ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
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2018
·Vol. 99
·期 2
·e21499
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IF 1.316
Lin Zhu,De-Qing Zou,Zuo-Qing Fan,Na Wang,Ying-Ying Bo,Yu-Qing Zhang,Guang Guo
In this study, a carboxymethyl chitosan derived from silkworm pupa (SP-carboxymethyl chitosan) was prepared. The physical characteristics of the SP chitin, chitosan, and carboxymethyl chitosan were analyzed. The scanning electron microscopy results showed that the surfaces of the samples from SP were more uneven, with more surface fractures compared with those of the reference substance (RS). Thermal analysis, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis showed that the main molecular chain structures of SP samples and RSs had no substantial differences. However, the crystallinity and thermal decomposition temperature of the SP samples were lower compared with those of the RSs. All of these results provide a theoretical basis for the development of applications for the SP-carboxymethyl chitosan.
研究领域:
生物材料学
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化学工程
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Soureh Sadat Mirzamani,Mohammad Reza Farahpour,Zohreh Ghazi Tabatabaei
The rampant use of commercial antibiotics not only increases drug resistance but also causes a significant threat to human health. This study assessed the wound healing efficacy of hydrogels crafted from carboxymethyl chitosan (Cmc), polyglutamic acid (γ-PGA), tannic acid (TA), and carbazole (Car), with the aim of expediting the wound healing process. Hydrogels were formulated using Cmc/γ-PGA, Cmc/γ-PGA/TA, and Cmc/γ-PGA/TA/Car, followed by a thorough evaluation of their physicochemical attributes. Additionally, assessments encompassed cytotoxicity, antibacterial efficacy, wound contraction rates, histopathological parameters, immunofluorescent staining of CD31, CD86, and COL1A, along with the determination of serum concentrations of IL-1β, IL-6, and IL-10. The physicochemical analyses validated the successful synthesis of the hydrogels, which exhibited both safety and potent antibacterial properties. Topical application of Cmc/γ-PGA/TA/Car hydrogels notably accelerated wound contraction, as evidenced by heightened expression of CD31 and COL1A, alongside reduced serum concentrations of IL-1β and IL-6. In essence, the Cmc/γ-PGA/TA/Car hydrogel demonstrated a dual effect of mitigating inflammation and modulating the proliferative phase, that shows their abilities for application in the wound healing process.
研究领域:
生物材料学
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药剂学
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免疫学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
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IF 5.162
Hongling Zhang,Jianzhe Ma,Fengyun Wang,Yuting Chu,Lei Yang,Mingzhu Xia
The carboxymethyl-chitosan-montmorillonite (CMC-MMT) organic-inorganic hybrid material was applied to adsorb Pb(II) and Congo red (CR) anionic dye from aqueous solution. Molecular dynamics(MD) simulation was carried out to reveal the mechanism of CMC hybrid MMT. The results suggested that CMC has been adsorbed on the interlayer space and surface of MMT, hydrogen bonds had been formed between hydroxyl & carboxyl groups of CMC with the surface of MMT, Van der Waals interaction was also existed, while amino groups of CMC hadn't obvious interaction with the surface of MMT. Batch experiments were executed to investigate the adsorption effect of CMC-MMT was compared with Na-MMT and CMC. The results showed that CMC-MMT exhibited the higher adsorption capacity than Na-MMT and CMC, The OH and COOH or NH 2 groups of CMC chains may serve as electrostatic interaction active sites and coordination sites, which improved the adsorption performance of CMC-MMT on Pb(II)，and the insertion of CMC enlarged the inter-layer space of MMT, resulting in more surface active sites in the CMC-MMT hybrid composite, which increased the adsorption of organic pollutant CR. The kinetic and isotherm studies indicated that the pseudo-second-order and the Langmuir model well described the adsorption equilibrium of Pb(II) and CR on CMC-MMT.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2021
