RSC Advances
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2022
·Vol. 12
·期 7
·3924-3930
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IF 4.036
Ting Zhang,Shasha Zhang,Zhenkun Gu,Rudai Zhao,Shiheng Wang,Lutong Guo,Tiesheng Li,Yiqiang Zhang,Yanlin Song
Paper is ubiquitous in the daily life and has been widely used for writing and drawing because of their low-cost, widely accessible, and degradable properties. However, simple ways to fabricate paper-based optoelectronic devices remain a great challenge. In this work, we report a facile method to fabricate high-quality perovskite films and optoelectronic devices on paper by direct pen-writing. Through introducing seed layers on papers, planar-integrated single-crystal perovskite films are easily prepared using commercial pens. Based on such a simple and convenient method, perovskite photodetector arrays and image sensors with graphite electrodes are fabricated on paper, and show satisfactory performances. This method provides a simple and effective approach for preparation of paper-based perovskite devices. It will be of significance for the development of degradable optoelectronic devices.
研究领域:
材料科学
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光学工程
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DOI
PubMed
高影响因子
Biosensors-Basel
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2020
·Vol. 10
·期 12
·211
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IF 3.24
Min-Xin Mao,Rong Zheng,Chi-Fang Peng,Xin-Lin Wei
In this work, a paper device consisted of a patterned paper chip, wicking pads, and a base was fabricated. On the paper chip, DNA–gold nanoparticles (DNA–AuNPs) were deposited and Hg2+ions could be adsorbed by the DNA–AuNPs. The formed DNA–AuNP/Hg2+nanozyme could catalyze the tetramethylbenzidine (TMB)–H2O2chromogenic reaction. Due to the wicking pads, a larger volume of Hg2+sample could be applied to the paper device for Hg2+detection and therefore the color response could be enhanced. The paper device achieved a cut-off value of 50 nM by the naked eye for Hg2+under optimized conditions. Moreover, quantitative measurements could be implemented by using a desktop scanner and extracting grayscale values. A linear range of 50–2000 nM Hg2+was obtained with a detection limit of 10 nM. In addition, the paper device could be applied in the detection of environmental water samples with high recoveries ranging from 85.7% to 105.6%. The paper-device-based colorimetric detection was low-cost, simple, and demonstrated high potential in real-sample applications.Keywords:paper device;signal enhancement;mercury ion;colorimetric detection
研究领域:
分析化学
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环境科学
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纳米技术
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DOI
PubMed
高影响因子
Biomicrofluidics
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2015
·Vol. 9
·期 4
·
IF 3.357
Cai Longfei,Zhong Minghua,Li Huolin,Xu Chunxiu,Yuan Biyu
We describe a simple and cost-effective strategy for rapid fabrication of microfluidic paper-based analytical devices and valves by inkjet printing. NaOH aqueous solution was printed onto a hydrophobic filter paper, which was previously obtained by soaking in a trimethoxyoctadecylsilane-heptane solution, allowing selective wet etching of hydrophobic cellulose to create hydrophilic-hydrophobic contrast with a relatively good resolution. Hexadecyltrimethylammonium bromide (CTMAB)-ethanol solution was printed onto hydrophobic paper to fabricate temperature-controlled valves. At low temperature, CTMAB deposited on the paper is insoluble in aqueous fluid, thus the paper remains hydrophobic. At high temperature, CTMAB becomes soluble so the CTMAB-deposited channel becomes hydrophilic, allowing the wicking of aqueous solution through the valve. We believe that this strategy will be very attractive for the development of simple micro analytical devices for point-of-care applications, including diagnostic testing, food safety control, and environmental monitoring.
