International Journal of Food Engineering
·
2025
·
IF 1.4
Yonghui Wang,Jingwen Wu,Weiyun Guo,Xueli Gao,Guanghui Li,Shenghua He,Jihong Huang,Zirui Du,Sa Wen
In this study, ammonium glycyrrhizate (AG) based curcumin (Cur) nanocomplexes (AG/Cur NCs) were prepared. Water solubility of Cur and the physical stability of AG/Cur NCs under varying conditions were investigated, and the stability and bioaccessibility of Cur during in vitro digestion were also studied. The results showed that Cur solubility and physical stability of the NCs increased significantly ( p < 0.05) with the increase of AG concentration. The solubility of encapsulated Cur and the physical stability of AG/Cur NCs were affected by the changes in pH, salt concentration, and temperature, but the NCs showed good stability against various environmental conditions. After in vitro simulated digestion, the stability and bioaccessibility of the embedded Cur in the NCs were 6.54 % and 21.70 % respectively, higher than that of free Cur. The formulation of AG/Cur NCs significantly enhanced the solubility and stability of Cur, indicating substantial promising for Cur-based functional foods.
研究领域:
食品科学
·
药理学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2025
·
IF 5.7
Zhou Jiang,Erhu Xiong,Songlan Pan,Jianhua Chen,Huihuang Yi,Yinfeng Li,Yi Qing,Zhen Zou
Abundant adenosine triphosphate (ATP), an important mediator of metabolic reprogramming in cancer progression, is regarded as a significant focus in cancer treatment. Nonetheless, due to low selectivity, the attempts of ATP exhaustion may induce unacceptable side effects because ATP also plays key roles in maintaining normal cell function. Inspired by feedback inhibition in nature, here, we propose feedback inhibition of mitochondrial ATP synthetic pathway for tumors inhibition while minimizing side effects. As a proof-of-concept, an ATP-responsive ZIF-90 as a broad framework for mitochondrial-targeted delivery of 2, 2’-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH) and an FDA-approved drug bedaquiline (BE). It was found that ZIF-90/AIPH/BE nanocomplex exhibits unique properties of high pulmonary accumulation and mitochondria-targeting capability. When ATP is present, the ZIF-90/AIPH/BE nanoparticles were eroded and release the wrapped contents because of the competitive binding between ATP and the Zn2+ in ZIF-90. The released AIPH and BE significantly reduced ATP-production, causing mitochondrial ATP depletion. The reduced ATP restricted the follow-up release of ZIF-90/AIPH/BE nanocomplex in a negative-feedback manner. The feedback inhibition mechanism expands the possibilities for targeted disease treatment and opens up new avenues for ATP-based nanomedicine.
研究领域:
生物化学
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肿瘤学
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药理学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Dan Deng,Runfu Chen,Suai Lin,Yanxin Tao,Gaojin Pei,Bofei Cheng,Mengzhen Zhao,Haoxin Cheng,Junze Yan,Xiaolei Wang
Psoriasis, an immune-mediated chronic inflammatory skin disorder, poses challenges for topical treatment due to the thickening of the stratum corneum, hindering drug penetration. Furthermore, long-term use of chemical drugs may lead to immunosuppression and abnormal hepatic or renal dysfunction. Inspired by traditional Chinese fire cupping (Ba Huo Guan), a negative-pressure microneedle syringe therapy has been proposed here for psoriasis treatment. This microneedle syringe demonstrated an enhanced transepidermal drug delivery efficiency. Additionally, the microneedles contain nanoparticles self-assembled from Chinese herbal monomers berberine (BBR) and ferulic acid (FA), which play vital roles in psoriasis treatment, including inhibiting abnormal proliferation of local microbial communities, scavenging excess reactive oxygen species, suppressing keratinocyte proliferation locally, and modulating macrophage polarization to mitigate inflammation.
