CURRENT TOPICS IN MEDICINAL CHEMISTRY
·
2024
·
IF 2.9
Su Hongbing,Lei Hong,Cao Ling,Zhou Xiaoying,Liu Yumeng,Li Ying,Yan Lili,Shaowa Lv,Wang Yanhong,Guan Qingxia
Background: Self-emulsifying nano-phase of traditional Chinese medicine are a research
hotspot. Xiao-Chai-Hu decoction is a commonly used compound decoction in clinical practice,
which is of great research significance. The aim of this study was to isolate and characterize
the self-emulsifying nano-phase and other phases of Xiao-Chai-Hu decoction, and to study the effects
of each phase on acute liver injury.
Methods: The liquid medicine was prepared employing centrifugation followed by dialysis. Single-
factor investigation methodology was utilized to optimize the preparation parameters for both
phases. Characterization of the formulated phase involved analyses such as surface morphology assessment,
measurement of nanoparticle size and Zeta potential using an analyzer, observation of
the Tyndall effect, conducting diffusion and dilution tests, examination under a microscope, and
structural visualization via transmission electron microscopy (TEM). Furthermore, an acute liver
injury model was established in rats through intraperitoneal injection of D-Galactosamine (D-Gal-
N). To assess hepatic function and oxidative stress status, serum levels of alanine aminotransferase
(ALT) and aspartate aminotransferase (AST), superoxide dismutase (SOD) activity, and
malondialdehyde (MDA) content in liver tissue were quantified. The liver coefficients for each
group were calculated as an additional parameter. For histopathological evaluation, liver tissue sections
from the experimental group were stained with Hematoxylin and Eosin (H&E) and examined
microscopically under light conditions. These revisions aim to enhance clarity, correct minor
grammatical errors (such as capitalization of “HE” to “H&E”), and ensure a smoother flow of
information without altering the scientific content of your original text.
Results: Successful establishment and separation of four distinct phases were achieved, including
the self-emulsifying nano-phase, precipitation phase, suspension phase, and true solution phase.
The self-emulsifying nano-phase was characterized as spherical particles with an average diameter
of approximately 100 nm. Pharmacodynamic assessments revealed that both Xiao-Chai-Hu decoction
and its self-emulsifying nano-phase significantly reduced liver coefficients and alanine aminotransferase
(ALT) levels compared to controls (P<0.05). However, no statistically significant differences
were observed in regards to aspartate aminotransferase (AST) concentrations, malondialdehyde
(MDA) content, or superoxide dismutase (SOD) activity between the treatment groups
and control (P>0.05). These findings indicate that both Xiao-Chai-Hu decoction and its self-emulsifying
nano-formulation ameliorated D-GalN-induced acute liver injury, albeit without statistically
distinguishable efficacy between them (P>0.05).
Conclusion: The presence of a self-emulsifying nano-phase within Xiao-Chai-Hu decoction is
confirmed, and this nano-phase emerges as a therapeutically efficacious component in mitigating
acute liver injury.
研究领域:
中药学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 21
·25895-25907
·
IF 2.478
Liu Xiaoling,Tang Zhiming,Xue Jimei,Wei Hanjun,Fan Xiaomeng,Liu Yongsheng,Cheng Laifei
Porous SiCN(Ti) composite ceramics with good microwave absorbing performance were fabricated by pyrolysis of solid polysilazane modified by tetrabutyl titanate. The introduction of Ti not only acted as active filler to react with free carbon in the matrix to form TiC, but also played the role as catalyst to promote the formation of SiC nanowires. Finally, SiCN(Ti) composite ceramics formed a microstructure containing multi-nanophases and multi-nano heterogeneous interfaces when annealing temperature reached 1500 °C. The complex microstructure annealed at 1500 °C made composite ceramics have good matching impedance, as well as greatly increase the interfacial polarization loss and dipole polarization loss. As a result, the TiC/SiC/SiCN composite ceramics showed the excellent performance of electromagnetic wave absorption in X band. The minimum reflection loss (RL) of samples was − 17.1 dB at the thickness of 1.9 mm, and the maximum effective absorption bandwidth (EAB) of composite ceramics was 3.2 GHz when the thickness of sample was 2.1 mm, which exhibited a promising prospect as a structural and microwave absorbing integration material.
