Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Jianhua Lv,Bin Sun,Jing Jin,Wei Jiang
Diatomite as a promising natural material is filled into poly(acrylamide) (PAAm) to synthesize PAAm/diatomite composite hydrogel. The internal chemistry structure of PAAm/diatomite composite hydrogel and the diatomite dispersion are characterized via Attenuated total reflection Fourier transform infrared (ATR-FTIR) and scanning electron microscopy (SEM). The mechanical property, water absorbency, and transparency of PAAm/diatomite composite hydrogels filled with different contents of diatomite are systematically investigated. The tensile and compressive strengths of PAAm/diatomite composite hydrogels are improved twice and 13-fold with 8 phr of diatomite. The water absorbency and transparency of PAAm/diatomite composite hydrogel decrease with the increase of diatomite content. The diatomite in PAAm hydrogels is not merely filling the bulk of PAAm hydrogel but is connecting with PAAm via hydrogen bonding. Carbendazim as a broad-spectrum benzimidazole fungicide is used to investigate the release property and kinetics of the composite hydrogels. The PAAm hydrogels can decrease the release rate of carbendazim and prolong the carbendazim efficacy, especially for the diatomite composite hydrogel. The time of half carbendazim release from the diatomite composite hydrogel is prolonged for almost 4 days, and the release mechanism is anomalous transport. Thus, diatomite can improve the mechanical property of PAAm hydrogel and extend the carbendazim efficacy loaded with PAAm hydrogel. Considering more widely applicable, the diatomite composite hydrogel can be applied to reduce the loss and waste of drugs and prolong the duration of drugs in biomedical materials.
研究领域:
材料科学
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环境科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Pan Xu,Zhijie Shang,Meiling Yao,Xinxue Li
In this investigation, the nanocomposite hydrogels were prepared by hydrophilic nanoscale silica secondary crosslinking hydrolytic polyacrylamide (HPAM) hydrogel to improve its strength and stability performance. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used to study the composition and microstructure of nanocomposite hydrogel. In addition, it increases the viscosity of the gel solution by increasing the amount of nano-silica. According to Sydansk coding system, the maximum gel strength of P (HPAM/HMAM/SiO 2 ) hydrogel increased from code “F” to codes “G” and “H”. The stability time of P(HPAM/HMAM/SiO 2 ) hydrogel increased from 30 days to 90 days. The results of molecular dynamics simulation (MDS) and differential scanning calorimetry analyses (DSC) showed that SiO 2 increases the interactions between the water molecules and colloidal phase, which is the main reason for improving the stability of the nanocomposite hydrogel. The dehydration rate of hydrogel decreased with the increase of nanoparticle content in terms of the dehydration tests. The dehydration rate of hydrogel increases with the increase of temperature. In addition, the kinetics of all nanocomposite hydrogels dehydration can be described by first-order kinetics at 35 °C, 45 °C, and 55 °C.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 11
·1845
·
IF 3.164
Jincheng Lei,Zidi Zhou,Zishun Liu
Existing theories cannot predict the mechanical property changes of polyacrylamide hydrogels with different water content because of the absence of side chains. In this study, polyacrylamide hydrogels are prepared and tested to investigate the side chain effect on their mechanical properties. First, the comparison between the effective chain density and total chain density provides proof of the large amount of side chains in the polymer network of PAAm hydrogel. We propose a practical chain density fraction to measure the side chain fraction. Then, the abnormal Young’s moduli-polymer volume fraction relationship reveals that side chains affect the mechanical properties of hydrogel through the insufficient lubrication of water. Water confined in narrow space within a molecular-level size can bear shear force to provide extra deformation resistance. A constitutive mode considering the effect of the insufficient lubrication of water is proposed. Combining this constitutive model with experimental results, we find that this insufficient lubrication of water exists even in equilibrium PAAm hydrogel. Molecular dynamics simulations reveal that this insufficient lubrication of water comes from the constraint of polymer chains. It also demonstrates that when there is insufficient lubrication, the rearrangement of water molecules leads to the persistent energy dissipation in the Mullins effect of PAAm hydrogel.Keywords:polyacrylamide hydrogel;side chains;insufficient lubrication of water;Mullins effect
研究领域:
材料科学
·
生物力学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2016
·Vol. 217
·期 19
·2139-2144
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IF 2.495
Xiuyin Zhang,Chuanzhuang Zhao,Nanping Xiang,Wei Li
Physical interaction between the microgel and the hydrogel matrix is a key issue in the rational design of microgel reinforced hydrogels. A pentaerythritol-crosslinked poly(acrylic acid) (PAAc) microgel, named Carbopol, is composited with polyacrylamide (PAAm) hydrogel. The toughness of the hydrogel is significantly improved by constructing an interpenetrating network of Carbopol and PAAm. Chain entanglements within the composited hydrogel result in a strain-hardening phenomenon and an efficient stress transfer from the PAAm matrix to the sacrificing network of Carbopol. Hydrogen bonds between PAAc and PAAm can be formed in an acidic environment, which function as reversible sacrificing bonds and further improve the stretchability of the hydrogel.
