ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Jianbing Wu,Wenjun Guo,Yongfeng Wang,Jian Liu,Heng Wang,Zhaozhu Zheng,Xiaoqin Wang,David L. Kaplan
Fragrances, which are commonly used in food, textiles, consumer products, and medical supplies, are volatile compounds that require stabilization and controlled release due to their sensitivity to environmental conditions such as light, oxygen, temperature, and humidity. Encapsulation in various material matrices is a desired technique for these purposes, and there is a growing interest in using sustainable natural materials to reduce environmental impact. In this study, fragrance encapsulation in microspheres made from silk fibroin (SF) was investigated. Fragrance-loaded silk fibroin microspheres (Fr-SFMSs) were prepared by adding fragrance/surfactant emulsions to silk solutions, followed by mixing them with polyethylene glycol under ambient conditions. The study investigated eight different fragrances, where citral, beta-ionone, and eugenol showed higher binding affinities to silk than the other five fragrances, resulting in better microsphere formation with uniform sizes and higher fragrance loading (10–30%). Citral-SFMSs showed characteristic crystalline β-sheet structures of SF, high thermal stability (initial weight loss at 255 °C), long shelf life at 37 °C (>60 days), and sustained release (∼30% of citral remained after incubation at 60 °C for 24 h). When citral-SFMSs with different sizes were used to treat cotton fabrics, about 80% of the fragrance remained on the fabrics after one wash, and the duration of release from the treated fabrics was significantly longer than that of control samples treated with citral alone (no microspheres). This method of preparing Fr-SFMSs has potential applications in textile finishing, cosmetics, and the food industry.
研究领域:
材料科学
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纺织工程
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化学工程
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产品关联
DOI
PubMed
高影响因子
POLYMER TESTING
·
2023
·
IF 5.1
Haohe Huang,Xingqiang Huang,Lanyu Zhang,Hui Zhao,Chongxing Huang,Lijie Huang,Zhanpeng Chen
In this study, stable sodium chlorite solution and water-borne polyurethane (WPU) were mixed to prepare a novel antibacterial film with sustained-release properties via a solvent casting method. For the first time, carboxyl in WPU was used as the activator to react with ClO − to produce gaseous ClO 2 under the trigger of moisture and without any other acid reagent. The results showed that the film had excellent antibacterial effect. However, as the content of stable ClO − increased, the mechanical strength and thermal stability of the film decreased, and its surface morphology showed irregular protrusions. In addition, the slow-release mechanism of the film with time under different temperatures was studied, whereby the release amount of the film was noted to be affected by temperature. This study explored the development of food packaging with efficient antibacterial activity and sustained-release performance without the use of acid reagents.
研究领域:
材料科学
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化学
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生物技术
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食品科学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 42
·
IF 1.866
Yu Zhang,Jia Song,Hongling Chen
The purpose of the present work was to develop a fragrance encapsulation system using polyacrylate/paraffin microcapsules. The Polyacrylate/paraffin microcapsules were fabricated by the method of suspension polymerization in Pickering emulsion. Morphology, size distribution, and thermal resistance of polyacrylate/paraffin microcapsules were investigated by scanning electron microscopy, light scattering particle size analyzer, and thermogravimetric analyzer. Results indicated that the crosslinked PMMA/paraffin microcapsules and P(MMA-co-BMA)/paraffin microcapsules prepared under optimal conditions presented regular spherical shape and similar size distribution. The crosslinked P(MMA-co-BMA)/paraffin microcapsules exhibited better thermal stability, with a thermal resistance temperature up to 184 °C. Fragrance microcapsules were prepared by encapsulating fragrance into crosslinked P(MMA-co-BMA)/paraffin microcapsules. The prolonged release performance of fragrance microcapsules was measured by ultraviolet-visible near-infrared spectrophotometer. 63.9% fragrance was retained after exposing fragrance microcapsules in air for 3 months, and the fragrance continued to release over 96 h in surfactant solution (sodium lauryl sulfonate, 20 wt %). © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 44136.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
·
IF 5.062
Xin Chen,Duanxiu Li,Yanwen Duan,Yong Huang
Drug co-amorphization is an emerging technology to improve the pharmacokinetic properties of drugs and overcome their side effects. Herein co-amorphization of sinomenine (SIN), an anti-rheumatoid arthritis alkaloid, and an antihistamine drug tranilast (TRA) was investigated for the sustained release of SIN and alleviating its histamine-release adverse reactions. The full co-amorphization of SIN-TRA was determined by powder X-ray diffraction and modulated temperature differential scanning calorimetry , while their CO 2 − and N + –H stretching vibrations in FTIR and protonated nitrogen signals in N 1s X-ray photoelectron spectra suggest the proton transfer between SIN and TRA. These intermolecular interactions could also be observed in their 1D and 2D NMR spectra. All co-amorphous samples exhibited sustained SIN release and excellent physical stability. Therefore, our study not only characterized the strong intermolecular interactions between SIN and TRA, but also discovered a promising drug combination strategy for the sustained release of SIN and reduction of its side effects.
