Frontiers in Cell and Developmental Biology
·
2025
·
IF 4.3
Wanying Cheng,Cenzhu Wang,Meican Ma,Yu Zhou
Background: Diabetic kidney disease (DKD) is the leading risk factor for end-stage renal disease (ESRD). Hydroxyurea (HU), a sickle cell disease (SCD) drug approved by FDA, shows protective effect in nephropathy. This study aims to understand whether the application of HU could be effective to treat DKD.Methods: The streptozotocin (STZ)-induced diabetic mice, and high glucose (HG)-treated human renal mesangial cells (HRMCs) were used to investigate the effect of HU on DKD. Serum creatinine and blood urea nitrogen levels reflecting renal function were evaluated. Histology was used to evaluate pathological changes. Indicators of inflammation and apoptosis were detected. Lastly, the mTOR-S6K pathway was explored by detecting the protein expression of S6K and phosphorylated S6K.Results: In STZ-induced diabetic mice, administration of HU (20 mg/kg) in drinking water for 16 weeks resulted in significant reductions in creatinine and urea nitrogen levels, alongside mitigating histopathological damage. Additionally, HU effectively suppressed the inflammatory response and apoptosis within the kidneys. HRMC cells were cultivated in HG conditions, and HU effectively attenuated the HG-induced inflammation and apoptosis. Moreover, HU treatment significantly inhibited the mTOR signaling pathway in both in both in vivo and in vitro experiments.Conclusion: This study unveils a new role of HU in alleviating diabetic kidney disease by modulating inflammation and apoptosis through the mTOR-S6K pathway. However, since HU did not significantly affect blood glucose levels, its therapeutic potential may be best realized when used in combination with standard antidiabetic therapies. Such a combination approach could simultaneously address hyperglycemia and renal dysfunction, offering a more comprehensive management strategy for DKD.
研究领域:
医学
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分子生物学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Shan Jiang,Tianyi Han,Tongshuai Tian,Chuanqing Yang,Li Liu
Compared with isocyanate-based polyurethanes (PUs), poly(hydroxyurethane)s (PHUs) are more likely to form phase mixing structure, inducing poor elastic properties. To avoid this, stronger interaction between hard segments is required. Herein, carbon dioxide-based poly(hydroxyurethane-urea)s (PHUUs) with different hard segment contents were prepared through polyaddition reaction using 5-membered dicyclic carbonate (BADC) as hard segment, poly(propylene glycol) bis(2-aminopropyl ether) (D2000) as soft segment, and amino-terminal polyurea oligomer (HMDA*) chain extender, and several PHUs were prepared by using hexamethylenediamine (HMDA) chain extender or without using chain extender as controls. The interaction between hard segments were strengthened with the introduce of chain extender. Compared with PHUs, PHUUs with HMDA* chain extender were more inclined to form significant microphase separation. For PHUUs, the hard segment T g appeared at around 60°C when hard segment content reached 40 wt%, and the interdomain spacings were in the range of around 14–23 nm with 40–50 wt% hard segment content. In addition, PHUUs exhibited better solvents resistance and mechanical properties than PHUs with the same hard segment content. PHUUs with certain hard segment content showed good elastic recovery, with a residual strain less than 2% after 10 cycles, which comparable with conventional isocyanate-based PUs.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Shan Jiang,Li Liu
Poly(hydroxyurethane)s (PHUs) are regarded as one of the most promising nonisocyanate-based polyurethanes, with their improved performance attracting widespread attention. As a type of PHU, poly(hydroxyurethane-urea)s (PHUUs) can effectively broaden the performance range of PHUs, demonstrating high potential for various applications. In this study, cross-linked PHUU elastomers were prepared through aminolysis of cyclic carbonate, using carbon dioxide-based tricyclic carbonate of glycerol (GTC) as the cross-linker, and carbon dioxide-based amino-terminal polyurea oligomer (TTD*/HMDA*) as the chain extender. The cross-linking density and thermal and mechanical properties of the PHUU elastomers could be tailored by controlling the feed ratio of GTC or TTD*/HMDA*. The reprocessability of the PHUUs was also investigated. To further optimize the properties of PHUUs, modified PHUUs with improved cross-linking density were prepared utilizing pendant hydroxyl groups as cross-linking points. Methacrylic acid (MA) was grafted onto the hydroxyl group, and simultaneously, a dense cross-linking network of the modified PHUUs was formed through the polymerization of MA. With the introduction of MA, modified PHUUs showed an increased glass transition temperature and adjustable mechanical properties. The tensile strength, Young’s modulus, and elongation at break of modified PHUUs were in the ranges of 1.19–15.00 MPa, 0.69–95.65 MPa, and 138–687%, respectively. Modified PHUUs exhibited significantly improved tensile strength and Young’s modulus than those of PHUUs. This work provides an option for preparing high-performance or functionalized PHUUs.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