研究领域:
材料科学
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生物材料
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2021
·
IF 7.46
Xueyan Liu,Zhuo Chen,Rongsheng Gao,Chengyou Kan,Jianhong Xu
Recently, the colorimetric quantitative method based on a smartphone and red–green–blue (RGB) analysis is applied to provide rapid on-site monitoring of metal ions. To develop such a fluorescent and colorimetric chemosensor for Fe 3+ , the functionalized polyacrylamide hydrogel P(AM- co -MBA- co -RhBUEA) was synthesized by free radical polymerization on the basis of a rhodamine-based probe RhBUEA. The physicochemical properties and sensing behavior of the functionalized hydrogel were investigated by FTIR, SEM and fluorescence spectral analysis. And the effects of MBA and RhBUEA amount on gel content and swelling properties were explored. According to the recipe of 1.0 wt.% MBA, 2.0 wt.% RhBUEA to the total monomers, the fabricated hydrogel displayed excellent selectivity, sensitivity and reversibility for Fe 3+ sensing in the pH range of 4.95–8.02, with the detection limit of 0.088 μM for the fluorescent quantitative method and the response time less than 20 min, accompanied with a distinct color change. Owing to the integration of RGB analysis with colorimetric responses, the functionalized hydrogel permitted the convenient, simplified and rapid colorimetric quantitative detection of Fe 3+ with the detection limit of 1.1 μM, which avoids the need of sophisticated instruments and trained operators.
研究领域:
分析化学
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环境科学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 19
·2617-2624
·
IF 4.927
Jianyu Xu,Ziwen Fan,Lijie Duan,Guanghui Gao
For hydrogels, toughness and adhesiveness are contradictable. However, the simultaneous requirement for both is very urgent in some practical applications, such as robotic joints, wound dressing, and surgical bandages. Herein, milk casein as a protein model was introduced into polyacrylamide (PAAm) hydrogel, which resulted in adequate adhesiveness and mechanical strength. Surprisingly, casein-PAAm hydrogel could repeatedly adhere to the surface of various solid materials and biological tissues by possible physical interactions. A maximum peeling force of 378 N m−1 for casein-PAAm hydrogel on an aluminum surface was measured. Moreover, casein-PAAm hydrogel exhibited adequate mechanical performance with fracture stress of 180 kPa at fracture strain of 2000%. Therefore, the strategy based on tough and adhesive hydrogels assisted by protein would broaden the direction to fabricate a new generation of soft materials with multiple adhesive properties and tough mechanical properties.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Yunlin An,Chang Shu,Yunqing Liu,Yilong Xu,Litao Kang,Xiaoyu Zhang,Jianchao Sun,Zuju Ma,Kan Zhao,Yongfeng Huang,Feiyu Kang,Fuyi Jiang,Wenbao Liu
Zinc-ion batteries become a major research focus in energy storage, valued for their low cost and high safety. However, their widespread application is hindered by poor zinc anode stability caused by dendrites, side reactions, and poor performance across a wide temperature range at a strong hydrogen bond network aqueous electrolyte. In this study, we propose a strategy for the synergistic combination of a polyacrylamide hydrogel with sucrose. The experimental and theoretical results demonstrate that through the synergistic effect of the polyacrylamide hydrogel and sucrose, they regulate the solvation structure of Zn2+ and the hydrogen bond network and inhibit the interfacial side reactions caused by active water. Zinc anode corrosion and dendrite growth issues were also effectively mitigated by this synergistic effect. Consequently, the Zn//Zn-symmetric battery achieved stable cycling performance exceeding 6240 h at room temperature at 0.5 mA cm–2 and 0.5 mAh cm–2. The Zn//VO2 full battery also has good stability, maintaining stable cycle performance even at low temperatures (10,000 cycles at 1 A g–1 at 0 °C). Even at −10 °C, it has a stable cycle (Zn//Zn-symmetric battery cycle more than 3970 h). This work provides an alternative strategy for developing low-cost, wide temperature range electrolytes for aqueous zinc-ion batteries.
