INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
·
IF 5.3
Li Ding,Xinghua Yu,Shihao Cai,Azhar Mahmood,Wenjing Meng,Xiaotong Liu,Jiahan Liu,Jieyun Li,Xuejuan Zhang,Chuanbin Wu
The cRGD peptide surface coating strategy for photothermal therapy nanoplatforms shows great promise in developing safe and effective cancer therapies. However, the precise intracellular mechanisms of these platforms remain unclear due to the complexity of intracellular trafficking and nano-bio interactions. This study investigates the nano-bio interactions of Bi 2 Se 3 nanofoams, a representative photothermal therapy nanoplatform, coated with cRGD peptide in cancer cells, focusing on endocytosis, exocytosis, and cellular trafficking. Our findings reveal that the cRGD-coated Bi 2 Se 3 nanofoams are internalized through three distinct endocytosis pathways: Rab34-mediated macropinocytosis, caveolae-dependent, and clathrin-dependent endocytosis. These nanofoams then accumulate in lysosomes via autophagy. Furthermore, inhibiting exocytosis reduces the loss of these nanofoams from cancer cells, enhancing photothermal and chemotherapy effects. This exocytosis-inhibiting strategy demonstrates significant potential for cancer therapy, validated by successful in vitro and in vivo results.
研究领域:
纳米医学
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细胞生物学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2021
·Vol. 8
·期 10
·2461-2467
·
IF 6.569
Yingchun Zhang,Changsheng Cao,Xin-Tao Wu,Qi-Long Zhu
Bismuth (Bi)-based nanomaterials are considered as promising electrocatalysts for the electrocatalytic CO2 reduction reaction (CO2RR), but it is still challenging to achieve high current density and selectivity in a wide potential window. Herein, Cu-decorated Bi/Bi2O3 nanofoam (P–Cu–BiNF) with a 3D porous network structure was prepared for the first time via a simple fast-reduction method. Characterizations indicate that the introduction of Cu can significantly regulate the microstructure and electronic states of Bi/Bi2O3. Consequently, the as-prepared P–Cu–BiNF exhibits excellent electrocatalytic performance toward the CO2RR. Remarkably, the faradaic efficiency of formate production can exceed 90% in a wide potential range from −0.78 to −1.08 V. Meanwhile, it can also deliver a high formate partial current density of up to 62.7 mA cm−2 at −1.18 V and long-term stability. This work provides a simple but effective way to synthesize advanced Bi-based materials with significantly improved electrocatalytic CO2RR performance.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Shanqiu Liu,Enze Yu,Taotao Ge,Qing Liu,Yu Zhong,Wei Cui,Jie Yu,Jingguo Li
Nanocellular polymer foams are highly valuble for their lightweight nature, high strength, and unique nanostructures, which offer significant potential across a variety of applications. However, their production and practical use are limited by low cell nucleation efficiency and the requirement for extremely high-pressure foaming processes. In this study, we successfully fabricated poly(methyl methacrylate) (PMMA) nanocellular foams with a cell density on the order of 1012 cells cm–3 at a relatively low foaming pressure of 6.0 MPa. This achievement was made possible through the use of defective UiO-66 nanoparticles as nucleation enhancers, which demonstrated a high nucleation efficiency of 1.11. We synthesized four types of defective UiO-66 nanoparticles, each with varying levels of defects, and confirmed their efficacy as nucleators for PMMA nanofoams. The successful synthesis of these defective UiO-66 nanoparticles was verified using Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray Spectroscopy. The cell size and density of the PMMA nanocellular foams were characterized via SEM analysis. Our findings showed that the incorporation of defective UiO-66 nanoparticles markedly reduced the cell size of the PMMA foam, achieving a higher cell density. This improvement is attributed to a decrease in the free energy required for cell nucleation within nanocavities located at the matrix–nucleator interface. Consequently, the careful design of high-performance nucleating particles and the judicious choice of foam matrix components emerge as critical strategies in developing polymer cellular materials with nanoscale cell dimensions. These insights significantly advance the fabrication of polymer foams with enhanced thermal insulation properties and have broad implications for the field of cellular materials science. By optimizing nucleation mechanisms and material combinations, this work opens new avenues for the development of advanced cellular polymers tailored for applications requiring superior insulation or lightweight yet robust structures.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
