Multifunctional nanoprobes that can be applied for real-time monitoring or precision treatment of tumors have received wide interest among researchers. However, most of these nanoprobes are obtained through chemical synthesis, and thereby may contain toxic residues or harmful reagents. In this article, a nano-bismuth-sphere-cluster (Bi) is synthesized via a one-step method (after an irradiation with ultra-violet) and is then applied in dual-mode computed tomography/photoacoustic imaging. Bismuth potassium citrate granules, which is a common gastric drug that is highly safe and has a low price (<1 China Yuan/g), is used as the only raw material. The results show that the Bi cluster has good stability with sizes of about 25–55 nm, and a photothermal conversion efficiency as high as 39.67%. After being adsorbed onto doxorubicin, the Bi cluster can be used directly in animal experiments. Due to the effect of enhanced permeability and retention, the probe can easily enter tumor cells. Drug release can be controlled by a near-infrared laser and the acidic environment of tumor cells, which indicates that the combined chemo-photothermal therapy is achieved. This work presents a new dual-mode bio-imaging and combined chemo-photothermal therapeutic nanoprobe that can be applied in theragnostics for tumors.
Mengying Wang,Zixiang Cui,Yongqiang Xue,Aijie Yan,Xing Yu,Xinru Song,Hongxing Li
Nano-bismuth has excellent electrochemical properties. However, it is still unclear how the particle size of nano-bismuth influences its electrochemical thermodynamic properties. In this paper, spherical bismuth nanoparticles with different particle sizes were prepared by solvothermal method; the electrode potentials, the temperature coefficients of the electrode potentials and the thermodynamic functions of reaction for nano-bismuth electrodes with different particle sizes at different temperatures were determined; and the effects of particle size on the electrode potential, the temperature coefficient and the thermodynamic functions were discussed. The experimental results show that particle size of bismuth nanoparticles has a significant influences on the electrochemical thermodynamic properties. The standard electrode potential of the nano-bismuth electrode with a diameter of 39.9 nm was 0.009 V lower than that of the ordinary standard electrode (0.308 V); the temperature coefficient of the electrode potential with a diameter of 39.9 nm was nearly double that of 85.9 nm. With the particle sizes decrease, the standard molar Gibbs energy of reaction, the standard molar enthalpy of reaction, the standard molar entropy of reaction, the molar reversible reaction heat and the temperature coefficient increase; and these quantities are linearly related to the reciprocal of the particle diameter.
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