Journal of Materials Chemistry A
·
2024
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IF 10.7
Ling-Xia Yun,Meng Qiao,Bin Zhang,Hang-Tian Zhang,Jie-Xin Wang
Utilizing plastic wastes as linker sources for metal–organic framework (MOF) synthesis is a green and sustainable methodology for the chemical upcycling of plastics. However, improving the depolymerization efficiency of polymers and avoiding highly corrosive solvents during the purification of the products remain significant challenges. Herein, we propose an approach to efficiently hydrolyze practical poly(ethylene terephthalate) (PET) wastes using aqueous dispersions of ultrasmall ZnO (6 nm) nanoparticles as the catalysts and subsequently synthesize five typical nano-MOFs by one-pot and two-pot strategies. The neutral hydrolysis of PET is greatly accelerated, with PET being completely depolymerized at 200 °C in 60 min with a terephthalic acid yield of 95.6%. The PET-derived MOF nanoparticles present high BET surface areas that are higher than or close to those of congeneric MOFs synthesized from petroleum-based and highly purified ligands. As a water absorbent, the two-pot MIL-101(Cr) exhibits high thermal stability with a water uptake capacity of 1327.3 mg g−1. For photocatalytic degradation of antibiotic pollutants, MIL-53(Al, Fe) samples derived from PET textiles show a high tetracycline removal efficiency of over 90% within 60 min without additives in an aqueous system, outperforming most of the conventionally prepared MOF catalysts. This approach disposes of discarded plastics in an eco-friendly way and produces value-added materials with excellent catalysis and adsorption properties.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
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2020
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IF 6.306
Guohuan Huang,Yuping Yan,Danxia Xu,Jia Wu,Chuanhui Xu,Lihua Fu,Baofeng Lin
Food spoilage is one of the biggest concerns for food safety worldwide. Here, we describe the construction of a carrier for biological agents by chemical combination of porous nanoMOFs and carboxymethylated filter paper (CMFP). When curcumin was encapsulated in nanoMOFs@CMFP, they showed the ability to act as super-long-acting food preserving agents with controllable release of curcumin. Although only 22.3% of curcumin was released into water in 600 h, 65.8% was released into PBS in the same time, and the release into PBS could be tuned by adding citric acid at the time of greatest requirement. Furthermore, the chemical stability of curcumin in nanoMOFs@CMFP was >4.9 times greater than for free curcumin. The outstanding antioxidant and antimicrobial activity of curcumin-loaded nanoMOFs@CMFP paste was demonstrated by prolonging the shelf life of pitayas, which illustrates its potential for development as long-acting and stable preserving paste for use in food preservation.
研究领域:
食品科学
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材料科学
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生物学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Lei Wang,Yuanyuan Liu,Juan Han,Yihan Liu,Huiling Lan,Chunmei Li,Yun Wang
Enzyme-nanoMOFs, a very recent and emerging green biocatalyst, has been widely researched to pursue the improvement of enzyme stability. However, MOFs coating decreases substrate accessibility and possesses nanometer size, thus restraining enzyme activity and controllable recycling. Here, inspired by natural biomineralization , we created a morphology-dependent intelligent [email protected] biocatalyst via rationally in situ tailoring the morphology of enzyme-nanoMOFs for enhancing the combination of substrate aptamers. The resulting [email protected] nanoflowers achieved an “on-demand” tuning of functionality, where self-enriching substrate by substrate aptamers acted in synergy with [email protected] enzyme mimics to significantly boost catalytic activity during biocatalysis. Moreover, after completing the catalytic reaction , easily magnetic separation and then competitive release to automatically start the cyclic catalysis were provided by automatic structure switch of aptamer-cDNA hybridization and aptamer-substrate binding. The degradation of BPA with laccase-Cu 3 (BTC) 2 @P1 reached 4.4-fold improvement in the catalytic efficiency. Laccase-Cu 3 (BTC) 2 @P1 could be controllably recycled to retain 76% initial activity after 8 catalytic cycles. These catalytic and recyclable performances were much better than laccase-Cu 3 (BTC) 2 . The combination of the unique morphology of enzyme-nanoMOFs and performance of aptamers brings hope for the industrial application of intelligent [email protected] systems.