SENSORS
·
2024
·Vol. 24
·期 24
·8100
·
IF 3.4
Zhenchao Sun,Shanfu Sun,Xidong Hao,Yinglin Wang,Caili Gong,Pengfei Cheng
Toxic acetone gas emissions and leakage are a potential threat to the environment and human health. Gas sensors founded on metal oxide semiconductors (MOS) have become an effective strategy for toxic gas detection with their mature process. In the present work, an efficient acetone gas sensor based on Au-modified ZnO porous nanofoam (Au/ZnO) is synthesized by polyvinylpyrrolidone-blowing followed by a calcination method. XRD and XPS spectra were utilized to investigate its structure, while SEM and TEM characterized its morphology. The gas sensitivity of the Au/ZnO sensors was investigated in a static test system. The results reveal that the gas-sensitive performance of porous ZnO toward the acetone can be enhanced by adjusting the loading ratio of noble Au nanoparticles. Specifically, the Au/ZnO sensor prepared by the Au loading ratio of 3.0% (Au/ZnO-3.0%) achieved a 100 ppm acetone gas response of 20.02 at the optimum working temperature of 275 °C. Additionally, a portable electronic device used a STM32 primary control chip to integrate the Au/ZnO-3.0% gas sensor with other modules to achieve the function of detecting and alarming toxic acetone gas. This work is of great significance for efficiently detecting and reducing acetone emissions.
研究领域:
材料科学
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环境科学
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电子工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 86
·70297-70301
·
IF 3.84
Yong Zhang,Youfu Wang,Aiguo Hu
Hierarchically porous carbon nanofoams (CNFs) with uniform cavity and highly porous skeleton have been prepared via the formation of core–shell organosilica nanoparticles in one-pot reaction and subsequent Friedel–Crafts chemistry. The porosity of the CNFs, which have macroporous cavity (∼50 nm), mesoporous windows (∼12 nm) between adjacent cavities and mesoporous skeleton (∼3 nm), were facially tuned by varying the amount of phenyltriethoxysilane (PTES) used in the first step. CNFs with high surface area (>1100 m2 g−1), large pore volume (∼2 cm3 g−1) and partially graphitized skeleton exhibited good performances as supercapacitor electrode materials. The specific capacitance of the porous CNFs reached 170 F g−1 at a current density of 0.5 A g−1 in an aqueous electrolyte.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Xin'ao Li,Yumeng Zong,Wenjuan Li,Jin Qian,Zhe Qiang,Changhuai Ye,Meifang Zhu
Transparent polymer nanofoams offer significant potential for thermal insulation, particularly for energy-saving windows, where both transparency and low thermal conductivity are crucial. However, grand challenges remain in preparing polymer nanofoam monoliths with pore sizes smaller than 40 nm to achieve high optical transparency via minimized light scattering. Herein, the preparation of highly transparent nanofoam monoliths based on fluorinated polyimide (FPI) using CO 2 foaming is reported for the first time. The high CO 2 absorption capacity and robust melt strength of the FPI matrix significantly promote bubble nucleation while minimizing cell coalescence during CO 2 foaming process, resulting in ultra-small pore sizes down to sub-10 nm. These FPI nanofoams, with a thickness of ≈0.2 mm, can exhibit high optical transmittance (>85% in the wavelength range of 500–700 nm) and low haze (≈18%), which is unprecedented for polymer foams prepared using foaming methods. Furthermore, these FPI nanofoams demonstrate superior mechanical and thermal insulation properties compared to micron-sized FPI foams and maintain remarkable mechanical flexibility and structural stability even under harsh conditions, including extreme temperatures and water exposure. Transparent nanofoams prepared using a scalable CO 2 foaming method can serve as the next-generation thermal insulation materials, with broad potential applications in energy-efficient buildings, and aerospace.