研究领域:
分析化学
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生物医学工程
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DOI
PubMed
高影响因子
RSC Advances
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2016
·Vol. 6
·期 20
·16500-16506
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IF 3.289
Min Su,Haiyun Liu,Shenguang Ge,Na Ren,Longhua Ding,Jinghua Yu,Xianrang Song
In this work, a novel paper-based electrochemiluminescence (ECL) immunosensor for ultrasensitive and selective detection of corresponding antigens on living cells was developed employing AuPd nanoparticles as a signal amplifier and macroporous Au-paper working electrodes (Au-PWE) for efficient cell capture. The porous AuPd nanoparticles are chosen as label nanomaterials due to their controllable three-dimensional porosity and peroxidase like activity, large surface area, superior conductivity, and favorable catalytic activity to H2O2 which could enhance the ECL intensity for signal amplification. CdTe QDs and luminol groups as ECL probes were linked with the antibodies to recognize the corresponding antigens on the cell surface and the wide potential range between them compared to conventional antigens sensors could prevent interfacing with each other. Using this strategy, human carcinoembryonic (CEA) and alphafetoprotein (AFP) antigens on living MCF-7 cancer cells as models were quantified serially through a potential scanning way. Significantly, this strategy may be quite promising in cancer early diagnosis due to the excellent analytical performance.
研究领域:
生物医学工程
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分析化学
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肿瘤学
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Shengmei Tai,Hui Cao,Alberta Osei Barimah,Yanan Gao,Chifang Peng,Jianguo Xu,Zhouping Wang
Background Sildenafil (SIL) is regarded as an illegal adulterant in functional foods. Some functional foods doped with SIL have posed significant concern about their safety risks. However, the facile colorimetric detection of SIL is rarely investigated. Results Herein, we prepared a monodispersed spherical composite nanozyme (Fe 3 O 4 –NH 2 /GONRs), possessing excellent peroxidase-like (POD-like) and catalase-like (CAT-like) activities and strong superparamagnetic property. The enzyme-like activities of Fe 3 O 4 –NH 2 /GONRs can be selectively inhibited by SIL due to the synergistic effect of hydrogen bonds and π-π stacking between Fe 3 O 4 –NH 2 /GONRs and SIL. Leveraging this mechanism, a highly sensitive and selective colorimetric detection for SIL with a detection limit (LOD) of 0.26 ng/mL was developed. In addition, we prepared a three-dimensional paper-based analytical device (3D-PAD) for SIL colorimetric detection with naked-eyes and the semi-quantitative analysis with a LOD of 88 ng/mL. Significance The proposed colorimetric and PAD detections demonstrated the advantages of low-cost, highly sensitive and selective, thus have promise application potential in the rapid detection of adulterated functional foods.
研究领域:
食品安全检测
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纳米生物技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2024
·
IF 6.7
Haorui Cao,Kang Mao,Jiajia Yang,Qingqing Wu,Jiming Hu,Hua Zhang
The arsM gene is a critical biomarker for the potential risk of arsenic exposure in paddy soil. However, on-site screening of arsM is limited by the lack of high-throughput point-of-use (POU) methods. Here, a multiplex CRISPR/Cas12a microfluidic paper-based analytical device (μPAD) was constructed for the high-throughput POU analysis of arsM, with cascade amplification driven by coupling crRNA-enhanced Cas12a and horseradish peroxidase (HRP)-modified probes. First, seven crRNAs were designed to recognize arsM, and their LODs and background signal intensities were evaluated. Next, a step-by-step iterative approach was utilized to develop and optimize coupling systems, which improved the sensitivity 32 times and eliminated background signal interference. Then, ssDNA reporters modified with HRP were introduced to further lower the LOD to 16 fM, and the assay results were visible to the naked eye. A multiplex channel microfluidic paper-based chip was developed for the reaction integration and simultaneous detection of 32 samples and generated a recovery rate between 87.70 and 114.05%, simplifying the pretreatment procedures and achieving high-throughput POU analysis. Finally, arsM in Wanshan paddy soil was screened on site, and the arsM abundance ranged from 1.05 × 106 to 6.49 × 107 copies/g; this result was not affected by the environmental indicators detected in the study. Thus, a coupling crRNA-based cascade amplification method for analyzing arsM was constructed, and a microfluidic device was developed that contains many more channels than previous paper chips, greatly improving the analytical performance in paddy soil samples and providing a promising tool for the on-site screening of arsM at large scales.