研究领域:
药剂学
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药物化学
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产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 1
·600-605
·
IF 1.556
Jiang Ping,Li Duxin,Xiao Ya,Yang Xingxing,Liu Yuejun
The biodegradable microcapsules based on chitosan for a controlled delivery of clove oil were prepared by the single coagulation process. The effect of chitosan concentration, core to shell ratio, types of emulsifier, flocculating agent and hardening agent on the microcapsule diameter
and the particle size distribution of microcapsule were investigated. The optimized conditions for the preparation of microcapsules with well-defined structure and narrow dispersibility were under that (1) the concentration of chitosan was 1.0 wt%, (2) clove oil to chitosan ratio was 75:25,
(3) OP-10 and 10 wt% sodium sulfate were used as emulsifier and flocculating agent respectively, and (4) the concentration hardening agent glyoxal was 1 wt% based on the weight of chitosan. The uniform spherical structures with smooth surfaces with a particle size distribution of 1–15
μm were evidenced by SEM images of microcapsules. Core–shell, hetero-structures were confirmed by optical micrograph. The chemical component of the microcapsules was determined by FTIR. Thermal analysis showed the microcapsules were thermally stable below 150°C. It was
found that the pH value and temperature play important roles on the release rate of clove oil from the microcapsules. The release volume of clove oil from microcapsules at pH = 7, and pH = 10 were smaller than that at pH = 2. And the release volume of Clove oil from microcapsules at 60°C
was smaller than that at 20°C and 40°C, which showed a sustained and prolonged release.
研究领域:
食品科学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Siyu Xiao,Aijie Ma,Yanzhuo Ma,Haiyan Bai,Binghong Zhang,Juan Li,Hongwei Zhou
Glaucoma is the leading cause of irreversible blindness, and its treatment is attracting widespread attention. Drug-loaded lacrimal suppositories can effectively treat xerophthalmia, but there is little research on the treatment of glaucoma with drug-loaded lacrimal suppositories. This article explored and expanded the non-pharmacological model of lacrimal suppository therapy for glaucoma by using a combination of lacrimal suppository and medication. The drug-loaded lacrimal suppository was rationally designed through the conjugation of gelatin with polyamide (PAM) via the formation of amide linkages, followed by Schiff base reaction grafting with latanoprost. In vitro drug release studies showed that latanoprost released from drug-loaded lacrimal embolus had sustained-release properties with a release time of 33 days and a drug release volume of 82.6%. The biological evaluation of drug-loaded lacrimal thrombus was carried out by IOP test, retinal potential test, and retinal H&E staining. The results showed that the IOP decreased to 27.125 ± 1.1254 mmHg, and the a and b waves of retinal potential increased to 4.39 ± 0.16 μV and 67.9 ± 2.17 μV, respectively. It indicated that latanoprost lacrimal suppository has a good therapeutic effect on glaucoma.
