COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2017
·
IF 2.714
Juan Guo,Wenbo Du,Yong Gao,Yuan Cao,Yafang Yin
A novel water-in-soybean oil Pickering emulsifier based on CNCs was fabricated via the intercalative chemical reaction between n -octadecyl isocyanates and hydroxyl groups in CNCs. The structural variations of alkyl intercalated CNCs with different degrees of substitution for hydroxyl groups were studied by TEM, AFM, FTIR, XRD , elemental analysis and liquid DSC . It is shown that O(2)H/O(6)H instead of O(3)H in CNCs were substituted after intercalative modification. And the particle thickness was increased after the intercalation, due to the enlargement of the basal spacing of (200) lattice plane in CNCs. While their cross section dimensions were unvaried. The structural variations in alkyl intercalated CNCs on their emulsifying capacity were further studied. Particle length has the insignificant influence on the emulsifying capacity. Alkyl intercalated CNCs with different particle lengths failed to stabilize water-in-soybean oil Pickering emulsion droplets, if O(2)H/O(6)H hydroxyl groups were fully substituted with alkyls. Alkyl intercalated CNCs with appropriate amounts of substituted hydroxyl groups possessed a good emulsifying capacity. After the initial coalescence, the average droplet size and its distribution polydispersity remained nearly constant with one year of storage. Results shown that alkyl intercalated CNCs with different degrees of substitution for hydroxyl groups had the similar interfacial tension at the soybean oil-water interface, the similar molecular arrangement of internal intercalated alkyls but different contact angles. These indicated that emulsifying capacity was mainly related to their surface alkyl chains. Besides, water-in-soybean oil Pickering emulsions stabilized by alkyl intercalated CNCs were from steric hindrance rather than interfacial tension reduction mechanism.
研究领域:
材料科学
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化学工程
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Li-Feng Li,Meng-Di Wang,Chen-Yang Zhang,Meng-Yao Jin,Hua-Lei Chen,Huan Luo,Tian-Yu Hou,Zhi-Jun Zhang,He Li
Advanced glycation end products (AGEs) generated from the Maillard reaction (MR) during food processing in the human physiological environment, have been proven to be significantly associated with various chronic metabolic diseases. In this study, 18 flavonoids were investigated to study their effects on AGEs formation during MR within a glucose-lysine-arginine model system. Five AGEs— N ε -carboxymethyl-lysine (CML), N ε -carboxyethyl-lysine (CEL), pyrraline, pentosidine, and argpyrimidine—were determined by high-performance liquid chromatography-mass spectrometry, with inhibitory rates ranging between 0 % and 71.35 %. Isorhamnetin and naringenin exhibited the strongest inhibitory effect on the formation of CML and CEL, respectively, whereas myricetin exhibited the strongest inhibitory effect on pyrraline, pentosidine, and argpyrimidine formation. In addition, each flavonoid was reacted with glyoxal (GO) and methylglyoxal (MGO) to investigate their trapping activities and adducts. The results showed that the 18 flavonoids could effectively clear GO and MGO, with clearance rates of 1.03 %–71.42 % and 0.93 %–69.37 % for GO and MGO, respectively. Six flavonoids—chrysin, naringenin, apigenin, luteolin, diosmetin, and kaempferol—could form adduct products with mono-/di-MGO, with flavonoid to mono-/di-MGO adduct ratios of approximately 6:1, 2:1, 8:1, 23:1, 10:1, and 3:1, respectively. The number and site of phenolic hydroxyl groups, as well as methoxy substitution on the B-ring in flavonoids, had little effect, but phenolic hydroxyl groups at the C-3 position in the C-ring impeded adduct formation. The flavonoids lowered the degradation of glucose itself, and decreased ammonia-induced degradation and Amadori rearrangement product oxidation due to their antioxidant activities, and they trapped the reactive 1,2-di‑carbonyl species via nucleophilic addition reaction to form AGEs.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Computational and Theoretical Chemistry
·
2024
·
IF 3
Xiong Zhang,Tingting Li,Qi Wang,Youyang Wang,Xiaodan Wu,Yingxue Jin,Wen Fang,Zhiqiang Wang
Numerous chlorophyll-based derivatives have found applications in the dye and pharmaceutical industries. Here, we report the synthesis of a poly-hydroxyl substituted chlorophyll molecule (THM) and its absolute configuration determination using experimental electron circular dichroism (ECD), nuclear magnetic resonance (NMR) spectroscopy, and density functional theory (DFT) calculations. Furthermore, the photoreaction types of THM (type I and type II) were investigated through theoretical calculations and validated by biological experiments. We provide a detailed analysis of electron transfer and excitation processes in THM through theoretical calculation of hole-electron distribution, as well as study intramolecular weak interactions and conjugation effects using Reduced Density Gradient (RDG), Interaction Region Indicator (IRI), and Natural Bond Orbital Analysis (NBO). The photoreaction types (type I, type II) of THM in tumor cells have also been investigated by biological experimental measures and theoretical calculation of the single-triplet state energy gap and hole-electron distribution. Molecular electrostatic potential has also been investigated by DFT methods to give insight into the molecular structure. This study provides useful guidance for the structural and photochemical studies of the chlorophyll-derived photodynamic therapeutic drugs.
