Materials Today Bio
·
2026
·
IF 10.2
Huajun Pan,Chengzhi Liang,Shuihua Ding,Peichuan Xu,Changxiong Cai,Chongzhi Pan,Wei Xiong,Haiyan Li,Xinxin Miao,Xigao Cheng
As a globally prevalent cause of disability, lumbar disc herniation has structural disruption of the annulus fibrosus (AF) as its pathological core. To address three critical bottlenecks in AF repair—microenvironmental imbalance (excessive inflammation/oxidative stress), inadequate cellular regeneration (low cell density), and mechanical instability—this study developed an ultrasound-responsive piezoelectric hydrogel scaffold (CPS gel) composed of cerium dioxide, poly-L-lactic acid fibers, and sodium alginate. The core mechanisms include: 1) Immune Reprogramming: Ceria nanoparticles exert dual superoxide dismutase/catalase-mimetic catalytic activity to scavenge reactive oxygen species, inhibit the NF-κB signaling pathway, downregulate IKKα/IκBα phosphorylation, and thereby drive macrophage polarization toward the M2 phenotype; 2) Directed Cellular Regeneration: Ultrasound-activated piezoelectric effects from PLLA fibers facilitate cell migration and proliferation via the ITGβ1/PI3K/AKT/ERK pathway, promoting collagen secretion; 3) Mechanical Reconstruction: The sodium alginate "egg-box" network provides physiologically matched compressive modulus, and in vivo experiments confirm the restoration of intervertebral disc compressive stiffness. Employing a triple synergistic strategy—immunomodulation, cell recruitment, and mechanical restoration—this study proposes a promising solution for structural regeneration of the annulus fibrosus.
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高影响因子
NATURE
·
2026
·Vol. 649
·期 8096
·366-374
·
IF 48.5
Lan Yuqun,Li Shuang,Guo Haitao,Liu Qinyuan,Wang Tairan,Zhou Lianqiao,Fang Jiahuiyu,Zhao Yang,Zhou Zanxin,Wang Qi,Li Jing,Zhu Yiping,Su Rongfang,Wen Xinyi,Xu Xinkai,Wu Yuhong,Wang Zixuan,Liu Bo,Li Jiaqi,Li Hui,Gao Hanfei,Wu Yuchen,Gu Qi,Feng Xi-Qiao,Yu Xinge,Su Yewang
Monitoring internal physiological signals is essential for effective medical care 1 , yet most current technologies rely on external measurements or imaging systems that cannot capture enough deep-tissue dynamics 2 , 3 , 4 , 5 , 6 . Implantable devices offer a solution, but conventional designs often require batteries or magnets 7 , 8 , 9 , 10 , 11 , which carry risks during removal, and existing biodegradable sensors based on passive inductor–capacitor circuits are limited by short readout distances and unstable communication issues 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 . Here we describe a soft, biodegradable, wireless sensing device that can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles. This is achieved through a ‘pole-moving sweeping’ readout system combined with a folded structure that integrates mechanical flexibility with electromagnetic function. In vivo tests in the abdominal cavity of horses reliably captured deep-tissue pressure and temperature, and ex vivo measurements demonstrated accurate strain monitoring without strict positional control. The long-distance and wide-angle readout of soft biodegradable implants holds translational promise for accessing deep-tissue physiological signals.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124157
·
IF 7.5
Junyi Shi,Hongjuan Wang,Peng Liu,Dehai Yu,Dandan Ji
PLA-based composite aerogels with high oil selectivity, good reusability, and gravity-driven transport capability are promising materials for oily-water treatment and spill remediation. However, many high-performance oil/water separation aerogels still rely on non-degradable matrices or fluorinated surface modifiers. Herein, ZIF-71 nanoparticles were incorporated into a polylactic acid (PLA) aerogel to construct a hydrophobic capillary-gating network through solution blending, water-assisted thermally induced phase separation, liquid-nitrogen freezing, and freeze-drying. The chlorinated imidazolate framework contributed hydrophobic/oleophilic domains, polyhedral roughness, and textural porosity, while the PLA matrix provided a lightweight biodegradable skeleton. Compared with pristine PLA, the optimized PZ71–3 aerogel increased the water contact angle from 114° to 136°, tensile strength from 0.088 to 0.166 MPa, elongation at break from 10% to 25%, and total pore volume from 0.0066 to 0.0091 cm³ g⁻¹ , while showing a BJH average pore diameter of 10.8 nm. The aerogel resisted a water head of 14.5 cm, selectively captured both floating heptane and sinking CCl₄, achieved oil recovery efficiencies of 98.2–99.2% with gravity-driven oil fluxes of 5300–17,200 L m⁻² h⁻¹ , and retained stable oil sorption capacity and flux over 20 cycles. Comparative benchmarking shows that PZ71–3 offers a balanced performance profile among MOF/polymer and biodegradable-polymer aerogels. This work demonstrates ZIF-71-induced hydrophobic capillary gating as an effective fluorine-free strategy for recyclable PLA-based sorbents for oil/water separation.