研究领域:
材料科学
·
电磁学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED THERMAL ENGINEERING
·
2020
·
IF 4.725
Qiang Chen,Lei Ni,Juncheng Jiang,Trent Parker,Zhiquan Chen,Zhen Cheng,Wei Jiang,Qingsheng Wang
Reaction inhibition is a promising option as an emergency measure to mitigate hazards caused by exothermic runaway reactions. The applications of phase change materials (PCMs) as inhibitors of runaway reactions have been influenced by thermal energy storage technologies. In this work, nano-PCMs powders with silica shells were fabricated using the sol–gel method at alkaline conditions. The prepared nano-PCMs had perfect core–shell microstructures and spherical morphologies, with an average encapsulated PCM particle diameter of 717.34 nm. In addition, the nano-PCMs exhibited high latent heats of fusion (129.1 J g −1 ), which could inhibit the uncontrolled self-heating caused by runaway reactions through conversion of the heats of reaction to the latent heats of PCMs. The homogeneous esterification of propionic anhydride with n -butanol catalyzed by sulfuric acid was chosen as target reaction with risk of exothermic runaway. Inhibition experiments was conducted in a batch reactor coupled with an in situ FTIR spectrometer. The heat transfer performance of reactant flow was studied to analyze the mechanism of thermal runaway inhibition with nano-PCMs. The results revealed that thermal runaway can be halted by applying nano-PCMs and that the reaction can proceed to completion steadily. The effect of Re on heat transfer performance was enlarged with addition of nano-PCMs. The enhancement in the heat transfer coefficient for PCM slurry was proved. Furthermore, the effectiveness of the thermal runaway inhibition can be significantly influenced by the warning temperature, stirring rate, and mass of added nano-PCMs. The applications of nano-PCMs for runaway reaction inhibition holds great potential for use in industrial processes.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2017
·
IF 3.684
Zhongying Wu,Yiyao Tang,Dewen Sun,Shujiang Zhang,Yixuan Xu,Hua Wei,Chenliang Gong
Organic-inorganic hybrid polymers based on poly(arylene ether sulfone) (PAES) containing multi-sulfonated polyhedral oligosilsesquioxane (POSS) pendants (PAES-sPOSS-x) were synthesized to improve the inorganic fillers' distribution in polymer matrix and to enhance the ion conductivity and swelling resistance of aromatic polymer electrolyte membrane. The synthesis of the graft hybrid polymers in this study involves the grafting of mono-functional 3-Iodopropylheptaphenyl POSS with an -OH functionalized polymer main-chain and postsulfonation of the POSS grafted PAES. Notably, nearly all of the benzene rings on the POSS side chains were sulfonated successfully without any sulfonation of main chains. The structure with hydrophobic aromatic backbone and hydrophilic hybrid side chains made an improvement of the nano-phase hydrophilic/hydrophobic separation, thereby facilitating the formation of continuous proton exchange channels. The transmission electron microscopy (TEM) images of the comb-shaped polymer membranes showed homogeneous sulfonated POSS (sPOSS) dispersion, significant phase separation and well-defined interconnected hydrophilic networks. This morphological structure leaded to dramatically enhanced comprehensive properties as proton conductive membranes.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2019
·
IF 6.864
Song Chen,Li Yuan,Zehao Wang,Aijuan Gu,Guozheng Liang
A new strategy to obtain nanodomain structure in thermoset/thermoset blends was developed via different dynamic reactions of cyanate ester (CE) and epoxy (EP) resins in the presence of zinc (II) acetylacetonate and glutaric anhydride. The resulting polymer systems show high mechanical property mainly attributed to EP nanophase and the excellent interfacial interaction between EP nanophase and CE matrix. Owing to the broad glass transition, the polymer systems display thermally activated triple shape memory effects in the temperature ranges of 150–225 °C. Moreover, the systems exhibit thermal self-healing behavior resulting from the transesterification and possible reactions between the residual cyanate ester and epoxy groups , and a 78–83% recovery of fracture toughness for the resulting polymers can be achieved after the first healing schedule of 200 °C/2 h.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2017
·Vol. 56
·期 1
·25-37
·
IF 2.952
Yunji Xie,Di Liu,Danqi Li,Xiaocui Han,Su Li,Zheng Chen,Haibo Zhang,Jinhui Pang,Zhenhua Jiang
