INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 7
·6451
·
IF 5.6
Yanning Wang,Boyou Hou,Liping Huang,Bingjian Li,Shi Liu,Mingyang He,Qun Chen,Jinchun Li
At present, the development and usage of degradable plastics instead of traditional plastics is an effective way to solve the pollution of marine microplastics. Poly (butylene adipate-co-terephthalate) (PBAT) is known as one of the most promising biodegradable materials. Nevertheless, the degradation rate of PBAT in water environment is slow. In this work, we successfully prepared four kinds of high molecular weight polyester copolyesters (PBATGA) via quaternary copolymerization. The results showed that the intrinsic viscosity of PBATGA copolymers ranged from 0.74 to 1.01 dL/g with a glycolic acid content of 0–40%. PBATGA copolymers had excellent flexibility and thermal stability. The tensile strength was 5~40 MPa, the elongation at break was greater than 460%, especially the elongation at break of PBATGA10 at 1235%, and the thermal decomposition temperature of PBATGA copolyesters was higher than 375 °C. It was found that PBATGA copolyester had a faster hydrolysis rate than PBAT, and the weight loss of PBATGA copolymers showed a tendency of pH = 12 > Lipase ≈ pH = 7 > pH = 2. The quaternary polymerization of PBAT will have the advantage of achieving industrialization, unlike the previous polymerization process. In addition, the polymerization of PBATGA copolyesters not only utilizes the by-products of the coal chemical industry, but also it can be promising in the production of biodegradable packaging to reduce marine plastic pollution.Keywords:methyl glycoacetate;glycolic acid;biodegradable;hydrolysis
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Junyao Li,Yu Wang,Yiying Yue
The opacity, fragility, and environmental unfriendliness of the traditional photocatalytic matrix cannot fully utilize the properties of photocatalysts and efficiently degrade pollutants. In this work, a transparent wood hydrogel with a core–shell structure was developed using transparent wood (TW) impregnated with polyacrylic acid (PAA) as the core layer and Bi-N-carbon dots/BiOBr (Bi-N-CDs/BiOBr) photocatalyst-initiated polymerization of acrylic acid (AA) monomers as the shell layer. In the shell layer, nanoscale CDs with rich hydrophilic groups built a link between BiOBr and PAA and strengthened the adsorption–photocatalysis synergistic removal for RhB. The original wood backbone well conserved during preparation led to an anisotropic structure in the resultant Bi-N-CDs/BiOBr@TW photocatalytic wood hydrogel. Namely, after introducing Bi-N-CDs/BiOBr as the linker and reinforcing agent, the tensile strength was up to 3.2 and 11.03 MPa along the radial (R-) and axial (A-) directions, which was 1.6- and 1.06-fold of R-TW and A-TW, respectively. Hence, Bi-N-CDs/BiOBr@TW with high strength furnishes multiple separations and reutilizations, and the RhB removal rate is approximately 85% after five cycles. The Bi-N-CDs/BiOBr@TW exhibited light transmittance up to 64.6 and 52.3% at 800 nm along the R- and A-directions, respectively. Moreover, the adsorption–photocatalysis synergistic rate of Bi-N-CDs/BiOBr@TW reached 93% in 300 min at pH = 7. This paper offers a strategy for fabricating wood hydrogels with outstanding stretchability, transparency, dye removal efficiency, and recyclability, opening a significant route for alleviating dye pollution.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 45
·39131-39136
·
IF 3.289
Kai Qin,Yani Yan,Yahong Zhang,Yi Tang
Cellulose without any pretreatment was directly converted into levulinic acid (LA) in a microwave-assisted acidic catalytic system with a high ionic strength. The highest LA yield could reach 67.3 mol% within 60 min even when the cellulose concentration was as high as 10 wt%. It is concluded that high ion strength and microwave irradiation were jointly responsible for the fast cellulose conversion and high LA yield, and a cooperative acceleration mechanism is finally proposed. The high ion concentration provided by alkali metal halides not only accelerated the cellulose hydrolysis but also facilitated glucose conversion into LA by shifting the weak acid ionization equilibria, and microwave irradiation further promoted this salt effect by its characteristic heating way of ion conduction. Such a one-pot catalytic system provides a possibility of practical application for direct highly efficient conversion of cellulose due to its green properties, low cost and efficient characteristics.
