POLYMER
·
2025
·
IF 4.5
Xiaoqiang Xue,Yangjing Chen,Xuepei Miao,Jian Liu,Yi Ding,Yuheng Zhang,Yunkai Sun,Wenyan Huang,Qimin Jiang,Hongting Pu
Environmentally sensitive polymer materials exhibit diverse properties due to their ability to respond to external environmental changes such as light, temperature, pH, and et al. These responses lead to corresponding alterations in their structure or state, resulting in unexpected performance. In this study, azo pyridine groups were introduced into the end groups and side chains of PNIPAM to synthesize two distinct polymer structures (PNIPAM-AZO and P (NIPAM- co -PAZO- co -OEGMA). This integration enables the polymers to respond to multiple stimuli, including temperature, light, pH, and gas (CO 2 ). A comprehensive investigation of the properties of these multi-responsive polymer materials was conducted. The findings reveal that the presence of azo pyridine units enables both polymers to modulate the (lower critical solution temperature) LCST of PNIPAM through UV, pH, and CO 2 , with a maximum temperature adjustment of 13 °C when CO 2 is introduced. This modulation range is influenced by the azo pyridine content in the polymer. Notably, when azo pyridine is present only at the polymer end group, the maximum LCST regulation range is limited to 3 °C. Moreover, the LCST of the two polymers can also be adjusted by pH. In the presence of carbonate ions, the protonation of azo pyridine by carbonic acid increases the solubility of the polymer and enhances the LCST. Introducing argon gas removes CO 2 , thereby restoring the polymer's solubility and LCST to their neutral condition levels. By alternately introducing CO 2 and argon gas, the LCST of the polymer exhibits cyclic changes.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
Polymers
·
2017
·Vol. 9
·期 7
·301
·
IF 3.364
Xiaoyan Tu,Chao Meng,Zhe Liu,Lu Sun,Xianshuo Zhang,Mingkui Zhang,Mingrui Sun,Liwei Ma,Mingzhu Liu,Hua Wei
Polymers with advanced topological architectures are promising materials for wide applications due to their structure-generated unique properties different from that of the linear analogues. The elegant integration of stimuli-responsive polymers with such advanced architectures can create novel materials with virtues from both moieties, are thus a hot subject of research for both fundamental and practical investigations. To fabricate cyclic brush polymer-based intelligent materials for biomedical applications, herein, we designed and synthesized thermo-sensitive cyclic brush polymers with poly(N-isopropylacrylamide) (PNIPAAm) brushes by controlled living radical polymerization using cyclic multimacroinitiator. The thermo-induced phase transition behaviors of the resultant cyclic brush polymers with different compositions were investigated in detail by temperature-dependent optical transmittance measurements, and compared with the properties of bottlebrush and linear counterparts. Interestingly, the cloud point transition temperature (Tcp) of cyclic brush PNIPAAm could be regulated by the chain length of PNIPAAm brush. Although the bottlebrush polymers with the same composition exhibited similarly structurally dependentTcps behaviors to the cyclic brush polymers, the cyclic brush PNIPAAm did show higher critical aggregation concentration (CAC) and enhanced stability against dilution than the bottlebrush counterpart. The readily tailorableTcps together with the ability to form highly stable nanoparticles makes thermo-sensitive cyclic brush PNIPAAm a promising candidate for controlled drug delivery.Keywords:cyclic brush polymer;thermo-sensitivity;poly(N-isopropylacrylamide)
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2012
·
IF 2.236
Xue-Wen Liu,Shen Zhu,Sheng-Rong Wu,Pu Wang,Guo-Zhi Han
A type of poly( N -isopropylacrylamide) (PNIPAM) hydrogel with specific ion-sensitivity originating from crown ether unit is synthesized. The impacts of crown ether unit on temperature-sensitivity and ion-sensitivity of hydrogel are investigated. The result showed that crown ether units in the hydrogel network contributed to the ion response though they would reduce temperature-sensitivity of the hydrogel compared with traditional PNIPAM. Furthermore, the thermo-sensitivity and ion-recognition behaviors of the hydrogel are detailedly demonstrated which showed its potential as a promising candidate material for environment inspection, sensors and drug delivery systems.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Coatings
·
2021
·Vol. 11
·期 6
·632
·
IF 2.881