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APPLIED SOIL ECOLOGY
·
2026
·
IF 5.6
Minying Huang,Ying Chen,Fu Chen,Saige Xu,Yan Zhu
Plant invasions and microplastic (MP) pollution are widespread environmental challenges with increasing impacts on soil ecosystems. Although their individual effects on soil faunal diversity are well-documented, the interactive effects of these co-occurring stressors remain poorly understood. We investigated the short-term (two months) responses of soil faunal communities to conventional (low-density polyethylene, LDPE) and biodegradable (polylactic acid, PLA) MPs in habitats with and without invasion by Solidago canadensis L. We found that invasion by S. canadensis significantly increased overall abundance and richness of soil fauna, particularly microbivores. However, MP addition—either alone or in combination with plant invasion—did not significantly affect the abundance or richness of the total soil fauna or most trophic groups. Structural equation modeling revealed that MPs not only attenuated the positive effect of invasion on overall abundance by 48.4%, but also reversed its effect on richness from positive to a net decrease of 120.6%. Moreover, while S. canadensis invasion significantly altered soil faunal community composition in plots without MPs, this effect disappeared in most MP-amended treatments. These findings suggest that short-term MP pollution may alter the impact of S. canadensis invasion on soil fauna. However, the magnitude of MP effects varied across trophic groups, with microbivores exhibiting the most notable response. This study underscores the necessity of considering interactions among co-occurring environmental stressors in soil biodiversity assessments, as their combined effects can reshape outcomes for key functional groups within ecosystems.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2026
·Vol. 114
·期 4
·e70066
·
IF 3
Kebi Li,Xiaopei Wu,Peijun Xiong,Hanping He,Zinuo Xia,Yang Zhou,Liang Zhao,Jiaxin Li,Tao Liu,Hongwei Shi,Peihu Xu,Haixing Xu
Peripheral nerve injury (PNI) remains a major clinical challenge due to the limitations of autologous nerve grafting. Herein, a multifunctional composite nerve conduit was developed by integrating an oriented collagen-grafted polylactic acid (PLA) electrospun scaffold with a conductive and anti-inflammatory hydrogel to enhance peripheral nerve regeneration. The hydrogel was fabricated by chemically cross-linking carboxymethyl chitosan (CMCS) and sodium carboxymethyl cellulose (CMC-Na), incorporating polyaniline (PANI) to impart electrical conductivity and loading rhein (RH) for sustained anti-inflammatory release. The PLA conduit was further modified with collagen and loaded with nerve growth factor (NGF), forming a structurally guided dual-drug delivery system. The modified conduit exhibited improved hydrophilicity (water contact angle reduced from 107.7° to 68.9°) and enhanced mechanical properties (Young's modulus of 9.88 MPa). Sustained NGF and RH release reached 81.53% and 76.37% within 30 days, respectively, with stable degradation over 72 days. The conductive hydrogel displayed a uniform porous structure with high porosity (> 70%) and an electrical conductivity of 12.19 mS/cm. The electrical conductivity of the composite nerve conduit is 3.27 mS/cm. In vitro experiments demonstrated enhanced Schwann cell adhesion, neurite outgrowth, neuronal differentiation, anti-inflammatory activity, and responsiveness to electrical stimulation. In vivo studies using a rat sciatic nerve defect model confirmed significantly accelerated nerve regeneration. Overall, this electrically responsive, dual-drug-loaded hydrogel-filled nerve conduit represents a promising alternative to autologous nerve grafts for peripheral nerve repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhentao Chen,Lijing Lei,Xiangze Fan,Jinhua Zhu,Haodong Zhou,Yun Zhang,Fanyi Ma,Xiuhua Liu,Md. Zaved H. Khan
