分析
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Yang Yuan,Jiaxin Wang,Xinjiong Ni,Yuhua Cao
A biosensor for determination of 3-chloro-1, 2-propandiol (3-MCPD) was developed based on the electrochemically catalytic reduction by hemoglobin (Hb). Hb was concentrated and immobilized with magnetic molecularly imprinted nanoparticles (MMIPs NPs). The MMIP NPs had a core-shell structure, with magnetic Fe 3 O 4 NPs as the core and SiO 2 as the shell. MMIPs NPs were modified on the surface of a magnetic electrode to constitute the Hb enzyme-like sensor. The biosensor could catalyze the electrochemical reduction of 3-MCPD, and a direct electrochemical determination of 3-MCPD could be achieved for the first time. The biosensor, where Hb immobilized with MMIPs NPs had high electrochemical response for 3-MCPD, increased by 37.5% compared with Hb immobilized with magnetic non-imprinted nanoparticle (MNIPs NPs). The biosensor increased the response by 19.56% again under an external magnetic field . The reduction peak current had a linear relationship with 3-MCPD concentration ranging from 1.0 mg·L −1 to 160 mg·L −1 with a detection limit (S/N = 3) of 0.25 mg·L −1 . The biosensor was applied to the determination of 3-MCPD in soy sauce samples successfully with recoveries between 97.4% and 99.6%.
研究领域:
生物传感器
·
分析化学
·
食品科学
·
电化学
·
分子生物学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2014
·Vol. 32
·期 8
·686-690
·
IF 1.342
LIU Lisha,CHEN Haohong,LIU Biqiu,ZHANG Hui,TANG Bin,FENG Xianjuan,SUN Zhijia,ZHAO Jingtai
To explore novel nano-scintillator with a controllable architecture, pure and Eu 3+ doped lutetium oxyfluoride (Lu 7 O 6 F 9 ) powder were synthesized by combining mild hydrothermal method and solid state calcination approach. The products were all pure orthorhombic Vernier phase demonstrated by X-ray powder diffraction (XRD). The detailed crystal structure was also studied by Reitveld refinement. Lath-like microcrys tals composed of nanoparticles with unique hollow tube of the products were supported by the images of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Excited by X-ray with W as the target, the pure product showed intense broad emission with the peak at about 400 nm suitable for modern photoelectric multiplier tube (PMT), while the Eu 3+ doped sample transferred the incident energy to Eu 3+ ions and gave strong 5 D 0 → 7 F j ( j =0, 1, 2 and 4) emission, which fitted for imaging and labeling measurements. From the luminescent properties, both pure and Eu 3+ -doped products are potential excellent scintillator for X-ray imaging and other high energy detectors, and the pure product is also a good host candidate for rare earth doping.
研究领域:
材料科学
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无机化学
·
发光材料
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纳米医学
·
生物成像
·
辐射探测
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 80
·76905-76914
·
IF 3.289
Liujie Zhang,Ying Kuang,Jia Liu,Zhilan Liu,Shiwen Huang,Renxi Zhuo
In this paper, a receptor-mediated liposomal drug delivery system (DDS) was developed aiming to deliver cisplatin (cis-diaminedichloroplatinum(II); CDDP) targeting the liver. Acetyl glycyrrhetinic acid (AGA) was chosen as the hepatic targeting ligand and acetyl glycyrrhetinic acid-poly(ethylene glycol)-stearate (AGA-PEG-ST) was synthesized. Anionic 5-cholestene-3-beta-ol-3-hemisuccinate (CHO-HS) was also synthesized. The liposomal CDDPs were prepared by employing these functional moieties with phosphatidylcholine (PC) at various ratios. Meanwhile, methoxypolyethylene glycol-stearate (MPEG-ST) with an analogous structure but without AGA was also prepared as a control. The particle sizes of AGA modified liposomes ranged from 120 nm to 180 nm and the zeta potentials were located between −39.7 mV and −3.18 mV. The liposomes had encapsulation percentages of 51.5–61.7% and a loading capacity of 23.2–26.7% for CDDP. The transmission electron microscopy (TEM) observations showed that the liposomes had spherical morphologies with homogeneous distribution. In vitro cytotoxicity of CDDP-loaded liposomes against HepG2 human liver cancer cells and A549 human lung epithelial carcinoma cells were evaluated by MTT assays. The results demonstrated that the introduction of AGA could enhance the cytotoxicity of liposomal CDDP against HepG2 cells but showed less significant impact on A549 cells. CLSM observation and FCM measurement further confirmed that AGA modified liposomes had a stronger affinity to HepG2 cells than that of liposomes without AGA. The tissue distribution of calcein in mice indicated that AGA modified liposomes resulted in higher accumulation in the liver than that of liposomes without the AGA ligand. These results demonstrated the promise of AGA decorated anionic liposomes for hepatic targeted delivery of cisplatin.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