POLYMER
·
2022
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IF 4.432
Shan Jiang,Li Liu
Poly(hydroxyurethane-urea)s (PHUUs), which have complementary thermal and mechanical properties with poly(hydroxyurethane)s (PHUs) and polyureas, are of great potential for practical applications. Herein, several novel PHUUs were synthesized through polyaddition reaction from 5-membered dicyclic carbonates and amino-terminal polyurea oligomers , and corresponding PHUs were also synthesized as controls. It was worth noting that carbon dioxide was starting materials in the synthesis of both 5-membered dicyclic carbonates and amino-terminal polyurea oligomers. The structures and properties of PHUUs and PHUs were characterized by FTIR , 1 H NMR, SEC , water contact angle measurement, TGA , DSC , and tensile test. The urethane-to-urea ratio of PHUUs depended on the diamines used in the synthesis of amino-terminal polyurea oligomers. With the introduction of urea moieties, PHUUs exhibited improved surface hydrophobicity and thermal properties. Meanwhile, the introduction of urea moieties and the structure of selected diamine influenced glass transition temperature (T g ) and mechanical properties of PHUUs. This work offered a fascinating option for preparing PHUUs and might contribute to tackling climate change.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Advanced Photonics Research
·
2021
·Vol. 2
·期 5
·2000161
·
IF 0
Bin Liu,Zheng Chen,Bo Chu,Ya-Ling Wang,Ning Li,Huinian Zhang,Yongzhen Yang,Shengliang Hu,Xing-Hong Zhang
Despite the advancements in synthetic methods, it is still challenging to prepare white light-emitting carbon dots for solid-state white light-emitting diodes (LEDs). Herein, the synthesis and characterization of a carbonized polymer dot (CPD) that emits white light in the solid state are presented. The reaction of an oxygen-rich precursor, trimethylolpropane tri(cyclic carbonate) ether, with nitrogen-rich melamine in an alcohol via a single-step solvothermal method affords CPDs with hydroxyurethane and CN groups. The morphology of the CPDs can be regulated by changing the reaction time. Transmission electron microscopy reveals structural evolution from flocculent polymers to dandelion-like and spherical particles with an increase in the carbonization time from 6 to 12 and 18 h, respectively. The dandelion-like CPDs exhibit a relatively high quantum yield of 7.5% in the solid state, which is ascribed to the abundant surface poly(hydroxyurethane) chains that restrict the aggregation-caused quenching of luminescence. It is proposed that multiple coexistent clusters generate different emission sites, thereby leading to white light emission. Loose clusters formed from hydroxyurethane and CN bonds, which have a low degree of conjugation, emit blue light, whereas compact clusters generated through interactions between the hydroxyurethane and CN bonds of poly(hydroxyurethane) and carbon cores emit yellow light.
研究领域:
材料科学
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光学
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产品关联
DOI
Journal of Cleaner Production
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2025
·
IF 10
Min Fan,Yuanmeng Wang,Jingbo Zhao
In the pursuit of green, environmental protection, and sustainability, the development of bio-based polyhydroxyurethanes (PHUs) to replace traditional petroleum-based polyurethanes has attracted widespread attention. In this study, new bio-based vanillin-PHU vitrimers (C-PHUs) with hydroxyurethane and imine dual dynamic bonds were synthesized. A new vanillin cyclic carbonate with an aldehyde group (V-C) was prepared from the cyclocarbonation of a vanillin-diol with dimethyl carbonate under normal pressure, and the C-PHUs were prepared from the aminolysis reaction of V-C with two triamines. The maximum tensile strength and elongation at break of the C-PHUs reach 79 MPa and 296 %, respectively, which are at the leading level among present PHUs. Aromatic structure makes the C-PHUs show excellent mechanical properties and relatively high T g . Hydroxyurethane and imine dual dynamic bonds result in good reprocessability and self-healing properties as well as low activation energy of 81.81–101.78 kJ/mol. At the same time, imine bonds enable C-PHUs to degrade at room temperature under acidic conditions, providing an efficient way for the post-waste treatment. Bio-based C-PHUs with excellent mechanical properties, reprocessability, and degradability were prepared successfully.