研究领域:
生物技术
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纳米技术
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催化
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环境科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 28
·6139-6147
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IF 5.344
Fan Wang,Jian Yang,Yongsheng Li,Qixin Zhuang,Jinlou Gu
Enzyme-activated prodrug therapy (EAPT) is an effective cancer treatment strategy able to transport non-toxic prodrugs and subsequently convert them into drugs at specific times and locations. However, due to the limitation of easy biodegradability and the membrane-impermeable characteristic of exogenous enzymes, there is a need to exploit suitable carriers for the effective protection and simultaneous delivery of activating enzymes into cancer cells. Herein, hierarchically porous MOFs were employed for the loading of enzyme and prodrug in a single nanocarrier thanks to their different cavity sizes. The simple loading process allows entrapping of horseradish peroxidase (HRP) and a monocarboxyl-containing indole-3-acetic acid (IAA) prodrug with high loading capacities in different spaces, which keeps the catalytic activity of the enzyme perfectly intact and avoids the premature activation of the prodrug. The encapsulated HRP and IAA exhibit sustained and synchronized release behaviors. Compared to the native HRP enzyme, the current MOF nanocarriers not only facilitate enzyme delivery into cellular lysosomes and subsequent endosomal escape, but also effectively release enzyme and prodrug in the intracellular environment within 48 h. Eventually, HRP and IAA loaded MOF nanocarriers cause significant cell death with a low IC50 of 4.2 mg L−1, while the IAA prodrug alone is non-toxic even at high concentrations. Thus, hierarchically porous MOFs might offer a promising platform for EAPT with a highly consistent spatiotemporal distribution of enzymes and prodrugs in target tissues.
研究领域:
药学
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纳米技术
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癌症治疗
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
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2016
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IF 4.035
Meng Chen,Ning Gan,You Zhou,Tianhua Li,Qing Xu,Yuting Cao,Yinji Chen
An ultrasensitive electrochemical aptasensor for simultaneous detection of oxytetracycline (OTC) and kanamycin (KAN) has been developed based on metal ions doped metal organic frame materials (MOFs) as signal tracers and RecJ f exonuclease-catalyzed targets recycling amplification. The aptasensor consists of capture beads (the anti-single-stranded DNA Antibody, as anti-ssDNA Ab, labeled on Dynabeads) and nanoscale MOF (NMOF) based signal tracers (simplified as Apts-MNM, the NMOF labeled with metal ions and the aptamers). Particularly, the MOF (UiO-66-NH 2 ), with large internal surface areas, ultrahigh porosity and abundant amine groups in the pores, was employed as substrates to carry plenty of metal ions (Pb 2+ or Cd 2+ ) and label aptamers of OTC or KAN. Thus, the aptasensor is formed by the specific recognition between anti-ssDNA Ab and aptamers. In the presence of targets (OTC and KAN), aptamers prefer to form targets-Apts-MNM complexes in lieu of anti-ssDNA Ab-aptamer complexes, which results in the dissociation of Apts-MNM from capture beads. With the employment of RecJ f exonuclease, targets-Apts-MNM in supernatant was digested into mononucleotides and liberated the target, which can further participate in the next reaction cycling to produce more signal tracers. After magnetic separation, the enhanced square wave voltammetry (SWV) signals were produced from signal tracers. The aptasensor exhibited a linear correlation in the range from 0.5 pM to 50 nM, with detection limits of 0.18 pM and 0.15 pM (S/N=3) toward OTC and KAN respectively. This strategy provides specificity and sensitive approach for multiplex antibiotics detection and has promising applications in food analysis.
研究领域:
分析化学
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环境科学
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食品安全
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生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jiabin Zhang,Kai Wang,Shiyao Xu,Linlin Chen,Haiquan Gu,Yujie Yang,Qi Zhao,Yurou Huo,Bo Li,Yufei Wang,Yubiao Xie,Nan Li,Jiali Zhang,Jianxu Zhang,Qianxue Li
Vaccines are widely regarded as one of the most effective weapons in the fight against infectious diseases. Currently, vaccines must be stored and transported at low temperatures as high temperatures can lead to a loss of vaccine conformation and reduced therapeutic efficacy. Metal–organic frameworks (MOFs), such as zeolitic imidazole framework-8 (ZIF-8), are a new class of hybrid materials with large specific surface areas, high loading rates, and good biocompatibility and are successful systems for vaccine delivery and protection. Silk fibroin (SF) has a good biocompatibility and thermal stability. In this study, the hepatitis B surface antigen (HBsAg) was successfully encapsulated in ZIF-8 to form HBsAg@ZIF-8 (HZ) using a one-step shake and one-pot shake method. Subsequently, the SF coating modifies HZ through hydrophobic interactions to form HBsAg/SF@ZIF-8 (HSZ), which enhanced the thermal stability and immunogenicity of HBsAg. Compared to free HBsAg, HZ and HSZ improved the thermostability of HBsAg, promoted the antigen uptake and lysosomal escape, stimulated dendritic cell maturation and cytokine secretion, formed an antigen reservoir to promote antibody production, and activated CD4+ T and CD8+ T cells to enhance memory T-cell production. Importantly, HSZ induced a strong immune response even after 14 days of storage at 25 °C. Furthermore, the nanoparticles prepared by the one-step shake method exhibited superior properties compared to those prepared by the one-pot shake method. This study highlights the importance of SF-coated ZIF-8, which holds promise for investigating thermostable vaccines and breaking the vaccine cold chain.
研究领域:
药学
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纳米技术
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免疫学
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疫苗开发
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）