Jia Li,Bo-Xiang Wang,De-Hong Cheng,Zhi-Mei Liu,Li-Hua Lv,Jing Guo,Yan-Hua Lu
There is a significant interest in developing environmentally responsive or stimuli-responsive smart materials. The purpose of this study was to investigate multi-function responsive cotton fabrics with surface modification on the nanoscale. Three technologies including electrospinning technology, interpenetrating polymer network technology, and cross-linking technology were applied to prepare the multi-function sericin/poly(N-isopropylacrylamide)/Poly(ethylene oxide) nanofibers, which were then grafted onto the surfaces of cotton textiles to endow the cotton textiles with outstanding stimuli-responsive functionalities. The multi-function responsive properties were evaluated via SEM, DSC, the pH-responsive swelling behavior test and contact angle measurements. The results demonstrate that with this method, multi-function responsive, including thermo- and pH-responsiveness, cotton fabrics were fast formed, and the stimuli-responsiveness of the materials was well controlled. In addition, the antimicrobial testing reveals efficient activity of cotton fabrics with the sericin/PNIPAM/PEO nanofiber treatments against Gram-positive bacteria and Gram-negative bacteria such asStaphylococcus aureusandEscherichia coli. The research shows that the presented strategy demonstrated the great potential of multi-function responsive cotton fabrics fabricated using our method.Keywords:sericin;poly(N-isopropylacrylamide);cotton fabrics;electrospinning
研究领域:
材料科学
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纺织工程
·
生物医学工程
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产品关联
DOI
高影响因子
TEXTILE RESEARCH JOURNAL
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2016
·
IF 1.299
Jindan Wu,Yuelin Jiang,Ju He,Sufang Zhao,Guoqiang Cai,Jiping Wang
Thermo-responsive textile is newly developed and has wide application potentials in various fields. As the most commonly used textile, polyester has advantages in easy care, great durability and low cost. Since it has no reactive groups in fiber for surface functionalization, amino groups were generated by aminolysis in this study. By applying alkali deweighting during the aminolysis process, more -NH2 was produced. Poly(N-isopropylacrylamide) (PNIPAAm) was then grafted onto the surface via surface-initiated atom transfer radical polymerization. Infrared and X-ray photoelectron scanning measurements confirmed the success of PNIPAAm grafting. The thermo-switchable surface wettability was then explored by the test of surface wettability and fiber swelling–deswelling behavior. When the temperature rose, the surface switched from hydrophilic to hydrophobic as the contact angle transited from 0° to 120° reversely. This work established a feasible way and provided a new insight for preparing thermo-responsive polyester fabrics with smart cleaning and smart comfort properties.
研究领域:
材料科学
·
纺织工程
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Hui Xue,Ziqing Zhao,Rui Chen,John L. Brash,Hong Chen
Hypothesis : Poly( N -isopropylacrylamide) microgels are used extensively in the design of drug carriers, surfaces for control of cell adhesion, and optical devices . Particle size is a key factor and has a significant influence in many areas. Experiments : In this work, precise control of the particle size of poly( N -isopropylacrylamide) microgels was achieved by controlling the separation distance of the poly( N -isopropylacrylamide) chains. Dibromoalkanes of different size were used as an adjustable “molecular ruler” to measure molecular dimensions in poly( N -isopropylacrylamide) nanoaggregates at the critical crosslinking temperature. Findings : We find that the chain separation distance decreases as the temperature increases with a sharp decrease over the 55-to-65 °C interval. Based on the observed relationships between chain separation and crosslinker, the particle size of poly( N -isopropylacrylamide) microgels can be regulated by changing the length of the “molecular ruler” (crosslinker) at the same temperature. Furthermore, for partly crosslinked poly( N -isopropylacrylamide) microgels that contain free crosslinkable sites, the particle size can be reduced still more by further crosslinking (“re-crosslinking”) with crosslinkers of different size. It is shown that the particle size can be regulated by adjusting the length of “molecular ruler” and the degree of crosslinking. This work provides a “molecular level” method for precise control of poly( N -isopropylacrylamide) microgel particle size.
