JOURNAL OF CONTROLLED RELEASE
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2025
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IF 11.5
Mengzi Hu,Yaqiong Wang,Xue-Bo Yin
In addition to the robust adhesive properties, there is a pressing demand for ideal adhesives in tumor surgery that possess anti-tumor therapeutic effects. In this study, we introduce BSA-MnO 2 -GP@Ca-Y (BMGY) bio-glue by integrating bovine serum albumin (BSA)-MnO 2 , genipin (GP), and Ca-Y zeolite. Ca-Y zeolite exhibits the thrombin activity for hemostasis, while the cross-linking of BSA, GP, and skin tissue induces wound adherence upon laser irradiation for normalized skin structure within nine days. The heat generated during the “photothermal suture” process ablates residual tumor cells and produces antigen fragments, which are internalized by antigen presenting cells. The released Mn ions subsequently activate the cGAS-STING pathway, enhancing immunogenicity. Consequently, tumor-infiltrating p-TBK1 and interferon-β levels are significantly increased, ensuring robust anti-tumor immunity following BMGY treatment. Thus, BMGY bio-glue achieves hemostasis, wound bonding, ablation of residual tumor cells, and tumor recurrence inhibition, simultaneously. Beyond Ca-Y zeolite, BSA-MnO 2 -GP serves as a versatile platform for loading other drugs or active species to boost therapeutic efficacy. Therefore, we present a successful bio-glue paradigm with significant translational potential for various postsurgical management applications.
研究领域:
生物医学工程
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肿瘤免疫学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hui Su,Yucheng Qiu,Jing Luo,Fei Liu,Jun Yang,Xiaofeng Sui,Yue Zhang,Yumei Zhang,Xianyu Zhou
Vascular anastomosis is the cornerstone in microsurgery. To assist complicated microvascular anastomosis with diameters <0.6 mm, nonsuture cuff technique was developed. However, cuff tube made from polyamide is not degradable, and their long-term retention in the body may cause stiffness in blood vessels at the anastomotic site. Thus, development of a biodegradable cuff tube would greatly enhance surgical operability and biosafety. In this study, biocompatible poly-L-lactic acid (PLLA) was chosen as the raw material to prepare cuff tube for nonsuture cuff technique. A customized ‘C’ shaped nozzle was adopted during the melting extruding process, and then was subjected to a water-cooling bath to maintain the round shape and inner diameter of 582 μm ± 20 μm. Its crystallization behavior was controlled through the cooling procedure to achieve the expected mechanical properties and operability. Its good hemocompatibility and genotoxicity were validated by various in vitro assays. Consequently, a PLLA cuff tube with a radial tensile strength of 12 MPa and an elastic modulus of 1685 MPa was prepared and used to assist establishing a rat orthotopic hindlimb transplantation model, which indicated that our PLLA cuff tube was suitable for microvascular anastomosis in organ or tissue repair.
研究领域:
医学
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生物材料学
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外科手术
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DOI
PubMed
高影响因子
Journal of Functional Biomaterials
·
2025
·Vol. 16
·期 2
·52
·
IF 5.2
He Bai,Wei Zhang,Xuanxuan Yan,Lin Qiu,Pengfei Cui,Weiyang Chen
In recent years, factors such as the postponement of childbearing and the relaxation of the childbearing policy have led to an increase in the proportion of cesarean sections and other intrauterine surgeries among pregnant women, further increasing the incidence of uterine scars. Currently, there is a lack of effective clinical treatment methods for uterine scars. In this study, a suture loaded with gene medicine was designed for the repair of uterine scars. Specifically, the non-viral vector Lipo8000 was first used to form a complex solution with the plasmid TGF-β3. Then, it was mixed and adsorbed with the surgical sutures pretreated with recombinant human type III collagen (RhCol III). In vitro experiments confirmed that RhCol III and the plasmid were successfully loaded onto the sutures and could be released and expressed. In vivo experiments were carried out using a rat model simulating uterine scars. The section results showed that compared with the scar model group, the expression level of TGF-β3 in the RhCol III+TGF-β3 group increased by 39%, the expression level of TGF-β1 decreased by 62.8%, and the fibrosis rate decreased by 16.8%, which has a positive effect on the prevention of uterine scars. This study integrates the therapeutic medicine into the sutures, ensuring that the medicine can come into contact with the wound site after suturing. Moreover, RhCol III and the gene medicine work synergistically to promote the repair of uterine wounds.
