Surfaces and Interfaces
·
2025
·
IF 6.3
Xiaoyu Chen,Jianwei Zhang,Hengtong Xia,Zhihao Chen,Xiaoshuang Yin,Ying Liu,Wenzhong Yang
Scale and biofouling are two critical problems in industrial circulating cooling water systems, urging the development of innovative solutions to address both issues simultaneously. The direct usage of liquid scale inhibitors and biocides often fails to provide long-term effective control and results in significant wastage of agents. In this work, the melamine formaldehyde resin/clove oil/1‑hydroxy ethylidene-1,1-diphosphonic acid (MCH) microcapsules were successfully synthesized by double emulsion water-in-oil-in-water (W/O/W) in-situ polymerization method. The 1‑hydroxy ethylidene-1, 1-diphosphonic acid (HEDP) acted as a scale inhibitor and clove oil as a natural biocide, which offered a comprehensive solution to both scaling and biofouling issues. The as-prepared MCH microcapsule exhibited a smooth multinuclear spherical structure, a uniform size. UV–vis results confirmed the successful encapsulation of HEDP and clove oil within the MF shell, with encapsulation amounts of approximately 7.47 % and 23.67 %, respectively. Remarkably, the release of the HEDP and clove oil could extend up to 60 h and 160 h, respectively, which was consistent with the First-order model, displaying an excellent sustained-release performance. Static scale inhibition experiments indicated that the microcapsules possess sustained scale inhibition ability. The scale inhibition efficiency of the dynamic release solution of MCH microcapsules remained above 90 % for the initial 14 h, with the highest scale inhibition rate exceeding 98 %. Furthermore, these microcapsules displayed remarkable antibacterial activity against Escherichia coli and Bacillus subtilis, with both antibacterial rates exceeding 99.9 %. Overall, the sustained release of the scale inhibitors and biocides ensures long-term control and reduction in agent wastage, which presents a promising application in addressing the scaling and biofouling issues in industrial circulating water systems.
研究领域:
材料科学
·
环境工程
·
工业水处理
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Xu-Chun Song,Ya-Lan Yu,Gui-Yuan Yang,A.-Li Jiang,Ying-jie Ruan,Shang-hua Fan
A simple and versatile strategy for controlled production of monodisperse ethyl cellulose (EC) microcapsules by a single-stage emulsification method has been developed. Monodisperse oil-in-water emulsions, obtained by a microfluidic device, are used as templates for preparing EC microcapsules. Oil-soluble ethyl acetate (EA) is miscible with water, so the interfacial mass transfer between EA and water occurs sufficiently, which leads to water molecules pass through the phase interface and diffuse into emulsion interior. Water molecules aggregate at the interface, and some merge into a large water drop in the central position of the emulsion. After evaporation of EA solvent, monodisperse EC microcapsules create large numbers of pits on the surface with a hollow structure. Curcumin is used as a model drug and embedded in the hollow structure. EC microcapsules have good, sustained drug release efficacy in a simulated intestinal environment, and the release process of EC microcapsules containing 6.14% drug-loaded capacity is fully consistent with the vitro drug release model. Such simple techniques for making EC microcapsules may open a window to the controlled preparation of other multifunctional microcapsules. Besides, it offers theoretical guidance for the study of EC microcapsules as drug carriers and expanding clinical application of curcumin.
研究领域:
药剂学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Yu Xiao,Lu Wang,Xueze Zhang,Yi Ren,Jianhong Wang,Baolong Niu,Wenfeng Li
In this study, to address the defects of sodium alginate (SA), such as its susceptibility to disintegration, silica was coated on the outer layer of sodium alginate hydrogel beads in order to improve its swelling and slow-release properties. Tetraethyl orthosilicate (TEOS) was used as the hydrolyzed precursor, and the solution of silica precursor was prepared by sol-gel reaction under acidic conditions. Then SA–silica hydrogel beads prepared by ionic crosslinking method were immersed into the SiO2 precursor solution to prepare SA–silica hydrogel beads. The chemical structure and morphology of the hydrogel beads were characterized by XRD, FTIR, and SEM, and the results showed that the surface of SA–silica beads was successfully encapsulated with the outer layer of SiO2, and the surface was smooth and dense. The swelling experiments showed that the swelling performance effectively decreased with the increase of TEOS molar concentration, and the maximum swelling ratio of the hydrogel beads decreased from 41.07 to 14.3, and the time to reach the maximum swelling ratio was prolonged from 4 h to 8 h. The sustained-release experiments showed that the SA–silica hydrogel beads possessed a good pH sensitivity, and the time of sustained-release was significantly prolonged in vitro. Hemolysis and cytotoxicity experiments showed that the SA-silica hydrogel beads were biocompatible when the TEOS molar concentration was lower than 0.375 M. The SA–silica-2 hydrogel beads had good biocompatibility, swelling properties, and slow-release properties at the same time.