研究领域:
材料科学
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生物医学工程
·
纳米技术
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Xi Huang,Xiaolan Liang,Chunzhi Zhang,Yunhua Chen,Chaoyang Wang,Li Zhou,Tao Wang,Chunlin Feng,Hongxia Liu
The rise of the Internet of Things highlights the need for wearable piezoresistive sensors capable of integrating sensing devices with broader applicability and more advanced sensing functionalities. However, the development of multifunctional hydrogel sensors that meet the diverse needs of practical applications continues to present a substantial challenge. In this study, N-isopropylacrylamide/MXene/Fe3O4 (PNMF) composite hydrogels were synthesized via a straightforward one-pot method. The PNMF-based sensor exhibits multimode sensing abilities for pressure, magnetic, and temperature, with MXene and Fe3O4 nanoparticle providing electrical and magnetic response properties. Importantly, the temperature response is controlled by adjusting the MXene nanosheet content, which modifies the lower critical solution temperature (LCST) of the PNMF composite hydrogels. The PNM2F2-based pressure/magnetic/temperature sensor shows sensitivities of 0.40 and 0.23 kPa–1 in the 0–390 and 390–1040 Pa ranges, respectively. In the magnetic field ranges of 0–1.61, 1.61–4.25, and 4.25–40.93 mT, the field sensitivities are 26.93, 4.54, and 0.36 T–1, respectively. The PNMF composite hydrogel, as a multimode sensor, not only detects real-time human joint movement through pressure sensing but also operates as both a magnetic and temperature control switch, enabling detection of magnetic field strength and body surface temperature. This demonstrates its multimode sensing capability in more complex scenarios.
研究领域:
材料科学
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生物医学工程
·
传感器技术
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产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
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2016
·Vol. 54
·期 12
·1145-1151
·
IF 3.318
Yating Gao,Jinxian Yang,Haiyan Fan,Yanwei Ding,Xiaodong Ye
The effect of different functional groups of methylated urea on the phase transition of poly( N -isopropylacrylamide) (PNIPAM) aqueous solutions has been studied by a high-sensitivity differential scanning calorimetry. The results reveal that with the addition of osmolytes with N H groups, the enthalpy change increases with the number of DSC cycles, presumably due to the gradual formation of hydrogen bonds with dehydrated CO groups of PNIPAM at high temperature. Moreover, with the addition of tetramethylurea (TMU) without hydrogen bond donor groups, the enthalpy change of PNIPAM solution remains unchanged with the number of DSC cycles and decreases with the TMU concentration, suggesting that the van der Waals interactions between TMU and isopropyl groups of PNIPAM and the weakening of hydrophobic interactions between isopropyl groups play a dominant role in the effect of TMU on the phase transition of PNIPAM. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54 , 1145–1151
研究领域:
高分子化学
·
物理化学
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DOI
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2014
·Vol. 90
·期 3
·407-414
·
IF 2.494
Xiangye Li,Ruting Chen,Shouhong Xu,Honglai Liu,Ying Hu
BACKGROUND Injectable polymer gels for tissue engineering offer specific advantages over preformed scaffolds. They can transform from a sol to a block gel as a response to an external stimulus. One effective strategy for improving the mechanical strength of a gel is to introduce an inorganic material. RESULTS Microparticles composed of a hard SiO 2 core covered with a thermoresponsive hybrid gel (sodium hyaluronate/poly( N -isopropylacrylamide); NaHA/PNIPAm) were synthesized. The microparticles were characterized by dynamic light-scattering and transmission electron microscopy; rheological measurements were also performed. The microparticles were perfectly spherical and had a core–shell structure. They can perform a sol–gel transformation, that is, they shrank and assembled to form a macroscopic hydrogel through physical cross-linking at the gelation temperature ( T gel ), which was determined by rheological measurements. The T gel was adjusted by changing the concentration of microparticles or Ca 2+ ions. CONCLUSION The introduction of NaHA and SiO 2 improved the mechanical properties of the macroscopic gels. The rigidity and stability of the macroscopic gel were controlled by the molecular weight of NaHA and the amount of PNIPAm. Such injectable hydrogels might have potential as scaffold biomaterials, and are expected to be the ‘ink’ for three-dimensional bioprinters. © 2014 Society of Chemical Industry