ZIF-8 as multi-dentate crosslinking hub converts weak CS/γ-PGA complexes into robust dual-network hydrogel. • Ultra-large pores eliminate diffusion limitation (Da ≈ 0.001) with K m increase of only 2.2-fold. • HSP regression (R 2 = 0.76, p ≈ 0.0002) validates synergistic thermodynamic exclusion and size-sieving mechanism. • Immobilized α-Glu@PC/ZIF-8 enables ligand fishing of two α-glucosidase inhibitors via capture-wash-elute workflow. Herein, a composite hydrogel based on two natural macromolecules—chitosan (CS) and γ-poly(glutamic acid) (γ-PGA)—was developed, crosslinked by zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, which serve as reactive crosslinking hubs to covalently connect the biopolymer chains for efficient immobilization of α-glucosidase (α-Glu). A carboxyl-terminated poly(ethylene glycol)–poly(glutamic acid) copolymer was first synthesized and its activated carboxyl groups underwent amidation with amino groups of CS to rapidly form a three-dimensional PC/ZIF-8 hydrogel. The effects of ZIF-8 content and CS concentration on micro-morphology, swelling behavior, and rheological properties were systematically investigated. ZIF-8-mediated crosslinking was essential for gel formation, enabling effective modulation of network density and pore architecture. The optimized hydrogel showed no inhibitory effect on α-Glu. Immobilized α-Glu@PC/ZIF-8 exhibited enhanced pH stability (retaining 53% and 70% activity at pH 4.0 and 9.0), outstanding storage stability (>90% after 4 weeks), excellent organic solvent tolerance (>90% in most solvents), and good reusability (near 100% activity over 6 cycles). Mass transfer studies confirmed that the designed crosslinking density provided efficient substrate/product diffusion channels, minimizing product inhibition. Hansen solubility parameter analysis revealed a synergistic “thermodynamic exclusion + size-sieving” mechanism for solvent tolerance. Coupled with HPLC, the immobilized enzyme successfully identified two α-glucosidase inhibitors—batatasin I and 2,4-dimethoxy-6,7-dihydroxyphenanthrene—from Dioscorea opposita Thunb. peel. This work demonstrates that rational chemical modification of natural macromolecular networks via MOF crosslinkers provides an effective strategy for constructing high-performance enzyme immobilization platforms. Download: Download high-res image (72KB) Download: Download full-size image
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ACS Applied Bio Materials
·
2026
·
IF 5.6
Shen Meng,Lu Meng,Sun Kainong,Zhao Ke,Wang Tingting,Luo Yongting,Zhang Qian
Neural regeneration is one of the potential therapeutic approaches for Alzheimer's disease (AD). While aligned electrospun fibers have shown promise in guiding neural regeneration, conventional materials face limitations such as poor hydrophilicity and acidic degradation byproducts. The amphiphilic copolymer poly(lactic- co -glycolic acid)- block -polyethylene glycol (PELA) combines mechanical tunability with enhanced biocompatibility, but its potential as an aligned fibrous membrane for neural regeneration remains unexplored. Here, we fabricated aligned electrospun PELA fibrous membranes (AEF) by modulating the collector rotation speeds. Compared to randomly oriented fibers, AEF exhibited highly ordered fiber alignment, enhanced molecular orientation and crystallinity, improved thermal stability, and increased mechanical anisotropy. When cultured with SH-SY5Y human neuroblastoma cells, AEF effectively directed oriented neural outgrowth and reduced cellular dispersion. In an okadaic acid (OA)-induced neural damage model, AEF significantly attenuated oxidative stress and rescued neuronal proliferation. Moreover, AEF mitigated OA-induced Tau hyperphosphorylation and protein aggregation, while restoring the expression of MAP2 and TUBULIN3. Collectively, these findings demonstrate that aligned electrospun PELA fibers not only provide guidance for neuronal orientation but also exert protective effects against Tau-induced neurotoxicity. This study suggests oriented PELA fibrous membranes as promising candidates for ameliorating neural damage in AD.