研究领域:
材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Zhengqiang Qin,Nuan Feng,Yao Li,Xu Fei,Jing Tian,Longquan Xu,Yi Wang
Lipase is the most widely used enzyme in industry. Due to its unique “lid” structure, lipase can only show high activity at the oil–water interface, which means that water is needed in the catalytic esterification process. However, the traditional lipase catalytic system cannot effectively control “micro-water“ in the esterification environment, resulting in the high content of free water, which hinders the esterification reaction and reduces the yield. In this paper, a promising strategy of esterification catalyzed by polyacrylamide hydrogel immobilized lipase is reported. The porous polyacrylamide hydrogel microspheres (PHM) prepared by inverse emulsion polymerization are used as carrier to adsorb lipase by hydrogen bonding interaction. These hydrogel microspheres provide a ”micro-water environment“ for lipase in the anhydrous reaction system, and further provide an oil–water interface for ”interface activation“ of lipase. The obtained lipase-porous polyacrylamide hydrogel microspheres (L-PHMs) exhibit higher temperature and pH stability compared with free lipase, and the optimum enzymatic activity reach 1350 U/g (pH 6, 40 °C). L-PHMs can still remain about 49% of their original activity after 20 reuses. Furthermore, L-PHMs have been successfully applied to catalyze the synthesis of conjugated linoleic acid ethyl ester . The results suggest that this immobilization method opens up a new way for the application of lipase in ester synthesis.
研究领域:
生物化学
·
酶工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 56
·15119-15125
·
IF 5.16
Xin Liu,Qin Zhang,Kunming Li,Lijie Duan,Guanghui Gao
Graphical Sticky gels : A novel adhesive hydrogel driven by A-U has been successfully synthesised and investigated (see figure). The hydrogel exhibits remarkable adhesive behaviour for various materials including fresh tissues from mice. The A-U adhesive hydrogels also exhibit iterative durable adhesion for various materials. The bioinspired adhesive strategy created by ribonucleic acid bases should promote the development of soft and wet adhesive materials. Nucleobase pairs of adenine and uracil (A-U) from ribonucleic acid are of particular interest for various promising material properties. Herein, a novel polyacrylamide hydrogel with adhesive properties that are assisted by adenine and uracil has been designed and investigated. The incorporation of adenine and uracil enables the formation of a polyacrylamide hydrogel with remarkable adhesive behaviour with various materials including polytetrafluoroethylene (PTFE), plastics, rubber, glasses, metal, ceramics and wood. Moreover, the adhesive hydrogel can easily and directly adhere to humid biological tissues without any extra process, including heart, liver, spleen, lung, kidney, bone and muscle of mouse. More impressively, even after repeated peeling tests (10×), the AU-mediated polyacrylamide hydrogel still exhibits excellent durable adhesion for various materials. From mechanical contact tests, the adhesion energy of the A-U adhesive hydrogel is 47.9 J m −2 , which is nearly nine times that of polyacrylamide hydrogel (5.3 J m −2 ). The 90° peeling strength for aluminium, titanium, silica rubbers, glasses, PTFE and hogskin is 518, 645, 445, 396, 349, and 119 N m −1 , respectively. The multipurpose and durable adhesive behaviour of hydrogels assisted by adenine and uracil indicated the promise of nucleobase pairs from ribonucleic acid for the future development of adhesive materials.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 34
·5230-5236
·
IF 5.047
Lin Guan,Su Yan,Xin Liu,Xinyao Li,Guanghui Gao