研究领域:
生物化学
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可再生资源工程
✓ 已验证
DOI
高影响因子
Materials
·
2019
·Vol. 12
·期 12
·1959
·
IF 2.972
Jiao Wang,Jianbo Li,Jie Ren
In this study, a series of poly(lactic-co-glycolic acid) (PLGA) microspheres with different particle sizes for arterial embolization surgery were prepared. The polydopamine (PDA) and polydopamine/polyethyleneimine (PDA/PEI) were respectively coated on the PLGA microspheres as shells, in order to improve the hydrophilicity and dispersibility of PLGA embolization microspheres. After modification, with the introduction of PDA and PEI, many hydrophilic hydroxyl and amine groups appeared on the surface of the PLGA@PDA and PLGA@PDA/PEI microspheres. SEM images showed the morphologies, sizes, and changes of the as-prepared microspheres. Meanwhile, the XPS and FT-IR spectra demonstrated the successful modification of the PDA and PEI. Water contact angles (WCAs) of the PLGA@PDA and PLGA@PDA/PEI microspheres became smaller, indicating a certain improvement in surface hydrophilicity. In addition, the results of in vitro cytotoxicity showed that modification had little effect on the biosafety of the microspheres. The modified PLGA microspheres suggest a promising prospective application in biomedical field, as the modified microspheres can reduce difficulties in embolization surgery.Keywords:functional;poly(lactic-co-glycolic acid);microspheres;surface modification
研究领域:
生物材料学
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医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 39
·期 2
·290-295
·
IF 2.726
Qin Chang,Dong Jing,Xie Beibei,Wang Hongkun,Zhang Na,Zhao Chunhua,Qiao Congde,Liu Mingxia,Yang Xiaodeng,Li Tianduo
Poly(lactic-co-glycolic acid)(PLGA) is one of the most representative degradable copolymers and promising drug carriers. In the current paper, the PLGAs with a lactic acid/glycolic acid(LA/GA) molar ratio of 52/48 and various molecular weights were prepared by a melting method. The molecular weight, molecular weight distribution, and thermal stability were determined by 1 H NMR and thermogravimetric analysis methods. The results demonstrated that PLGAs with the fixed LA/GA molar ratio(52/48), different molecular weights, and narrow molecular weight distribution could be obtained by solely altering the reaction time. The PLGA films were prepared, and their properties including micro-structure, mechanical property, in-vitro cytotoxicity, and biodegradability were characterized. In combination with the homogeneous microstructures and mechanical properties, the drug-loading and releasing properties of PLGA 3.2 films were investigated. The results show that PLGA 3.2 film with an LA/GA molar ratio of 52/48 is a promising curcumin carrier.
研究领域:
生物材料学
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药物递送系统
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高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Nanomaterials
·
2020
·Vol. 2020
·期 1
·6014816
·
IF 1.98
Cijun Shuai,Chen Wang,Fangwei Qi,Shuping Peng,Wenjing Yang,Chongxian He,Guoyong Wang,Guowen Qian
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has a great potential in bone repair, but unfortunately, the poor mechanical properties limit its further application. In this work, zinc oxide (ZnO) nanoparticles were incorporated into PHBV porous scaffold fabricated by selective laser sintering technique. It was because ZnO nanoparticles could provide nucleating sites for the orderly stacking of polymer chains, thereby enhancing the crystallinity of PHBV. It was well known that the mechanical properties of PHBV scaffold could be enhanced with the increase of crystallinity. More significantly, the released Zn 2+ would combine negatively charged cell membranes of bacterial through electrostatic interaction and consequently destructed the protein structure and resulted in the death of bacterial, which was highly desired in reducing the risk of implant infection. Results indicated that the relative crystallinity of scaffold with 3 wt.% ZnO increased remarkably from 38% to 64% compared to pure PHBV scaffold, which effectively enhanced the compression strength and modulus by 56% and 51.5%, respectively. Moreover, the scaffold had a favorable antibacterial activity. Cell culture experiments proved that the scaffold could promote the cell behaviors. The positive results demonstrated the scaffold may serve as a potential replacement in bone repair.