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 45
·28867-28877
·
IF 4.036
Shuqiong Liu,Zhenyi Xu,Jiapeng Hu,Zhenzeng Wu,Yuying Zheng
Biomimetic scaffolds loaded with drugs can improve the osteogenesis and neovascularisation of scaffolds. A series of PLA/GO/Sal-B drug-loaded scaffolds was prepared by thermally induced phase separation. The addition of Sal-B increased the diameter of the fibres, but the scaffold showed a porous nanofibrous structure after drug release. X-ray diffraction results showed that the addition of Sal-B did not affect the formation of the nanofibre biomimetic structure of the scaffold. FTIR results indicated a certain interaction between Sal-B and PLA/GO. Water absorption and porosity test results revealed that the scaffolds had good hydrophilicity and appropriate porosity. The addition of Sal-B was also conducive to the formation of sediments possibly due to the good water solubility of Sal-B itself. The prepared scaffolds had good blood compatibility and cytocompatibility, and a small additional amount of Sal-B could significantly promote cell proliferation and alkaline phosphatase activity. Their sustained release performance indicated that the biomimetic scaffolds had controlled the release of Sal-B. The kinetic model showed that the PLA/GO/Sal-B drug-loaded biomimetic scaffolds followed the diffusion mechanism.
研究领域:
生物材料学
·
药剂学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2019
·Vol. 19
·期 7
·4147-4153
·
IF 1.093
Wang Shuo,Zhang Wei,Chen Yanfang,Zhang Shilong,Wang Wei
Lavender fragrance loaded polyurea microparticles were successfully prepared via interfacial polymerization. The microcapsulated lavender essence was directly impregnated into the fabrics as an aromatic reagent. And the encapsulation efficiency measured was 75.68% when the core-wall
ratio (Mlavender: MHDI) was 2:1. Laser light particle size analyzer showed that the size of spherical nanocapsule varied in the range 2–20 μm. The release process of microcapsules conformed to pseudo-first order kinetics. And the release contents of main
lavender fragrance components involved D-limonene, cineole, linalool and propyl propionate from the cotton fabrics were accurately calculated. These aroma compounds of the cotton fabrics impregnated with microcapsulated lavender only lost less than 50% of their aroma after 12 weeks of deposition.
Gas chromatography/hydrogen flame ionization detection (GC-FID) indicated that aromatic fabrics treated with microcapsulated lavender exhibited a better sustained-release properties than that of fragrance emulsion.
研究领域:
材料科学
·
纺织工程
✓ 已验证
DOI
高影响因子
Microfluidics and Nanofluidics
·
2021
·Vol. 25
·期 2
·1-13
·
IF 2.529
Ge Xue-hui,Du Yu-han,Huang Xiaolian,Mo Liangji,Wang Hongxing,Qiu Ting
In this paper, the peppermint oil/HP-β-CD (2-hydroxypropyl-β-cyclodextrin)/chitosan composite microcapsules were prepared. The release ability of these microcapsules was improved for peppermint oil through the combination of molecular encapsulation by HP-β-CD and physical encapsulation by chitosan shell. First, stable peppermint oil/HP-β-CD pre-emulsion was prepared by stirring, based on which the optimal conditions were determined for producing the pre-emulsions with the highest encapsulation efficiency. Then, the pre-emulsion was moved into the flow-focusing microfluidic device as the inner phase and was cut into droplets by chitosan aqueous solution as the middle phase and the octanol as the outer phase to obtain templated emulsions. They were collected using a Petri dish with n-octane coagulation bath containing glutaraldehyde and 2 wt% span80 to be cured into microcapsules. The crosslinking time and the ratio of HP-β-CD in the templated emulsions were adjusted to investigate their impact on the microcapsule structures and correspondingly the capability of the microcapsules to retain peppermint. It was found out that the extended crosslinking time and the addition of HP-β-CD can improve the capability of the composite microcapsules to retain peppermint oil. It provides a straightforward method to produce composite microcapsules. Besides, the microcapsules with improved retaining ability were obtained by combing molecular and physical encapsulation, thus laying a foundation for the exquisite, efficient and polylaminate protection of the volatile perfume or other physically or chemically active components.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD PROTECTION
·
2015
·
IF 1.849
Shengfeng Peng,Liqiang Zou,Wei Liu,Lu Gan,Weilin Liu,Ruihong Liang,Chengmei Liu,Jing Niu,Yanlin Cao,Zhen Liu,Xing Chen
Eugenol is a major phenolic component with diverse biological activities. However, it is difficult to formulate into an aqueous solution due to poor water solubility, and this limits its application. In the present study, eugenol nanoliposomes (EN) were prepared by combining the ethanol injection method with the dynamic high-pressure microfluidization method. Good physicochemical characterizations of EN were obtained. The successful encapsulation of eugenol in nanoliposomes was confirmed by Fourier transform infrared spectroscopy. A good storage stability of EN was confirmed by its low variation of average particle diameter and encapsulation efficiency after 8 weeks of storage. No oil drops were found in EN after 8 weeks of storage at 4°C and at room temperature, which suggested that the poor water solubility of eugenol was overcome by nanoliposome encapsulation. Compared with that of eugenol solution, a relatively good sustained release property was observed in EN. The antibacterial activity of EN against four common foodborne pathogenic bacteria (Staphylococcus aureus, Escherichia coli, Salmonella enterica serovar Typhimurium, and Listeria monocytogenes) was evaluated in both Luria broth and milk medium.
