MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xingjie Wu,Hong Liu,Jialin Chen,Ling Tao,Shi Zhou,Xiangchun Shen
In recent years, glycoproteins have gained increasing attention due to their pivotal roles in cellular chemistry and signal transduction. However, the limited availability of rapid and wash-free analytical tools has impeded their utilization as circulating biomarkers for disease diagnosis in clinical settings. To address this challenge, we developed a gold nanoshell-mediated method for analyzing glycoprotein composition directly in native biofluids. Initially, glycoproteins are captured at the micelle surface through aptamer-protein interactions and were labeled with fluorescent lectin. Subsequently, the fluorescence of the lectin is locally quenched by the in-situ formation of gold nanoshell on micelle surface, while free-floating lectin remains unresponsive throughout this process. After optimizing the HAuCl 4 dosage for gold nanoshell formation, we achieved rapid and strong fluorescence quenching against fluorescent lectin captured at micelle surface. Using this method, we analyzed the glycan compositions of CEA, HER2 and MUC1 with fluorescent ConA, Jacalin, LCA and PHA. The analyzing results demonstrated that our method can discriminate between glycoprotein compositions of plasma samples obtained from breast cancer patients and those from healthy donors.
研究领域:
生物化学
·
医学诊断
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Jingxuan Lu,Juan Li,Shiyan Fu,Huanhuan Tan,Yuhui Hao
The combined chemotoxicity and radiotoxicity associated with uranium, utilized in nuclear industry and military applications, poses significant threats to human health. Among uranium pollutants, uranyl is particularly concerning due to its high absorptivity and potent nephrotoxicity in its + 6 valence state. Here, we have serendipitously found Na 2 SeO 3 facilitates the conversion of U(VI) to U(IV) precipitates. A novel approach involving nano-chitosan loaded internally with melatonin and externally modified with selenite (NPs Cs-Se/MEL) was introduced. This modification not only enhances the conversion of U(VI) to U(IV) but also preserves the spherical nanostructure and specific surface area, leading to increased adsorption of U(VI) compared to unmodified samples. Selenite modification improves lysosomal delivery in HEK-293 T cells and kidney distribution of the nanoparticles. Furthermore, NPs Cs-Se/MEL demonstrated a heightened uranium concentration in urine and exhibited remarkable efficiency in uranium removal, resulting in a reduction of uranium deposition in serum, kidneys, and femurs by up to 52.02 %, 46.79 %, and 71.04 %, respectively. Importantly, NPs Cs-Se/MEL can be excreted directly from the kidneys into urine when carrying uranium. The results presented a novel mechanism for uranium adsorption, making selenium-containing nano-materials attractive for uranium sequestration and detoxification.
研究领域:
环境科学
·
毒理学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Research
·
2021
·
IF 0
Yao Chen,Dong Yang,Yuchen Gao,Runlai Li,Ke An,Wenjing Wang,Zhanfeng Zhao,Xin Xin,Hanjie Ren,Zhongyi Jiang
The rational design of an outer shell is of great significance to promote the photocatalytic efficiency of core-shell structured photocatalysts. Herein, a covalent organic framework (COF) nanoshell was designed and deposited on the cadmium sulfide (CdS) core surface. A typical COF material, TPPA, featuring exceptional stability, was synthesized through interfacial polymerization using 1, 3, 5-triformylphloroglucinol (TP) and p-phenylenediamine (PA) as monomers. The nanoshell endows the CdS@TPPA nanosphere with ordered channels for unimpeded light-harvesting and fast diffusion of reactants/products and well-defined modular building blocks for spatially charge separation. Moreover, the heterojunction formed between CdS and TPPA can further facilitate the effective charge separation at the interface via lower exciton binding energy compared with that of pristine TPPA. By modulating the thickness of TPPA nanoshell, the CdS@TPPA nanosphere photocatalyst with the nanoshell thickness of about 8±1 nm exhibits the highest photocatalytic H2 evolution of 194.1 μmol h-1 (24.3 mmol g-1 h-1, 8 mg), which is superior to most of the reported COF-based photocatalysts. The framework nanoshell in this work may stimulate the thinking about how to design advanced shell architecture in the core-shell structured photocatalysts to achieve coordinated charge and molecule transport.