研究领域:
材料科学
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绿色化学
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产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2021
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IF 8.198
Xiuxiu Liu,Xinxin Yang,Siheng Wang,Shibo Wang,Zhiping Wang,Shiwei Liu,Xu Xu,He Liu,Zhanqian Song
Polyhydroxyurethanes (PHUs), polyurethanes with excellent properties, are cured without poisonous isocyanate. The carbamate groups in the structure can undergo bond exchange in the presence of amino groups to improve their reprocessing and recyclability. As the demand for more “sustainable” polymers increases, research has focused on replacing fossil materials with renewable alternatives. 1,8-Menthane diamine (MDA) derived from turpentine is a potential raw material for curing with cyclic-carbonated soybean oil (CSBO) for preparing fully bio-based PHUs without solvents and catalysts. The amino groups from MDA facilitate bond exchange under autocatalysis in PHUs, and the rigid structure improves the thermal and mechanical properties of PHUs. PHUs with different cyclic carbonate/amino ratios are characterized to explain the importance of MDA in the performance of PHUs. Dynamic covalent bond exchange was studied through stress relaxation, which results in self-healing, recyclability, reprocessing, and shape memory. The mechanical properties and thermal stability can be almost completely recovered (>85%) after reprocessing several times, indicating that the network will be repaired by bond exchange. This work provides a promising strategy to utilize sustainable feedstocks for designing fully bio-based non-isocyanate polyurethanes and reveals the effect of the structure on the material properties.
研究领域:
材料科学
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化学工程
·
可持续发展
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yafeng Jin,Fangming Han,Xiaobo Li,Haibo Shang,Huan Zhang,Li Yang,Tao Wang,Jun Chen,Guangri Xu,Cheng-Xing Cui
Accurate monitoring of hydroxyurea (HU) dosage is imperative in the administration of anticancer drugs. Existing determination methods face challenges such as operational complexity, low sensitivity, or high oxidation potentials. In this study, a novel HU electrochemical sensor (Zn/N-PC/GO/GCE) was synthesized using flower-shaped Zn/N co-doped porous carbon (Zn/N-PC) with graphene oxide (GO) through a one-step electrodeposition . The sensor features a distinctive three-step oxidation process for HU with a low oxidation potential, attributed to an electrochemical activation electrode strategy and crucial Zn/N co-doping in Zn/N-PC. Three electrons involved oxidation process of HU and Zn/N-PC/GO adsorption energy through transferred electrons and density functional theory (DFT). Under optimized conditions, the sensor demonstrated a broad linear detection range (1–1000 μM) and an impressive limit of detection (LOD) of 0.52 μM. Applicability was confirmed by analyzing HU in tablet formulations, urine and serum samples. This study presents an innovative electrochemical method for accurate HU monitoring, elucidating a potential three-step oxidation mechanism.
研究领域:
生物医学工程
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药物分析
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材料科学
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产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2024
·
IF 4.5
Muhammad Usman Saeed,Guohua Hang,Yuan Gao,Jiawei Hu,Lei Li,Tao Zhang,Sixun Zheng
Poly(N-vinyl pyrrolidone) (PVPy) chains were grafted onto the surfaces of barium titanate (BaTiO 3) nanoparticles via the surface-initiated living/controlled radical polymerization of N-vinyl pyrrolidone. The PVPy-grafted BaTiO 3 nanoparticles were then incorporated into a crosslinked polyhydroxyurethane (PHU) which was derived from bis(six-membered) cyclic carbonate and a triamine ( i.e., Jeffamine T400). It was found that BaTiO 3 nanoparticles were uniformly dispersed into the PHU matrix. The generation of nanocomposites resulted that the glass transition temperatures ( T g ’s) and mechanical properties were significantly enhanced. In the meantime, the nanocomposites had the dielectric properties superior to control PHU; the shape memory properties of the materials were significantly improved in terms of response, fixity of transient shape and recovery of the original shapes. Thanks to transcarbamoylation of hydroxyurethane structural units, the crosslinked nanocomposites can be reprocessed at elevated temperature. It was found that dibutyltin dilaurate (DBTDL) was an effective catalyst to decrease the Arrhenius activation energy of the dynamic reaction; the reprocessing of the nanocomposites can be carried out at the temperature as low as 120 °C.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 37