研究领域:
生物材料学
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组织工程学
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高分子化学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 50
·期 14
·4914-4925
·
IF 2.371
Cheng Cui,Xia Dandan,Zhang Xiuli,Chen Li,Zhang Qiqing
The therapeutic concentration of cisplatin (CDDP) is usually associated with dose-limiting side effects. To avoid these harmful effects, a biocompatible hydrogel carrier which consisted of poly( N -isopropylacrylamide) and carboxymethyl chitosan was designed to deliver CDDP to the local environment of a solid tumor. The poly( N -isopropylacrylamide)-g-carboxymethyl chitosan hydrogels were synthesized by chemical crosslinking. Scanning electronic microscopy images showed that the hydrogels exhibited a cross-linked structure with the average pore size from 100 to 200 µm. Water contact angles and swelling studies suggested that the hydrogels had good hydrophilicity and the lower critical solution temperature lay in the vicinity of 32 °C. The MTT assays implied that the hydrogels were non-cytotoxic on NIH3T3 cells. In vitro release experiment demonstrated that the release of CDDP was controllable and sustained over a long period. Moreover, the released CDDP retained its anticancer activity on A549 cells. The hydrogels are promising carriers for sustained release of cisplatin.
研究领域:
生物医学工程
·
药剂学
·
肿瘤学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 115
·94582-94590
·
IF 3.84
Keyong Liu,Pengju Pan,Yongzhong Bao
A series of poly(vinyl chloride)-g-poly(N-isopropylacrylamide) (PVC-g-PNIPAM) amphiphilic copolymers with different graft lengths and densities were synthesized via the single electron transfer-living radical polymerization (SET-LRP) of NIPAM using poly(vinyl chloride-co-allyl α-bromoisobutyrate) as macroinitiator. The living nature of SET-LRP grafting copolymerization was verified by the kinetics study and narrow molecular weight distribution of PNIPAM grafts. The chemical structure, micellisation, and thermally-induced multistep aggregation of PVC-g-PNIPAMs were investigated. PVC-g-PNIPAMs form micelles comprised of a PVC core and PNIPAM corona in water at room temperature. These micelles are thermoresponsive and show a lower critical solution temperature (LCST). The micelle size and LCST of PVC-g-PNIPAM increase with increasing the graft density and length of PNIPAM. PVC-g-PNIPAM exhibits a very unique aggregation behavior above its LCST and forms a three-dimensional macroscopic aggregate with a well-defined and tunable shape at an extremely low concentration (∼0.1 wt%). The aggregate shrinks to a more compact structure with the further increase of temperature. Higher copolymer concentration, longer graft length, and lower graft density are favorable for the macroscopic micelle aggregation of PVC-g-PNIPAMs. A self-standing and superporous PVC-g-PNIPAM material having an extremely low density of ∼0.01 g cm−3 and a high porosity of >99% is attained after freeze-drying the micelle aggregate.
研究领域:
高分子化学
·
材料科学
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产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2024
·
IF 4.3
Chen Yue,Hanlin Zhai,Hong Zhang,Tingting Wang,Zhangpeng Li,Limin Ma,Jinqing Wang,Shengrong Yang
Herein, a poly(N-isopropylacrylamide)-based conductive composite hydrogel system coenhanced by clay and polydopamine-modified MXene was synthesized to achieve strain and temperature sensibility simultaneously. The noncovalently cross-linked network via MXene, clay, and polymer chains endowed the synthesized hydrogel with excellent mechanical properties (tensile strength at a break of 117 kPa and elongation at a break of 1723%). This hydrogel also exhibits strong adhesion and good electrical conductivity (0.13 S/m). Regarding the sensing properties, its temperature sensitivity is 2.749 °C–1, while its strain detection limit is as low as 0.05%. Based on the unique characteristics of the prepared hydrogel, the as-assembled sensor can detect stress and temperature simultaneously, exhibiting great application potential in human physiological monitoring.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）