A new bisphenol monomer containing a pair of electron-rich tetra-arylmethane units was designed and synthesized. Based on this monomer, along with commercial 4,4′-(hexafluoroisopropylidene)diphenol A and 4,4′-difluorobenzophenone, a series of novel poly(arylene ether ketone)s containing octasulfonated segments of varying molar percentage (x) (6F-SPAEK-x) were successfully synthesized by polycondensation reactions, followed by sulfonation. Tough, flexible, and transparent membranes, exhibiting excellent thermal stabilities and mechanical properties were obtained by casting. 6F-SPAEK-x samples exhibited appropriate water uptake and swelling ratios at moderate ion exchange capacities (IECs) and excellent proton conductivities. The highest proton conductivity (215 mS cm −1 ) is observed for hydrated 6F-SPAEK-15 (IEC = 1.68 meq g −1 ) at 100 °C, which is more than 1.5 times that of Nafion 117. Furthermore, the 6F-SPAEK-10 membrane exhibited comparable proton conductivity (102 mS cm −1 ) to that of Nafion 117 at 80 °C, with a relatively low IEC value (1.26 meq g −1 ). Even under 30% relative humidity, the 6F-SPAEK-20 membrane (2.06 meq g −1 ) showed adequate conductivity (2.1 mS cm −1 ) compared with Nafion 117 (3.4 mS cm −1 ). The excellent comprehensive properties of these membranes are attributed to well-defined nanophase-separated structures promoted by strong polarity differences between highly ionized and fluorinated hydrophobic segments. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 25–37
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED THERMAL ENGINEERING
·
2023
·
IF 6.4
Jinjie Zhang,Guanhua Zhang,Yanping Du,Guomin Cui,Wei Lu,Qiguo Yang
Improving the thermal performance of mini-channels is crucial. The nature of working nanofluids and the mini-channel structure can have a significant impact on the thermal efficiency of mini-channels. This study investigated the flow and heat transfer characteristics of a manifold mini-channel heat sink (MCHS) structure. The working fluids were composite nano-phase change emulsions (NPCE), which were prepared from eicosane, eicosanol, and metal oxide particles (nano-MgO). They possess low supercooling, high thermal conductivity, and high stability. Using these NPCEs, convective heat transfer studies were conducted in the two mini-channels. The impacts of the channel type, NPCEs, and Re on the heat transfer characteristics, flow characteristics, and overall performance were investigated. The results showed that the prepared NPCE can improve the heat transfer coefficient in mini-channels compared to water. The incorporation of nano-MgO particles effectively enhanced the heat transfer capacity with the highest enhancement (17.7%) in the heat transfer coefficient compared to water. The addition of alcohol further enhanced the heat transfer performance. A mixture of 6 wt% eicosane + 1 wt% nano-MgO + 0.6 wt% eicosanol yielded the highest enhancement in the heat transfer coefficient of 29.7%. In addition, a manifold mini-channel was found to have a better comprehensive performance than a rectangular mini-channel. The maximum reductions in pressure drop and thermal resistance of the manifold MCHS were 51.2% and 53.9%, respectively, compared to the rectangular mini-channel. Overall, the evaluated performance indicators of the manifold MCHS with composite nanofluid were 17.9% higher than those of the rectangular MCHS.
研究领域:
工程热物理
·
纳米材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Wenshuo Wang,Pengju Pan,Yongzhong Bao
To meet improved requirements for proton-exchange membranes (PEMs) applied in medium- and low-temperature fuel cells, novel PEMs with superior performance are prepared by using commercial perfluorinated sulfonic-acid ionomer (PFSA) and a dopant, tetraphenylporphyrin tetrasulfonic-acid (TPPS). Different from physically blending PFSA with another polymer or a nano-material, the membrane-forming mechanism of TPPS modified PFSA PEMs is highly dependent on the efficient interaction between PFSA and TPPS molecules. The unique three-part nested hydrophilic-hydrophobic-hydrophilic molecular structure of TPPS plays a crucial role in the co-assembly of PFSA with TPPS. The more intensive ionic cross-linking and hydrogen-bond networks are formed through hydrophilic groups in the outer and internal parts of TPPS and sulfonic-acid groups of PFSA. Meanwhile, secondary cross-linking of these hydrophilic groups is induced by rigid hydrophobic groups in the middle part of TPPS. Therefore, these molecular interactions induce the formation of more stable and stronger nano-phase separation with more uniform size. This novel nano-phase separation structure endows PEMs with elevated applicable temperatures, much increased proton conductivity and thus superior fuel cell performances, which are the keys to the development of more advanced hydrogen fuel cells.