研究领域:
食品科学
·
药物递送
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 3
·785-796
·
IF 2.2
Fan Liya,Zhao Xiaoyan,Zhu Xiao,Li Yangsong,Cui Zhaoliang
The spraying of pesticides not only causes the waste of chemicals but also air pollution. To make the use of pesticides become more environmentally friendly and effective, biodegradable material polylactic acid (PLA) was chosen to package pesticides in this work. Three different film preparation methods (drying, coagulation bath shaping, and steam treatment) were used to study the morphology of PLA coated films. From FESEM images, it could be observed that the steam treatment was more easy in forming pore structures of the films. The sustained release performances of PLA film with the pore size around 800 nm for tetracycline hydrochloride (TC) and hymexazol (HYM) were investigated. The results showed that both chemical temperature and solubility could affect the sustained release effect of films. Due to the slower dissolution rate of TC compared to HYM, it was prone to aggregation in PLA films, which affected the sustained release of TC. The release rates of TC and HYM could reach 98.2% (40 °C, 2.5 h) and 99.51% (60 °C, 3.0 h), respectively. The release processes of TC and HYM conformed to the first-order kinetic model. It promotes the application of environmental friendly materials in pest control of plants.
研究领域:
环境科学
·
高分子科学
·
农药技术
·
材料工程
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Simin Feng,Yitong Tian,Jiahao Yu,Yang Lin,Alan Giovanini de Oliveira Sartori,Ping Shao
Improving the acid stability of nanostructured lipid carriers (NLCs) is critical for broadening their engineering applications. The integration of NLCs with hydrogels results in a more stable, multifunctional system that facilitates the effective and sustained release of bioactive ingredients. In this study, The chitosan/alginate hydrogel (CAH) exhibited minimal limonene release under combined high-temperature and acidic conditions when the degree of carboxyl substitution (DS) of chitosan reached 17.68 ± 0.14 % (NLC-CAH1). It exhibited the lowest release rate and superior stability under high-temperature and acidic conditions. The cumulative release rates of limonene in NLC and NLC-CAH1 within 3 h of acid solution were 35.24 ± 0.97 % and 22.41 ± 2.09 %, respectively. The hydrogels effectively delayed the release of NLCs, reducing the release rate of limonene and facilitating a prolonged release of bioactive ingredients. Consequently, the NLCs-hydrogel system represents a novel delivery mechanism, and offers innovative strategies for the administration of lipophilic bioactive compounds.