研究领域:
妇产科学
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分子生物学
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生物医学工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Yimei Yang,Tian Hu,Hongyan Zhang,Bu-Ning Liu,Jinwen Liu,Wei-Xiong Li,Kui Song,Gang-Biao Jiang
The mechanical mismatch between soft hydrated tissues and sutures has become a common negative impact on wound healing process. A novel method of coating multilayer polymer shells is thus reported to improve the mechanical performance of hydrogel sutures. It is suitable for tissue patching and shows advantages of convenient, efficient, and biosafety. Specifically, a precursor hydrogel (Cu@CMC) consisted of carboxymethyl chitosan and copper modified by carbon dots was used as the inner sheath, and then bonding the precursor hydrogel sheath with toughening polyethylene glycol network by anchoring sites composited from rigid chitosan shell integrated a whole structure. Subsequently, the whole system was soaked with EtOH, and rapid dehydration of EtOH was used to accelerate the entanglement process between the two coatings by constricting the molecular chains. Finally, an ideal suture (Cu-fiber) with both toughness and rigidness was obtained. The data showed that the tensile strength and biosafety of the hydrogel sutures prepared by the new strategy were significantly improved, and the skin, liver and vessel of rodents can be sutured without secondary damage. Moreover, it can inhibit inflammation response and promote the healing process of skin wound, indicating that the Cu-fiber will become a great candidate for tissue patching.
研究领域:
生物材料学
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医学工程
·
组织工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Chang Liu,Xin Hu,Xiang Zhou,Yan Ma,Polly H.M. Leung,John H. Xin,Bin Fei
The bacterial infection of surgical wounds results in prolonged hospitalization and even death of patients, calling for antibacterial function in modern suture products. To tackle this challenge, cationic guanidine-containing copolymer was synthesized, exhibiting antibacterial potency over 5 log reduction against both Gram-positive S. aureus and Gram-negative E. coli . Furthermore, we developed a double-network silk suture by integrating a guanidine-containing copolymer network into the silk fibroin network. This suture exhibited biocidal activity against S. aureus and E. coli , and superior strength compared to the commercial product in both dry and wet conditions. These results may bring general benefits to public health and medical equipment sustainability.
研究领域:
生物医学工程
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材料科学
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感染控制
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DOI
PubMed
高影响因子
Journal of Functional Biomaterials
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2023
·Vol. 14
·期 5
·248
·
IF 4.8
Ching-Wen Lou,Chun-Yu Hung,Mengdan Wei,Tingting Li,Bing-Chiuan Shiu,Jia-Horng Lin
A significant amount of research has been conducted on applying functional materials as surgical sutures. Therefore, research on how to solve the shortcomings of surgical sutures through available materials has been given increasing attention. In this study, hydroxypropyl cellulose (HPC)/PVP/zinc acetate nanofibers were coated on absorbable collagen sutures using an electrostatic yarn winding technique. The metal disk of an electrostatic yarn spinning machine gathers nanofibers between two needles with positive and negative charges. By adjusting the positive and negative voltage, the liquid in the spinneret is stretched into fibers. The selected materials are toxicity free and have high biocompatibility. Test results indicate that the nanofiber membrane comprises evenly formed nanofibers despite the presence of zinc acetate. In addition, zinc acetate can effectively kill 99.9% ofE. coliandS. aureus.Cell assay results indicate that HPC/PVP/Zn nanofiber membranes are not toxic; moreover, they improve cell adhesion, suggesting that the absorbable collagen surgical suture is profoundly wrapped in a nanofiber membrane that exerts antibacterial efficacy and reduces inflammation, thus providing a suitable environment for cell growth. The employment of electrostatic yarn wrapping technology is proven effective in providing surgical sutures with antibacterial efficacy and a more flexible range of functions.Keywords:HPC;zinc acetate;electrostatic wrapping yarns;surgical sutures
研究领域:
生物医学工程
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材料科学
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DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Chenguang Ouyang,Tian Tu,Haojie Yu,Li Wang,Zhipeng Ni,Jian Yang,Yanzhao Dong,Xiaodi Zou,Weijie Zhou,Jinyi Liu,Dingning Chen,Yu Wang,Xudong Wu,Hong Yi,Xunchun Yuan,Zhenfeng Liu,Hui Lu
