INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Qin Shi,Jialve Zhang,Zhenjie Duan,Yanqing Wang,Yumin Wu,Yuetao Liu
With the rapid development of science and technology, the discharge of industrial wastewater, especially dye wastewater, has caused great harm to the ecological environment. In response to the pollution caused by cationic organic dyes in industrial wastewater, this study employed free radical polymerization to prepare a new hydrogel adsorbent, PAA-PA-CMC, which exhibits both reusability and a large adsorption capacity. Phytic acid (PA) and carboxymethyl cellulose (CMC) were introduced into the acrylic acid-based polymer network using N, N ‘-methylene-bisacrylamide (MBA) and glycidyl methacrylate (GMA) as cross-linking agents. Phytic acid serves as both a cross-linking agent and an active component in the adsorption of methylene blue cationic dyes. Methylene blue (MB) adsorption experiments demonstrated that PAA-PA-CMC possesses a porous structure and abundant functional groups, primarily utilizing hydrogen bonds and electrostatic interactions for efficient MB adsorption. The adsorption capacity of PAA-PA-CMC for MB can reach 1005.41 mg/g and has good reusability. After 5 cycles, its adsorption efficiency remains at about 85 %. The adsorption behavior of PAA-PA-CMC conforms to the pseudo-second-order kinetic model and the Langmuir isotherm adsorption model, which is a monolayer chemical adsorption. In summary, the PAA-PA-CMC hydrogel prepared in this investigation shows great potential for treating MB dye wastewater.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
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2016
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IF 0
Xia Dong,Chang Wei,Hongli Chen,Jingwen Qin,Jie Liang,Deling Kong,Tianjun Liu,Feng Lv
Real-time tracking of a drug delivery system and its therapeutic effects in vivo are crucial to designing a novel pharmaceutical system and revealing the mechanism of drug therapy. Multispectral fluorescence imaging can locate the drug and carrier simultaneously without interference. This advanced method enables the tracking of a drug delivery system. Herein, a doxorubicin (Dox) loaded zinc phthalocyanine incorporated hydrogel was developed as a dual fluorescent drug delivery system to monitor the release of the drug and the degradation of the carrier. An injectable thermosensitive hydrogel based on a four-arm poly(ethylene glycol) (PEG)–poly(ε-Caprolactone) (PCL) copolymer was prepared and characterized with a zinc phthalocyanine core as the drug carrier. The hydrogel degradation and drug delivery in vivo were tracked by a multispectral fluorescence imaging system in nude mice bearing hepatic tumors. Moreover, the real-time tumor inhibition progress was tracked in vivo for 18 days by bioluminescence imaging. A multispectral analysis can separate the fluorescence signals from the drug and carrier in the Dox loaded hydrogel and provide their location in the tumor tissue. The drug release and hydrogel degradation can be drastically tracked respectively without mutual interference. The fluorescence imaging results reveal improved tumor inhibitory effects of the Dox loaded hydrogel. Optical imaging allows for visible tracking of the entire drug delivery process. The Dox loaded phthalocyanine incorporated thermosensitive hydrogel is a potential visible drug delivery system for tumor therapy.
研究领域:
药剂学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Shixin Lu,Zhaopeng Cai,Yuheng Lu,Youchen Tang,Jiapeng Song,Jiajun Huang,Ziying Cheng,Dingcai Wu,Peng Wang
Growing hydrogel coatings in a controlled manner exhibits promising potential for various applications, but lacks a universal method especially from polymer precursors. Herein, we propose a facile yet effective strategy to controllably grow various types of hydrogel coatings, either from polymers or monomers, on diverse polymer substrates via Fenton reaction. By immersing the pretreated polymer substrate in the given precursor solution, peroxide adsorbed into/on the substrate surface and Fe 2+ in the solution trigger continuous Fenton reaction at the solid–liquid interface to drive polymer chains interlinking to the substrate and crosslinking into a network synchronously. Furthermore, due to the high viscosity of the newly formed hydrogel, radicals are confined close to the interface by diffusion, which not only allows for precise control over the coating thickness but also enables the reutilization of precursor solution. As proof of concept, our method is successfully applied to produce hydrogel coatings with adjustable micron-scale thickness, impart excellent low-friction and antifouling properties to polymer substrates, and manipulate a series of fine hydrogel patterns. Therefore, this work presents a pioneering universal approach for growing hydrogel coatings on various polymer surfaces and implies significant potential applications.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Materials Today Bio
·
2025
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IF 10.2
Xintao Jia,Zixuan Dou,Ying Zhang,Changxiang Yu,Mengru Yang,Haonan Xie,Yun Lin,Zhidong Liu