研究领域:
药剂学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hongfa Duan,Xiaochi Liu,Lulu Bian,Zhongyi Li,Ning Li,Muhammad Umair Sial,Zhe Sun,Haiqiang Gao,Beixing Li,Daxia Zhang,Feng Liu
The preparation of pesticide-loaded microcapsules using biodegradable polymers and the balance between their sustained-release performance and small-size effects represent an effective strategy to enhance pesticide utilization efficiency. This study devised a one-step sol-gel self-assembly approach to fabricate abamectin-loaded microcapsules using biodegradable polyvinyl alcohol (PVA) and butylated hydroxytoluene (BHT) as raw materials. The results demonstrated that the reaction through hydrogen bonding by PVA and BHT at the o/w interface could generate shells and encapsulate pesticides to make microcapsules. Increasing PVA usage could reduce the particle size and enhance shell stability. The addition of BHT also improved the shell structure stability and encapsulation efficiency, whereas 3 %–7 % concentrations impeded the formation of the shell structure. Abamectin, which has a self-polymerizing ability, also increases microcapsule stability. A 54 °C temperature increase was maintained for 24 h to induce emulsion separation. Subsequent cooling and agitation prompts the reconstitution of pesticide-loaded microcapsules. The synergistic effect of the water-responsive mechanism, high encapsulation efficiency, and thicker shells endows nano-formulations with superior sustained-release performance compared to micro-scale formulations. The photostability of abamectin nanocapsules is significantly enhanced by 68.26 % compared to conventional suspensions, and the content of active ingredients remains at 50.54 % after 60 h of release under light conditions. Owing to their nanoscale sustained-release characteristics, their biological safety is improved by 36.43 %. The encapsulated Aba@BHT-PVA nano-system, leveraging excellent rainwater erosion resistance and leaf surface affinity, significantly prolongs its leaf retention time. Synergizing with the small-size effect, it demonstrates substantial enhancement in both the control efficacy and persistence against Plutella xylostella . Owing to its unique properties and easy regulation, this fabrication technique has great application value in the future.
研究领域:
农药化学
·
纳米材料
·
药物递送系统
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tong Ye,Qile Chen,Shujuan Yang,Haifang Liu,Yan Zhou,Yuhong Feng,Jiacheng Li,Yujuan Wang,Gaobo Yu,Jun Dai
Achieving high bioavailability of dendrobine (DDB) necessitates the development of simplified available and efficient delivery systems. Pickering emulsions (PEs) derived from biomass represent a promising option. However, the physicochemical properties of PEs interfacial films were insufficient to prevent DDB leakage, thereby reducing bioavailability. Herein, a supramolecular host-guest interfacial recognition strategy was proposed in-situ between amphipathic sodium alginate-functionalized cyclodextrin (SAE-CD) and hydrophobic DDB at oil-water interface, further forming the SAE-based supra-amphiphiles to efficient stabilize the high internal phase Pickering emulsions (HIPPEs) with gel-like characteristics. A multiscale methodology was empolyed to investigate the interfacial assembly behavior and emulsification properties of supra-amphiphilic SAE-CD/DDB interfacial system, focusing on molecular interactions, interfacial adsorption, and overall stability. Notably, the SAE-CD/DDB-based supramolecular assembly/disassembly behaviors could be self-adjusted for regulating the aggregation particle size and thickness of interfacial self-assembled films. The SAE-CD/DDB co-stabilized HIPPEs exhibited favorable drug release capabilities, enabling sustained effects of DDB. Overall, the SAE-CD/DDB co-stabilized HIPPEs demonstrated excellent properties in terms of stability, drug loading capacity, and sustained release performance, highlighting their potential for in oral delivery and sustained-release systems.
研究领域:
食品科学
·
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Advanced Research
·
2020
·
IF 6.992
Jinyun Li,Ming Guo,Yiping Wang,Bihuan Ye,Youwu Chen,Xuejuan Yang
Introduction Green algae seriously affect the quality and yield of Torreya grandis, it is important to explore new, environmentally friendly ways to control it. Objectives The present study aimed at preparing sustained-release algae-killing nanocapsules without pollution to the environment. Methods In this work, sodium carboxymethylcellulose (CMC), sodium alginate (SA), and chitosan (CTS) were used as raw materials in acylation reaction with the photosensitive catalytic material iron octaaminophthalocyanine (T) to generate the photoactive bio-based materials T-CMC, T-SA, and T-CMCS. Cinnamaldehyde and 2-aminobenzimidazole were combined using chemical grafting to produce a new algicide, and then formed nanocapsules by phase separation. The molecular structure of products was characterized by UV–Vis, FTIR, and NMR ( 1 H NMR, 13 C NMR). The particle size of the nanocapsules was determined by Zeta particle size analysis and TEM; DSC was used to investigate the thermal stability; The encapsulation efficiency and sustained-release performance were determined by HPLC. Then the phytotoxic of the new algicide was measured. Results The bio-based nanocapsules was successfully synthesized, which had a particle size of 10–30 nm and was stable at 40 °C. The encapsulation efficiency of the nanocapsules was 48.77%, the cumulative release rate was 83%, and the new algicide killed the green algae in a dose-dependent way. Conclusions The bio-based nano capsule is a new and valuable Sustained-release capsule, which is the method of green algae.
研究领域:
环境科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）