CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yuheng Zhang,Wen Xue,Jinghong Liu,Jing Yang,Hanyang Song,Xiashi Zhu
2D/2D S-scheme heterojunction membrane of covalent triazine frameworks@TiO 2 (CTFs@TiO 2 ) was fabricated through electrospinning, hydrothermal reaction, and vapor-assisted in situ polymerization. This hierarchical structure was composed of TiO 2 nanosheets uniformly grown on electrospinning fiber, and the loading of tiny CTFs flakes. The CTFs@TiO 2 heterojunction membrane achieved complete removal of antibiotic and dyes within 100 min of visible light irradiation. This highly enhanced photoactivity and hierarchical morphology also exhibited strong anti-fouling ability that backwash and photo-induced self-cleaning were responsible for membrane regeneration. In dynamic photocatalysis-separation system, the constructed membrane was capable of simultaneous purification of multiple pollutants of organics and oils, indicating the satisfactory adaptability and practical value. Based on XPS, DRS and selective deposition of Pt, a possible mechanism on the formation of S-scheme heterojunction, and an optimal state of “efficient match” between CTFs and TiO 2 nanosheets were proposed.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Expert Opinion on Drug Delivery
·
2024
·
IF 5
Zhutian Zhang,Qian Ma,Zhaoxing Dai,Jiaxu Hong,Jifeng Gu,Rong Shi,Jianjiang Xu,Yaling Ma,Xinghuai Sun,Jianguo Sun
Background Glaucoma is one of the major irreversible blinding eye diseases in the world. Reducing intraocular pressure (IOP) is the primary treatment option, and taking eye drops daily is the common method. However, short drug duration and poor bioavailability of eye drops may lead to unsatisfied therapeutic effects and inadequate patient compliance.Methods A brimonidine-loaded silicone rubber insert (BRI@SR@PT) was prepared by loading brimonidine into a surface-modified silicone rubber ring, followed by polydopamine/thermoplastic polyurethane coatings. The physical properties, in vitro cytocompatibility and drug release of BRI@SR@PT were investigated. The BRI@SR@PT was administrated in the conjunctival sac of rabbit eyes, and its in vivo drug release, IOP-lowering efficacy and biosafety were assessed.Results The BRI@SR@PT presented great thermal stability and excellent elasticity. The BRI@SR@PT was able to release BRI sustainably for 28 days with little toxicity in vitro. Compared to BRI eye drops, the BRI@SR@PT effectively lowered IOP for 21 days based on the sustained BRI release with great biosafety when administrated in conjunctival sac of rabbit eyes in a noninvasive fashion.Conclusions The conjunctival sac insert (BRI@SR@PT), as a promising drug-delivery platform, may provide a sustained IOP-lowering treatment for patients with ocular hypertension or glaucoma, without the need for invasive procedures.
研究领域:
药剂学
·
眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 35
·期 17
·175404
·
IF 2.9
Yafei Xu,Cong Yan,Hongfei Liang,Sheng Huang,Ping Feng,Jian Song
Silicon solar cell is the most mature photovoltaic conversion device, and in order to further improve the performance of the device, application of downshifting films has become a research hotspot. In this paper, CsPbBr3 perovskite quantum dot/EVA composite adhesive film was prepared by melting method with CsPbBr3 perovskite quantum dot film under solution processing as masterbatch and EVA particles as excipient. The effect of synthesis conditions on the luminescence properties of the composite films were thoroughly studied. The optimized CsPbBr3 perovskite quantum dot/EVA composite adhesive film has excellent performance, and its light transmission reaches 85%. The CsPbBr3 perovskite quantum dot/EVA composite adhesive film absolutely improves the efficiency of silicon solar cells by 1.08%, which is much higher than that of pure EVA adhesive film (0.63%). In addition, the device efficiencies have almost no change after 30 d in the air, maintaining the working stability of the device and contributing to industrial applications. This study provides a novel, industrial and low-cost synthesis route for the synthesis of CsPbBr3 perovskite quantum dot/EVA composite adhesive film, which is expected to have broad application.