·
IF 5.909
Bianyang He,Yaoyao Zhang,Bojie Li,Yuhan Chen,Lei Zhu
Carboxymethyl chitosan (CMCS) aerogels were prepared through sol-gel combining with freeze drying technology . The effects of CMCS concentration on the gelation time, volume shrinkage, density, porosity, compressive strength and hygroscopicity were investigated. Meanwhile, the CMCS aerogel was characterized by Fourier transform infrared (FTIR) and scanning electron microscopy (SEM). Then the CMCS aerogel was hydrophobic, modified through cold plasma modification technology, and oil absorbency of hydrophobic modified CMCS (HMCMCS) aerogel was researched. The results showed that the CMCS aerogel had the lowest density of 0.022 g/cm 3 , the maximum porosity of 95.34%, the highest compressive strength reached 1.74 MPa and a three-dimensional (3D) network heterogeneous porous structures in the inner areas. After hydrophobic modification, the water contact angle of 2% for HMCMCS aerogel with 20 min under 60 W reached 117 °. Besides, the HMCMCS aerogel represented excellent oil adsorbing property and outstanding recyclability , for the oil adsorption rate was up to 31.6 g/g and stable in multiple cycles.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2023
·
IF 11.2
Fengjiao Zhang,Sufeng Zhang,Shuyuan Cui,Xiaokai Jing,Yao Feng,Sergiu Coseri
In this study, the quaternized carboxymethyl chitosan (QCMCS), oxidized hyaluronic acid (OHA), 3,3′-dithiobis-(propionohydrazide) (DTP) were used as raw materials for the synthesis of hydrogels with excellent properties as carriers for drug release. The hydrogels were prepared by a simple “one-pot” method without external stimuli on the basis of interactions between formed dynamic covalent bonds (imine bonds, acylhydrazone bonds, disulfide bonds) and hydrogen bonds . The hydrogels had rapid self-healing properties, with a self-healing rate of 96 % after 30 min, as well as good pH responsiveness and excellent cytocompatibility (up to 98 % cell survival). The compressive stress of the hydrogels reached 423 kPa. Moreover, a representative drug (acetylsalicylic acid) demonstrated sustained release in the hydrogels (>72 h). The drug release behaviour was shown to be consistent with the Fick diffusion mechanism by kinetic modelling. Collectively, the findings demonstrate that the QCMCS + OHA + DTP injectable self-healing hydrogels are a potential material for the construction of pH-controlled drug delivery platforms.
研究领域:
生物材料学
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药剂学
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产品关联
DOI
PubMed
高影响因子
POWDER TECHNOLOGY
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2021
·
IF 5.134
Hongyang Wang,Lizhangzheng Wang,Siyuan Yang,Cheng Liu,Yanling Xu
Depressant carboxymethyl chitosan (CMCS) was introduced to reverse flotation of quartz from hematite using collector DDA. Microflotation experiments presented that CMCS completely depressed the hematite flotation while it had little effect on quartz flotation. The mineral mixture flotation confirmed the reagent scheme of DDA/CMCS could achieve efficient separation of quartz from hematite. It was also found that CMCS has better selective depression ability than the widely-used starch . Zeta potential measurements illustrated that CMCS could prevent DDA adsorption onto the hematite surface, while it did not affect the interaction between DDA and quartz surface. X-ray photoelectron spectroscopy (XPS) indicated that CMCS interacted with the Fe(III) components of hematite by chemisorption , which was stronger than the bonding between starch and hematite. Molecular dynamics simulation (MDS) further revealed the twice interaction energy of CMCS with (001) hematite surface than that of starch. Hence, CMCS has the potential to replace starch in practice.