研究领域:
环境科学
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分子生物学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 43
·20419-20425
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IF 3.591
Siqi Chen,Tingting Li,Donglian Deng,Xiaoyue Zhang,Yibing Ji,Ruijun Li
The integration of paper-based devices with fluorescent nanomaterials as recognition elements has offered novel opportunities for biosensing with enhanced sensitivity and selectivity, as well as stable signals. This work innovatively designed a fluorescent paper-based device for enantioselective sensing of D-alanine (D-Ala), where carbon dots (CDs) grafted cellulose paper (PCD) was used as the fluorophore and the in situ generated gold nanoparticles (AuNPs) were used as quenchers. D-α-Amino acid oxidase (DAAO) stereo-selectively catalyzed D-Ala to produce hydrogen peroxide (H2O2), which mediated the in situ formation of PCD/AuNPs composites and quenched the fluorescence of PCD based on fluorescence resonance energy transfer (FRET). Under optimal conditions, the designed PCD/AuNPs demonstrated a reliable quenching response to D-Ala in the range of 1–100 μM and the limit of detection was 0.55 μM. Moreover, the platform was applied to detect D-Ala in serum, simulated gastric fluid samples, and was further employed to determine D-Ala in BGC-823 gastric cancer cells with satisfactory results. Ultimately, the PCD/AuNPs platform provided a novel strategy for the development of reliable and sensitive assays based on paper-based devices. It has great potential to be utilized in enantioselective sensing and clinical early diagnosis.
研究领域:
分析化学
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生物医学
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材料科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
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2024
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IF 6.7
Shuang Mu,Zhaowei Tian,Wei Ren,Chenghui Liu
Surface-enhanced Raman scattering (SERS) has emerged as a powerful tool for contamination detection. Fabricating efficient nanostructures with hotspots for signal enhancement and concentrating diluted target analyte molecules to the hotspots are critical for ultrasensitive SERS detection, which generally requires advanced instruments and intricate manipulations. Herein, we report a simple, low-cost, and high-efficiency paper device that can simultaneously concentrate the analytes and generate SERS hotspots rapidly with the assistance of laser-induced thermophoresis. After dropping the target- and plasmonic nanoparticle-containing solution on a paper substrate, the evaporative gradient created by the laser-induced thermophoresis can promote the delivery of the analytes and plasmonic nanoparticles simultaneously to the tiny area of the laser spot, forming compact SERS hotspots to significantly amplify the analyte’s Raman scattering signals. This convenient thermophoretic strategy can be accomplished rapidly within ∼4 min and exhibits more than 104-times higher sensitivity than that without the assistance of laser-based thermophoresis. This elegant paper device is successfully applied to the detection of contaminants such as pesticides and nanoplastics in fruit and water samples, holding the potential to provide a simple, fast, and cost-effective approach for on-site detection of environmental contaminants.
研究领域:
分析化学
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环境科学
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材料科学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Lili Yuan,Yongkang Yan,Yiyue Tang,Xueer Huang,Jiajing Liao,Jianmei Zou,Jinfang Nie,Lang Zhang,Shan Liao,Yun Zhang
This study initially reports a distance-based quantitative assay of pyrophosphate ion (PPi) based on analyte-triggered decomposition of metal–organic framework (MOF) in microfluidic paper-based analytical devices (µPADs). The µPADs were created using a mini-cutter machine and a home-use hot-pressing machine for loading one type of MOF of NH 2 -MIL-88 (Fe) prepared with Fe 3+ and fluorescent ligand of 2-aminoterephthalic acid (NH 2 -BDC). Upon sample introduction, the PPi could compete with NH 2 -BDC to bind Fe 3+ , leading to disintegration of the MOF and releasing of the fluorescent ligand in paper channel. The length (distance) of the NH 2 -BDC’s flow trace, when irradiated by a money tester pen, is proportional to the PPi level. The results show that the developed method only requires a ruler to linearly quantify PPi in a concentration range of 0–1000 μM, with a limit estimated to be ∼0.25 μM. Furthermore, recovery of PPi in orange juice and human urine was between 95.72 and 108.11 %, further validating its high detection accuracy. The fabrication method for µPADs offers many attractive advantages kike simplicity, batch production capability and low cost. Moreover, to our knowledge, this may be the first report of a portable quantitative MOF-based PPi assay with distance-based readout in µPADs.