研究领域:
材料科学
·
燃料电池技术
✓ 已验证
DOI
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 19
·9264-9269
·
IF 6.97
Jinxin Liu,Luyang Wang,Yumin Da,Liang Li,Xuefeng Ruan,Mengqi Zeng,Lei Fu
Nanophase graphene frameworks (NGFs) assembled by interconnected domains have massive interfaces, where the interfacial interaction and the compact architectures drastically elevate the durability of graphene towards physical and chemical destruction. The excellent electrical conductivity of the NGFs can be perfectly maintained even after 1500 friction cycles or 3 h flame treatment.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 21
·3615-3626
·
IF 5.342
Quan Zhou,Qi Liu,Yueru Yu,Yuxiao Zhuang,Yizhe Lv,Hanliang Xiao,Ning Song,Lizhong Ni
A novel epoxy-reactive amphiphilic poly(3,4-epoxy cyclohexyl methyl methacrylate)-block-poly(dimethylsiloxane)-block-poly(3,4-epoxy cyclohexylmethyl methacrylate) (PMETHB-b-PDMS-b-PMETHB) triblock polymer was synthesized via atom transfer radical polymerization (ATRP) with a controlled molecular chain length and low dispersion, characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance analysis (NMR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC). It can be found that a nano-microphase structure was obtained by introducing the triblock copolymer to the epoxy matrix following a self-assembly mechanism, and the internal and surface morphology evolution has been evidenced by small-angle X-ray scattering (SAXS), atomic force microscopy (AFM) and transmission electron microscopy (TEM). The morphology of the nano-microphase was interconnected from small-size spherical particles to worm-like structure particles, and transformed into a network structure due to the intermolecular hydrogen-bonding and covalent bond cross-linking ability of the epoxy-reactive PMETHB sub-chain with hardener methyl hexahydrophthalic anhydride (MHHPA). The MHHPA-cured PMETHB sub-chain phase can be deemed as the “anchor chain” structure connecting the two hydroxy ether structural units of the PDMS-rich microphase and matrix, which provided a theoretical basis for the toughening and strengthening rigidity of the thermoset matrix. It has been verified by fracture toughness investigation (KIC) and differential scanning calorimetry (DSC) that the fracture toughness of nanodomain blends was 72.8% higher than that of neat epoxy and Tg increased by 13.5 °C.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Zutao Sheng,Sisi Xiao,Guang Zeng,Qing He,Zhaoyong Chen,Junfei Duan,Sangshan Peng
Pseudo-nanophase separation, enabled by noncovalently grafted sidechains, offers a promising approach for constructing high-performance membranes, featuring rapid ion transport, robust chemical stability, and simplified manufacturing. However, striking a balance between ionic conductivity and mechanical/chemical stability proves challenging since excessive hydrophilic grafting leads to overswelling and compromised integrity of the membranes, rendering them unsuitable for demanding applications like vanadium redox flow batteries (VRFBs). In this study, we describe a new approach for achieving high-performance VRFB membranes via employing polymer as supramolecular sidechains, rather than small molecules. This strategy achieves remarkable pseudo-nanophase separation while minimizing the utilization of functional (hydrophilic) sites. As a result, the resulting membranes exhibit exceptional robustness and proton conductivity, with an extraordinarily low area resistance of merely 0.11 Ω cm 2 , thus circumventing the prevailing trade-off between ionic conductivity and mechanical/chemical stability. Ultimately, VRFBs integrated with these membranes achieve energy efficiencies up to 80 % even at high current densities of 240 mA cm −2 , accompanied by a remarkably low capacity decay rate of 0.064 % per cycle during long-cycle tests. This work not only achieves ultra-high conductivity with minimal functional groups, but also advances pseudo-nanophase separation strategies and provides valuable insights into optimized utilization of limited functional groups in membrane design.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
He Liu,Zhujun Chen,Xinyiming Lin,Xinzeyu Zhang,Ying Cai,Yumeng Zhang,Bin Sun,Xianming Mei,Wei Lyu,Richard B. Kaner,Meifang Zhu,Yaozu Liao
Engineering high-performance stretchable fibrous organohydrogels is of significant importance for precise motion monitoring in next-generation flexible and wearable soft strain sensors due to their stability in various harsh environments. However, owing to the uniformly distributed ion carriers throughout the entire materials, they suffer from an unsatisfactory limit of detection for subtle deformations. Herein, we design an efficient nanophase separation strategy to endow organohydrogels with unevenly distributed and breakable hydrogen bonding networks, serving as pathways for ionic transport, for achieving ultralow-detection-limit and high-stretch-sensitivity fibrous organohydrogels. These fibers consist of poly(vinyl alcohol) (PVA), tetraaniline (TANI), ethylene glycol (EG), and water abbreviated as PTOHF and are prepared using a coaxial wet-spinning combined with an orientational freezing approach. Such a nanophase-separated network features a 28 nm amorphous nanophase rigidly cross-linked by 5 nm nanocrystalline domains. The breakable intermolecular hydrogen bonds in the physical fixed amorphous nanophase facilitate the formation of molecular-scale cracks for an ultralow detection limit (0.005%, 8 μm), while those in the nanocrystalline domains provide PTOHF with high strain sensitivity under large deformation, with gauge factor values of 7.0 at a strain of 180–300% at room temperature and 9.5 at a strain of 140–200% at −40 °C. As a result, as-prepared anti-freezing PTOHF not only enables the detection of human motion and the capture of high-quality pulse waves for real-time healthcare monitoring but also transmits Morse code by detecting the minor deformation of the metacarpophalangeal joints of the fingers. This study opens up a new avenue for designing and fabricating high-performance organohydrogel fibers tailored for precise motion monitoring in next-generation wearable soft strain sensors.
研究领域:
材料科学
·
生物医学工程
·
柔性电子
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）