研究领域:
生物材料
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组织工程
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纳米医学
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骨修复
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抗菌材料
✓ 已验证
DOI
高影响因子
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
·
2021
·Vol. 53
·期 8
·1027-1036
·
IF 3.848
Yao Wang,Yao Jialiang,Qian Fangfang,Que Zujun,Yu Pan,Luo Tianle,Zheng Dan,Zhang Zhanxia,Tian Jianhui
Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and alleviating the side effects of chemotherapy agents in cancer treatment. However, availability of only a few studies that discuss organic nanomedicines with these properties limits the development prospects of nanomedicines. In the present study, folic acid (FA)-targeted delivery and glutathione (GSH) smart responsive nanomedicine were rationally designed for paclitaxel (PTX) delivery for the treatment of lung cancer. Compared with other stimuli-responsive nanomedicines, this nanocarrier was not only sensitive to biologically relevant GSH for on-demand drug release but also biodegradable into biocompatible products after fulfilling its delivery task. The nanomedicine first entered tumor cells via FA and its receptor-mediated endocytosis. After the lysosomal escape, poly(lactic-co-glycolic acid) (PLGA) nanomedicine was triggered by a higher level of GSH and released its cargo into the tumor microenvironment. In vitro and in vivo results revealed that the PLGA nanomedicine not only inhibited the proliferation and promoted the apoptosis of lung cancer cells significantly but also possessed less toxic side effects when compared with free PTX. Therefore, the proposed drug delivery system demonstrates the potential of a multifunctional nano-platform to enhance bioavailability and reduce the side effects of chemotherapy agents.
研究领域:
药剂学
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肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2017
·Vol. 29
·期 1
·384-393
·
IF 1.907
Qing Shang,Aixin Zhang,Zhaoying Wu,Sijin Huang,Ruiqiong Tian
The aim of this study was to fabricate different risperidone (RIS)–loaded poly(lactic-co-glycolic acid) microspheres (PLGA MS) with various viscosity of PLGA polymers and investigate the RIS release profiles. Risperidone-loaded PLGA MS were fabricated via an oil/water–type emulsion solvent evaporation method, using ethyl acetate and benzil alcohol as the dispersed solvents. The PLGA (75:25) with the viscosity of 0.82, 0.93, and 1.10 dL/g was used in the fabrication. The morphology and the degradation of the RIS-PLGA MS were investigated with a scanning electron microscope. The distribution states of RIS in the PLGA MS were studied with differential scanning calorimetry. The residual of ethyl acetate and benzil alcohol in the resulting MS was monitored with gas chromatography. The in vitro release profiles of RIS from PLGA MS were also studied. Scanning electron microscope photographs illustrated that the obtained PLGA MS were monodisperse spheres with an average diameter of 100 μm. Gas chromatography results suggested that no residual ethyl acetate was left in the final RIS-PLGA MS, and the residue amount of benzil alcohol was about 1%. In vitro drug release profiles from the microsphere showed a substantially sigmoidal pattern of negligible initial burst up to 24 hours and minimal release (time lag) for 14 days. After the lag phase, slow release took a place up to 30 days, and then rapid release occurred sharply for about 2 weeks. The RIS release reached equilibrium around day 50. All release profiles showed the similar trend, and no significant difference was observed among these release profiles ( P > .05). This phenomenon indicated that RIS-loaded PLGA MS with the viscosity of 0.82 to 0.93 dL/g showed the optimal release behavior. However, no obvious differences were found among the MS obtained from the viscosity of 0.82 to 1.10 dL/g. These studies provided basis for the quality control in the industrial production of PLGA MS.
研究领域:
药剂学
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生物材料学
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS & POLYMER COMPOSITES
·
2015
·
IF 0.271
Xiaojing Zhang,Chong Li,Yuelei Hu,Jiashu Sun,Shaoming Fang
In this paper, a series of star-shaped poly(lactide-co-glycolide)s (sPLGA) with different block ratios were prepared by the ring-opening copolymerization of D,L-lactide (LA) and glycolide (GA) with multi-hydroxyl polyhedral oligomeric silsesquioxane core as an initiator and tin (II) 2-ethylhexanoate (Sn(Oct)2) as the catalyst. The products were characterized by NMR, FT-IR, GPC, XRD, DSC, TGA and viscosity measurements. The results show that the contents of PLA and PGA segments in sPLGA can be controlled by the feed ratios of the copolymerization. The glass transition temperature and crystallinity of sPLGA decrease and the crystalline sPLGA becomes amorphous with increasing the molar feed ratio between GA and LA from 10:90 to 50:50. The drug-loaded sPLGA microspheres were prepared by an emulsion solvent evaporation method. The morphology and the drug release property were investigated by SEM, dynamic light scattering (DLS) and ultraviolet spectrophotometry (UV). The results indicate that the sPLGA80 microsphere surface was smooth and the mean diameter was about 1.27μm. The sPLGA80 microspheres showed good drug loading and release properties.