Flexible hydrogel-based sensors have attracted significant attention due to promising applications of wearable devices. However, fabricating a flexible hydrogel combining toughness, stickiness, anti-freezing capability and conductivity is still a great challenge. Here, casein and LiCl are successfully introduced into a polyacrylamide hydrogel to prepare a tough and adhesive PAAm/casein hydrogel, which exhibits good mechanical properties and excellent reversible adhesive behavior for diverse materials and human skin. Due to the presence of conductive ions, the PAAm/casein hydrogel exhibits high conductivity (0.0753 S cm−1) and anti-freezing properties (−21 °C). Moreover, the PAAm/casein hydrogel as a flexible wearable strain sensor is sensitive to both large-scale human motions (e.g., joint bending) and tiny physiological signals (e.g., speaking). It is envisioned that the strategy would provide novel inspiration for the development of flexible wearable protein-driven hydrogel devices.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2023
·
IF 13.1
Haiyang Liao,Wenzhao Zhong,Chen Li,Jieling Han,Xiao Sun,Xinhui Xia,Ting Li,Abolhassan Noori,Mir F. Mousavi,Xin Liu,Yongqi Zhang
The anti-freezing strategy of hydrogels and their self-healing structure are often contradictory, it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-freezing/self-healing for meeting the rapid development of flexible and wearable devices in diverse service conditions. Herein, we design a new hydrogel electrolyte (AF/SH-Hydrogel) with intrinsic anti-freezing/self-healing capabilities by introducing ethylene glycol molecules, dynamic chemical bonding (disulfide bond), and supramolecular interaction (multi-hydrogen bond) into the polyacrylamide molecular chain. Thanks to the exceptional freeze resistance (84% capacity retention at −20 °C) and intrinsic self-healing capabilities (95% capacity retention after 5 cutting/self-healing cycles), the obtained AF/SH-Hydrogel makes the zinc||manganese dioxide cell an economically feasible battery for the state-of-the-art applications. The Zn||AF/SH-Hydrogel||MnO 2 device offers a near-theoretical specific capacity of 285 mA h g −1 at 0.1 A g −1 (Coulombic efficiency ≈100%), as well as good self-healing capability and mechanical flexibility in an ice bath. This work provides insight that can be utilized to develop multifunctional hydrogel electrolytes for application in next generation of self-healable and freeze-resistance smart aqueous energy storage devices.
研究领域:
材料科学
·
能源存储
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 14
·48541
·
IF 2.188
Yinyan Guan,Li Wang,Li Cui,Xinjun Shen,Weichun Gao,Jing Meng,Dan Li,Chenguang Shen,Yichen Zhang,Guodong Hu,Jiyan Liang
In this article, tough hydrogels are prepared by introducing the polyethyleneimine (PEI) with branched structure and a large number of NH 2 and NH groups into permanently crosslinked polyacrylamide (PAAm) hydrogels matrix. To investigate the effects of B-PEI and chemical crosslinking agent (Bis) on the strength and toughness of hydrogels, a series of B-PEI/PAAm hydrogels with different mass percentage of Bis and B-PEI were manufactured and the rheological and swelling properties were compared. For all hydrogels, the storage modulus ( G ′) was much higher than the loss modulus ( G ″) in the linear viscoelastic region through the whole frequency range. The solid-like behavior and elastic nature ( G ′ > G ″) are attributed to the permanent covalence crosslinking. Therefore, G ′ increased when more Bis was added. For the nonlinear oscillatory shear measurement, hydrogels with B-PEI broke at larger γ than the pure PAAm hydrogels, indicating that the toughness of B-PEI/PAAm hydrogels has been improved by introducing B-PEI. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48541.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）