研究领域:
皮肤病学
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药剂学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yunran Zhang,Haiping Zhou,Zhe Zhang,Yijun Zhu,Tao Wang,Liguo Yu,Hongrui Song
Betulinic acid (BA) is a new class of anticancer drug , but its relatively short half-life and poor water solubility limit its therapeutic effect and clinical application. Herein, to tackle the dilemma, BA prodrugs were prepared by conjugating BA onto the polyethylene glycol (PEG) polymer via cleavable disulfide bonds. The prodrugs exhibited high water solubility (270-fold of free BA) and a relatively high drug-loading efficiency of 14.2 %. To further endow the BA prodrugs with a photothermal therapeutic effect, the near-infrared (NIR) agent Cypate was grafted on the Pluronic triblock copolymer . The different PEG polymers and different Pluronic polymers were chosen to obtain the optimal drug loading efficiency and the photothermal generation effect. The P-SS-BA/F68-Cy prodrug micelles integrate the redox-responsive BA prodrugs and the NIR-responsive amphiphilic triblock polymer into one single nanocomposite . The release of BA was less than 20 % in pH 7.4 PBS in the absence of glutathione (GSH), whereas the release of BA was obviously accelerated in pH 5.0 PBS with 10 mM GSH. In addition, the release of BA was further accelerated under the NIR irradiation. The P-SS-BA/F68-Cy micelles showed an excellent photothermal heating effect under NIR irradiation. The prepared P-SS-BA/F68-Cy micelles showed the synergistic thermochemotherapeutic effect on tumors both in vitro and in vivo . Therefore, the present study shows the great potential of dual-triggered drug delivery and thermochemotherapy for combination therapy.
研究领域:
药学
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肿瘤学
·
生物材料学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Hongying Xiao,Jinrui Liu,Minglong Huang,Wenfeng Zang,Bowen Zhang,Shufang Zheng,Xin Li,Zhonggui He,Xin Wang,Huaiwei Ding,Lingxiao Li,Bingjun Sun
The rational design of doxorubicin (DOX)-based delivery platforms with efficient and selective features remains a major challenge. The launch of Amphotec®, formed by assembling the positive electrical amphotericin B with negatively electrical sodium cholesterol sulfate (SCS), provides effective reference. Herein, we prepared an acid-sensitive prodrug (DOX-C14) by linking DOX with myristic acid (C14) via the acylhydrazone bond. Then, the positively electrical DOX-C14 was assembled with various negatively electrical cholesterol analogs in different molar ratios to optimize the stable DOX-C14 nanocomplex. Under the combined action of electrostatic and hydrophobic forces, nanocomplexes formed by DOX-C14 with SCS at ratios of 1:2 (DOX-C14-SCS (1:2)) and 1:3 (DOX-C14-SCS (1:3)) exhibited excellent performance. Subsequently, DOX-C14-SCS (1:2) and DOX-C14-SCS (1:3) were modified with DSPE-PEG 2k or CHOL-PEG 2k to further improve their stability and pharmacokinetic behavior. As a result, the obtained PEGylated nanocomplexes could efficiently accumulate in the tumor and then released DOX to exert antitumor effects under the stimulation of acidic environment. Meanwhile, there is no significant toxicity to normal tissues even at very high doses (10 mg/kg equivalent to DOX), demonstrating superior tumor selectivity. Our findings provide novel insights into the rational design of positive electrical drug for efficient and selective cancer therapy.
CAS / MDL:
研究领域:
药学
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肿瘤学
·
生物医学工程
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2021
·
IF 9.147
Liang Yao,Jiang Xu,Liwei Zhang,Lei Liu,Lei Zhang
Generally, anthocyanin is extremely vulnerable when exposed to oxidants, alkaline, heat, and metallic ions in the ambient environment. In this research, we use an amphiphilic peptide of eighteen amino acids , named C6M1, to encapsulate anthocyanin by co-assembly mechanism. The representative size of anthocyanin-encapsulated peptide nanocomposites is less than 100 nm, with a high encapsulation efficiency of 77.06% and a maximum mass loading capability over 600 wt % (w/w). Particularly, we find that the co-assembly with anthocyanin causes a conformational change of the C6M1 peptide, switching from α-helical structure to β-sheet dominating structure, thus realizing the encapsulation of anthocyanin. The intermolecular interaction between C6M1 peptide and anthocyanin is further characterized via fluorescence quenching experiments. Moreover, stability enhancement of anthocyanin and physicochemical properties of the C6M1-anthocyanin nanocomposites are investigated quantitatively. Briefly, our results show that the C6M1 peptide greatly improves the tolerance of anthocyanin to increase of pH, metallic ions, and hot temperature; and maintains the intrinsic capacity of anthocyanin of scavenging free radicals .