Janus hydrogels have promising applications in tendon healing and anti-peritendinous adhesions. However, their complicated preparation methods, weak mechanical properties, and unstable adhesion interfaces have severely limited their application in suture-free and high-quality tendon healing. In this work, by controlling the interfacial distribution of free -COOH groups and cationic-π structures on both sides of the hydrogels, a series of PZBA-EGCG-ALC Janus hydrogels with varying degrees of asymmetric properties are successfully prepared using a simple and efficient one-step synthesis method. The tensile strength and elongation at the break of the Janus hydrogel are as high as 0.51 ± 0.04 MPa and 922.89 ± 28.59%. In addition, the Janus hydrogel can achieve a high difference in adhesion strength (nearly 20-fold) while maintaining a strong adhesion strength on their bottom sides (up to 524.8 ± 33.1 J m −2 ). In the spatial dimension, its excellent mechanical compliance and one-sided adhesion behavior can provide effective mechanical support and physical barriers for the injured Achilles tendons. More importantly, the Janus hydrogel can also minimize early inflammation generation in the time dimension via its ROS-responsive PZBA-EGCG prodrug macromolecules. This study provided a more effective and convenient suture-free strategy for constructing Janus hydrogels to promote high-quality tendon healing.
研究领域:
生物材料学
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再生医学
·
创伤修复
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DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Qing Li,Ruyin Zhang,Chengpei Ouyang,Shuo Wang,Shanshan Li,Xinchao Yin,Zimeng Deng,Baoqin Han,Jinhua Chi
Corneal transplantation remains the prevailing treatment for corneal defects, which is always restricted by donor shortages and numerous postoperative complications accompanying suturing. Photocurable hydrogels have emerged as alternative therapeutic strategies for the repair of corneal defects, but most hydrogels focus on repairing focal corneal defects and still suffer from low transparency and poor mechanical properties. Herein, photocurable hydrogel GelMA/OCS composed of gelatin methacryloyl (GelMA) and oxidized chondroitin sulfate (OCS) is developed for sutureless repair of large corneal defects (6 mm). This injectable hybridized hydrogel demonstrates excellent transparency, low swelling rate, enhanced mechanical properties, and superior adhesion properties. In vitro experiments reveal that GelMA/OCS hydrogel can support the proliferation and migration, and adhesion growth of human corneal epithelial cells (HCECs), demonstrating satisfactory cytocompatibility and cell affinity. In addition, GelMA/OCS hydrogel is capable of accurately filling the large corneal defects in rabbits and forming hydrogel grafts with smooth surfaces. Postoperative slit lamp, histological evaluation, and transcriptomic analysis reveal that GelMA/OCS hydrogel can significantly facilitate corneal re-epithelialization and the integration and reconstruction of stromal structures, as well as reduce inflammation responses and scar formation. Therefore, GelMA/OCS hydrogel may provide a promising alternative for the sutureless treatment of large corneal defects.
研究领域:
生物材料学
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眼科医学
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再生医学
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DOI
PubMed
高影响因子
Heliyon
·
2023
·
IF 4
Weifeng Li,Feng Xiong,Cheng Yao,Tingbao Zhang,Liangshuang Zhou,Zhanyue Zhang,Zhaodong Wang,Yingji Mao,Pinghui Zhou,Jianzhong Guan
Background Wound gnawing and/or scratching in rats often occurs in experimental models, causing suture breakage and wound dehiscence, and consequently affecting experimental results and wasting resources. This study aimed to investigate the impact of the combined postoperative use of the Allgower-Donati (A-D) suture pattern and sweet foods on suture breakage, inflammation, and healing in wounds. Materials and methods Sprague Dawley (SD) rats (n = 48) were treated for linear wounds on the back by four procedures: simple suture, simple suture with postoperative sweet foods, A-D suture, and A-D suture with postoperative sweet foods. Additionally, CD68 immunofluorescence and CD31 immunohistochemistry were used to analyze wound inflammation and vascularization, respectively, on postoperative day 7. Sirius red staining was used to assess collagen deposition on postoperative day 14. Results Gnawing and scratching of wound sutures were significantly reduced in treated rats (P < 0.01). Neovascularization and collagen deposition were significantly increased (P < 0.001), and inflammatory responses were significantly reduced (P < 0.001) in animals receiving AD sutures and postoperative sweet foods. CD31/CD68 analyses showed that A-D suture and postoperative sweet foods regulated wound angiogenesis and attenuated wound inflammation. Conclusions Sweet food provision after A-D suture union surgery could reduce wound gnawing and/or scratching, suture breakage, incisional dehiscence, wound inflammation, and promote wound healing in rats.
