NANO
·
2025
·
IF 1.1
Guangyu Wu,Fangzhou Wen,Lini Huo,Peiyuan Li
In this study, a novel chitosan carbon dot/quercetin (CS-CDs/Que) composite nanosystem was constructed. Utilizing the abundant carbon, nitrogen, hydroxyl, and amino functional groups in the molecular structure of chitosan, carbonization, molecular polycondensation, and surface passivation were achieved through a hydrothermal method, ultimately forming chitosan carbon quantum dot carriers (CS-CDs) with an average size of 6.27 nm. Quercetin (Que) was then loaded onto these carriers to construct the composite nanosystem. Structural characterization of the composite nanosystem was conducted using techniques such as transmission electron microscopy and infrared spectroscopy, confirming the successful hybridization of the nanocomposites. Notably, compared with Que alone, the CS-CDs/Que composite nanosystem exhibit significantly enhanced antioxidant capacity under the same mass concentration. The scavenging rates of CS-CDs/Que for DPPH and ABTS can reach 92% and 62%, respectively; their chelating ability for ferrous ions is also much stronger than that of Que. Furthermore, CS-CDs/Que can effectively scavenge superoxide anion free radicals and hydroxyl free radicals. When the concentration of CS-CDs/Que is 15 µg mL −1 , it achieved a 100% scavenging rate for hydroxyl radicals. Overall, the prepared CS-CDs/Que composite nanosystem show excellent antioxidant activity, providing new insights for the development of novel antioxidants.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Ya-nan Yao,Ya-wen Zhu,Yu-wen Wei,Xuan Zhou,Shu-di Li,Jing-yi Ma,Jing Qiu
Excessive reactive oxygen species (ROS) around titanium implants under pathological conditions can cause mitochondrial dysfunction, potentially resulting in implant failure or related complications. This study designs a titanium implant functionalized with cerium oxide nanoparticles (CeNPs) using phenylboronic acid-modified hyaluronic acid (HA-PBA) and carboxylated chitosan (CCS) as polyelectrolytes, with the primary objective of modulating the local microenvironment around the implant. Owing to the responsive properties of HA-PBA, the embedded CeNPs are released in an on-demand manner as the coating degrades under different conditions. The Ti-HAPBA/CCS-CeNPs implants not only directly stimulate osteoblast differentiation under physiological conditions but also mitigate oxidative stress-induced mitochondrial dynamics imbalance and dysfunction. This protective effect is achieved by scavenging intracellular ROS, downregulating DRP1 expression, and restoring mitochondrial membrane potential (MMP). The osteoinductive efficacy of the Ti-HAPBA/CCS-CeNPs implants is further assessed using a femoral implantation model in diabetic rats, which demonstrates significantly enhanced bone remodeling and osseointegration at four and eight weeks post-implantation compared to the Ti-SLA group. Collectively, this study demonstrates the therapeutic potential of Ti-HAPBA/CCS-CeNPs implants under both physiological and pathological conditions, and provides a novel biopolymer-based strategy for improving dental implant outcomes.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Yibing Shi,Xiaoyi Zhu,Qingyuan Xu,Yanling Wu,Yishuo Sun,Xin Zhao,Yulong Liu,Wei Feng,Youhua Xie,Tianlei Ying,Zhenlin Yang
The oral administration of immunofluorophores has been limited by gastrointestinal degradation. To address this, a novel immunofluorophore (ICGM-B9-FCS), based on a single-domain antibody-dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg kg −1 ) for NIR-II bioimaging of colorectal cancer and its distant metastases. ICGM-B9-FCS demonstrates unique advantages over existing intraoperative tumor-guidance bioagents, including resistance to liver metabolism, well-retained bioaffinity (EC 50 = 58.09 nmol L −1 ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary-lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.
