Pharmaceutics
·
2018
·Vol. 10
·期 4
·230
·
IF 3.746
Xingzheng Liu,Rongrong Fan,Boting Lu,Yuan Le
Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by1H NMR, FT-IR and gel penetration chromatography. The polymers can self-assemble to form micelles in aqueous medium and their critical micelle concentrations values were examined. The micelles were spherical shape with size of 50–100 nm and especially can arranged in a regular manner. Sorafenib was selected as the model drug and the drug loading performance was dependent on the composition of the block copolymer. In vitro drug release indicated that the polymers can realize controlled and sustained drug release. Furthermore, in vitro cytotoxicity assay showed that the polymers were biocompatible and the drug-loaded micelles can increase toxicity towards tumor cells. Confocal fluorescence microscopy assays illustrated that the micelles can be uptaken quickly and release drug persistently to inhibit tumor cell growth.Keywords:methoxy-poly(ethylene glycol);polypeptide;methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine);micelles;drug delivery
研究领域:
高分子化学
·
药物递送系统
·
肿瘤治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2015
·
IF 3.65
Lijuan Chen,Liwei Tan,Xiaoning Zhang,Jun Li,Zhiyong Qian,Mingli Xiang,Yuquan Wei
In this paper, we systemly compared the two kinds of VP16 (etoposide) loaded polymers micelles , monomethyl poly (ethylene glycol)-poly (lactic acid) (MPEG-PDLLA) and monomethyl poly (ethylene glycol)-poly (ϵ-caprolactone) (MPEG-PCL) in vitro and in vivo . Molecular modeling study was used as a novel means to compare the two formulations. In vitro , the micelle samples were fully characterized by TEM, XRD, drug loading (DL), Encapsulation efficiency (EE), stability and MTT. The stability study revealed that MPEG-PDLLA-VP16 had the significant advantage of 100% drug retention within 48 h compared to MPEG-PCL-VP16 with 40%, conform to the computer simulation model results. Cellular uptake figured that MPEG-PDLLA-VP16 had a 7 times larger uptake rate in the H460 cell line. In vivo , pharmacodynamics results showed MPEG-PDLLA-VP16 perform no significant difference with VP16 clinical formulations (10, 20 mg/kg). However, MPEG-PCL-VP16 had no difference between different dosages on anticancer activities. Plasma pharmacokinetics results showed that the two micelle formulations prolong the half-life of VP16 twice than that of VP16 clinical formulations. In conclusion, micelle were better choice for cancer treatment on reducing drug toxic. In this study, the results also indicated that MPEG-PDLLA was more suitable for VP16 than MPEG-PCL as a more promising formulation for clinical cancer treatment.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Chao Zheng,Xiaoyan Yu,Xiaoyi Chen,Mingming Chang
Poly(ethylene oxide)- b -poly(propylene oxide)- b -poly(ethylene oxide) (PEO-PPO-PEO) and acrylamide are both commercially available and widely used water-soluble substances. There are many situations that PEO-PPO-PEO coexist with acrylamide in industry applications, while little is known about the influence of acrylamide on cloud point of PEO-PPO-PEO aqueous solution. In this work, it reveals a universal solubilization of PEO-PPO-PEO by acrylamide. There is always an increase in cloud point with addition of acrylamide no matter what the molecular structure and concentration of PEO-PPO-PEO is. It is found the solubilization is more pronounced when PEO-PPO-PEO is with lower molecular weight or lower weight fraction of PPO segments. On the other hand, the cloud point of systems at lower concentration is more sensitive to addition of acrylamide. On the contrary, polyacrylamide exhibits an opposite impact on cloud point of PEO-PPO-PEO. Acrylamide/PEO-PPO-PEO solution changes from clear to cloudy after polymerization of acrylamide.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Guifeng Miao,Yuejian He,Keren Lai,Yan Zhao,Peiyi He,Guozhu Tan,Xiaorui Wang
PEGylated nanomedicines have been extensively developed and applied to cancer therapy. However, the antitumor efficacy of these nanoparticles is hampered by the accelerated blood clearance (ABC) effect caused by anti-PEG antibodies in vivo . There is still limited understanding about the cause of pre-existing anti-PEG antibodies in the human body. Herein, we discovered that PEG-based pharmaceutical excipients, commonly used in clinical and daily settings, could induce anti-PEG antibodies in vivo and lead to considerable potential clinical impacts on pharmacokinetics and pharmacodynamics of PEGylated nanoparticles. Specifically, we investigated the ability of poloxamer 188 (F68) and poloxamer 407 (F127), the two most frequently used PEG-based pharmaceutical excipients, to elicit the production of anti-PEG antibodies and influence the pharmacokinetics of PEGylated nanoparticles, with PEGylated liposome nanoparticles (L-NPs) as a model. Anti-PEG IgG and IgM levels were significantly boosted 3.8- and 32.2-fold, respectively, after pre-injection with F68, leading to rapid clearance of subsequently injected L-NPs from circulation due to the capture by neutrophils and monocytes. However, pre-injection of F127 did not induce the production of anti-PEG IgG, although there was a 7.7-fold increase in IgM level, which resulted in minimal effect on circulation time of L-NPs. Furthermore, the potential clinical impacts of F68 and F127 were further inspected for PEGylated liposomal doxorubicin (PLD). It was found that administering F68 prior to treatment led to over a one-third decrease in the antitumor effectiveness of PLD, while F127 had a negligible impact. Our study elucidates the mechanism by which PEG-based pharmaceutical excipients influence the effectiveness of PEGylated nanomedicines. It also highlights the significance of considering the potential for an ABC effect induced by PEG-based pharmaceutical excipients in patients.