研究领域:
材料科学
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光伏技术
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纳米技术
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Yanbai Chen,Wenxuan He,Jun Li,Yarui Tan,Lin Chen,Hongxing Shi,Shuai He,Yau Kei Chan,Yi Deng
Ferroelectric materials with piezoelectric and pyroelectric properties have shown promise for antimicrobial therapy by generating reactive oxygen species (ROS) under external stimuli. However, the single catalytic approaches relying on either piezoelectric or pyroelectric effect compel ferroelectric materials to yield inadequate ROS, ultimately dampening the sterilization speed and efficiency. To address the daunting issue, a dual catalytic membrane composed of BaTiO 3 /MgO 2 and electrospun poly (lactic-co-glycolic acid) nanofibers is devised, which integrates both pyroelectric and piezoelectric effects of BaTiO 3 by encapsulating polydopamine. The dual catalytic membrane potentiates polarization charge generation under ultrasound and near-infrared stimulation. Subsequently, the polarized charge participates in the generation of germicidal ·OH by reacting with H 2 O 2 from MgO 2 , thus achieving rapid antimicrobial activity. More intriguingly, in vitro and in vivo experiments have demonstrated that the dual catalytic membrane substantially facilitates cell proliferation and promotes the regeneration of infected wounds through bacterial slaughter, NF-κB inflammatory pathway inhibition, pro-angiogenesis, as well as collagen deposition. As envisaged, such a proposal provides a bright prospect for ferroelectric materials in addressing acute infections and advancing the remediation of refractory infected wounds.
研究领域:
材料科学
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生物医学工程
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感染与免疫
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Immunology
·
2021
·
IF 7.561
Wu Binxin,Gao Furong,Lin Jianhua,Lu Lixia,Xu Huiming,Xu Guo-Tong
Allergic conjunctivitis (AC) is the most prevalent form of mucosal allergy, and the conditioned medium (CM) from mesenchymal stem cells has been reported to attenuate some allergic diseases. However, the therapeutic effects of CM from different tissue stem cells (TSC-CM) on allergic diseases have not been tested. Here, we studied the effects of topical administration of different human TSC-CM on experimental AC (EAC) mice. Only human amniotic epithelial cell-CM (AECM) significantly attenuated allergic eye symptoms and reduced the infiltration of immune cells and the levels of local inflammatory factors in the conjunctiva compared to EAC mice. In addition, AECM treatment decreased immunoglobulin E (IgE) release, histamine production, and the hyperpermeability of conjunctival vessels. Protein chip assays revealed that the levels of anti-inflammatory factors, interleukin-1 receptor antagonist (IL-1ra) and IL-10, were higher in AECM compared to other TSC-CM. Furthermore, the anti-allergic effects of AECM on EAC mice were abrogated when neutralized with IL-1ra or IL-10 antibody, and the similar phenomenon was for the activation and function of B cells and mast cells. Together, the present study demonstrated that AECM alleviates EAC symptoms by multiple anti-allergic mechanisms mainly via IL-1ra and IL-10. Such topical AECM therapy may represent a novel and feasible strategy for treating AC.
研究领域:
眼科学
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免疫学
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干细胞治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Fiber Materials
·
2024
·Vol. 6
·期 1
·278-296
·
IF 17.2
Cui Jie,Cai Yuchen,Yu Xiao,Shen Yihong,Zhou Tianyi,Sun Binbin,Cai Pengfei,Yuan Zhengchao,Shafiq Muhammad,EL-Newehy Mohamed,EL-Hamshary Hany,Zhou Xingping,Fu Yao,Mo Xiumei
The conjunctiva is crucial in safeguarding the eye from harm or infection, thereby ensuring the preservation of the vision. The repair of infected conjunctival damage is necessary. The objective of this study is to develop copper-doped flexible silica nanofibers (SiO 2 @Cu NFs) with multifunctional antibacterial and anti-inflammatory characteristics. The continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive functions. Nanofiber membranes also exhibit biocompatibility and promote cell growth, angiogenesis, and inflammation modulation. In vivo evaluations further reveal the therapeutic efficacy of SiO 2 @Cu NFs to promote the structural and the functional recoveries of the conjunctiva. Taken together, SiO 2 @Cu NFs may hold significant promise for the fabrication of alternative ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines. Graphical Abstract Schematic diagram showing the fabrication of SiO 2 @Cu NFs for the regeneration of infected conjunctiva.