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ACS Omega
·
2025
·
IF 4.3
Yawei Zhao,Yuqing Liu,Tailai Yan,Malcolm Xing,Wen Zhong
Hydrogels have acquired numerous attentions in biomedicine and smart bioelectronics due to similar properties to our tissues. Initiators are crucial in vinyl polymerization for hydrogel preparation which can influence mechanical properties and physical/chemical structures. We report α-ketoglutaric acid (αKG), an intermediate in the citric acid cycle, as an ecofriendly photoinitiator for vinyl polymerization. We comprehensively investigated the mechanical properties of hydrogels initiated by comparing αKG with Irgacure 2959 (I-2959) and ammonium persulfate (APS). We found that αKG successfully initiated the polymerization in both synthetic and natural hydrogels (polyethylene glycol, polyacrylamide, gelatin, alginate, and chitosan). Meanwhile, the interactions between αKG and functional groups of macromolecules make αKG a potential additive in hydrogels, which could influence the hydrogel mechanics. In contrast to the potential toxicity of unreacted APS and the limited water solubility of I-2959, αKG proves to be a more versatile and sustainable option in gelation than the other two. This work throws new light on hydrogel fabrication with the initiator alteration for potential biomedical applications.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yubo Liu,Zhenghao Li,Shiwen Xie,Dezhi Lu,Daoyuan Liu,Huiping Xu,Peifeng Wu,Boyu Si,Chaoyi Zhang,Xiangde Lin,Hui Yang
Green hydrogels hold promise for biomedical applications but are limited by weak mechanical properties. Here, we report a chitosan (CS)–reinforced polyvinyl alcohol hydrogel (PVA) fabricated via eco-friendly freeze–thaw cycles, achieving dual enhancement in mechanical strength and antibacterial efficacy. Incorporating 3 wt% chitosan increased compressive strength from 0.36 MPa in pure PVA to 2.92 MPa at 80% strain, while maintaining over 80% recovery after cyclic compression. The porous structure of the fabricated hydrogel and hydrogen-bonded network enabled sustained ciprofloxacin (CIP) release over 72 h. Antibacterial performance against Escherichia coli and Staphylococcus aureus improved significantly with CS addition, reaching 99% efficiency at 3% CS content, while CIP integration achieved complete bacterial eradication (100% efficiency). Synergistic action between the contact-based bactericidal activity of CS and CIP sustained release eliminated colony formation, demonstrating superior inhibition of both Gram-negative and Gram-positive bacteria. This green strategy delivers a mechanically robust, multifunctional hydrogel for infection-resistant biomedical applications.
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Polymers
·
2025
·Vol. 17
·期 21
·2904
·
IF 4.9
Shiyi Ming,Piao Wang,Shaoyuan Wu,Jinghan Hu,Jie Zhang,Lianlian Li,Bingyue Huang,Weijiang Huang,Xingyu Guan,Kui Wang,Wei Yan
The morphology and composition of inorganic particles play a vital role in controlling the flame-retardant characteristics of polymers. Halogen-free flame-retardant polymers have also become a current research hotspot. Boron nitride (BN), phytic acid (PA), and chitosan (CS), a natural polysaccharide with a nitrogen content of approximately 6.8–7.5%, show great promise as flame retardants owing to their high thermal stability, P-based flame retardancy, and natural polysaccharide properties, respectively. In this study, BN (BN@PA-CS) particles coated with PA and CS were designed and prepared via a facile modification strategy. The effect of BN@PA-CS on the mechanical and flame-retardant properties of polyvinylidene fluoride (PVDF) was further investigated, and it was found that both characteristics were improved. Compared to pure PVDF, the PVDF composite films exhibited a significantly lower peak heat release rate and total heat release. With a BN@PA-CS content of 20%, the peak was the lowest at 18.25 W/g, corresponding to a decrease of 77.83%. This phenomenon may be attributed to the synergistic effect of the BN nanosheets and PA-CS in the BN@PA-CS particles. This work describes a facile and effective method of modifying the morphology and composition of inorganic particles, thereby controlling the properties of polymers, and provides a new approach to improving the safety of PVDF battery separators.
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Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Yuanxin OuYang,Qian Wang,Yi’er Lou,Xueping Song,Min Wu
Smart antibacterial packaging films with pH-responsiveness have the potential to reduce food spoilage and enhance food safety. In this study, composite nanoparticles were fabricated via electrostatic adsorption by adjusting the mass ratio of TEMPO-oxidized cellulose nanocrystals (TOCNC) to chitosan (CS), yielding acid-responsive TC 6 (TOCNC:CS = 6:1) and alkali-responsive TC 40 (TOCNC:CS = 40:1). Both TC 6 and TC 40 nanoparticles exhibited sensitivity to pH stimuli, as evidenced by changes in particle size, contact angle, and Zeta potential. Pickering emulsions with the oil-water ratio of 3:7 and the particle concentration of 1.5 wt% showed excellent stability and pronounced pH responsiveness. Smart antibacterial packaging films (F PTC6 and F PTC40 ) were fabricated by incorporating emulsions into the cellulose nanofibril (CNF) suspension serving as the film-forming matrix. The F PTC6 films showed sensitive response to acidic conditions, while F PTC40 films exhibited sensitive response to alkaline conditions, with 24 h cumulative cinnamaldehyde release rates of 50.7 % and 41.7 %, respectively. In addition, the smart antibacterial packaging films possessed excellent mechanical and barrier properties. Compared with pure CNF and F PTC40 films, the F PTC6 films significantly inhibited the increases in TVB-N and TVC of pork and extended pork shelf life to 9 days by responding to acidic stimuli to release active components. The developed smart antibacterial packaging films would provide a novel material and have the potential in food packaging.