研究领域:
食品科学
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生物化学
·
材料科学
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DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2024
·Vol. 39
·期 4
·1048-1052
·
IF 1.3
Yu Dan,Ye Liyuan,Li Binbin,Mou Fangzhi,Yin Yixia
pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic self-assembly. The morphology, particle size and zeta potential of the nanocomposites were analyzed by transmission electron microscopy and dynamic light scattering. The synthesis of the polymer was analyzed by 1 H-NMR. The zeta-potential changes and cellular uptake effects of the nanocomplexes under different pH environments were investigated. The experimental results show that the surface morphology of the nanocomposite is spherical, and the average particle size is about 135 nm. As the pH value of the solution gradually decreases, the surface charge of the nanocomposite reverses from negative charge to positive charge (from −9.4 to +17.1 mV). Cellular uptake mediated by pH-responsive nanocomposite is selective for tumor cells, and the cellular uptake effect in tumor cells at pH 6.5 was approximately 3 times higher than that at pH 7.4. This pH responsive charge reversal nanocomposite has promising application prospects for gene delivery in the weak acid environment of tumors.
研究领域:
生物材料学
·
分子生物学
·
药物递送系统
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xian Liu,Qiwu Yuan,Yang Yang,Ke Li,Nanjiong Pang,Jiangtao Wang,Ming Yang,Xia Li,Junling Guo,Xuepin Liao,Bi Shi
Antibiotic resistance poses a significant threat to global public health, urgently demanding the development of new antibacterial agents with high efficacy and low resistance potential. In this study, we engineered self-assembled nanocomplexes of the gallic acid (GA) with rare earth (Re) ions (Ce 3+ , Gd 3+ , and Yb 3+ ), leveraging the unique multidentate structures of polyphenols to enhance antibacterial performance while minimizing resistance. These GA-Re nanocomplexes demonstrated potent activity against both antibiotic-sensitive Staphylococcus aureus (ASSA) and methicillin-resistant S. aureus (MRSA), with minimum inhibitory concentrations as low as 0.5 mmol/L. Viable MRSA cell numbers decreased from 7.40 × 10 7 CFU/mL to 8.43 × 10 6 and 7.33 × 10 2 CFU/mL when treated with penicillin (PEN) and GA-Gd for 24 h, respectively, indicating higher bactericidal efficiency of GA-Gd. Remarkably, no resistance developed in ASSA even after 60 days(d) of continuous exposure to GA-Gd, in contrast to the significant resistance observed with PEN (1024-fold) and neomycin (256-fold) after 28 d. The multidentate structure of GA facilitated versatile interactions with bacterial surface structures, enabling multiple mechanisms of action targeting cell walls, membranes, DNA, and cellular metabolism. Moreover, in vivo studies revealed that GA-Gd was effectively metabolized and excreted without accumulation or toxicity, and also accelerates the healing of MRSA infected wounds. These findings suggest the potential of self-assembled Re-based phenolic nanocomplexes as promising candidates for combating antibiotic-resistant bacterial infections, and pave the way for next-generation antibacterial agents.
研究领域:
微生物学
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药理学
·
材料科学
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产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 12
·9443-9453
·
IF 4.6
Anyu Zhang,Manish Mahotra,Hong Yu,Tianqi Zhu,Say Chye Joachim Loo
Curcumin, a natural polyphenol, has various biological functions including antioxidant and antimicrobial properties, but the functions are limited by its low aqueous solubility. To address this, two proteins, bovine serum albumin (BSA) and gelatin were used to form curcumin–protein nanocomplexes using a charge-switch method, by mixing oppositely charged curcumin and proteins. Complexation with BSA and gelatin increased the curcumin solubility to 391.77 (±15.70) μg mL−1 and 143.64 (±2.29) μg mL−1 respectively, and the loading amount (LA) of curcumin to 21.36% and 15.57%, respectively. Moreover, enhanced bioaccessibility, and antioxidant and antimicrobial properties were observed after complexation. After complexation, the minimum inhibitory concentration (MIC) of curcumin decreased by eightfold against Vibrio parahaemolyticus, more than eightfold against Vibrio harveyi, and twofold against Bacillus cereus and Streptococcus iniae, which are food and aquaculture related pathogens. The curcumin–protein nanocomplexes presented in this work could serve as non-antibiotic additives for preventing and managing microbial diseases in agri-food applications.