研究领域:
材料科学
·
药剂学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 19
·6871-6878
·
IF 2.562
Delin Cheng,Xiaodong Cao,Huichang Gao,Yingjun Wang
Biodegradable polymer microspheres have been increasingly attracting attention in bone repair. In this work, superficially porous poly(lactic-co-glycolic acid)/calcium carbonate (PLGA/CC) composite microsphere is prepared by spontaneous pore-forming emulsion method. In addition to being the component that neutralizes the acidic products from PLGA degradation, calcium carbonate (CC) also constructs macropores on the surface of microsphere and thus exempts the use of extraneous porogens, which simplifies the preparation process and avoids problems related to extraneous porogen. It is found that the size of CC plays the most essential role in forming the superficial macropores because it determines the water absorption capacity of CC. Release of dexamethasone from the superficially porous composite microspheres shows a mild burst and the subsequent tri-phase profile. Meanwhile, the cell culture test demonstrates that MG-63 cells grow well on the superficially porous composite microsphere and proliferate better than those on pure PLGA microsphere. Therefore, this versatile composite microsphere has a promising application for bone repair.
研究领域:
生物材料学
·
医学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 19
·11074
·
IF 6.208
Yanning Wang,Haicun Yang,Bingjian Li,Shi Liu,Mingyang He,Qun Chen,Jinchun Li
The main problem of manufacturing with traditional biodegradable plastics is that it is more expensive than manufacturing with polymers derived from petroleum, and the application scope is currently limited due to poor comprehensive performance. In this study, a novel biodegradable poly(butylene adipic acid/terephthalate-co-glycolic acid) (PBATGA) copolyester with 25–60% glycolic acid units was successfully synthesized by esterification and polycondensation using cheap coal chemical byproduct methyl glycolate instead of expensive glycolic acid. The structure of the copolyester was characterized by ATR-FTIR,1H NMR, DSC, and XRD; and its barrier property, water contact angle, heat resistance, and mechanical properties were tested. According to the experiment result, the PBATGA copolyesters showed improved oxygen (O2) and water vapor barrier character, and better hydrophilicity when compared with PBAT. The crystallization peaks of PBATGAs were elevated from 64 °C to 77 °C when the content of the GA unit was 25 mol %, meanwhile, the elongation at the break of PBATGA25 was more than 1300%. These results indicate that PBATGA copolyesters have good potentiality in high O2and water vapor barrier and degradable packaging material.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
·
2017
·
IF 0
Jiale Cui,Zhihua Zhou,Yun Yang,Wenjuan Liu,Yunfei Zhao,Cheng Peng,Tianlong Huang,Hu Zhou,Lihua Liu,Qiao Zhang
In order to improve hydrophilicity and settle the acidity in hydrolysis, a novel ethanediamine (EDA) and maleic anhydride (MAH) modified poly(D,L-lactide-co-glycolide) (PLGA) polymer (EMPLGA) was synthesized. Fourier Transform Infrared Spectrometer (FTIR), Gel Permeation Chromatography (GPC), Nuclear Magnetic Resonance (1HNMR), titration and the water contact angles were employed to characterize the synthesized polymer. The effects of various polymerization conditions on weight average molecular mass (Mw), polydispersity index (PDI) and anhydride content of MPLGA were investigated. The degradation behaviors of PLGA, MPLA and EMPLGA were also studied by observation of the changes of the pH value of incubation medium, molecular weight and weight loss ratio for a time interval of 25 days in-vitro, respectively. The results showed that MPLGA with high anhydride content was successfully obtained by directly ring-opening polymerization and ethanediamine was further grafted onto MPLGA, and there is almost unchanged in Mw between MPLGA and EMPLGA polymers. The introduction of anhydride and amino groups improved the hydrophilicity of PLGA. A uniform degradation of EMPLGA was observed in comparison with an acidity-induced auto-accelerating degradation featured by PLGA and MPLGA. The results revealed that the introduction of ethanediamine into PLGA has weakened or neutralized the acidity of PLGA degradation products.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）