Zhecheng Kang,Qian Zhou,Kun Wang,An Wang,Tianyi Chen,Hongbo Wei,Tengjiao Wang
Graphical An anti-infection nanocomposite was constructed by loading bactericide Roxarsone onto nitrosylated mesoporous polydopamine. The designed nanocomposite achieves NO-enhanced chemo-photothermal antibacterial therapy under near-infrared laser irradiation, and in vitro antibacterial evaluation has confirmed the effective elimination against the Gram-negative tetracycline-resistant Escherichia coil and Gram-positive methicillin-resistant Staphylococcus aureus of the nanocomposite. Current treatments for infections caused by multidrug-resistant bacteria still remain challenging and therapeutic materials with high efficacy are of demand. Herein, a bactericidal nanocomposite was constructed by loading Roxarsone (ROX) onto nitrosylated mesoporous polydopamine (named mPDA@NO-ROX). The designed nanocomposite exhibited considerable photothermal effect and controlled NO and ROX co-delivery under the irradiation of near-infrared laser (NIR) to achieve enhanced chemo-photothermal antibacterial therapy. The in vitro antibacterial evaluation of the mPDA@NO-ROX demonstrated the effective elimination of the Gram-negative tetracycline-resistant Escherichia coil and Gram-positive methicillin-resistant Staphylococcus aureus under mild NIR irradiation compared to merely ROX loaded unmodified mPDA, indicating the NO enhanced chemo-photothermal therapy. In addition, the cytotoxicity experiments indicated that mPDA@NO-ROX exhibited only 5 % of hemolysis rate and high cell viability at 1 mg mL −1 against mammalian fibroblasts, suggesting the excellent biocompatibility. In conclusion, the mPDA@NO-ROX could be a promising candidate for anti-infection therapy of multidrug-resistant bacteria.
Jian Luo,Yonghui Lin,Yanfeng Liu,Siliang Wang,Yiduo Chen,Xudong Tian,Weiting Yang,Zhongmin Su
Roxarsone (3-nitro-4-hydroxyphenylarsenic acid, ROX) is easily converted into highly toxic inorganic arsenic compounds, therefore, the development of highly efficient adsorbents for the removal of ROX from wastewater is necessary but remains challenging. In this study, NH 2 -MIL-101 (Fe) was synthesised and modified with TPA-CHO (4-(N, N-diphenylamine) benzaldehyde) to obtain TPA-MIL-101(Fe) with triphenylamine functionalised groups. The modified TPA-MIL-101(Fe) exhibits the very high adsorption capacity (728.2 mg g −1 ) and fast adsorption equilibrium (2 h). The TPA-MIL-101(Fe) showed excellent selectivity, and the adsorption efficiency hardly decreased in the presence of competing ions (Cl − , NO 3 − , SO 4 2− ). The TPA-MIL-101(Fe) showed good adsorption performance for ROX at pH 3–13, with the best performance at pH = 9. In addition, TPA-MIL-101(Fe) was able to remove trace amounts of ROX from actual water samples (<5 mg L −1 ) with an efficiency of 99.46 %, and the remaining ROX content meets the international drinking water standards of the World Health Organization (29 μg L −1 ). The mechanism studies have shown that the Fe-O-As coordination and the π-π stacking interaction between TPA-MIL-101(Fe) and ROX greatly enhance its adsorption performance. In conclusion, this work provides a promising material for effective removal of ROX from the environmental water.
危险品化学品经营许可证（带存储）