研究领域:
材料科学
·
能源化学
·
光催化技术
✓ 已验证
DOI
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Xiangren Bai,Xiang Zhang,Dongdong Zhao,Xudong Rong,Naiqin Zhao,Chunnian He
Strain localization at grain boundaries (GBs) is one of the key factors contributing to the trade-off between strength and ductility in engineering alloys. To address this issue, we developed a unique perpendicular interlocking structure connecting the matrix GBs by introducing trans -granular graphene nano-shells (SGSs) via a two-step targeted localized Cu–Al interdiffusion process. In the as-built structure, the original GBs served as the soft component, while the perpendicularly intersecting SGSs acted as the hard component. This configuration not only promotes sustainable dislocation accumulation in the vicinity of the GBs but also facilitates plastic strain delocalization through stress shielding effects from the SGSs. By effectively impeding the extension of shear bands and redirecting crack propagation towards the grain interiors, these hetero-structured GBs contribute to reducing the intrinsic brittleness of GBs. Consequently, the SGS/AlCu composite demonstrates a remarkable balance of tensile strength (∼574 MPa) and ductility (∼17 %). Our findings suggest that restructuring the geometry of GBs in metallic alloys presents a promising strategy for mitigating strain localization at GBs, offering potential for enhancing the properties of metallic alloys in various engineering applications.
研究领域:
材料科学
·
力学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscience and Nanotechnology Letters
·
2017
·Vol. 9
·期 12
·1947-1952
·
IF 1.889
Wu Han,Zhou Liyan,Yan Shancheng,Song Haizeng,Shi Yi
Recently, layered IV–VI metal monochalcogenides have attracted a lot of attention because of their unique properties. Among them, tin monoxide (SnO) has been widely studied as thin films for the application in high-mobility p-channel transistor and photoelectricity device
fabrication. In this work, we successfully synthesized SnO nanoshells through a facile solution chemical method. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images confirmed the morphology of these nanoshells. The surface chemical composition was investigated
by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Raman and photoluminescence spectra were used to study the optical properties of nanoshells with different sizes, which were formed in different concentrations. We found that the special nanostructure may result in abundant
Sn or O vacancies on the surface of nanoshells, and these defects resulted in a broad photoluminescent signal. This work provided a solution synthesis method to prepare SnO and other IV–VI metal monochalcogenides as well as their promising applications in optical device.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Ziyi Cai,Jiafu Shi,Weiran Li,Yizhou Wu,Yishan Zhang,Shaohua Zhang,Zhongyi Jiang
Enclosed films, also called capsules, bearing an ultrathin and robust nanoshell have sparked much interest for use in many applications, for which facile preparation methods are urgently pursued. Inspired by the pH-programmed adhesion/cohesion of mussel-secreted foot proteins, polyphenol/polyamine capsules with an ultrathin and robust nanoshell are fabricated through a pH-switched assembly on sacrificial calcium carbonate (CaCO3) templates. Polyphenols adhere to the templates at pH 6.0 and rapidly cohere with polyamines at pH 8.0. The pH-switched assembly process is accomplished in only a few minutes where multiple instances of electrostatic interactions and chemical conjugation between polyphenols and polyamines occur. As a result, the capsules exhibit a nanoshell thickness of ∼10 nm and a superior mechanical strength of ∼1.575 GPa (elasticity modulus). Cell mimics are prepared through encasing enzymes in the lumen and present an activity recovery of ∼70% along with little activity decline during reuse. Amine or phenolic groups on the nanoshell of capsules are then applied to induce the generation of titania or silver nanoparticles, which may expand the applications of the capsules to the photo- and biorelated realms. Our study not only deepens the understanding of the adhering process of mussels but also offers a generic method toward functional materials for diverse applications.
研究领域:
材料科学
·
生物化学
·
仿生学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-22
·
IF 12.6
Zhang Lian-Ying,Chen Xiao-Tong,Li Rong-Tian,Meng Wei,Huang Guo-Qin,Chen Yong-Jian,Ge Feng-Jun,Zhang Qun,Quan Yu-Jun,Zhang Cai-Tao,Liu Yi-Fei,Chen Ming,Chen Jin-Xiang
Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, a common feature of solid tumor, is associated with drug resistance and a poor prognosis in BC. In this study, we present a strategy to overcome hypoxia-induced chemotherapy tolerance in BC. Specifically, we synthesized a hollow gold (Au)-platinum (Pt) bimetallic nanoshell for the first time, which acted as a drug delivery system (DDS) for doxorubicin (DOX). The photothermal effect, induced by the surface plasmon resonance (SPR) from the Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through photothermal therapy (PTT), but also significantly enhances the catalase-like activity between Pt nanoparticles and endogenous H 2 O 2 . This, subsequently, results in a heightened yield of O 2 , which further facilitates the release of DOX. This process alleviates tumor hypoxia and down-regulating hypoxia-inducible factor-1α (HIF-1α), multidrug resistance gene 1 (MDR1), and P-glycoprotein (P-gp), which can reverse drug resistance and achieve more effective DOX chemotherapy effects. Significantly, the increased availability of oxygen further re-polarizes immunosuppressive M2 macrophages into antitumor M1 macrophages. This study presents a novel strategy to tackle tumor proliferation and enhance tumor response to chemotherapy, offering hope for reversing in drug resistance in cancerous lesions. Graphical
研究领域:
肿瘤学
·
药理学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Zheng Zhong,Fengjiao Zhang,Wei Chen,Xiaguo Wei,Yiwen Zhang,Yanbo Lu,Hongbin Luo,Liangqian Fan
ABSTRACT A dual-function chitosan-based flocculant named nano-chitosan-graft-poly(acrylamide and acryloyloxyethyltrimethyl ammonium chloride (NCS-g-P(AM-DAC)) with flocculation and sterilization properties was successfully synthesized by using nano-chitosan (NCS), acrylamide, and acryloyloxyethyltrimethyl ammonium chloride (DAC) under ultraviolet irradiation with 2,2’-Azobis(2- methylpropionamidine) dihydrochloride as the photo-initiator. NCS was obtained via ion cross-linking between chitosan and sodium tripolyphosphate. The structure and physicochemical properties of the product were characterized by various methods. The influence of different factors on the intrinsic viscosity of synthetic copolymer was investigated to optimize the synthetic condition. The flocculation performance of NCS-g-P(AM-DAC) was evaluated. Results showed that the superior flocculation efficiency was acquired under pH = 6 and flocculant dosage of 5 mg L –1 , in which turbidity removal efficiency was above 85%. Considering that the quaternary ammonium salt was grafted and the nanoparticle generated, NCS-g-P(AM-DAC) was also applied to flocculate Escherichia coli (E. coli) suspension to evaluate the sterilization performance. At suitable dosage and pH conditions, the flocculant effectively removed turbidity and bacterial cells. 3D fluorescence spectroscopy analysis of E. coli suspension after the flocculation was conducted to investigate the sterilization mechanism. The results showed that NCS-g-P(AM-DAC) could destroy cell membranes, indicating its bactericidal, not simply antibacterial, effect during flocculation.
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Meidong Yu,Zhenping Huang,Zhengqi Liu,Jian Chen,Yi Liu,Li Tang,Guiqiang Liu
Surface-enhanced Raman scattering (SERS) technique has presented great potential in medical diagnosis, environment monitoring and food detection due to its high sensitivity, rapid response and fingerprint effect. Many efforts have been concentrated on all kinds of strategies to produce efficient SERS substrates. Here, we report on a simple and controllable method to produce large-area efficient SERS substrates with abundant discrete Au nanoparticles or clusers. The SERS substrates are easily fabricated via a simple annealing process of plasmonic nanoshells coated on photonic structures. The optimally designed Raman substrates show prominent Raman enhancement effect and extremely low detection limit. In comparison to the bare continuous gold film, the optimal SERS substrates annealed at 300 °C present a Raman enhancement of more than 6 orders of magnitude. The ultrasensitive SERS sensing capability is demonstrated down to 10 −12 M by detecting rhodamine 6G (R6G) molecules. The superior Raman properties of the proposed SERS substrates can be ascribed to the highly-dense electric field hotspots mainly formed by interpartice plasmons and crevice gap plasmons. The simple and controllable fabrication strategy and superior performance make the substrates promising candidates for the development of inexpensive, efficient and mass-produced SERS substrates.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Longqian Xu,Kaili Yan,Yunfeng Mao,Deli Wu
Using copper and/or iron based nanomaterial to activate dioxygen to produce free radicals is an alternative and environmental friendly technique, but the low conversion efficiency of oxygen and the rate-limiting step of superoxide radical generation limit current application. In present work, Cu 0 nano-shell-decorated nZVI (CFNs) was synthesized and employed to enhance the activation of oxygen for the removal of arsenic at circumneutral pH. The adsorption and oxidation pathways of arsenic were investigated by determination of arsenic distribution and radical scavenger methods. The results showed that the removal of arsenic by CFNs involved the initial step of As III adsorption by ferrihydrite followed by the oxidation of As III by hydroxyl radical ( OH abs ) and superoxide radical ( O 2 − abs ) radicals. In the presence of oxygen, the removal capacity of CFNs was improved twice than that of conventional nZVI (i.e. 453 mg/g and 263 mg/g, respectively). We inferred that Cu I in-situ generated in heterogeneous catalysis was of increasing importance and the O 2 – abs produced from the activation of dioxygen was regarded as the key factor in the generation of H 2 O 2 at pH 7. The enhancement of Cu I generation mainly because of: (i) the facial loading of Cu 0 shell accelerated the generation of Cu I , (ii) reductive Fe 0 core contributed to the regeneration of Cu I , and (iii) the generation of ferrihydrite with high specific surface area favored the adsorption of oxygen. Hence, CFNs enhanced the electron transfer between Cu I /Fe II and O 2 , increased the utilization efficiency of oxidants and improved the effectiveness of the functional nanoparticles for environmental applications.