·
药物递送系统
·
肝病学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Chao Liu,Jing Dong,Geoffrey I.N. Waterhouse,Ziqiang Cheng,Shiyun Ai
A sensitive sandwich-type electrochemical immunosensor was developed for the detection of avian leukosis virus subgroup J (ALV-J), which benefitted from multiple signal amplification involving graphene-perylene-3,4,9,10-tetracarboxylic acid nanocomposites (GR-PTCA), nanocellulose-Au NP composites (NC-Au) and the alkaline phosphatase (ALP) catalytic reaction . GR-PTCA nanocomposites on glassy carbon electrodes served as the immunosensor platform. Due to their excellent electrical conductivity and abundant polycarboxylic sites, the GR-PTCA nanocomposites allowed fast electron transfer and good immobilization of primary antibodies, thereby affording a strong immunosensor signal in the presence of ALV-J. The detected signal could be further amplified by the introduction of NC-Au composites as a carrier of secondary antibodies (Ab 2 ) and by harnessing the catalytic properties of Au and ALP. Under optimized testing conditions, the electrochemical immunosensor displayed excellent analytical performance for the detection of ALV-J, showing a linear current response from 10 2.08 to 10 4.0 TCID 50 /mL (TCID 50 : 50% tissue culture infective dose) with a low detection limit of 10 1.98 TCID 50 /mL (S/N = 3). In addition to high sensitivity, the immunosensor showed very good selectivity, reproducibility and operational stability, demonstrating potential application for the quantitative detection of ALV-J in clinical diagnosis.
研究领域:
免疫学
·
生物传感器
·
分子诊断
·
兽医病毒学
·
纳米医学
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2017
·
IF 2.572
Shu-Hui Xia,Shu-Hua Teng,Peng Wang
Polyvinyl alcohol/silica (PVA/SiO 2 ) hybrid fibers were prepared via a sol–gel combined electrospinning technique, and their potential application in bone tissue engineering was evaluated in terms of in vitro bioactivity. When the PVA concentration was 8%, the obtained PVA/SiO 2 hybrid fibers exhibited a uniform and continuous morphology, with an average fiber diameter of about 542.9 nm. The SiO 2 xerogel phase was uniformly distributed within the PVA matrix, and its actual content was very close to the theoretical value. After 3 days of immersion in simulated body fluid (SBF), the PVA/SiO 2 hybrid fibers displayed a vigorous precipitation of lamellar apatite crystals, reflecting their excellent in vitro bioactivity.
研究领域:
生物材料学
·
组织工程
·
纳米医学
·
生物医学工程
·
无机非金属材料
·
再生医学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Xian-peng Zhang,Jian Luo,Da-xia Zhang,Tong-fang Jing,Bei-xing Li,Feng Liu
In this paper, porous microcapsules with tunable pore sizes were prepared using interfacial polymerization by employing a temperature-responsive cross-linking agent above its so-called cloud point temperature ( T scp ). The influences of porosity on the surface morphology , release profile and biological activity of the microcapsules were investigated. The results showed that both pore size and pore density could be controlled by regulating either the amount of cross-linking agent or the ratio of core material to shell material. Furthermore, the porosity of the microcapsules determined their release properties and further regulated the bioactivity of the microcapsules. In addition, the mechanism of pore formation was confirmed by investigating the morphology of microcapsules below the T scp . The microencapsulation methodology described here is convenient and versatile, which can be easily extended to encapsulate a broad range of lipophilic core materials.
研究领域:
药剂学
·
生物材料
·
纳米医学
·
药物递送
·
高分子科学
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2014
·Vol. 44
·期 1
·237-246
·
IF 4.097
Ying Liu,Lining Sun,Jinliang Liu,Yu-Xin Peng,Xiaoqian Ge,Liyi Shi,Wei Huang
A novel mesoporous nanosphere functionalized with 3-(aminopropyl)triethoxysilane (APTES) and 2-(5-bromothiophen)imidazo[4,5-f][1,10]phenanthroline (5-Br-Tip) was synthesized (denoted as Tip-MSS). With the coordinating function of the 5-Br-Tip to lanthanide (Ln) ions, for the first time, LnL3(5-Br-Tip) complexes were linked to the mesoporous nanospheres. The derived materials, named Ln-Tip-MSS (Ln = Eu, Tb, Sm, Nd, Yb), were characterized by Fourier-transform infrared (FT-IR) spectroscopy, TEM, XRD (wide-angle and small-angle), N2 adsorption/desorption analysis, and fluorescence spectroscopy. Upon excitation in the ligand absorption, the Ln-Tip-MSS nanomaterials show characteristic visible (Eu, Tb, Sm) and NIR (Sm, Nd, Yb) luminescence (multicolor emission covered from 450 nm to 1400 nm spectral region). Of importance is that, with low cytotoxicity and good biocompatibility given by the methyl thiazolyl tetrazolium (MTT) assay, the Eu-Tip-MSS was successfully applied to cell imaging in vitro based on the Eu3+ luminescence (under 405 nm excitation).
