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International Journal of Nanomedicine · 2022 · IF 7.033

Photothermal Nanoheaters-Modified Spores for Safe and Controllable Antitumor Therapy

Xin Zhang,Yang Zhang,Ning Wang,Yetong Shen,Qing Chen,Lu Han,Bo Hu

NCs (1:1:4, 6 μL) to synergistically reduce the viability of HCT116 cells to 15.63± 2.90%.Conclusion: By using NIR-irradiation, the “transitive” nanoheaters can remotely control the activity of both bacteria (germinated from spore) and cancer cells. This discovery provides basis and a feasible plan for controllable safer treatment of bacteria therapy, especially anaerobes with spores in hypoxic areas of the malignant solid tumors.

CAS / MDL: 57-09-0

研究领域: 癌症研究 · 生物医学工程 · 纳米技术 · 治疗递送系统

✓ 已验证产品关联 DOI PubMed 高影响因子

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CELLULAR SIGNALLING · 2023 · IF 4.8

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism

Jinmiao Tian,Lichao Zhang,Xiaoqin La,Xiaxia Fan,Aiping Li,Changxin Wu,Yuxuan An,Shuning Yan,Xiushan Dong,Haitao Wu,Zhuoyu Li

Macrophages in hypoxic regions of advanced colorectal tumors often exhibit M2-type features, but prefer oxygen-consuming lipid catabolism , which is contradictory in oxygen demand and supply. In this study, the results from bioinformatics analysis and intestinal lesions immunohistochemistry of 40 colorectal cancer patients illustrated that glucose-regulatory protein 78 (GRP78) was positively correlated with M2 macrophages. Furthermore, tumor-secreted GRP78 could enter macrophages and polarize them to M2-type. Mechanistically, entered GRP78 located in lipid droplets of macrophages, and elevated protein stabilization of adipose triglyceride lipase ATGL by interacting with it to inhibit its ubiquitination . Increased ATGL promoted the hydrolysis of triglycerides and the production of arachidonic acid (ARA) and docosahexaenoic acid (DHA). Excessive ARA and DHA interacted with PPARγ to encourage its activation, which mediated the M2 polarization of macrophages. In summary, our study showed that secreted GRP78 in the tumor hypoxic microenvironment mediated the domestication of tumor cells to macrophages and maintained tumor immunosuppressive microenvironment by promoting lipolysis, and the lipid catabolism not only provides energy for macrophages but also plays an important role in maintenance of immunosuppressive properties.

CAS / MDL: 506-32-1 313516-66-4

研究领域: 肿瘤学 · 免疫学 · 细胞生物学 · 生物化学

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Photothermal Nanoheaters-Modified Spores for Safe and Controllable Antitumor Therapy

Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism