ANALYST
·
2018
·Vol. 143
·期 8
·1899-1905
·
IF 3.864
Wei Ji,Xue Zhang,Jianzhang Zhao,Ye Gao,Wei Song,Yukihiro Ozaki
A simple and ultrasensitive surface-enhanced Raman scattering (SERS) assay for heparin detection has been demonstrated based on an in situ hot spot assembly method using N,N′-bis[3,3′-(trimethylammonium)propylamine]-3,4,9,10-perylenediimide (bis-quaternized perylene dye, abbreviated as BQPER). In this assay, a BQPER probe with two positive charges is employed as both Raman reporter and electrostatic bridge to cause the aggregation of citrate-capped Ag nanoparticles (Ag NPs), resulting in a strong SERS signal due to the formation of numerous hot spots in the gaps of the aggregates. The SERS intensity of BQPER decreases in the presence of heparin, because BQPER binds primarily to heparin due to its high anionic charge to mass ratio compared to that of Ag NPs. Accordingly, a novel method for the detection of heparin has been developed based on SERS of the unbound BQPER probe. Two obvious advantages of the proposed heparin assay over other reported methods are: its much wider linear concentration range (10−5–10−10 g mL−1) and lower limit of detection (0.08 ng mL−1). Besides, our proposed heparin assay has been successfully applied to the detection of heparin in serum samples, indicating its great potential in the diagnosis of heparin-related diseases. This work provides a new Raman probe for the SERS analysis of heparin and opens a different perspective for SERS-based transducer design in charged analytes.
研究领域:
生物医学分析
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纳米技术
·
药物检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Lei Sun,Hao Guo,Zhilan Pan,Bingqing Liu,Ning Wu,Yinsheng Liu,Zongyan Lu,Xiaoqin Wei,Wu Yang
Owing to the high toxicity of acetaminophen (ACOP) and 4-aminophenol (4-AP) when they are overused, the simultaneous determination of ACOP and 4-AP is crucial. In this present paper, an electrochemical sensor based on the nanocomposite of sulfurbridged covalent triazine frameworks (S-CTFs) and in situ formed nickel cobaltite (NiCo 2 O 4 ) nanoflowers on S-CTFs, denoted as S-CTFs@NiCo 2 O 4 , was fabricated for the first time for sensitive detection of ACOP and 4-AP. S-CTFs@NiCo 2 O 4 modified electrode exhibited the outstanding synergetic effects of S-CTFs (prominent enrichment ability and large surface area) and NiCo 2 O 4 (excellent electrocatalytic activity). The developed electrode had the advantages of high reproducibility, repeatability, anti-interference and stability, and it exhibited a wide linear concentration range (2 ∼ 360 μM) and a low limit of detection (0.18 μM and 0.35 μM) for ACOP and 4-AP, respectively. In addition, the designed electrochemical sensor was evaluated towards the detecting ACOP and 4-AP in real samples with satisfactory recovery, illustrating that electrode has a broad prospect in the clinical application.
研究领域:
分析化学
·
电化学
·
纳米材料
·
药物分析
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Su-Juan Li,Zhen-Zhen Qi,Zhi-Wen Luo,Shuang Miao
Solvothermal method was used to synthesize a unique nanostructure with hedgehog shaped microspheres assembled by ordered Mn 2 CuO 4 nanobelts, which was characterized by SEM, TEM and XRD. These Mn 2 CuO 4 microspheres were loaded on graphene oxide (GO) support to form Mn 2 CuO 4 /GO nanocomposites, and its application for highly efficient sensing of hydrogen peroxide (H 2 O 2 ) was demonstrated. The CV and amperometry results indicated that Mn 2 CuO 4 /GO nanocomposites exhibited superior electrocatalytic performance over Mn 2 CuO 4 for H 2 O 2 detection. The developed sensor shows a high detection sensitivity (838.9 μA mM cm -2 ), a wide linear concentration range (0.5-2352 μM), and a low limit of detection (20 nM). In addition, the Mn 2 CuO 4 /GO based H 2 O 2 sensor possesses good reproducibility, stability, selectivity and effective sample application.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Yuanyuan Shao,Chenchen Song,Zeyi Yue,Sheng Peng,Wuduo Zhao,Wenfen Zhang,Shusheng Zhang,Gangfeng Ouyang
Sensitive detection of trace Phthalate esters (PAEs) in ambient air has great significance for environmental supervision and human health. In this research, a sensitive analytical method was established to determine trace PAEs in ambient air by combining the needle trap device (NTD) with gas chromatography-mass spectrometry (GC–MS). The operating parameters were optimized for the PAEs detection. In addition, the preservation capacity and repeatability of the sampling needle were also investigated. Under the optimized conditions of sampling flow rate of 5 mL min -1 , breakthrough volume of 100 mL, desorption temperature of 290 ºC, and desorption time of 150 s, the satisfactory extraction stability (intraday and daily) of PAEs with relative standard deviations (RSDs) was less than 10%, and the average recovery was ranged from 88.89% to 93.77% within seven days. The wide linear concentrations of 0.04 µg L −1 -10 µg L −1 and low detection limits of 0.050–3.6 ng m −3 demonstrated that the established method based on the micro-extraction device of NTD was competitive and had a potential application for trace PAEs in ambient air.