研究领域:
生物材料学
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眼科医学
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组织工程学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 5
·2848-2853
·
IF 3.361
Xiaoliang Ren,Shufang Wang,Xiaoshu Ding,Dongsheng Zhang,Yanji Wang
In the chemical industry, reactors are typically designed and filled with supported catalyst particles. However, the intrinsic problems associated with the internal/external diffusion effect and catalyst separation/loss in these traditional reactors can be very challenging to mitigate. To address these issues, herein, an active metal sintered membrane reactor anchored with Pt atoms was successfully developed, and applied into continuous, liquid-phase, hydrogenation processes. The catalyzing reactions transpired on the active sites that were fastened onto the surface of the reactor's microchannels. As a result, the mass transfer at the gas–liquid–solid three-phase was greatly enhanced, and an incredibly high reaction efficiency was obtained. The novel, active reactor demonstrated a superior catalytic performance and stability to nitrobenzene (NB) hydrogenation at 120 °C and 0.5 MPa H2, which enabled an aniline (ANI) yield of 19.28 molANI h−1 L−1. This work opens a new window for the design of high-performance gas–liquid–solid reactor toward multiphase catalytic reactions.
研究领域:
化学工程
·
催化材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Pharmaceutical Analysis
·
2025
·
IF 8.9
Jiawei Li,Pengyue Liu,Yue Zhang,Fan Yang
Allergic conjunctivitis is a common ocular surface condition. Although corticosteroids are potent anti-inflammatory agents for its management, their use is often restricted by potential side effects. Conventional eye drops face challenges such as short retention time and poor corneal permeability, resulting in low drug bioavailability. To overcome these limitations, we developed a preservative-free synthetic high-density lipoprotein (sHDL) nanodisc eye drop containing dexamethasone palmitate. This novel formulation enhances drug stability and extends retention time on the ocular surface. In a mouse model of ovalbumin (OVA)-induced allergic conjunctivitis, the nanodisc eye drop significantly alleviated symptoms while reducing corticosteroid concentration, demonstrating excellent safety and biocompatibility. This innovative approach shows great promise for the treatment of allergic conjunctivitis and may lay the groundwork for new therapeutic strategies in anterior ocular disease management.
研究领域:
眼科
·
药物递送系统
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
iScience
·
2023
·
IF 5.8
Yi Lin,Wangdu Luo,Bingcai Jiang,Qianyi Lin,Min Tang,Xiangji Li,Lin Xie
Excessive scarring is the main cause of surgical failure in glaucoma filtration surgery. S58 has been shown to have an excellent antifibrotic effect but its duration of action is not sufficient to achieve the desired antiscarring effect. In this study, a light-cured bioadhesive hydrogel composed of GelMA and oxidized dextran (ODex), namely, GelDex, was used to load S58 (GelDex-S58). The microscopic morphology of GelDex-S58 appeared to be a porous structure with good slow-release properties and suitable degradation time. Cell Counting Kit-8, cell scratch and transwell assays showed that GelDex-S58 significantly reduced TGF-β-induced fibroblast proliferation, increased migration and invasion ability. In in vivo studies, GelDex-S58 treatment prolonged follicular retention, reduced mean intraocular pressure, and significantly reduced collagen deposition and α-SMA expression levels in the conjunctival tissue compared to treatment with S58 alone. In conclusion, GelDex-S58 could reduce scar formation after glaucoma filtration surgery.