研究领域:
药理学
·
肿瘤学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2019
·
IF 7.467
Dandan Li,Xiaoxiao Ji,Xianjing Gong,Fangchang Tsai,Qunchao Zhang,Li Yao,Tao Jiang,Robert K.Y. Li,Hengchong Shi,Shifang Luan,Dean Shi
Si doped-poly(ethylene glycol) ( Si-PEG) hybrid polymer electrolyte with Si O C bonds in the main chain obtains high ionic conductivity even at room temperature because of the more flexible molecule chains. In this work, poly(ethylene glycol)-borate ester (B-PEG) is further covalent bonded into the crosslinked Si-PEG network to form the hybrid solid polymer electrolyte (HSPE). Comparing to previous works in which B-PEG is just added as a plasticizer , the Lewis acidity of boron (B) in the network of polymer chains is less shielded by the connected PEG chains, which is more effective to improve lithium ion transference number ( t L i + ) and reduce the interfacial polarization of LiFePO 4 /HSPE/Li cells by attracting the anions of lithium salt . The t L i + increases monotonously along with the increase of B-PEG contents in HSPE, while the ion conductivity has a peak value. When B-PEG content is 23.1 wt%, the highest ionic conductivity of the hybrid polymer electrolyte reaches up to 1.6 × 10 −4 S/cm and t L i + is 0.68 at 25 °C. And the initial capacity of LiFePO 4 /HSPE/Li cells are 120 mAh/g and 90 mAh/g at 0.5C and 1C at 25 °C. After 100 cycles under 1C at 25 °C, the capacity retention of the LiFePO 4 /HSPE/Li cell is 84%, which is higher than that of 65% for LiFePO 4 /PSPE/Li cell. (PSPE indicates the Si-PEG polymer electrolytes with B-PEG just as plasticizer).
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 3
·564
·
IF 5
Huafen Wang,Huanhuan He,Jiaxiang Zhang,Juntao Liu,Yuwei Zhuang,Yuanyuan Yin,Zhiyong Ren,Yang Fu,Suqin He
Novel monomethoxy poly(ethylene glycol) (mPEG) modified hydroxylated tung oil (HTO), denoted asmPEG-HTO-mPEG, was designed and synthesized for drug delivery.mPEG-HTO-mPEG consists of a hydroxylated tung oil center joined by twomPEG blocks via a urethane linkage. The properties ofmPEG-HTO-mPEG were affected by the length of the mPEG chain. ThreemPEG with different molecular weights were used to preparemPEG-HTO-mPEG. The obtained threemPEG-HTO-mPEG polymers were characterized by nuclear magnetic resonance (NMR), Fourier transformation infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC), respectively. Furthermore, the particle sizes ofmPEG-HTO-mPEG micelles were evaluated by dynamic light scattering (DLS) and transmission electron microscope (TEM). A critical aggregation concentration (CAC) ranged from 7.28 to 11.73 mg/L depending on the chain length of mPEG. The drug loading and release behaviors ofmPEG-HTO-mPEG were investigated using prednisone acetate as a model drug, and results indicated that hydrophobic prednisone acetate could be effectively loaded intomPEG-HTO-mPEG micelles and exhibited a long-term sustained release. Moreover, compared with HTO,mPEG-HTO-mPEG had no obvious cytotoxicity to HeLa and L929 cells. Therefore, monomethoxy poly(ethylene glycol) modified hydroxylated tung oilmPEG-HTO-mPEG may be a promising drug carrier.Keywords:hydroxylated tung oil;poly(ethylene glycol);drug delivery
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zhenyu Zhang,Juan Liu,Ting Li,Zhikai Fu,Jinshui Mao,Xiaocheng Li,Sili Ren