研究领域:
环境科学
·
纳米材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2020
·Vol. 20
·期 3
·1832-1837
·
IF 1.134
Wu Han,Song Haizeng,Lin Zixia,Yan Shancheng,Shi Yi
Tin monoxide is a kind of IV–VI metal monoxides that has attracted great deal of attention due to its wide optical band gap and high field effect mobility in the past decade. On the other hand, nanoshell is a unique porous structure. Its curved shell provides a shelter for the
hollow core, as well as a much bigger special surface area. We in this study systematically prepared SnO nanoshells through a facile self-assembly method under different annealing conditions. The lithium ion batteries were fabricated immediately based on the as prepared nanoshells. The capacity
of as fabricated lithium ion batteries was 559.3 mAhg-1 at rate performance of 0.1 Ag-1 and 497.5 mAhg-1 at 1 Ag-1 in 30th cycle. This work exhibited high application performance of SnO nanoshells. We hope this work will help study similar structure
and applications of IV–VI metal monoxides.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
PubMed
高影响因子
WOOD SCIENCE AND TECHNOLOGY
·
2025
·Vol. 59
·期 4
·1-25
·
IF 3
Ding Jiarong,Tian Shiyu,Hu Zewen,Zhao Aichen,Liu Yu,Zhu Xiaodong
Formaldehyde released from particleboard poses a serious threat to indoor air quality, and there is an urgent need to develop efficient adsorbents to reduce its release. This study introduces micro-nano chitosan (multiscale chitosan cross-linked polymers, MNCs) as a novel adsorbent, synthesized via ionic gelation and systematically characterized in terms of their specific surface area (0.301 m 2 /g), average particle size (19.96 μm), spherical morphology, and surface functional groups. The formaldehyde emission from particleboard treated with 3% MNCs was found to be reduced to 70.7% of that of the control group on day 28 by the 1 m 3 climate chamber experiment, which was a significant emission reduction effect. The adsorption kinetic analysis showed that the adsorption of formaldehyde by MNCs conformed to the pseudo-second-order adsorption kinetic model, and its chemical adsorption mechanism was attributed to the Schiff base reaction between the amino group on the chitosan ring and formaldehyde. In the C-history experiment, the C m0 of control panel was measured to be 1.94 × 10 5 mg/m 3 and D m to be 2.7 × 10 −8 m 2 /s, whereas after treatment with 3% MNCs, the C m0 ' was reduced to 0.29 × 10 5 mg/m 3 , the D m ' was reduced to 4.31 × 10 −10 m 2 /s and the partition coefficient K was enhanced from 243.9 to 855.5 in the original panels, indicating that the addition of MNCs significantly inhibited the diffusion of formaldehyde, enhanced the retention capacity of formaldehyde in the particleboards, and reduced the initial volatilizable formaldehyde reserves. This study provides theoretical basis and experimental support for the application of MNCs in the pollution control of wood-based panels, whose efficient emission reduction performance originates from the unique nanoporous structure and the active amino sites in chitosan molecules.
研究领域:
材料科学
·
环境科学
·
室内空气质量
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）