研究领域:
药剂学
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眼科医学
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DOI
PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2022
·Vol. 78
·期 10
·4407-4416
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IF 4.462
Liyin Shi,Weiyao Yan,Li Sun,Chaoqun Hou,Nuo Wei,Zhiyang Chen,Jianguo Feng
Background Developing pesticide-controlled release formulations with foliage adhesion has become the focus of current research in the field of crop protection. In this study, an excellent adhesive nanocapsule loaded with emamectin benzoate (Eb@PDA) was prepared via emulsion interfacial polymerization based on the self-polymerization ability and adhesion properties of polydopamine (PDA). Results The physicochemical properties of the Eb@PDA were characterized by scanning electron microscopy, transmission electron microscopy, particle size statistics, Fourier transform infrared spectroscopy and X-ray diffraction. The Eb@PDA presented a regular spherical shape, with an average particle size of 163.8 nm. Compared with conventional formulations, it had higher pesticide-loading content (34%) and excellent adhesion onto corn leaf. In addition, Eb@PDA showed sustained-release characteristics, facilitating the release of Eb at low pH and high temperature. Eb@PDA could effectively protect Eb against photodegradation and had a longer effective period for controlling Spodoptera frugiperda and Spodoptera exigua . Furthermore, acute toxicity tests showed that the 50% lethal concentration (LC 50 ) was 80.91 and 57.91 mg kg −1 at 7 and 14 days, respectively, indicating a lower toxicity of the Eb@PDA to earthworms. The cells (L02) treated with Eb@PDA showed a higher cell viability but a lower apoptosis rate (only 5.75%), demonstrating the lower cytotoxicity of the Eb@PDA. Conclusion The self-prepared Eb@PDA could be used as a formulation with the advantages of slow release, UV shielding, strong leaf adhesion, superior insecticidal properties, sustained effectiveness and biosafety. It will also facilitate the development of an efficient and safe pesticide delivery system. © 2022 Society of Chemical Industry.
研究领域:
农药科学
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材料科学
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植物保护
✓ 已验证
DOI
高影响因子
APPLIED CLAY SCIENCE
·
2024
·
IF 5.3
Aihua Xiang,Yifan Li,Kun Liu,Xin Wang,Tuanliu Hu
Selenium (Se) is a beneficial plant micronutrient, and the application of Se fertilizers can promote plant growth and enhance the Se content in crops. However, traditional soluble Se fertilizers have low utilization efficiency of Se due to adsorption or leaching. Here, selenite (SeO 3 2− ) -intercalated Mg/Al layered double hydroxide (Se-Mg/Al) for SeO 3 2− slow-release was synthesized by co-precipitation and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). Se-Mg/Al possessed a typical lamellar structure, combining with selenite by electrostatic interaction in interlayer and chemisorption on the surface. The release mechanism of selenite in distilled water from Mg/Al layered double hydroxide (Mg/Al LDH) was Fickian diffusion with gradually released 97.86% after 20 h (Over 90% within 2 h for sodium selenite). At pH range 4.0–8.0, Se-Mg/Al had a stable slow-release ability. And, the sulfate and phosphate anions could effectively trigger the release of selenite through anions exchange. The pot experiments showed that Se-Mg/Al increased Se content of vegetables, more than twice that of directly using sodium selenite. Compared with control treatment, the average stem height and fresh weight per 10 plants with Se-Mg/Al treatment improved approximately 1.48 times and 2.34 times, respectively. This work provides a feasible way for achieving crops selenium supplementation and improving selenium utilization efficiency.
研究领域:
农业科学
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植物营养学
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产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Yafu Tang,Xinying Wang,Yuechao Yang,Bin Gao,Yongshan Wan,Yuncong C. Li,Dongdong Cheng
In this work, lignite, a low-grade coal, was modified using the solid-phase activation method with the aid of a Pd/CeO2 nanoparticle catalyst to improve its pore structure and nutrient absorption. Results indicate that the adsorption ability of the activated lignite to NO3–, NH4+, H2PO4–, and K+ was significantly higher than that of raw lignite. The activated lignite was successfully combined with the polymeric slow-release fertilizer, which exhibits typical slow-release behavior, to prepare the super large granular activated lignite slow-release fertilizer (SAF). In addition to the slow-release ability, the SAF showed excellent water-retention capabilities. Soil column leaching experiments further confirmed the slow-release characteristics of the SAF with fertilizer nutrient loss greatly reduced in comparison to traditional and slow-release fertilizers. Furthermore, field tests of the SAF in an orchard showed that the novel SAF was better than other tested fertilizers in improve the growth of young apple trees. Findings from this study suggest that the newly developed SAF has great potential to be used in apple cultivation and production systems in the future.