研究领域:
食品科学
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生物化学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 13
·2345
·
IF 5.1
Yifei Guo,Xinyu Yu,Rongrong He,Jianfei Pei,Haiming Chen,Weijun Chen
Ferulic acid (FA) exhibits beneficial properties in ulcerative colitis (UC) pathogenesis, while sensitivity to the environment and enzymes limits its use in UC therapy. Therefore, this study aims to develop a colon-targeted nanocomplex delivery system using FA and investigate its protective effects and underlying regulatory mechanisms in UC mice. A novel Zein/FA–pectin (PEC)/chitosan (CS) nanocomplex was successfully fabricated in this study. Through systematic adjustment of the PEC/CS-to-Zein/FA ratio, optimal encapsulation efficiency (60.1%) and loading capacity (26.2%) were achieved. The characterized data indicated that hydrogen bonds, electrostatic interactions, and hydrophobic forces were the main driving forces maintaining the formation of the nanocomplexes, accompanied by alterations in the secondary structure of Zein. The Zein/FA–PEC/CS nanocomplexes demonstrated excellent thermal/storage particle size stability and exhibited both protective and sustained-release effects of FA during simulated gastrointestinal digestion. Furthermore, the results demonstrated that the nanocomplexes potentially alleviate UC by regulating inflammatory cytokines, oxidative stress, and gut microbiota. Compared to unencapsulated FA, the nanocomplexes have a better effect on alleviating UC symptoms. In summary, Zein/FA–PEC/CS nanocomplexes have promising prospects in alleviating colitis in UC mice.
研究领域:
生物医学
·
药剂学
·
食品科学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2022
·
IF 9.336
Jiayuan Liu,Gongshuai Song,Yawen Yuan,Like Zhou,Danli Wang,Tinglan Yuan,Ling Li,Guanghua He,Qingyu Yang,Gongnian Xiao,Jinyan Gong
It is essential to understand the ultrasound-induced changes in assembly of proteins and polyphenols into non covalent nanocomplex. β-Lactoglobulin (LG) and chlorogenic acid (CA) with various biological activities can be combined to form food-grade nanocomplexes. This study systematically explored the role of high-intensity ultrasound pretreatment on the binding mechanisms of LG and CA, and the potential biological function for embedding curcumin (Cur). The scanning electron microscopy (SEM) revealed that ultrasound treatment could destroy the structure of LG, and the particle size of the protein was reduced to<50 nm. The change in secondary structure of the protein by ultrasound treatment could be revealed by the fourier transform infrared (FTIR) and fluorescence spectra. Besides, it was found that LG and CA were combined to form a complex under the hydrophobic interaction, and CA was bound in the internal cavity of LG with a relatively extended conformation. The result demonstrated that the ratio of Cur embedded in the ultrasonic sample could be effectively increased by 7% − 10%, the particle size in the emulsion was smaller, and the dispersion was more stable. This work contributes to the development of protein–polyphenol functional emulsion systems with the ability to deliver Cur.
研究领域:
食品科学
·
生物化学
·
营养学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2022
·
IF 2.712
Lumin Li,Xiaofeng Ji,Kai Chen
The rapid development of flexible electronic technology has led to the in-depth study of flexible wearable sensors to achieve accurate sensing under different external stimuli. However, it is still a huge challenge to develop hydrogel-based wearable skin-like sensors with super ductility, high sensitivity, and self-healing properties. Herein, the Ti3C2 type of MXene was synthesized, and the Ag/MXene nanocomplexes were incorporated into polyvinyl alcohol-borax matrix to construct a novel composite hydrogel as the multifunctional nanofillers, which could bring both improved properties and novel functionalities. The Ag/MXene-Poly (vinyl alcohol) (PVA) hydrogel displayed integrated merits of highly strain sensitive (GF = 3.26), self-healing (within 10 min, 91% healing efficiency), and excellent antibacterial activity. The hydrogel could be assembled into a wearable skin-like sensor to monitor human movement, including large deformations (finger, elbow, wrist, and knee bending) and tiny deformations (mouth’s movement and throat vocalization) in real time. Therefore, this work shed a new light on the development of flexible wearable skin-like sensors for the personalized healthcare monitoring, human–machine interfaces, and artificial intelligence.
研究领域:
材料科学
·
生物医学工程
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）