JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Min Xiao,Zifeng Wang,Yanru An,Yingqi Dai,Xinghao Wang,Zhigang Zhu
Microneedles offer minimally invasive, user-friendly, and subcutaneously accessible transdermal drug delivery and have been widely investigated as an effective transdermal delivery system. Ibuprofen is a common anti-inflammatory drug to treat chronic inflammation. It is crucial to develop microneedle patches capable of efficiently delivering ibuprofen through the skin for the effective treatment of arthritis patients requiring repeated medication. In this study, the mechanical properties of a new type of polymer microneedle were studied by finite element analysis, and the experimental results showed that the microneedle could effectively deliver drugs through the skin. In addition, a high ibuprofen-loaded microneedle patch was successfully prepared by micromolding and subjected to evaluation of its infrared spectrum morphology and dissolve degree. The morphology of microneedles was characterized by scanning electron microscopy, and the mechanical properties were assessed using a built linear stretching system. In the in-vitro diffusion cell drug release test, the microneedle released 85.2 ± 1.52% (210 ± 3.7 μg) ibuprofen in the modified Franz diffusion within 4 h, exhibiting a higher drug release compared to other drug delivery methods. This study provides a portable, safe and efficient treatment approach for arthritis patients requiring daily repeated medication.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Defence Technology
·
2021
·
IF 3.172
Fuwei Li,Yue-ting Wang,Cheng-ai Wang,Yun Shen,Ze-hua Zhang,Jian Cheng,Shuang-zhang Wu,Ying-hua Ye,Rui-qi Shen
The core-shell metastable intermolecular composites (MIC) have attracted much attention in the past few years due to their unique properties. Here, the preparation of Al-Core heterojunction fibers using PVP as a template is proposed. The nano-Al was directly added to the precursor solution of cupric acetate monohydrate (CAM)/Polyvinylpyrrolidone (PVP), and the initial Al@CAM/PVP fibers were obtained via electrospinning. The core-shell MIC fibers are then obtained by calcining the initial fibers. The morphology, structure, and composition of Al-core MIC fibers were characterized, that the energetic fibers calcined at 300 °C, 350 °C, and 400 °C have a core-shell structure with shell compositions Cu x O and PVP, Cu x O and CuO, respectively. The energy release characteristics of Al-core MIC were investigated, and preliminary ignition tests were performed using an ignition temperature measuring instrument and a pulsed laser. The energetic fibers calcined at 300 °C exhibited unique properties. The decomposition of PVP in the shell layer promoted exotherm, and a low-temperature exothermic peak was shown at 372–458 °C. Lower ignition temperatures and higher flame heights were observed in the combustion tests than calcination at 350 °C and 400 °C. An unexpected result was that PVP can play a positive role in Al/CuO nanothermites. Simultaneously, this preparation method provided an idea for the integrated preparation of core-shell Al-Core MIC fibers and tuning the properties of MIC.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Yeshuang Wang,Chao Yang,Chaonan Zhang,Mingxian Duan,Hui Wang,Huiling Fan,Yuankai Li,Ju Shangguan,Jianying Lin
Hierarchical porous MOF-199 with small crystal sizes was synthesized via PVP (Polyvinylpyrrolidone) regulation in an aqueous system, in which PVP acted as nucleating, coordination and template agent. The ambient desulfurization performance of the obtained MOF-199 regulated with different PVP amounts toward CH 3 SCH 3 and H 2 S and their structure-performance relationship were systematically studied. It is found that CH 3 SCH 3 was first chemisorbed on the surface of the adsorbent in a monolayer by weak coordination and then physisorbed in multilayers. This whole process was reversible and the structure of MOF kept stable. The hierarchical pores plus the small crystal size of MOF-199-P 1 , especially to the latter, endowed the uptake for CH 3 SCH 3 reaching 88.1 mg S/g, 42% higher than that of pristine MOF-199. However, the adsorption of H 2 S by MOF-199 is chemical and the collapse of the MOF structure was observed. The hierarchical porous structure helped H 2 S access as many active sites as possible before the blockage of pores caused by the structural damage. As a result, MOF-199-P 2 achieved the optimum breakthrough capacity of 74.3 mg S/g towards H 2 S, 34 % higher than the bare MOF-199. This study provides new strategies and insights for the adsorption process between sulfide and adsorbents in different reaction modes.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Yanglei Xie,Jiajun Zhu,Licai Fu,Wulin Yang,Deyi Li,Lingping Zhou
Hydrophilic thermoplastic polyurethane (TPU) is applicable in the fields of packaging, oil–water separation, and biomedical. Nevertheless, the process of its preparation is still a great challenge. The objective of this study is to develop TPU with excellent wettability and hydrophilic stability by surface modification. Four methods were evaluated: coating with PVP (polyvinylpyrrolidone) solution, immersion in PVP solution, N 2 /Ar plasma treatment, and N 2 /Ar plasma-induced graft polymerization with PVP. Finally, the results indicate that the sample called TPU-g-PVP, which utilizes plasma-induced grafting, exhibits the best performance. The water contact angle (WCA) reduces from 109° to 9.2°, and maintains within 20° after 80 days under atmospheric conditions. Its surface energy (72.4 mN/m) is increased by 2.8 times than untreated TPU. The surface morphology and roughness are almost unchanged when compared to the original TPU. Some characteristic peaks (–OH and C = O) of PVP on the TPU-g-PVP were found by infrared spectroscopy. X-ray photoelectron spectroscopy (XPS) examination revealed a reduction in C on the TPU surface as the content of N and O increases. Experiments on biocompatibility showed that the PVP deposited substrates improved cell adherence without generating new cytotoxicity.