研究领域:
化学
·
生物学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Food Frontiers
·
2022
·Vol. 4
·期 1
·289-296
·
IF 0
Hongting Deng,Yuanju He,Hui Cao,Lei Chen,Hui Teng
The aim of the present work was to evaluate different structures of flavonoids interfering with the cytotoxicity of heterocyclic amines (HCA). Eight flavonoids with similar structure including myricetin, rutin, fisetin, quercetin, myricetrin, quercetrin, kaempferol, and galangin were coincubated with 2-amino-4-methylimidazo[4,5-f]quinolone (IQ) respectively to determine the cytotoxicity. The results revealed that IQ at low doses showed no cytotoxicity; however, in the presence of myricetin and rutin, the cytotoxicity significantly elevated. It seems that C-3′, C-4′, C-5′, and C-5 hydroxyl substituents on the flavonoid skeleton of B ring play important role in the increasing cytotoxicity induced by IQ in HepG2 cells. Interestingly, the data obtained from the present study revealed an unexpected adverse effect of the supposed beneficial food ingredient myricetin, which appears to be able to increase the cytotoxicity of the procarcinogen HCA.
研究领域:
药理学
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毒理学
·
癌症研究
✓ 已验证
产品关联
DOI
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2018
·
IF 3.974
Xiaoxin Chen,Sheng He,Xiaolu Liu,Jiye Hu
Using sequential soil and liquid culture enrichments with cyprodinil as the sole carbon source, a Gram-negative cyprodinil-degrader from cyprodinil-polluted agricultural soil was isolated. The sequencing analysis of 16 S rRNA indicated that the strain showed 99% homology to Acinetobacter sp. The strain could effectively degrade cyprodinil at the neutral condition. At the initial concentrations of 10, 20, 50, 100, 150 and 200 mg L −1 in minimal medium, cyprodinil was degraded by 10, 20, 49.3, 64.2, 57 and 24 mg L −1 within 14 days, respectively. Two metabolites (4-cyclopropyl-6-methyl-2-pyrimidpyridine amine and monohydroxylated para-substitution) were identified using high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS/MS). A biodegradation pathway involving imines hydrolysis and monohydroxyl substitution on benzene ring was proposed on basis of the identified metabolites. Acinetobacter sp. would have a potential application in bioremediation of cyprodinil-contaminated soil, and the strain might have important implications in detoxification and bioremediation of pyrimidine analogues.
研究领域:
环境微生物学
·
生物修复
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农药降解
·
土壤科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PHYSICS
·
2021
·
IF 2.348
Deying Meng,Huangmei Zhou,Jianhua Xu,Sanjun Zhang
Salicylic acid and its monohydroxy substituted derivatives are usually used as food additives . They can interact with bovine serum albumin (BSA) through π-π stacking, the monohydroxy substitutions can hinder the interactions through steric effects . In this paper, we systematically studied the interactions between BSA and salicylic acid and its monohydroxy substituted derivatives under simulative physiological conditions by diverse spectroscopic methods and molecular docking studies. The spectroscopic studies showed that the intrinsic fluorescence of BSA could be quenched by salicylic acid and its derivatives. The quenching mechanism is a combination of static and dynamic quenching. Furthermore, the molecular docking simulation revealed the binding sites (near the Trp-213 in the BSA) and the distance (2.1 nm, 2.9 nm, 2.0 nm, 2.7 nm and 3.3 nm, respectively) between ligand and protein, which is in good agreement with the calculated results of the energy transfer process . Our research may provide guidance for understanding the interactions between serum albumin and salicylic acid food additives.
研究领域:
药学化学
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生物化学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）