研究领域:
环境科学
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分析化学
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公共卫生
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2019
·Vol. 145
·期 2
·619-625
·
IF 4.019
Nuo Zhang,Yaoguang Wang,Guanhui Zhao,Chao Wang,Yueyuan Li,Yong Zhang,Huan Wang,Qin Wei
An ultrasensitive label-free photoelectrochemical (PEC) immunosensor was developed to detect amyloid β-protein (Aβ) based on CdS/CdTe-cosensitized SnO2 nanoflowers. Specifically, SnO2 with a flower-like porous nanostructure was utilized as a perfect substrate for the construction of PEC immunosensors, and the SnO2-modified electrode was first coated with CdTe quantum dots (QDs) and then further deposited with CdS by successive ionic layer adsorption and reaction techniques. The formed SnO2/CdS/CdTe-cosensitized structure exhibited excellent photocurrent intensity and was employed as an excellent photoactive matrix to immobilize Aβ antibody to further construct the immunosensor. Under optimal conditions, the as-constructed PEC immunosensor was used to detect Aβ and exhibited a wide linear concentration range from 0.5 pg mL−1 to 10 ng mL−1, with a low limit of detection (LOD, 0.18 pg mL−1, S/N = 3). Meanwhile, it also presented good reproducibility, specificity, and stability and may open a new promising platform for the clinical detection of Aβ or other biomarkers.
研究领域:
生物传感器
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纳米技术
·
光电化学
·
分析化学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Lisi Wang,Xiaoqing Li,Yijing Ai,Xiao Han,Mansoor Ahmad,Xiaoping Zhang,Amir Badshah,Wei Sun,Hongji Li
A novel electrochemical method for sensitive detection quercetin (QU) was constructed with graphitic carbon nitride (g-C 3 N 4 ) and black phosphorene (BP) composite (g-C 3 N 4 @BP) modified carbon ionic liquid electrode (CILE) as signal amplified interface. g-C 3 N 4 @BP was synthesized by a hydrothermal method with the characteristics investigated by SEM, XPS, FT-IR, XRD and electrochemical methods. Electrochemical behaviors of QU on the modified electrode (g-C 3 N 4 @BP/CILE) was investigated with the electrochemical parameters calculated and the experimental conditions optimized. The excellent electroanalytical result of QU was realized with the linear concentration range from 5.0 nmol/L to 90.0 µmol/L and a lower detection limit of 1.7 nmol/L (3σ). It was proved that the composite exhibited the synergistic effect of BP and g-C 3 N 4 with more active sites, porous structure, large specific surface area, good electrical conductivity and strong electrocatalytic activity. The g-C 3 N 4 @BP/CILE was successfully used to detect the practical drug and food samples with satisfactory recoveries.
研究领域:
分析化学
·
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 30
·3642-3649
·
IF 3.1
Kai Zhang,Xiaoyuan Zhang,Yanqin Rong,Qingfang Niu,Pengyue Jin,Xuewen Ma,Cheng Yang,Wenting Liang
Ractopamine (RAC) is universally known for improving lean meat percentage in livestock and thus is widely introduced as a feed additive. However, it is difficult to eliminate the RAC residue in animal tissues from the biological system and will inevitably harm human health. Hence, detecting RAC molecules in biological samples is extremely significant. Herein, a novel strategy of supramolecular recognition-enhanced electrochemical sensing is presented. This platform was constructed by coupling β-cyclodextrin (β-CD) with palladium nanoparticles (Pd NPs)-functionalized three-dimensional reduced graphene oxide (3D-rGO) to form a nanocomposite (3D-rGO/Pd/β-CD), which was further used to modify a glassy carbon electrode (GCE) for RAC detection. Benefiting from the attractive electrical conductivity and catalytic activity of 3D-rGO/Pd, as well as the unique small-molecule-recognition ability of β-CD demonstrated by 1H NMR spectrum, which revealed the 1 : 2 binding mode of RAC with β-CD, increased peak current signals of RAC were observed in the cyclic voltammetry (CV) test. Under optimized conditions, the wide linear concentration range spanned 1–95 μM, along with a relatively low detection limit of 0.12 μM (S/N = 3), as evidenced by the differential pulse voltammetry (DPV) approach. The platform also exhibited satisfactory stability and fine reproducibility, as well as high selectivity and good anti-interference capability. Moreover, this as-obtained sensor was efficiently applied in pork samples with a high recovery rate (96.44–103.99%), which provides a promising view of its electrochemical biosensing ability in practical applications.
研究领域:
分析化学
·
纳米技术
·
电化学
·
生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROANALYSIS
·
2019
·Vol. 31
·期 7
·1390-1400
·
IF 2.691
Ying Wang,Xamxikamar Mamat,Yongtao Li,Xun Hu,Ping Wang,Yemin Dong,Guangzhi Hu
In this study, a molybdenum disulfide/multiwalled carbon nanotubes (MoS 2 @MWCNTs) nanocomposite was synthesized by employing a simple hydrothermal method. The flower-like structure of the MoS 2 @MWCNTs was characterized via scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the load of crystalline MoS 2 was verified via X-ray diffraction (XRD) and energy-dispersive spectroscopy (EDS). The as-prepared MoS 2 @MWCNTs nanocomposite was used to modify glassy carbon electrode (GCE) as an electrochemical sensor for detecting aristolochic acids (AAs). With the optimized parameters, the proposed electrochemical sensor exhibited good sensitivity and a broad linear concentration range for detecting AAs from 0.2 to 10 μ mol/L and 10 to 100 μ mol/L, with the sensitivity of −3.10 μ A/( μ mol/L) and −0.91 μ A/( μ mol/L), respectively. The detection limit was also calculated as 0.06 μ mol/L (S/N=3) based on the low background signal. Furthermore, the modified electrochemical sensor exhibited good selectivity, repeatability, reproducibility, and stability, thus showing potential application for detecting AA in chinese herbs with good mean recovery and accuracy. In other words, the MoS 2 @MWCNTs/GCE can be used as an excellent platform to detect AAs.
研究领域:
分析化学
·
纳米材料
·
电化学
·
药物分析
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）