Recycling of Nd(III) and Dy(III) from waste NdFeB magnets is increasingly critical in the sustainable development of rare-earth elements (REEs) industry. The efficient separation of Nd(III) and Dy(III) from conventional aqueous solution by solvent extraction (SX) is facing huge challenge due to the high activity, high interfacial tension and the high dielectric constants of water that affect the coordination of REEs with the extractant. Herein, a novel non-aqueous solvent extraction (NASX) system based on neutral extractant P350 was developed to extract Nd(III) and Dy(III) with high extraction efficiency and separation factor. In this extraction system, the majority of water in the aqueous phase was replaced by different low-dielectric-constant polar molecular organic solvents (PMOSs) to reduce the influence of water during extraction. The effect of the type and content of PMOSs, P350 concentration, extract equilibration time and temperature on the separation performance were systematically investigated. It was encouraging to find that the favorable separation factor of Nd(III) and Dy(III) elements ( β Nd/Dy ) was determined to be 201 when extracted from 70 vol% PEG 200 with 0.2 mol/L P350, which was higher than that in traditional extraction from aqueous phase. Slope analysis method was used to determine the extractant stoichiometry and the main species of extraction complex was identified as DyCl 3 ·2L which was verified by Fourier infrared spectroscopy (FT-IR). Furthermore, in the simulation of recovery of NdFeB magnetic immersion solution experiment, the extraction efficiency (E%) of Dy(III) can reach 85 %, while co-extraction of Nd(III) was only 6 % and the β Dy/Nd was as high as 83.4. According to the McCabe-Thiele diagram, 3-stages counter-current solvent extraction was needed to completely extract Dy(III). Moreover, 97.11 % of Nd(III) and 98.5 % of Dy(III) in the loaded organic phase can be sequentially stripped by 0.04 mol/L and 0.4 mol/L HCl, respectively. These results indicated that the developed processes in this work have superior extraction efficiency, large separation factors and excellent stripping stability. Eventually, a P350-PEG 200 extraction system-based separation process was proposed in the hope of providing a novel and low-cost alternative to the efficient recycle of Nd(III) and Dy(III) from end-of-life NdFeB.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Lingli Jin,Fengjiao Chen,Xianwu Chen,Shun Zhang,Zhenjiang Liang,Lingling Zhao,Hui Tan
Thrombolytic therapy for ischemic stroke still has several limitations, such as a narrow therapeutic time window and adverse effects. Therapeutic hypothermia is a neuroprotective strategy for stroke. In this study, we developed pH/temperature dual-responsive protein–polymer conjugates (PEG–uPA–PEG–PPG–PEG) by modifying a urokinase-type plasminogen activator (uPA) with polyethylene glycol (PEG) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG–PPG–PEG, a thermosensitive polymer) via pH-sensitive imine bonds and disulfide bonds, respectively. At 37 °C and pH 7.4 (normothermia and physiological pH), PEG–uPA–PEG–PPG–PEG exhibits antiprotease hydrolysis and masked bioactivity of uPA due to the protective effect of the polymer segments wrapped around the protein surface. However, at 33 °C and pH 6.0 (hypothermia and pH at the thrombotic site), uPA loses the protective effect and recovers its bioactivity due to PEG dissociation and PEG–PPG–PEG stretching. The masked bioactivity of uPA at normothermia and physiological pH could reduce the risk of acute hemorrhage complication, and the recovery of protein activity at acidic pH and 33 °C is of great significance for thrombolytic therapy at mild hypothermia. Thus, PEG–uPA–PEG–PPG–PEG provides promising potential for therapeutic hypothermia in ischemic stroke.