研究领域:
眼科
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Xue Sun,Haohao Cui,Jingfan Li,Boyuan An,Ruixing Liu,Zhihua Guo,Dandan Chu,Xingchen Geng,Bingbing Cui,Lei Zhu,Jingguo Li,Zhanrong Li
Subconjunctival fibrosis (SCF) is a common and refractory eye disease that is a serious threat to vision. The severe side effects of existing drugs and low drug bioavailability due to the ocular barrier are major challenges in SCF treatment. Hence, there is an urgent need to explore safer and more effective strategies for administering anti-SCF drugs. Herein, an injectable and adaptable hydrogel system containing the antifibrotic drug rapamycin was fabricated to address this complex need. This system possesses moderate mechanical properties, self-healing and shape-adaptive capabilities, injectability, and biosafety. It is designed to promote autophagy by modulating the PI3K/AKT/mTOR/WIPI2 pathway, thereby inhibiting SCF. In vivo experiments utilizing a rat subconjunctival injury model indicated that in situ administration of this hydrogel system effectively inhibited SCF. This system constitutes a promising method for promoting autophagy to protect against SCF, which will foster its widespread application for other fibrotic diseases.
研究领域:
眼科学
·
药学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Jinbin Liu,Huanglan Yan,Dengning Xia
Corneal neovascularization (CNV) severely compromises vision and remains difficult to manage with current pharmacotherapies, which are often limited by rapid drug clearance, poor tissue penetration, and adverse effects. Although polymer-based drug carriers can provide sustained drug release, they frequently suffer from low drug-loading capacity, suboptimal release kinetics, or induce inflammatory responses. Tacrolimus (FK506), a potent immunosuppressant with anti-inflammatory activity, is similarly limited by poor water solubility and rapid ocular clearance when administered as eye drops. In this study, we developed a polymer-free tacrolimus microsphere system using an emulsion-solvent evaporation method. The resulting microspheres exhibited uniform morphology (6.8 ± 1.0 μm) with a high drug-loading capacity (up to 98 ± 2 %) and a dense amorphous internal structure. In vitro , the microsphere showed a sustained release profile, reaching 85 % cumulative release by Day 30. In a rat CNV model, subconjunctival injection of tacrolimus microsphere maintained elevated drug concentrations in the cornea (81.0 ± 21.2 ng/g) and sclera (114.2 ± 34.9 ng/g) for at least one month and significantly suppressed CNV progression, reduced corneal opacity, and decreased the expression of inflammatory (TNF-α, IL-1β) and angiogenic (VEGF) markers. Histological analysis further confirmed improved corneal architecture, minimal inflammatory infiltration, and reduced neovascularization. In contrast, tacrolimus eye drops demonstrated limited therapeutic benefit and rapid clearance. Overall, these findings highlight polymer-free tacrolimus microsphere as a promising long-acting delivery platform for effective CNV management upon subconjunctiva injection, with the potential to improve therapeutic outcomes by enabling sustained drug release and reducing administration frequency.
研究领域:
药剂学
·
眼科学
·
药物递送
·
纳米技术
·
免疫药理学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Jinhui Lu,Xiaomeng Zhu,Meng Zhang,Xunchan Jiang,Wei Guo,Feng Jiang,Feng Cao
Investigating the structural integrity of carriers in transit from ocular surface to ocular posterior segment is essential for an efficient topical drug delivery system. In this study, dual-carrier hydroxypropyl-β-cyclodextrin [email protected] ( [email protected] ) nanocomposites were developed for the efficient delivery of dexamethasone . Förster Resonance Energy Transfer with near-infrared I fluorescent dyes and in vivo imaging system were used to investigate the structural integrity of [email protected] nanocomposites after crossing Human conjunctival epithelial cells (HConEpiC) monolayer and in ocular tissues. The structural integrity of inner HPCD complexes was monitored for the first time. The results suggested that 23.1 ± 6.4 % of nanocomposites and 41.2 ± 4.3 % of HPCD complexes could cross HConEpiC monolayer with an intact structure at 1 h. 15.3 ± 8.4 % of intact nanocomposites could reach at least sclera and 22.9 ± 1.2 % of intact HPCD complexes could reach choroid-retina after 60 min in vivo , which showed that the dual-carrier drug delivery system could successfully deliver intact cyclodextrin complexes to ocular posterior segment. In conclusion, in vivo assessment of structural integrity of nanocarriers is greatly significant for guiding the rational design, higher drug delivery efficiency and clinical transformation for topical drug delivery system to the posterior segment of the eye.
研究领域:
药学
·
眼科
·
纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）