研究领域:
材料科学
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能源工程
·
化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yang Wang,Yingying Wei,Pengcheng Gao,Si Sun,Qian Du,Zhifei Wang,Yong Jiang
Magnetic material is considered to as a major concern material for the enrichment of histidine-rich proteins (His-proteins) via metal-ion affinity. In this work, magnetic polymer microspheres with core–shell structure (Fe3O4@PMAA@Ni) were successfully prepared via reflux-precipitation polymerization followed by in situ reduction and growth of Ni2+. The obtained Ni nanofoams with flower-like structure and uniform pore size (3.34 nm) provided numerous binding sites for His-proteins. The adsorption performance of Fe3O4@PMAA@Ni microspheres for His-proteins was estimated via selectively separating bovine hemoglobin (BHb) and bovine serum albumin (BSA) from a matrix composed of BHb, BSA, and lysozyme (LYZ). The results indicated that Fe3O4@PMAA@Ni microspheres could efficiently and selectively separate His-proteins from the matrix, with a maximum adsorption capacity of ∼2660 mg/g for BHb. Moreover, Fe3O4@PMAA@Ni microspheres exhibited good stability and recyclability for BHb separation over seven cycles. Therefore, this work reported a novel and facile strategy to prepare core–shell Fe3O4@PMAA@Ni microspheres, which was promising for practical applications of His-protein separation and purification in proteomics.
研究领域:
生物化学
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蛋白质组学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Huaxing Xu,Yinshi Li,Rui Wang
Developing cost-effective electrocatalysts is crucial for oxygen reduction reactions . In this work, a highly active iron-nitrogen co-doped carbon nanofoam is proposed and developed via a facile salt-assisted pyrolysis process of chitooligosaccharides . i) Chitooligosaccharides, a nitrogen-rich polymer with high water solubility and high thermostability, induce a coordination reaction between iron ions and amino/hydroxyl groups, forming large active sites. ii) FeCl 3 /KCl salt, acting as a template, etching agent and catalyst for graphitization , facilitates the formation of pore-rich carbon, leading to enhanced mass transfer and electronic conduction. It has been found that this iron-nitrogen co-doped carbon nanofoam presents competitive activity over commercial Pt/C, as follows: i) a high onset potential approximately 0.965 V, ii) strong durability with a current retention rate of 88% after 30000 s, and iii) excellent fuel tolerance to methanol, ethanol and formate. This work provides a simple, low-cost and environmentally friendly method to prepare iron-nitrogen co-doped carbon materials that has great potential to be extended to other catalysts for energy-related applications.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Siqi Wu,Fei Wang,Shenghua Zhou,Li Long,Zhe Yang,Chuyang Y. Tang
Thin-film composite (TFC) reverse osmosis (RO) membranes fabricated by interfacial polymerization (IP) have been widely applied in seawater desalination. Nevertheless, their separation performance is limited by the permeance-selectivity upper bound. Compared to conventional synthesis/modification techniques, the manipulation of amine monomer distribution for the IP reaction has been far less investigated. In this study, we systematically investigated three classical approaches for m -phenylenediamine (MPD) loading during the IP reaction, i.e., vacuum filtration (TFC-V), roller (TFC-R), and air gun (TFC-A). Our results suggested that the vacuum-assisted approach can greatly enhance the availability of MPD monomers , which could, in turn, result in enhanced “ridge-and-valley” morphology of the polyamide rejection layer as a result of the enhanced nanofoaming effect. Furthermore, the TFC-V membrane demonstrated the highest water permeance of 2.8 ± 0.4 L m -2 h −1 bar −1 compared to TFC-R and TFC-A membranes of 2.1 ± 0.2 L m -2 h −1 bar −1 and 2.1 ± 0.4 L m -2 h −1 bar −1 , respectively. This study provided mechanistic insights to facilitate an improved understanding of membrane synthesis–structure–performance relationships.