研究领域:
材料科学
·
表面化学
·
高分子科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2019
·
IF 4.85
Jiannan Lin,Zheng Hu,Hui Li,Jianqiang Qu,Miao Zhang,Wenjie Liang,Shi Hu
Bismuth oxyhalide (Bi-O-X) is a group of layered semiconductors, which are promising candidates for photocatalysis due to their inherent internal electric field and adjustable band gap through composition and morphology control. Bismuth-rich Bi-O-X has improved stability and advantageous band structure compared to those of Bi-O-X and hence has attracted an increasing amount of research interest. In this work, ultrathin nanotubes of Bi5O7I with a 5 nm diameter and a 1 nm wall are obtained through a hydrothermal method while the phase and morphology of the products are regulated by the pH values and polyvinylpyrrolidone (PVP) concentration of the reaction system, of which the products can be tuned from BiOI nanosheets to Bi5O7I nanobelts and ultrathin Bi5O7I nanotubes. PVP and pH control is important to the formation of the nanotubes as formation occurs via a PVP-guided oriented attachment from primary nanoparticles of Bi5O7I. The poorly crystalline and porous structure of the resultant bismuth-rich ultrathin nanotubes not only exposes more surface atoms but also exhibits a highly reduced conduction band minimum. The resultant band gap of 2.39 eV (as compared to 3.20 eV for the nanobelts) arises from the undercoordinated bismuth centers brought about by the rich oxygen vacancies in the nanotubes. The largely reduced band gap effectively enhances visible-light absorption, while the short charge-diffusion length of the nanotubes further reduces the charge-carrier loss in recombination.
研究领域:
材料科学
·
纳米技术
·
光催化
·
半导体物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Catalysts
·
2017
·Vol. 7
·期 7
·194
·
IF 3.082
Yuanliang Ma,Zhongkun Zhao,Zhurui Shen,Qiang Cai,Huiming Ji,Leichao Meng
Herein, a novel CdS nanocomposite is fabricated by a facile one-pot hydrothermal method assisted by glucose and polyvinylpyrrolidone (PVP). The as-prepared CdS is coated with a thin layer, which is determined to be hydrothermal carbonation carbon (HTCC) mainly containing semiconductive polyfuran. The as-prepared HTCC-coated CdS shows superior photocatalytic activity for the degradation of Rhodamine B (RhB) under visible light irradiation (λ ≥ 420 nm). The optimum sample (glucose content of 0.1 g) shows a degradation rate four-times that of pure CdS reference. Moreover, it also shows an improved stability, and the activity can be maintained at 96.2% after three cycles of recycling. The enhanced photocatalytic activity and stability of nanocomposite can mainly be attributed to: (i) The addition of PVP in the reaction solution can significantly increase the specific surface area of CdS and thus offer more active sites; (ii) The HTCC in the nanocomposite can expand the range of light absorption; (iii) The HTCC layer can form a heterojunction with CdS and improve the charge separation and transfer.