研究领域:
农业科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 39
·18839-18847
·
IF 3.925
Hongxia Chen,Haiyan Yan,Peiyu Cao,Yufeng He,Pengfei Song,Rongmin Wang
Semicoke (SC) is a kind of powder of industrial by-products that easily cause environmental pollution due to the presence of stable organic matter in clay minerals. In this work, a porous magnetic semicoke-based geopolymer (MSC-GP) was prepared using SC as the raw material. Then, 2-methyl-4-chlorophenoxyacetic acid (MCPA), a typical herbicide, was loaded into the porous MSC-GP and composited with sodium alginate (SA) using calcium as a crosslinking agent, which afforded MSC-GP/SA encapsulating MCPA (MCPA@MSC-GP/SA). The structure and micromorphology of SC, SC-GP and MCPA@MSC-GP/SA were characterized by FT-IR spectroscopy, TG-DTG, SEM and EDS. After measuring the swelling behavior in water and saline solutions, the water retention capacity, pH effect, degradation efficiency, site-specific targeted release, recovery, slow-release behavior, and pot experiments of MCPA@MSC-GP/SA were assessed. This indicated that the water retention capacity of soils was improved by the addition of MCPA@MSC-GP/SA. The release rate of the herbicide in MCPA@MSC-GP/SA was 65.2% in 90 days, which indicated that MCPA@MSC-GP/SA possessed a higher utilization efficiency and control of weeds compared to traditional herbicide. In summary, this study opens up a new avenue for improving the utilization efficiency of SC and prolonging the duration of herbicide action, which may have potential applications in agricultural production.
研究领域:
环境科学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2020
·
IF 6.155
Mi Wu,Wen Liu,Jinrong Yao,Zhengzhong Shao,Xin Chen
The controlled release of antibiotic drugs to injured sites has great advantages over the conventional intravenous administration of antibiotics, which is associated with systemic toxicity, for wound care. Electrospun nanofibrous/microfibrous mats, with a similar structure to the native extracellular matrix, is a promising wound dressing. Herein, drug-loaded halloysite nanotubes (HNTs) incorporated into regenerated silk fibroin (RSF) microfibrous mats were prepared by electrospinning to achieve sustained drug release and long-lasting antimicrobial protection. A broad-spectrum antibiotic, tetracycline hydrochloride (TCH), was selected as the model drug. Transmission electron microscopic images revealed that the TCH-loaded HNTs were homogeneously embedded in the RSF electrospun microfibers without significant changes in morphology. The drug release profiles showed that the RSF microfibrous mats with TCH-loaded HNTs exhibited a significantly reduced burst phase and a long release time over two weeks compared to the pure TCH-loaded HNTs and the TCH-loaded RSF microfibrous mats without HNTs. These results were attributed to the two-step release of TCH first from the HNTs and then RSF matrix in the electrospun mats. Finally, the antimicrobial properties of the RSF microfibrous mats with TCH-loaded HNTs were evaluated using both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. The results demonstrated long-lasting antimicrobial activity for at least one week, showing the great potential of TCH-loaded RSF microfibrous mat as a wound dressing material. Therefore, these TCH-loaded RSF microfibrous mats with excellent biocompatibility and sustained antimicrobial protection are extremely attractive systems for clinical applications.
研究领域:
生物材料学
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医学
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 3
·454
·
IF 3.164
Qian Wang,Fuping Dong,Jun Dai,Qingpo Zhang,Meng Jiang,Yuzhu Xiong
Fertilizer is very important for increasing food yield, but the extensive use of fertilizer will cause environmental pollution. To enhance the effectiveness of fertilizer, we developed the double organic silicone-modified recycled-oil-based polyurethane as a coating material to prepare degradable polymer coating urea for constant fertilizer release. The moisture, heat resistance, and sustained release properties of polyurethane coating materials were investigated by modification with hydroxyl-terminated polydimethyl silicone (HTPMS) and γ-Aminopropyl triethoxy silane (KH550). The content and distribution of the siloxane groups were effectively controlled by adjusting the content ratio of two kinds of organosilicon. Meanwhile, the organic–inorganic hybrid structure was further controlled to form three-dimensional networks with a uniform distribution and a small scale. The moisture and heat resistance of polyurethane were thus improved, resulting in reduced porosity and an excellent sustained release performance. Observably, the best sustained release property of modified polyurethane coated urea was obtained when the ratio of KH550 to HTPMS is 0.3:0.7.Keywords:recycled oil;polyurethane;coating materials;three-dimensional networks;sustained release
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）