JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Zhuge Deli,Li Li,Sun Xueying,Liang Hui,Jin Chenjie,Lu Ailing,Gao Wenli,Zhong Yutong,Li Wenlu,Chen Sihao,Wang Fang,Yan Linzhi,Meng Weiyang,Lin Xiaoji,Zhang Xufei,Liu Yong,Li Yuanfeng,Zhao Yingzheng,Zhang Xiang,Chen Mengchun,Chen Yijie
Phototherapy holds great potential for treating cancer and infections but faces limitations related to photosensitizer accumulation, tissue penetration, and diminished photo-conversion efficiency, particularly in deep-seated tumors and infections. Here, a biomimetic phototherapeutic nanodisc platform consisting of erythrocyte membranes and the photosensitizer IR780 is developed. With the advantages of the ultra-small size and exceptional biosafety of cell membrane-derived nanodiscs, this platform facilitates efficient accumulation and deep tissue penetration at disease sites. Upon near-infrared (NIR) irradiation, IR780 delivered via the nanodisc exhibits enhanced photothermal conversion efficiency, markedly inhibiting tumor growth in an orthotopic 4T1 breast cancer model and reducing bacterial load in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection model. Furthermore, the nanodisc platform demonstrates outstanding biocompatibility in mice. In conclusion, this nanodisc system significantly extends the functional potential of cellular nanodiscs, presenting a promising strategy to address the challenges of photosensitizer delivery and biosafety in phototherapeutic applications.
研究领域:
生物医学工程
·
肿瘤学
·
微生物学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xingliang Dai,Dongdong Liu,Pengyu Pan,Guobiao Liang,Xianwen Wang,Weiwei Chen
Photothermal therapy (PTT) has gained widespread attention due to its significant advantages, such as noninvasiveness and ability to perform laser localization. However, PTT usually reaches temperatures exceeding 50 °C, which causes tumor coagulation necrosis and unfavorable inflammatory reactions, ultimately decreasing its efficacy. In this study, multifunctional two-dimensional Bi 2 Se 3 nanodisks were synthesized as noninflammatory photothermal agents for glioma therapy. The Bi 2 Se 3 nanodisks showed high photothermal stability and biocompatibility and no apparent toxicology. In addition, in vitro and in vivo studies revealed that the Bi 2 Se 3 nanodisks effectively ablated gliomas at relatively low concentrations and inhibited tumor proliferation and migration. Moreover, the multienzymatic activity of the Bi 2 Se 3 nanodisks inhibited the PTT-induced inflammatory response through their high ability to scavenge reactive oxygen species. Finally, the Bi 2 Se 3 nanodisks demonstrated computed tomography capabilities for integrating diagnosis and treatment. These findings suggest that multifunctional Bi 2 Se 3 nanodisk nanozymes can enable more effective cancer therapy and noninflammatory PTT.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2018
·
IF 7.877
Huan Wang,Xiaoyi Wang,Cao Xie,Mingfei Zhang,Huitong Ruan,Songli Wang,Kuan Jiang,Fei Wang,Changyou Zhan,Weiyue Lu,Hao Wang
Heptapeptide ATWLPPR (A7R) binds specifically to vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1) overexpressed in glioma cells, exhibiting high potential to achieve glioma targeted drug delivery . However, in vivo application of A7R peptide remains challenging due to the poor proteolytic stability and inaccessibility of A7R to the brain. To tackle these problems, we identified a glycosylated A7R derivative to enhance in vivo stability and brain transport efficacy. Our results showed that glycosylation of peptide could efficiently improve stability in serum, traverse the blood-brain barrier (BBB) and be uptaken by glioma cells. Furthermore, a novel glioma-targeted drug delivery system was constructed successfully employing glycopeptide as the targeting moiety and nanodisk as the carrier of paclitaxel (PTX). Physicochemical characterization showed that the nanodisk presented suitable size of 50 nm and adequate loading capacity of PTX. Compared to non-glycosylated nanodisk, glycopeptide modification could significantly enhance the uptake of disks by brain capillary endothelial cells through glucose transporter 1 (GLUT1). In vivo imaging and glioma fluorescence section results also indicated that nanodisks modified with glycopeptide showed a higher accumulation in glioma. The glycopeptide-enabled PTX delivery system exhibited superior anti-glioma efficacy in intracranial glioma xenograft model. These results suggested that glycosylation of peptides provided an efficient pathway to design multifunctional and stable brain targeting ligands.