研究领域:
药学
·
生物医学工程
·
神经病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SUPRAMOLECULAR CHEMISTRY
·
2024
·
IF 2.1
Caixia Li,Qin Zhou,Haoliang Huang,Liang Li
In this paper, Biocompatible supramolecular hydrogels, composed of β-cyclodextrin-modified hyaluronic acid, pluronic F127, α-cyclodextrin and doxorubicin, were constructed, which can be employed for targeted delivery system. The chemical composition and rheological properties of the obtained hydrogels were fully characterised. Considering the controlled complexation between DOX and the hydrogel skeletons, the controlled release of hydrogel G[5, 10, 5] was investigated to exhibit a better pH- and temperature-controlled release behavior. The data of DOX release kinetic was fitted well with Higuchi and Korsmeyer-Peppas models. Moreover, the cellular toxicity experiments indicated that the hydrogel DOX@G[5, 10, 5] exhibited a similar anticancer ability in comparison with free DOX. Due to the hyaluronic acid-targeted effects, the cytotoxicity of the hydrogel DOX@G[5,10,5] to HepG2 cells was lower than that to SKOV-3 cells upon increasing the concentration. Therefore, these hydrogels may act as a potential prospect for the targeting release of anticancer drugs.
研究领域:
药剂学
·
生物材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2012
·Vol. 20
·期 2
·528-539
·
IF 1.349
Wang Jiwen,Zhai Wentao,Zheng Wenge
The main purpose of this study is challenging to dramatically improve the toughness of poly(lactic acid) (PLA)/starch by adding poly (ethylene glycol) (PEG) into the composites and grafting PEG molecules onto the surface of starch particles. It was found that the surface grafting of PEG onto starch induced the presence of PEG-rich regions located around the starch particles, caused by migration and aggregation of free PEG molecules. A novel interphase transition layer between PLA and starch was formed, which showed great ability for cavitation and vested large-scaled plastic deformation to PLA matrix. Further mechanical properties tests indicated the formation of interphase layer significantly increase the elongation at break from 10.2 to 254.5%, and notched impact strength from 1.56 to 2.37 kJ/m 2 for PLA/PEG/starch ternary composites. The influence of PEG component, ethanol extraction and annealing was also investigated.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2023
·Vol. 15
·期 7
·1673
·
IF 5
Zhenzhen Pi,Changyu Deng,Hongmei Pan,Kemei Pei
Polyethylene glycol 1000 (PEG1000) and epoxy resin E20 were used to synthesize the E20/PEG1000 polymer (EP1K), which was later transformed into a self-emulsifying water-based epoxy curing agent by reacting with m-Xylylenediamine (MXDA). The effects of molecular weight, the molar ratio of the raw materials, the catalyst dosage, and the different co-solvents on the properties of the prepared curing agent were systematically explored. The infrared absorption spectra of E20, EP1K, and the water-based epoxy curing agent were compared and analyzed. The coating properties of the waterborne epoxy varnish, which was based on water-based epoxy curing agents to emulsify and cure the resin E44, were systematically tested. The results demonstrated that with a molar ratio of 1:1:4 of PEG1000, E20, and MXDA, the boron trifluoride etherate (BF3·Et2O) as catalyst accounts for 0.3% of the total mass of E20 and PEG1000, and an applicable period of 3 h for the prepared varnish, the anti-corrosion performance, and mechanical properties of the coatings were excellent.Keywords:epoxy resin;curing agent;polyethylene glycol;self-emulsifying
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2016
·
IF 4.843
Zichao Luo,Ling Jin,Lu Xu,Zhao Liang Zhang,Jing Yu,Shuai Shi,Xingyi Li,Hao Chen
Development of efficient ocular drug delivery systems was still a challenging task. The objective of this article was to develop a thermosensitive PEG–PCL–PEG (PECE) hydrogel and investigate its potential application for ocular drug delivery of diclofenac sodium (DIC). PECE block polymers were synthesized by coupling MPEG-PCL co-polymer using IPDI reagent, and then its sol–gel transition as a function with temperature was investigated by a rheometer. The results showed that 30% (w/v) PECE aqueous solution exhibited sol–gel transition at approximately 35 °C. In vitro release profiles showed the entrapped DIC was sustained release from PECE hydrogels up to 7 days and the initial drug loading greatly effect on release behavior of DIC from PECE hydrogels. MTT assay results indicated that no matter PECE or 0.1% (w/v) DIC-loaded PECE hydrogels were nontoxic to HCEC and L929 cells after 24 h culturing. In vivo eye irritation test showed that the instillation of either 30% (w/v) PECE hydrogels or 0.1% (w/v) DIC-loaded PECE hydrogels to rabbit eye did not result in eye irritation within 72 h. In vivo results showed that the AUC0–48 h of 0.1% (w/v) DIC-loaded PECE hydrogels exhibited 1.6-fold increment as compared with that of commercial 0.1% (w/v) DIC eye drops, suggesting the better ophthalmic bioavailability could be obtained by the instillation of 0.1% (w/v) DIC-loaded PECE hydrogels.
研究领域:
药剂学
·
生物医学工程
·
眼科研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）