研究领域:
纳米医学
·
生物成像
·
材料科学
·
分子探针
·
化学生物学
✓ 已验证
DOI
高影响因子
RUSSIAN JOURNAL OF ELECTROCHEMISTRY
·
2012
·Vol. 48
·期 11
·1135-1139
·
IF 0.534
Sun Xuping,Liao Fang,Lu Wenbo,Chang Guohui
In this paper, electrodeposition technique, in combination with well-established microfabrication techniques, is used for the first time herein to the controllable fabrication of novel Pd nanotextured micro-electrodes (NTMEs). This NTMES system is proven to be particularly powerful and versatile with two degrees of freedom: nanoscale control of electrode nanotexturing and the microscale control of the electrode size and shape.
研究领域:
生物医学工程
·
纳米医学
·
电化学传感
·
微系统技术
·
分子诊断
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Zhijia Zhang,Xiaole Zhao,Yingchun Su,Defeng Xing,Xiaojun Han
We demonstrate that antibacterial agent N , N′ -[(4, 5-dihydroxy-1, 2-phenylene)bis(methylene)]bisacrylamide (OHABA) can be assembled on the surface of vinyl organosilicon nanospheres (VOSNs) by atom transfer radical polymerization (ATRP). Chemically cross-linked vinyl organosilicon cores were facilely fabricated by sol-gel method as support, which densely grafted poly-OHABA (POHABA) as shells. Antibacterial assessment test results revealed that POHABA-based core@shell structure displayed high antibacterial performance, long-term stability, and kept broad-spectrum antibacterial effect of against Gram-negative and Gram-positive bacteria.
研究领域:
材料科学
·
纳米医学
·
抗菌材料
·
高分子化学
·
表面功能化
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2018
·
IF 2.687
Huan Zhou,Ying Yang,Mengmeng Yang,Wenjie Wang,Yaping Bi
Mesoporous hydroxyapatite is widely applied in biomedical and environmental fields due to its high surface area and adsorption capacity. In current work a one-step hydrothermal method to synthesize mesoporous HA was developed with the assistance of a cost-effective template vitamin C. It was observed the pore size and morphology of hydrothermally synthesized HA were correlated to applied solution composition. A combination of calcium hydroxide, orthophosphate, and vitamin C can finally result in mesoporous rod-like HA nanoparticles with surface area of 88 m 2 .g −1 and pore size of 15.7 nm on average. The mesoporous HA exhibited enhanced adsorption of model drug doxorubicin in comparison to conventionally synthesized HA as expected. Consequently, this work provides new pathway to prepare mesoporous HA with advantages of economy and convenience.
研究领域:
生物材料学
·
纳米医学
·
药剂学
·
环境科学
·
生物无机化学
✓ 已验证
DOI
高影响因子
Small
·
2017
·Vol. 14
·期 7
·1702288
·
IF 8.643
Meiling Zhu,Kongchang Wei,Sien Lin,Xiaoyu Chen,Chia-Ching Wu,Gang Li,Liming Bian
Targeted and sustained delivery of drugs to diseased tissues/organs, where body fluid exchange and catabolic activity are substantial, is challenging due to the fast cleansing and degradation of the drugs by these harsh environmental factors. Herein, a multifunctional and bioadhesive polycaprolactone-β-cyclodextrin (PCL-CD) polymersome is developed for localized and sustained co-delivery of hydrophilic and hydrophobic drug molecules. This PCL-CD polymersome affords multivalent crosslinking action via surface CD-mediated host–guest interactions to generate a supramolecular hydrogel that exhibits evident shear thinning and efficient self-healing behavior. The co-delivery of small molecule and proteinaceous agents by the encapsulated PCL-CD polymersomes enhances the differentiation of stem cells seeded in the hydrogel. Furthermore, the PCL-CD polymersomes are capable of in situ grafting to biological tissues via host–guest complexation between surface CD and native guest groups in the tissue matrix both in vitro and in vivo, thereby effectively extending the retention of loaded cargo in the grafted tissue. It is further demonstrated that the co-delivery of small molecule and proteinaceous drugs via PCL-CD polymersomes averts cartilage degeneration in animal osteoarthritic (OA) knee joints, which are known for their biochemically harsh and fluidically dynamic environment.
研究领域:
药物递送
·
生物材料
·
组织工程
·
纳米医学
·
再生医学
·
关节生物学
·
转化医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）