研究领域:
矿物加工工程
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材料科学与工程
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
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2022
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IF 5.532
Taotao Qiang,Boqiang Qiu,Lu Chen,Longfang Ren
In this work, a novel adsorbent for the removal of hexavalent chromium (Cr(VI)) in aqueous solution was successfully prepared by altering the 2D Ti 3 C 2 /chitosan composite with disodium ethylenediaminetetraacetate (EDTA·2Na) agent. The successful surface loading of chitosan on Ti 3 C 2 was demonstrated by various characterization methods, including scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The adsorption of Cr(VI) by Ti 3 C 2 -based composite under various circumstances was evaluated using batch adsorption experiments. The adsorption performance of the optimal sample for Cr(VI) was investigated in detail through different influencing factors, and the adsorption process was analyzed by adsorption kinetics and isotherm model. In addition, XPS analysis of adsorbents before and after adsorption showed that some Cr(VI) was reduced to Cr(III) during the whole process, which was conducive to reducing the biological toxicity of Cr(VI). The mechanism analysis showed that the adsorption was mainly electrostatic physical adsorption, supplemented by chemical reduction adsorption. Finally, through the regeneration cycle experiment, it was found that the adsorption rate of Cr(VI) remained above 80% after six repeated adsorptions, indicating that the composite material had good stability and might have certain practical application value in the treatment of Cr(VI)-containing wastewater.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2023
·
IF 11.2
Jiaqi Wang,Yuanhang Li,Xiaotong Li,Jiangbo Pan,Di Wang,Shuangying Wei,Chengyu Wang,Jian Li
Biological macromolecules had been studied as ligands in recent years, which not only give the complexes excellent polymer properties, but also have many advantages such as biodegradability. Carboxymethyl chitosan (CMCh) is excellent biological macromolecular ligand because of its abundant active amino and carboxyl groups, and it can smoothly transfer energy to Ln 3+ after coordinating. To further study the energy transfer mechanism of CMCh-Ln 3+ complexes, CMCh-Eu 3+ /Tb 3+ complexes with different Eu 3+ /Tb 3+ ratios were prepared by using CMCh as a ligand. The morphology, structure, and properties of CMCh-Eu 3+ /Tb 3+ were characterized and analyzed by infrared spectroscopy, XPS, TG and Judd-Ofelt theory, thus the chemical structure of CMCh-Eu 3+ /Tb 3+ was determined. The mechanism of energy transfer was explained in detail, also the Förster resonance transfer model is confirmed, and the hypothesis of energy transfer back was verified by the characterization and calculation methods of fluorescence spectra, UV spectra, phosphorescence spectra and fluorescence lifetime. Finally, CMCh-Eu 3+ /Tb 3+ with different molar ratios were used to prepare a series of multicolor LED lamps, and it extends the application range of biological macromolecules as ligands.
研究领域:
材料科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xubing Sun,Shiyu Yin,Li Zhao,Wenhua Yang,Yaohui You
In this work, tannic acid was selected as a green cross-linking agent to cross-link carboxymethyl chitosan to prepare a magnetic adsorbent (CC-OTA@Fe 3 O 4 ), which was used to remove methylene blue (MB) and Cu 2+ . CC-OTA@Fe 3 O 4 was characterized by FTIR, 13 C NMR, XRD, VSM, TGA, BET and SEM. The adsorption behavior was studied using various parameters such as pH value, contact time, initial concentration of MB and Cu 2+ , and temperature. The results showed that adsorption of MB and Cu 2+ followed the pseudo-second-order model and the Sips model. The maximum adsorption capacities were determined to be 560.92 and 104.25 mg/g MB and Cu 2+ at 298 K, respectively. Thermodynamic analysis showed that the adsorption is spontaneous and endothermic in nature. According to the results of FTIR and XPS analyses, the electrostatic interaction was accompanied by π–π interaction and hydrogen bonding for MB adsorption, while complexation and electrostatic interaction were the predominant mechanism for Cu 2+ adsorption. Furthermore, CC-OTA@Fe 3 O 4 displayed remarkable stability in 0.1 M HNO 3 , exhibited promising recyclability, and could be easily separated from aqueous solutions in the magnetic field. This study demonstrates the potential of CC-OTA@Fe 3 O 4 as an adsorbent for the removal of cationic dyes and heavy metals from wastewater.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2024
·
IF 10.7
Tian Hu,Bu-Ning Liu,Huaitian Bu,Han-Jian Hu,Qi-Shun Zhu,Shipeng Tang,Yongtao Li,Jinjin Wang,Gang-Biao Jiang