研究领域:
材料科学
·
纳米技术
·
环境科学
·
光化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Zhouyue Lei,Wencheng Zhu,Shengjie Xu,Jian Ding,Jiaxun Wan,Peiyi Wu
A facile poly(vinylpyrrolidone) (PVP)-assisted exfoliation method is utilized to simultaneously exfoliate and noncovalently modify MoSe2 nanosheets. The resultant hydrophilic nanosheets are shown to be promising candidates for biocompatible photothermal therapy (PTT) agents, and they could also be encapsulated into a hydrogel matrix for some intelligent devices. This work not only provides novel insights into exfoliation and modification of transition metal dichalcogenide (TMD) nanosheets but also might spark more research into engineering multifunctional TMD-related nanocomposites, which is in favor of further exploiting the attractive properties of these emerging layered two-dimensional (2D) nanomaterials.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
诊疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2021
·Vol. 10
·期 23
·2101618
·
IF 9.933
Ning Zhao,Fei-Er Yang,Cong-Ying Zhao,Shi-Wen Lv,Jin Wang,Jing-Min Liu,Shuo Wang
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo 2 O 4 @PVP is constructed via a step-by-step strategy. Noticeably, the existence of oxygen vacancy in the NiCo 2 O 4 @PVP is helpful for capturing oxygenated compounds, while both redox couples of Co 3+ /Co 2+ and Ni 3+ /Ni 2+ will offer richer catalytic sites. As expected, the obtained NiCo 2 O 4 @PVP exhibits pH-dependent multiple mimic enzymatic activities. Benefiting from the introduction of polyvinylpyrrolidone (PVP), the NiCo 2 O 4 @PVP possesses good physiological stability and excellent biosafety in stomach and intestines’ environment. Meanwhile, the NiCo 2 O 4 @PVP also presents strong scavenging activities to ROS in vitro, including • O 2 − , H 2 O 2 , as well as • OH. Furthermore, a dextran sodium sulfate (DSS)-induced colitis model is established for evaluating the anti-inflammatory activity of NiCo 2 O 4 @PVP in vivo. Based on the size-mediated and charge-mediated mechanisms, the nanozyme can pass through the digestive tract and target the inflamed site for oral-administrated anti-inflammatory therapy. More interestingly, compared with the model group, the expression levels of inflammatory factors (e.g., Interleukin- 6 (IL-6), Interleukin- 1β (IL-1 β) , tumor necrosis factor-α (TNF- α ), and inducible nitric oxide synthase (iNOS)) in colon of mice show a significant decrease after nanozyme intervention, thereby inhibiting the development of IBD. In short, current work provides an alternative therapy for patients suffering from IBD.
研究领域:
纳米技术
·
生物医学工程
·
药学
·
炎症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Jinxiong Song,Lijun Song,Biao Ai,Youcai Chen,Ying Liu,Yuzhang Zhu,Jian Jin
Thin-film composite (TFC) polyamide (PA) nanofiltration (NF) membranes are essential for separating ions and small molecules in the industries, including water treatment, chemical processing, energy production, and pharmaceuticals. These membranes are typically fabricated via interfacial polymerization (IP) on polysulfone (PSf) or polyethersulfone (PES) ultrafiltration (UF) supports. Apparently, optimizing the physicochemical properties of the UF support is very important for achieving TFC-PA NF membranes with superior separation performance. This study systematically investigated the influence of common pore-forming agents used in UF membrane fabrication, specifically polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and lithium chloride (LiCl), on the desalination performance of resulting TFC-PA NF membranes. We characterized the zeta potential, pore structure, and surface wettability of PSf UF membranes prepared with each pore agent. These characteristics were then correlated with the adsorption and desorption behavior of piperazine (PIP) monomers during the IP process. Our findings indicate that employing PVP as a pore-forming agent not only enhanced PIP adsorption within the UF support but also facilitated its rapid release during the IP reaction. This dual effect resulted in a PA selective layer with reduced thickness and smaller pore size. Consequently, the TFC-PA NF membrane fabricated on the PVP-modified UF support exhibited both higher water permeance and improved salt rejection. This research highlights the significant role of the pore-forming agent in determining the performance of TFC-PA NF membranes. The results suggest that UF supports prepared using PVP as a pore agent may be optimal for creating NF membranes with enhanced overall performance.