研究领域:
医学
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生物学
·
动物实验研究
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DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Xuchen Wang,Hongqiang Shen,Dahua Shou,Yu Liu,Tianyi Wang,Zhaozhu Zheng,Zeyu Zhao,Xiaoqin Wang,Gang Li
Surgical sutures are essential in wound closure, with different wound sites demanding sutures with specific mechanical properties and biodegradation rates. While silk sutures have a rich history of clinical use, they are typically regarded as nonabsorbable due to their slow degradation in the human body. In this study, we present the development of an absorbable surgical silk suture (ASS) that features controllable biodegradability and mechanical properties, along with excellent biocompatibility and antibacterial attributes. The ASS was created through a straightforward enzymatic hydrolysis process using proteinase K on degummed braided silk sutures. Additionally, we enhance the mechanical properties of the ASS by applying a regenerated silk fibroin (RSF) coating technology, which uses vapor treatment under water and methanol atmospheres. This combination of enzymatic hydrolysis and RSF coating technology allows for the customization of ASS's biodegradation rates while ensuring that the suture diameter and tensile strength comply with the United States Pharmacopeia (USP) standards for absorbable sutures. This innovative approach addresses the dynamic needs of medical professionals and patients alike, providing a novel solution for wound closure.
研究领域:
生物医学工程
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材料科学
·
外科医学
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DOI
高影响因子
Polymers
·
2020
·Vol. 12
·期 8
·1630
·
IF 3.426
Gangqiang Zhang,Jiewen Hu,Tianhui Ren,Ping Zhu
With the development of fine surgery and desire for low-injury methods, the frictional properties of surgical sutures are one of the crucial factors that can cause damage to tissue, especially for some fragile and sensitive human tissues such as the eyeball. In this study, dopamine hydrochloride and graphene oxide were used as external application agents to prepare a biological coating for the surface of multifilament surgical sutures. The effects of this biocoating on the surface morphology, chemical properties, mechanical properties, and tribological properties of surgical sutures were studied. The friction force and the coefficient of friction of surgical sutures penetrating through a skin substitute were evaluated using a penetration friction apparatus and a linear elastic model. The tribological mechanism of the coating on the multifilament surgical sutures was investigated according to the results of the tribological test. The results showed that there were uniform dopamine and graphene oxide films on the surface of the surgical sutures, and that the fracture strength and yield stress of the coated sutures both increased. The surface wettability of the surgical sutures was improved after the coating treatment. The friction force and the coefficient of friction of the multifilament surgical sutures with the dopamine hydrochloride and graphene oxide coating changed little compared to those of the untreated multifilament surgical sutures.
研究领域:
生物材料学
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医学工程
·
表面科学
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DOI
高影响因子
MATERIALS LETTERS
·
2022
·
IF 3.574
Fei Yu,Hengyu Feng,Zhen Yan,Xudong Liu,Yu Liu,Linghan Xiao
The self-assembling process was conducted to fabricate graphene oxide microcapsules containing light-curing epoxy resin based on the Pickering emulsions in a single step. The chemical stability of microcapsules was improved through chemical stitching of GO nanosheets with polyether amine, while the content of epoxy resin reaching above 85 wt%. The entire highly-efficient process was energy-efficient, which ended up without barely wastes and residuals. In addition, the self-repairing coatings also produced satisfactory self-healing property and protective effect, due to the fracture of microcapsules and the reactions occurring under UV light irradiation on the surface of hot-dip galvanized steel.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）