研究领域:
生物医学工程
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 11
·1705516
·
IF 13.325
Ximin Cui,Feng Qin,Qifeng Ruan,Xiaolu Zhuo,Jianfang Wang
2D or pseudo-2D plasmonic Au nanocrystals, such as circular Au nanodisks, possess unique plasmonic properties. Circular Au nanodisks not only possess two large surfaces with circular symmetry but also exhibit the wide tunability for their plasmon resonance. However, the lack of effective synthetic methods for producing size-tunable and monodispersed circular Au nanodisks hinders further studies on their properties and applications. Herein, the synthesis of uniformly sized circular Au nanodisks with synthetically tunable diameters and thicknesses is reported. By performing mild anisotropic oxidation on pregrown Au nanoplates with different thicknesses, the thicknesses of the obtained nanodisks are varied from ≈10 nm to ≈50 nm. The nanodisk diameters are tailored from ≈50 nm to ≈150 nm by controlling the oxidation time. Moreover, both homodimers and heterodimers made of circular Au nanodisks are constructed using molecular linkers. They exhibit rich plasmon modes. In particular, dark multipolar plasmon resonance modes can be excited and observed in the asymmetric heterodimers. Such circular Au nanodisks with controllable sizes, large atomically flat surfaces, and a dominant dipolar plasmon mode are ideal building blocks for constructing plasmonic assemblies and plasmon-coupled systems with desired plasmonic properties and functions.
研究领域:
材料科学
·
纳米技术
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Chaoqun Gu,Yu Yan,Tong Sun,Zhenyu Wang,Sisi Jiang,Wei Zhou,Zonghua Wang
Developing highly active and stable non-noble metal electrocatalysts is an imperious demand to achieve practical H2 production via electrocatalytic water splitting. Herein, cobalt nanodisks (Co Nds) were synthesized on the basal plane of sulfur-vacancy-containing molybdenum disulfide (MoS2–x), resulting in optimized active sites and improved conductivity of MoS2–x without covering the original active sites, the sulfur vacancies, due to the unique nanodisk structure. In addition, the synergistic interaction between the Co Nds and sulfur vacancies further enhanced the catalytic performance of MoS2–x. As a result, the Co Nds/MoS2–x composite demonstrated outstanding electrocatalytic performance for the hydrogen evolution reaction (HER) in both acidic and alkaline solutions, exhibiting low overpotentials (179 mV in 0.5 M H2SO4 and 151 mV in 1.0 M KOH), relatively small Tafel slopes (62.5 mV dec–1 in 0.5 M H2SO4 and 99.8 mV dec–1 in 1.0 M KOH), and superior HER durability at the optimal Co/Mo molar ratio of 0.46. This work provides an innovative design strategy by introducing a sheeted non-noble metallic nanostructure to develop durable high-efficiency pH-universal transition metal dichalcogenide-based HER electrocatalysts.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Jingjing Wang,Guotao Duan,Yue Li,Guangqiang Liu,Weiping Cai
A simple and facile strategy is presented to fabricate the metal nanodisk and nanohole arrays based on a wet etching-assisted polystyrene colloidal lithography. Gold is chosen to demonstrate the validity of such a strategy. The hexagonally arranged Au nanodisk and nanohole arrays are thus fabricated with large area and good uniformity. The structural parameters of the arrays, such as thicknesses, diameters, and spacings of the nanodisks or nanoholes, are facilely tunable and controllable by predeposition conditions, etching conditions and colloidal monolayer structure. More importantly, these arrays can be produced on any supporting substrates, such as conductive or nonconductive and even flexible substrates with flat, rough, or even curved surfaces. In general, the presented strategy is low in cost, simple in operation and arbitrary in substrate, and the as-prepared arrays could find potential devices’ applications with nice compatibility in the fields of optics, surface-enhanced Raman spectroscopy, biosensing, and so forth.
研究领域:
纳米技术
·
材料科学
·
光学
·
生物传感
✓ 已验证
DOI
高影响因子
Optical Materials Express
·
2020
·Vol. 10
·期 4
·1053-1060
·
IF 3.064
Sen Zhang,Lei Feng,Hui Zhang,Mingze Liu,Ting Xu
The electrochromic modulation of plasmonic metasurfaces showing structural colors is a promising strategy to realize dynamic electronic reflective displays. However, hybridizing electrochromic polymers with large-area plasmonic metasurfaces remains challenging. In this study, we present a poly(3,4-ethylenedioxythiophene) (PEDOT)-coated gold nanodisk (PCGN) metasurface, which is fabricated based on techniques of large-area anodic aluminum oxide template-assisted deposition and electrochemical polymerization. Experimental and numerical results demonstrated that fast and reversible electrochromic modulation was realized within the PCGN metasurface. The wavelength control of the localized surface plasmon resonance of the PCGN metasurface originated from the electrically driven refractive index change of the PEDOT layer. The PCGN metasurface is promising for the high yield manufacturing of devices applied in dynamic reflective displays.
研究领域:
材料科学
·
光学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2017
·
IF 13.942
Qun Li,Xianfu Wang,Kai Tang,Mengfan Wang,Chao Wang,Chenglin Yan
Cu-based electrocatalysts have seldom been studied for water oxidation because of their inferior activity and poor stability regardless of their low cost and environmentally benign nature. Therefore, exploring an efficient way to improve the activity of Cu-based electrocatalysts is very important for their practical application. Modifying electronic structure of the electrocatalytically active center of electrocatalysts by metal doping to favor the electron transfer between catalyst active sites and electrode is an important approach to optimize hydrogen and oxygen species adsorption energy, thus leading to the enhanced intrinsic electrocatalytic activity. Herein, Co-doped Cu7S4 nanodisks were synthesized and investigated as highly efficient electrocatalyst for oxygen evolution reaction (OER) due to the optimized electronic structure of the active center. Density-functional theory (DFT) calculations reveal that Co-engineered Cu7S4 could accelerate electron transfer between Co and Cu sites, thus decrease the energy barriers of intermediates and products during OER, which are crucial for enhanced catalytic properties. As expected, Co-engineered Cu7S4 nanodisks exhibit a low overpotential of 270 mV to achieve current density of 10 mA cm–2 as well as decreased Tafel slope and enhanced turnover frequencies as compared to bare Cu7S4. This discovery not only provides low-cost and efficient Cu-based electrocatalyst by Co doping, but also exhibits an in-depth insight into the mechanism of the enhanced OER properties.