研究领域:
膜科学
·
分离技术
·
高分子科学
·
水处理
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Zheqin Chen,Yongmin Xie,Zhibin Lu,Xiaocong Zhong,Zhifeng Xu
This research addresses the issue of particle agglomeration and a low catalytic activity in the traditional sol–gel preparation of LaNi 0.5 Co 0.5 O 3 (LNCO). A new synthetic strategy is proposed, leveraging the combination of polyvinylpyrrolidone (PVP) serving as a complexing agent and graphene nanosheet (GN) functioning as a template, successfully producing a high-activity LNCO cathode material (GN-LNCO) with a layered structure. Various characterizations confirmed that incorporating PVP and GN effectively suppressed particle agglomeration at high temperatures. The optimized GN-LNCO exhibited excellent physicochemical properties, including a specific surface area of 45.21 m 2 g −1 , a more regular mesoporous structure, a higher electronic conductivity, and a greater oxygen vacancy concentration. Electrochemical performance tests showed that the GN-LNCO cathode demonstrated an outstanding performance in solid oxide fuel cells at 800 °C, with a peak power density of 350.91 mW cm −2 . This represented an improvement of 28.65% over the conventional LNCO. Additionally, a 72 h long-term stability test of a GN-LNCO single cell revealed a voltage decay rate of only 1.60%, indicating its excellent stability. Overall, this study provides a novel material design strategy for developing high-performance cathodes, which has significant implications for advancing solid oxide fuel cell technologies.
研究领域:
材料科学
·
电化学
·
能源技术
·
纳米技术
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 5
·765-778
·
IF 7.571
Maolei Sun,Yun Liu,Kun Jiao,Wenyuan Jia,Kongzhao Jiang,Zhiqiang Cheng,Guomin Liu,Yungang Luo
Guided tissue regeneration (GTR) strategies are an effective approach to repair periodontal defects by using GTR membranes. However, commercial GTR membranes still have limitations in periodontal tissue regeneration owing to lack of antibacterial and osteogenic properties. The development of novel Janus nanofibers with biphasic release characteristics based on the therapeutic needs of GTR is essential to tackle this issue. Here, we developed a multifunctional Janus nanofiber via uniaxial electrospinning, with zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP) loading in the hydrophilic polyvinylpyrrolidone (PVP) part and FK506 embedding in the hydrophobic polycaprolactone (PCL) part. The release of Zn2+ conformed to the Ritger–Peppas kinetics which could effectively prevent bacterial infection, and the release profile of FK506 was fitted to a first-order equation which could provide persistent osteogenic stimulation for osteogenesis. The periodontal tissue regeneration data from a rat periodontitis model revealed that the multifunctional electrospun Janus nanofibers could be used as an effective bioplatform to restore alveolar bone impairment, compared with the control group. In summary, the Janus nanofibers with biphasic release characteristics quickly exert antibacterial function as well as continuously provide a microenvironment beneficial to the osteogenesis process, demonstrating its great potential for GTR treatment in dental clinic applications.
研究领域:
牙科材料
·
组织工程
·
生物材料
·
牙周病学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Rongrong Mu,Guoquan Suo,Chuanjin Lin,Jiarong Li,Xiaojiang Hou,Xiaohui Ye,Yanling Yang,Li Zhang
In recent years, aqueous zinc-ion batteries (ZIBs) have emerged as a prominent research topic due to their inherent safety attributes, relatively low cost, and comparatively higher energy density. However, the challenges associated with the zinc metal anode in the form of dendrite formation, hydrogen evolution, and severe side reactions have proven to be particularly vexing. Thus, it is imperative to investigate novel intercalation-type anode materials for ZIBs that exhibit exceptional structural properties and appropriate redox potentials based on conversion mechanisms. In this work, through adding polyvinylpyrrolidone (PVP) surfactant to precursors and tailoring reaction time, hierarchical CuS hollow spheres are successfully constructed by a facile one-step hydrothermal process. When applied as an anode in ZIBs, the hollow hierarchical CuS with large surface area can effectively reduce the transport distance of electrons and Zn 2+ and alleviate volume expansion during the insertion/extraction of Zn 2+ . The hierarchical CuS hollow spheres prepared over 8 h (CuS-8) exhibit a specific capacity of 126 mAh/g and long-term cycle life (1500 cycles) at a current density of 3 A/g. In addition, CuS-8//MnO 2 @CNTs full-cell shows a capacity retention of 117 mAh/g after 300 cycles at 1 A/g current density, which proves the advantage of hierarchical CuS hollow spheres in serving as an efficient and durable anode material for ZIBs.
研究领域:
材料科学
·
电化学
·
能量存储
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）