Diabetic foot ulcers (DFUs), a severe and common complication of diabetes, present significant treatment challenges due to the limitations of conventional dressings, such as poor mechanical properties, bioactivity, and limited functionality, which hinder fast and effective wound healing. To address these issues, we developed a novel natural amino acid-based hydrogel loaded with paeoniflorin (PF@PNMA1) and comprehensively evaluated its properties and functions. The nanogel particles (NGs) were synthesized via emulsion polymerization using N-isopropylacrylamide (NIPAM), methacrylic acid (MAA), and chemically modified arginine (MArg). The poly(NIPAM-co-MAA) (PNM) and poly(NIPAM-co-MAA-co-MArg) (PNMA) gels were prepared by functionalizing the NGs with glycidyl methacrylate (GMA). The different concentrations of amino acids were added to explore the optimal mechanical properties of the gel. Through the rheological measurement, we found that PNMA1 gel has good ductile properties with a critical strain up to about 63 %. At the same time, we also verified its antibacterial activity and found that the viability of bacteria decreased to 47.46 % after 3 h. Preliminary tests using network pharmacology and molecular docking confirmed the therapeutic potential of PF for DFUs. The PF@PNMA1 gel demonstrated excellent biocompatibility, and in vivo experiments revealed its effectiveness in promoting angiogenesis and wound healing. After 10 days, the wound healing rate was 25.6 % higher than that of the control group. The PF@PNMA1 shows great potential as an effective therapy for DFUs treatment.
研究领域:
生物材料学
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药理学
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医学工程
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 40
·19065-19072
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IF 3.591
Yandi Liu,Yijun Hao,Yingjiao Wu,Sha Lu,Juan Li,Zhijun Zhou
Owing to its excellent biocompatibility, abundant functional groups and injectability, the gellan hydrogel is widely used in the biomedical field. In this work, a Au/MnO2@GG nanocomposite hydrogel was prepared by a one-pot method using the gellan hydrogel as a template. The obtained Au/MnO2@GG exhibits a broad plasmon-enhanced absorption in the near-infrared region. As a result, the nanocomposite hydrogel has an enhanced photothermal conversion efficiency of 71.3% at 808 nm, superior to those of MnO2@GG (27.1%) and Au@GG (25.7%) alone. The local surface plasmon resonance induced by Au could transfer energy to MnO2, and thus improve the photothermal conversion efficiency through non-radiative energy dissipation. Moreover, the nanocomposite hydrogel displays excellent biocompatibility, long-term stability, good shear-thinning and self-recovery properties. In vivo antitumor studies proved that the nanocomposite hydrogel could completely ablate the solid tumors under NIR illumination. This work may encourage the development of more advanced nanocomposite materials with high photothermal conversion efficiency, stability, and multiple functionalities.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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产品关联
DOI
高影响因子
IRANIAN POLYMER JOURNAL
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2023
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IF 3.1
Zou Yilong
Heavy metal pollution is a global environmental threat that jeopardizes both human health and ecosystems. To combat this issue, the adsorption method has emerged as a cost-effective, efficient, and environmentally friendly solution. Hydrogels, three-dimensional hydrophilic polymer networks, display remarkable swelling and adsorption capabilities, making them superior to other adsorbents. They facilitate easier adsorbate transfer, resulting in enhanced adsorption efficiency. This study introduces a novel, energy-efficient approach for crafting metal-ion hydrogel adsorbents. The process involved grafting catechol groups onto chitosan (CS-CH) and then forming a hydrogel through a Schiff base reaction between CS-CH and oxidized carboxymethyl cellulose (OCMC). Successful hydrogel formation was confirmed using FTIR and UV–Vis spectroscopies. The hydrogel’s dual interaction mechanism, facilitated by catechol and amine groups, enhanced its pollutant-binding capacity. Under optimal conditions (pH = 7) and a 180-min adsorption period, the OCMC/CS-CH hydrogels exhibited significant practical adsorption efficiencies: 89.6% for Cu 2+ , 80.5% for Cd 2+ , and 91.8% for Pb 2+ ions. Subsequent experiments reaffirmed its exceptional adsorption performance for these ions. Notably, the hydrogel maintained its efficacy even after five cycles of adsorption and desorption in 0.1 mol/L HCl, showcasing its impressive regeneration potential. Collectively, the straightforward fabrication process, consistent performance, and negligible secondary pollution make this hydrogel a promising candidate for a wide array of applications in addressing heavy metal contamination. Graphical abstract
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2023
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IF 4.8
Shuyue Jiang,Haifeng Zhang,Zhaoxin Li,Liang Chen,Xiaowei Liu
This paper proposed a novel integrated detector with nanostructured hydrogel electrode (IDNHE) for ascorbic acid detection. The electrochemical detector was integrated on printed circuit board (PCB). The IDNHE employed the nanostructured multi-walled carbon nanotubes/polyaniline/polyvinyl alcohol (MWCNTs/PANI/PVA) hydrogel as the working electrode. The PVA hydrogel can not only effectively combine the PANI and substrate through hydrogen bonds, but also greatly improve the stability and durability of the detector. MWCNTs were used to fabricate the nanostructures, increasing the surface area of electrode. The detection mechanism is based on the redox reaction of PANI with ascorbic acid. The detection limit and the sensitivity of IDNHE were 0.9 μM (S/N = 3) and 161.46 mA·μM −1 ·cm −2 , respectively. Moreover, IDNHE has a satisfactory reproducibility (RSD = 1.43 %), repeatability (RSD = 2.35 %) and long-term stability for 90 days. Therefore, this work undoubtedly provides a considerate choice for the lab on a chip, and further a promising application prospect for developing the portable real-time monitoring device.