研究领域:
材料科学
·
电化学
·
理论计算
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 6
·2828-2833
·
IF 9.931
Yuewu Zhao,Ling Jiang,Li Shangguan,Li Mi,Anran Liu,Songqin Liu
A novel porphyrin-based two-dimensional metal–organic framework (MOF) nanodisk with small size and few layers was prepared by coordination chelation between meso-tetra(4-carboxyphenyl)porphine ligand and Zn(II) paddlewheel metal nodes. With 4,4′-biphenyldicarboxylic acid (BPDC) as nucleation modulator, the anisotropic growth of MOF was impeded by the increased steric hindrance, yielding small Zn–TCPP(BP) MOF crystals. The as-prepared MOF nanodisk exhibited good electrocatalytic activity and selectivity towards nitrite due to the independent distribution of the porphyrin molecules in the framework and the sandwich structure of the prepared Zn–TCPP(BP) nanodisk, which increased the accessible active sites.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS LETTERS
·
2011
·
IF 2.12
Peisong Tang,Haifeng Chen,Feng Cao
Bismuth Tungstate (Bi 2 WO 6 ) nanodisks were synthesized using Bi (NO 3 ) 3 ·5H 2 O and Na 2 WO 4 ·2H 2 O as starting materials by a one-step hydrothermal process in the presence of ethylene glycol. The prepared sample was characterized by powder X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), Brunauer–Emmett–Teller (BET) measurement, Fourier transform infrared spectroscopy (FTIR) and UV–visible diffuse reflectance spectrum (DRS). The prepared Bi 2 WO 6 nanodisks consist of fine particles and possess an optical band gap of 2.76 eV. The photocatalytic experiment demonstrates that the prepared Bi 2 WO 6 nanodisks exhibit high photocatalytic activity for decomposition of Rhodamine B under visible-light, which is ascribed to the unique shaped structures as well as narrow optical band gap.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Kaixiang Huang,Dongmei Li,Liu Yang,Song Liu,Fan Yang
All-inorganic cesium lead halide , a kind of promising semiconductor materials with fantastic properties for photoelectronic and photovoltaic applications, emerged recently. Herein, we report new strategies for synthesizing of trigonal Cs 4 PbBr 6 nanodisks (NDs), which are also of ultrahigh luminescent (PLQY reached 85%). The key points to the high-yield synthesis of perovskite NDs are the elevated concentration of Cs precursor and proper temperature. Transmission electron microscopy studies of reaction products at various stages of the synthesis reveal that the Cs 4 PbBr 6 NDs are built due to a selectivity of the ligands capping the different facets of a seed. Particularly, we find that by using cesium acetate as cesium source instead of cesium carbonate, the geometric construction of NDs is more defined, which indicates that the extra anions have a substantial effect on the perovskite crystal growth kinetics and their morphologies. Our work presents a new opportunity for better understanding the effect of composition, surface chemistry and intrinsic efficient luminescence in perovskite nanoparticles .
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Ning Wang,Jingyi Li,Jie Wang,Di Nie,Xiaohe Jiang,Yan Zhuo,Miaorong Yu
Nanoparticle shape has been recognized as a crucial parameter to affect the transport across various biological barriers, but its impact on drug release and the resulting therapeutic efficacy is less understood. Inspired by erythrocytes with shape-facilitated oxygen-carrying and penetrating abilities, we constructed artificial erythrocyte-like nanoparticles (RNDs) by wrapping discoidal mesoporous silica nanoparticles with red blood cell membrane . We observed that, compared with their spherical and rod-shaped counterparts with monotonic drug release profiles, RNDs displayed an on-demand drug release pattern mimicking natural erythrocytes, that is, they could rapidly release loaded oxygen and doxorubicin (DOX) in hypoxic condition but were relatively stable in high oxygen areas. Besides, the discoidal shape also endowed RNDs with facilitated transport capability in tumor extracellular matrix, contributing to increased tumor permeability. In tumor models, systemically administrated RNDs efficiently infiltrate throughout tumor tissue, successfully relieve tumor hypoxia , and further altered the cancer cell cycle status from G1 to G2 phase, enhancing cancer cell sensitivity to DOX correlated with improved chemotherapy efficacy. In contrast, nanospheres show hampered permeability, and nanorods suffer from insufficient intratumoral drug accumulation. These findings can offer guidelines for the use of particle shape as a design criterion to control drug release, transportation, and therapeutics delivery.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）