·47957
·
IF 2.188
Jingtao Dai,Zhijun Wu,Liuyang Tang,Jinqing Qu
Cyclic carbonates reacted with diamines or polyamines have been proposed as a greener and safer method to prepare free isocyanate polyurethane coatings. Here, five kinds of bis(cyclic carbonate)s (TDC: toluene bis(cyclic carbonate), MDC: 4,4′-diphenylmethane bis(cyclic carbonate), IPDC: isophorone bis(cyclic carbonate), HMDC: 4,4′-methylenebis(cyclohexyl cyclic carbonate), HDC: hexamethylene bis(cyclic carbonate)) were prepared by reacting glycerol carbonate with diisocyanate under atmospheric pressure. Their structures were verified by 1 H-NMR and 13 C-NMR. These difunctional cyclic carbonates were then reacted with several amines to prepare new polyhydroxyurethane (PHU) coatings, and the film properties were tested. It was found that PHUs based on aromatic and alicyclic structures including TDC, MDC, IPDC, and HMDC displayed high hardness but had poor flexibility and impact resistance, whereas PHUs based on aliphatic structures such as HDC exhibited good flexibility and impact resistance and low hardness. When the length of the alkyl groups in the amine curing agents increased, the impact resistance and flexibility of the PHUs increased, but their pencil hardness decreased. PHUs from TDC, MDC, and IPDC had excellent chemical resistance, but the PHUs from HMDC and HDC had less chemical resistance. Some films displayed excellent properties including 4H pencil hardness, 100 cm kg impact resistance, and excellent flexibility. Some PHUs exhibited good thermal stability, with T 5% values all above 242°C. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47957.
研究领域:
材料科学
·
有机化学
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产品关联
DOI
高影响因子
ACS Applied Energy Materials
·
2025
·
IF 5.5
Miaoyou Li,Bailiang Xue,Xiaojie Xie,Mengqi Song,Wenliang Wang,Haiwei Wu,Wei Zhao,Weijing Chen
Lithium metal batteries (LMBs) have emerged as a pivotal next-generation energy storage technology due to their exceptional theoretical energy density. Their development faces fundamental challenges from conventional poly(vinylidene fluoride) (PVDF) binders, including high crystallinity, insufficient adhesion, and poor interfacial compatibility with electrode active materials. In this work, we developed a convenient one-pot strategy to enhance the performance of the traditional PVDF binder by using lignin-derived polyhydroxyurethane (PHU). The ultra-low-dosage (1 wt %) lignin-derived PHU-modified PVDF binder (LP1) effectively enhanced the flexible amorphous domains and interfacial adhesion, leading to significantly improved Li+ transport and cyclic stability. The electrode with LP1 binder exhibited a substantially higher Li+ diffusion coefficient of 3.47 × 10–14 cm2 s–1 than that of the PVDF binder (2.05 × 10–15 cm2 s–1). The LP1-based battery demonstrated a capacity retention of 93.8% after 400 cycles at 1C compared to the 82.5% of the PVDF-based battery. This work not only establishes a foundation for the application of lignin-derived binders but also provides important guidance for binder design toward next-generation binder systems in advanced LMBs.
研究领域:
储能技术
·
高分子科学
·
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2021
·Vol. 59
·期 10
·904-911
·
IF 0
Ye Tian,Cong Du,Bin Liu,Hao Nan Qiu,Xing-Hong Zhang,Zi Liang Wu,Qiang Zheng
Fluorescent hydrogels have promising applications in biomedical and engineering fields. However, they are usually mechanically weak. Here, we report a fluorescent composite hydrogel with high toughness, which is facilely prepared by solution casting ethanol solution of poly(hydroxyurethane) (PHU) and poly(stearyl acrylate- co -acrylic acid) (P[SA- co -AAc]) followed by swelling the casted film in water. The composite hydrogels with water content of 62–78 wt% possess remarkable mechanical performances, with tensile breaking stress of 0.3–1.1 MPa, breaking strain of 280%–400%, Young's modulus of 0.2–0.7 MPa, and tearing fracture energy of 1250–2630 J/m 2 . The high toughness is attributed to the effective energy dissipation of the network with hydrophobic association of SA units and hydrogen bonds between PHU and P(SA- co -AAc) as the physical crosslinks. The intense aggregation of carbamates and the formation of carbamate clusters through intra- and intermolecular hydrogen bonds endow the composite hydrogel with strong fluorescence. These hydrogels with high toughness and strong fluorescence should find applications in flexible electronics, information display, and biomedical devices. Graphical
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
危险品化学品经营许可证（带存储）