研究领域:
分析化学
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生物医学工程
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材料科学
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DOI
高影响因子
Nanoscale Horizons
·
2018
·Vol. 4
·期 2
·452-456
·
IF 9.391
Yong Zhang,Wenxin Xu,Xiaojie Xu,Wei Yang,Siyuan Li,Jiaxin Chen,Xiaosheng Fang
It has always been a challenge to prepare self-powered ultraviolet photodetectors (UV PDs) utilizing a green, facile and low-cost method. Here, we provide such an approach for fabricating self-powered photodetectors based on Te nanowire/TiO2 nanoparticle (NP) and Te nanowire/ZnO nanoparticle (NP) heterojunctions. It is noteworthy that such devices were prepared via simply brushing non-toxic solution-processed Te nanowires and commercial TiO2 and ZnO nanoparticles onto paper. The as-obtained UV PDs can work under zero bias due to photovoltaic effects from the Te/TiO2 and Te/ZnO heterojunctions. This study not only presents high-performance UV PDs, but also provides a general and effective method for developing environmentally-friendly and energy-efficient optoelectronic devices for practical applications. The concept of employing daily-use brushes and recyclable paper provides a facile way to fabricate green low-cost PDs.
研究领域:
材料科学
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纳米技术
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光电子学
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环境友好型器件
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能源效率
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DOI
高影响因子
LAB ON A CHIP
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2016
·Vol. 16
·期 18
·3460-3465
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IF 5.586
Biao Ma,Yi-Zhen Song,Ji-Cheng Niu,Zhi-Yong Wu
We present a novel electrokinetic stacking (ES) method based on field amplification on a simple paper device for sample preconcentration. With voltage application, charged probe ions in a solution of lower conductivity stack and form a narrow band at the boundary between the sample and the background electrolyte of higher conductivity. The stacking band appears quickly and stabilizes in a few minutes. With this ES method, three orders of magnitude signal improvement was successfully achieved for both a fluorescein probe and a double-stranded DNA within 300 s. This enhanced stacking efficiency is attributed to a focusing effect due to the balance between electromigration and counter electroosmotic flow. We also applied this ES method to other low-cost fiber substrates such as cloth and thread. Such a simple and highly efficient ES method will find wide applications in the development of sensitive paper-based analytical devices (PADs), especially for low-cost point-of-care testing (POCT).
研究领域:
分析化学
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即时诊断
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生物化学
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DOI
PubMed
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 22
·3375-3379
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IF 1.9
Lang Zhang,Jinfang Nie,Huili Wang,Juanhua Yang,Bingyue Wang,Yun Zhang,Jianping Li
Almost all the existing assay methods for alkaline phosphatase (ALP) require expensive analytical instruments and well-trained users to achieve quantitative results. This work initially describes a quantitative ALP assay that integrates low-cost microfluidic paper-based analytical devices (μPADs) with an instrument-free length-measuring readout. The detection motif of length measurement is based on the starch-mediated wettability change of the μPAD from hydrophilic to hydrophobic. Under optimal conditions, this new method is quantitatively sensitive to ALP levels in buffer samples ranging from ∼0.075 to 5 U mL−1, with a visual detection limit of 0.075 U mL−1. The satisfactory recovery results of assaying several human serum samples additionally prove its practicability. The proposed method needs only a ubiquitous cheap ruler to realize quantitative analysis, thus making it a simple, cost-efficient, and promising alternative tool for potential broad applications in the diagnosis of ALP-relevant diseases or assessment of ALP functions in biological systems especially in resource-poor settings.
研究领域:
生物化学
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分析化学
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即时诊断
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生物医学工程
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DOI
高影响因子
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