研究领域:
分析化学
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生物医学工程
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传感器技术
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
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2025
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IF 5.7
Rui Wang,Yan Zhou,Han Wang,Yan Li,Khaydar E. Yunusov,Lei Nie,Sedrati Manar,Jianwei Pan,Guohua Jiang
An efficient and long-term stable non-oral drug delivery system is preferable for treating hyperuricemia, as it can minimize adverse effects and prolong treatment efficacy. Herein, the hydrogel microneedles (HMNs) system with dual modulation strategy was proposed to regulate the serum uric acid (SUA) levels. First, allopurinol (AP) loaded metal-organic frameworks (MOFs) (ZIF-8) composite nanoparticles were absorbed on to the lamella of MnO2 nanosheets to form the environment-responsive nanoformulations (AP@ZIF-8@MnO2,APZM). Then, these environment-responsive nanozymes and free AP were further mixed with the methacrylate hyaluronic acid (MeHA) to fabricate HMNs by vacuum template and UV light cross-linking technologies. In vitro experiments on mice models showed that the free AP could be rapidly released to inhibit the production of UA after the these MNs absorption of interstitial fluid. And APZM nanoformulations encapsulated in HMNs could be slowly released due to the swelling of HMNs. The MnO2 from APZM could be acted as a potent oxidase-like nanoenzyme, scavenging the existing SUA. And the degradation of ZIF-8 triggered the high SUA levels micro-environment provided a secondary release of AP to maintain the longer normouricemia state. The SUA level could be maintained for more than 32 h under the normal level, leading a long-term therapeutic effect.
研究领域:
生物医学工程
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药剂学
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纳米医学
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产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
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2023
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IF 3.1
Hui Huang,Yabin Dai,Yuefen Zhang,Yongning Li,Huazhen Ye,Dan Guo,Qiaomei Lu,Xiaohua Cai
Analytical screening and validation systems based on a combination of cell membrane chromatography and two-dimensional chromatography-tandem mass spectrometry are incapable of providing prepared samples containing the active ingredients found in traditional Chinese medicine; therefore, these samples cannot be directly used in subsequent studies. In this study, a semi-preparative cell membrane chromatography column was developed using a hydrogel-modified carrier and human umbilical vein endothelial cells to optimize prepared conditions, such as hydrogel polymerization, cell fragmentation, and cell membrane volume. This increased the binding ratio of membrane protein and carrier to 15.79 mg/g. The column was systematically evaluated using multitarget tyrosine kinase inhibitors that displayed good specificity and reproducibility. Subsequently, using the column coupled with a semi-preparative high-performance liquid chromatography-offline-high-performance liquid chromatography-mass spectrometry system, 15 active ingredients were screened and purified from Indigo naturalis , and five main components were identified: l -lysine, oxyresveratrol, tryptanthrin, isorhamnetin, and indirubin. Furthermore, the pharmacological effects of the ingredients were confirmed using cell proliferation and apoptosis assays. Results revealed potent proliferation-inhibiting and apoptosis-promoting abilities on human chronic myelogenous leukemic cells and human promyelocytic leukemic cells ( p < 0.001). Overall, the system presented screening and purification functions that could be used to prepare I. naturalis samples acting on the epidermal growth factor receptor and vascular endothelial cell growth factor.
研究领域:
药理学
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分析化学
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中医药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）