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Stem Cell Research & Therapy
·
2025
·Vol. 16
·期 1
·1-17
·
IF 7.3
Wei Kang,He Lu,Shi Yiran,Zhang Wen,Wu Meng,Zhang Shengdan,Wang Haijie,Xu Huanhuan,Hu Liangcong,Li Wei,Guo Liang
Diabetic wounds exhibit impaired angiogenesis, drug-resistant bacterial infections, and oxidative damage to the microenvironment, presenting ongoing clinical challenges. In this research, we designed a core-shell structured multifunctional microneedle (MN) array patch (CS-SDFP/HA-Ag@MOF-PAL) to expedite the healing of infected diabetic wounds. The core consists of 10,000 MV hyaluronic acid (HA) and sucrose, integrated with Ag@MOF loaded with Palmatine (Ag@MOF-PAL). The shell, composed of chitosan (CS), encapsulates SDFP (CS-SDFP). Upon application to an infected diabetic wound, the shell swells, releasing the HA core, which dissolves to release Ag@MOF-PAL. The Ag@MOF targets and eradicates bacteria and eliminates biofilms of bacteria in the wound area, such as Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa , while PAL mitigates chronic inflammation in wound macrophages via the NF-κB and MAPK signaling pathways. As the wound microenvironment normalizes, the SDFP released from the swollen CS recruits adipose-derived stem cells (ADSCs) and promotes angiogenesis to facilitate wound repair. Our experiments demonstrate that CS-SDFP/HA-Ag@MOF-PAL accelerates wound healing in a diabetic rat model with Pseudomonas aeruginosa -infected wounds. The property of this core-shell structured multifunctional MN patch presents considerable potential for the development of therapeutic strategies aimed at the healing of infected diabetic wounds.
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JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Peng Jiang,Yongnian Zeng,Wen Zhang,Jiapeng Lei,Xue Jiang,Wei Li
Reactive oxygen species (ROS)-based therapies have emerged as promising non-antibiotic strategies for treating infected wounds due to their broad-spectrum antimicrobial activity and low risk of resistance development. However, their clinical translation remains limited by low delivery efficiency, poor bacterial targeting, and uncontrolled post-treatment inflammation. To address these challenges, we reported a multifunctional bilayer microneedle patch (LFT/S-MN) designed for efficient bacterial eradication and enhanced wound healing. The patch integrates positively charged lactoferrin-based nanoparticles (LFT NPs) conjugated with a porphyrin sonosensitizer (TAPPFe) in the dissolvable base layer, and a pH-responsive tip layer loaded with the anti-inflammatory agent spermidine (SPD). Upon insertion into infected tissue, the released LFT NPs efficiently target and aggregate negatively charged bacteria, enabling robust ROS generation through synergistic chemodynamic and sonodynamic therapy (CDT/SDT) under ultrasound stimulation. Concurrently, the acidic wound microenvironment triggers the gradual degradation of the tip layer, allowing controlled SPD release for immunomodulation. In a murine P. aeruginosa -infected wound model, the LFT/S-MN patch significantly reduced bacterial load, suppressed inflammation, promoted collagen deposition and neovascularization, and accelerated wound closure. This work presents a promising non-antibiotic strategy for wound disinfection and regeneration through synergistic CDT/SDT and inflammation modulation.