研究领域:
材料科学
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环境工程
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产品关联
DOI
高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 12
·2510
·
IF 4.324
Naila Arshad,Iftikhar Ahmed,Muhammad Sultan Irshad,Hong Rong Li,Xianbao Wang,Shafiq Ahmad,Mohamed Sharaf,Muhammad Firdausi,Mazen Zaindin,Muhammad Atif
Clean water scarcity is still an intense, prolonged global issue that needs to be resolved urgently. The solar steam generation has shown great potential with a high energy conversion efficiency for clean water production from seawater and wastewater. However, the high evaporation rate of water cannot be preserved due to the inevitable fouling of solar absorbers. Herein, a self-floatable and super hydrophilic solar-driven steam generator composed of activated carbon coated melamine foam (ACM). The deposited ACM photothermal layer exhibits outstanding solar absorption (92%) and an efficient evaporation rate of 1.27 kg m−2h−1, along with excellent photothermal conversion efficiency (80%) as compared to commercially available primitive solar stills. The open porous assembly of melamine foam equipped with 80% flexibility (0.8 MPa) enabled smooth water transport and sustain heat accumulation within the matrix. The thermal insulation of ACM is 10 times greater than pure water. Moreover, open porous assembly of designed solar-powered steam generator rejects salt ions as well as volatile organic compounds efficiently. The low-cost and facile fabrication of photothermal based water production presents a potential solution to single step drinking water supply from various resources of the sea, the lakes and mixtures of emulsified oil and industrial wastewater.Keywords:activated carbon;melamine nanofoam;nano-desalination;photothermal steam
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
Materials Research Express
·
2019
·Vol. 6
·期 5
·055033
·
IF 1.449
Ying Chang,Pei Liang,Qian-min Dong,De Zhang,Jing Xia,Yong-feng Zhou,Zhi Yu,Jie Huang,Dejiang Ni,Shangzhong Jin
A three-dimensional surface enhanced Raman scattering (SERS) substrate based on graphene nanofoam (GNF)/AgNPs hybrid nanostructure has been prepared using a typical liquid phase reduction synthetic method. The synthesized materials which utilized the three-dimensional framework structure of NF with micropore diameter 50–500 μm were illustrated by scanning electron microscope (SEM) images. Meanwhile, the NF was coated with graphene oxide (GO) evidenced by energy dispersive spectra (EDS) images. In addition, the composite was modified with Ag nanoparticles (AgNPs) whose average size was about 500 nm. The preparation process is very economic and environmental-friendly. The SERS experiment of hybrid nanostructure substrate using Rhodamine 6 G (R6G) as probe molecules showed that the concentration of GO aqueous solution and the Ag NPs growth time were two key factors to determine the intensity of SERS signal and the limit of detection of the hybrid nanostructure is as low as 1 × 10−8 M. 30 different test areas were selected to evaluated the homogeneous SERS platforms, and the RSD is only 8.2%, indicating highly uniformed and reproducibility. In summary, the three-dimensional (3D) substrates by a simple method showed a good sensitivity, stability and reproducibility, and it is promising for application in the field of rapid trace molecule detection in the realistic environment.
研究领域:
材料科学
·
分析化学
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产品关联
DOI
高影响因子
ChemCatChem
·
2024
·
IF 3.8
Hongyu Zhang,Shaojuan Zeng,Chongyang Jiang,Kuilin Peng,Jiaqi Feng,Lei Yuan,Xin Li,Fei Xu,Xiangping Zhang
The application of electrochemical CO2 reduction reaction (CO2RR) to generate value-added products, including carbon monoxide (CO), represents a sustainable strategy for addressing the global carbon balance. Silver (Ag) has gained significant attention as an attractive and cost-effective electrocatalyst for CO2RR-to-CO due to high activity. Here, the porous Ag nanofoam catalysts with Ag(111)-dominant were prepared by in-situ electrolysis-deposition method in the ionic liquid (IL) electrolyte. The Ag nanofoam catalysts exhibited exceptional activity in converting CO2 to CO, with a high Faradaic efficiency (> 95%) in a wide range of -1.9 ~ -2.4 V vs. Ag/Ag+ in the 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) electrolyte. The maximum CO partial current density of -125.40 mA cm-2 was obtained on this Ag nanofoam catalyst, representing 62% improvement over Ag(110)-dominant Ag electrode (-77.35 mA cm-2) at -2.4 V vs Ag/Ag+ in the [Bmim][BF4] electrolyte. Density functional theory calculations demonstrate that the Ag(111) crystal facet formed by in-situ electrolysis-deposition method prefers to adsorb [Bmim][BF4] which can stabilize the reaction intermediate, thereby weakening the reaction free energy and promoting CO2 electroreduction.
研究领域:
材料科学
·
电化学
·
能源转化
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）