Cadmium (Cd) removal from soil is crucial as Cd enters the food chain and affect food safety, thus impose severe threaten to human health. We developed PPC@PC-Fe, a dual-functional core-shell sphere for efficient soil Cd reduction. The shell (PPC) was composed of encapsulated citric acid (CA) in a polylactic acid (PLA) and polyethylene glycol (PEG) network, which endows a function of activating Cd; and the core (PC-Fe) consisted of a polyacrylic acid/carboxymethyl chitosan (PAA/CMC) hydrogel with Fe 3 O 4 nanoparticles to adsorb adjacent activated Cd. Upon water contact, the shell dissolved, releasing CA to activate soil Cd. Simultaneously, the swellable PC-Fe core absorbed water and expanded in size, promoting the disintegration of PLA in the shell, which triggered the automatic separation of core from shell, enabling the exposed PC-Fe core to rapidly adsorb Cd. Furthermore, the PC-Fe core can be magnetically removed after adsorption of Cd. Soil culture tests showed that 2 % PPC@PC-Fe reduced soil Cd from 6.009 mg/kg to 4.834 mg/kg in 10 days, with the acid-soluble Cd being the predominantly target to be activated and remove. This study demonstrates an effective stepwise activation and adsorption mechanism by a single carrier, with simple magnetic collection minimizing secondary pollution. It offers an innovative approach to the remediation of cadmium-contaminated sites in the field.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
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2024
·
IF 3.9
Yufang Ren,Zeyuan Sun,Yong Huang,Xiaoyan An,Xiaona Bian,Zhenhao Cao,Yifan Liu,Kanwal Javed,Tetiana Derkach,Xue Li
Excessive bleeding can give rise to a range of pathologies, encompassing hypothermia, coagulation disorders, infection, and hemorrhagic shock. Uncontrolled massive blood loss stands as one of the foremost contributors to mortality. Consequently, higher requirements are put forward for the promptness and efficacy of hemostasis. At present, the hemostatic materials available on the market still have the problem that the hemostatic effect is not ideal, the antibacterial effect is poor, which is easy to cause wound infection, and the removal of hemostatic materials will cause secondary bleeding. The present study describes the development of a novel multifunctional hemostatic material based on carboxymethyl chitosan (CMC). First, the fluorinated CMC (CMC-FDA) is successfully synthesized via the Michael addition reaction utilizing 1H, 1H, 2H, 2H -fluorodecyl alcohol (FDA), followed by the preparation of CMC-FDA/PHMB materials through electrostatic interactions with polyhexamethylene biguanide (PHMB). The successful synthesis of CMC-FDA/PHMB was characterized by XPS, FT-IR, NMR, and so forth. The CMC-FDA/PHMB coating exhibits excellent hemostatic properties through in vivo liver hemostasis and in vitro caudation hemostasis experiments. The hemostatic effect of CMC-FDA/PHMB is highly pronounced, as evidenced by the results obtained for hemostasis time and blood loss. The experiment of simulating dynamic blood loss further confirmed that the gauze coated with CMC-FDA/PHMB has excellent hemostatic performance. Moreover, the synthesized CMC-FDA/PHMB coating demonstrates significant anti-adhesion and antibacterial properties of Staphylococcus aureus and Escherichia coli , which could prevent of wound infection. Furthermore, the CMC-FDA/PHMB coating exhibits non-wettability due to its low surface energy of FDA, which can prevent blood wetting and thus play a hemostatic effect, synergistically with CMC. Additionally, the CMC-FDA/PHMB coating demonstrates easy separation from the wound site attributed to it hydrophobic property. The results of the hemolysis and cytotoxicity tests verified the excellent biocompatibility of the CMC-FDA/PHMB coating. This CMC-FDA/PHMB material hold promising potential for rapid hemostasis and prevention of wound infection. Graphical
研究领域:
生物医学工程
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材料科学
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药学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2024
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IF 4.1
Junkai Hao,Jing Feng,Shuo Sun,Zhongxiang Cao,Wenjing Xu,Lei Hu,Wenli Yao,Zhengquan Yan
To reliably monitor dopamine (DA), a common neurotransmitter, a kind of nano CeO 2 /CuO modified carboxylated chitosan nanozyme (CeO 2 /CuO@CC) was constructed under microwave-assisted conditions. The proposed CeO 2 /CuO@CC exhibited superior synergistic- enhancement oxidase-like activity, with high specific surface area and superior stability. It could accelerate the oxidization of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue oxTMB in the air. What’s more, the presence of trace DA could exclusively change the enzyme-like activity of CeO 2 /CuO@CC, accompanied with visual color changes from blue to colorless. Under the optimized conditions, there expressed double ratiometric linear relationships between lg( A 652 / A 285 )/lg( A 370/ A 285 ) and c DA , with a large linear range between 6.0 × 10 −9 and 1.0 × 10 −5 M of DA. When applied for visual detection of DA in real samples, the detection limit was low to 2.0 × 10 −9 M with RSD % less than 4.14 %. The mechanisms for enhanced oxidase-mimic activity of CeO 2 /CuO@CC and its selective detection of DA were proposed. This work will offer an insight to design efficient nanozyme for visual detection of bio-analytes in practice.
研究领域:
生物化学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）