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Materials Today Bio
·
2025
·
IF 10.2
Qiumei Lan,Mengtian Fan,Fengmei Zhang,Qian Gong,Jiayan Zhong,Miao Yi,Qiqi Zeng,Jianqiang Chen,Yiming Pan,Nana Geng,Biao Kuang,Yu Du,Chuanrong Zhao,Deping Zeng,Chunliang Zhao,Zhen Li,Guixue Wang,Fengjin Guo
Bone regeneration remains a formidable challenging due to impaired energy metabolism and the limited osteogenic potential of transplanted stem cells. Mitochondrial homeostasis orchestrates osteogenesis, with mitophagy maintaining the metabolic rhythm essential for bone formation. However, the role of autophagy related gene 7(ATG7), a pivotal regulator of mitochondrial function, in bone regeneration remains elusive. In this study, we developed a ATG7-overexpressing bone marrow mesenchymal stem cells (ATG7-BMSCs) encapsulated within a thermoresponsive chitosan (CS) hydrogel, creating a biocompatible, living platform capable of adapting to physiological conditions. The hydrogel exhibited excellent injectability, physiological gelation at 37 °C, and prolonged biocompatibility, providing a favorable microenvironment for stem cell survival and proliferation. The system was evaluated through in vitro assays for mitochondrial function and osteogenic differentiation, as well as in vivo using rat cranial and femoral defect models. Mechanistically, ATG7 activation enhanced mitophagy, preserved mitochondrial integrity, reduced reactive oxygen species (ROS) accumulation, and reactivated oxidative phosphorylation via the PI3K-AKT signaling pathway, thereby reprogramming osteogenic metabolism and promoting differentiation. Conversely, ATG7 deficiency led to mitochondrial dysfunction, glycolytic dependence, and impaired bone formation. In vivo, the ATG7-BMSC@CS hydrogel markedly accelerated new bone formation and mineral density recovery while maintaining excellent injectability, biocompatibility, and systemic safety. Collectively, this study identifies ATG7-driven mitophagy as a critical regulator of osteogenic metabolism and bone formation, and establishes a smart, living hydrogel platform that seamlessly integrates metabolic reprogramming with stem cell delivery. This strategy provides a conceptual blueprint for next-generation, metabolism-oriented bone repair at the intersection of cell biology, biomaterials, and precision medicine.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yantao Liu,Xuxi Ma,Chen Huang,Yujia Wan,Qiuyu Deng,Siqi Chen,Jun Tian,Fusheng Sun,Zhengqi Wu,Duoxia Xu,Nan Yang
The interfacial behaviors of microgels at the oil-water interface were significantly affected by the properties of the oil phase, which in turn influence their emulsification ability. In this study, the effects of oil polarity on the interfacial behaviors of hydrophobic modified chitosan microgels ( h -CSMs) at five typical oil-water interfaces (decane, 1-chlorodecane, decanol, medium-chain triglycerides (MCT), and paraffin) were investigated. The interfacial adsorption results show that h -CSMs can rapidly adsorb onto the selected oil-water interfaces, with the ability to reduce surface tension ( γ ) increased as the polarity of the oil phase increased. The saturation adsorption interfacial pressure ( π ) has a power law index (α) equal to 1.19 with the initial oil-water interfacial tension ( γ ow ) indicating that the h -CSMs are soft particles with interfacial deformability between surfactants and flexible proteins. The h -CSMs formed strong viscoelastic interfacial layers at all of the oil-water interfaces except decanol with the dilatational modulus ( E ) positively correlated to the thickness and amount of adsorbed microgels at the interface. From the interfacial microstructure analysis, weakly polar oils (such as paraffin, n-decane) contributes to the expansion of h -CSMs particles, thereby forming a thicker adsorption layer. The polar oil phase suppresses the excessive expansion of h -CSMs, resulting in a compact and thinnest adsorption layer (such as decanol). Emulsion stability studies showed that the polarity and viscosity of the oil phase, and the interfacial properties of the h -CSM film affect the stability of the emulsions, but the interfacial viscoelasticity dominated. Paraffin emulsions (particularly the high internal phase emulsions, HIPEs) stabilized by h -CSMs exhibit superior storage, mechanical, thermal, and ion stability, but the addition of excessive salt ions will introduce emulsion instability by changing the charge properties and thus the morphology and interaction of the microgels at the interface.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lin Jiang,Liting Yao,Fan Wu,Chenjiang Liu,Weiwei Jin,Qi Ao,Maofeng Wang
Glucose offers basic power for the daily activities of human beings, and the concentration of glucose in serum influences health. At present, the main problems faced by nanogel glucose detection include: the sensitivity and selectivity need to be further improved, and the long-term in vivo stability is insufficient. Here, a cyclodextrin-based multi-functional nanogel was synthesized for glucose detection. In such a nanogel, glucose oxidase (GOx), chitosan (CS) and β-cyclodextrin (β-CD) were cross-linked in the nanogel net and Fe ions coordinate with multiple groups and cyclodextrin lumen. A cascade catalysis of GOx and Fe nanoparticle could enhance the detection sensitivity for better sensitivity. 1 H nuclear magnetic resonance result confirmed that β-CD has a host-guest interaction with the substrate glucose for better catalysis with GOx for selectivity. Moreover, the Fe coordination with nanogel make the structure stable for long-term detection. Overall, the Fe-based nanogel strategy provides a new glucose detection method.
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