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Nature Communications
·
2026
·
IF 18.1
Wang Mingqiang,Yu Hui,Wang Benshan,Xu Zebo,Cai Zhenguang,Huang Chaoran,Zhao Ni
Recent advances in in-sensor computing demonstrate the potential of integrating sensing and computation at the perception front end; however, many existing approaches rely on customized devices, facing scalability, uniformity, and power challenges. Here, we present a cross-platform in-sensor computing strategy that embeds multiply–accumulate operations directly into the physical sensing process. We identify a mathematical isomorphism between carry propagation in computation and sensor’s exponential decay response, establishing a general LinExp-τ principle that enables diverse sensing devices to function as efficient computational units. The approach is experimentally validated across different devices, including semiconductor photodetectors, oxide transistors, and conductive polymer-based neural probes. A high-speed photodetector implementation achieves gigascale operation rates with high area efficiency and zero static power consumption during core operations. Beyond device-level performance, the architecture enables real-time visual preprocessing and in-sensor physiological signal solving, including event-driven functional near-infrared spectroscopy. These results provide a scalable, energy-efficient framework for sensing-as-computing systems.
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-18
·
IF 23.2
Zhao Kui,Qi Luming,Li Qi,Wang Yin,Qian Cheng,Shi Zhengjun
Biocompatible and mechanically stable porous hydrogels are promising materials for artificial skin in wound healing. The rigid PVA phase was selected to make the scaffold, and a dense and uniform porous phase was formed in both transverse and longitudinal phases by freezing casting technology. The names PVA and PVA + PNS2A were used in in vitro activity tests using polymer solutions that had not been molded before. The crosslinked materials were named Base, CP1 (0.1% PNS2A), and CP2 (0.5% PNS2A). HUVEC and HaCat cell proliferation experiments proved to be safe and non-toxic and significantly promoted proliferation activity after 48 h. The cell model with Raw 264.7 proved anti-inflammatory effect by mixed polymer solution. The scratch test showed that the CP2 promotes the migration of HaCat cells more effectively at 48 h. The cell adhesion experiment showed that the skin-like composite material grew rapidly along the void direction. Animal experiments showed that the multi-layer skin-like CP2 increased the mechanical properties, gelation, and hemostasis (58.8% reduction) and inhibits inflammation through active polysaccharide in the early stage of wound healing. It promoted collagen formation in the late stages of the healing process. Upon contact with the wound, the material undergoes gelation to isolate the wound and completely healed the hurt after 12 days. Stent disintegration and 48-h absorption time provide support for implant material development. Graphical
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xinqing Duan,Yanxin Liu,Lei Li,Kuan-Chang Chang
The growing computational bottleneck of von Neumann systems underscores the urgent need for a brain-inspired, energy-efficient approach. In response, a fully biocompatible multiterminal neuromorphic biodevice was developed using an acellular dermal matrix (ADM) as a biocompatible substrate, polylactic acid (PLA) as an insulator, quaternized chitosan (QCS) as a functional layer, and Au metal as electrodes while eliminating biological rejection risks. Operating at ultralow voltages (≤5 mV), the biodevice reproduces complex neurodynamic spatial integration processes, surpassing conventional two-terminal designs and enabling the simulation of the visual nervous processor system in the context of light adaptation. Different visual receptive fields were also studied. This work provides a feasible strategy for high-performance biohybrid computing systems with minimal power consumption and further functional biomimicry.
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Fungal Biology
·
2023
·
IF 2.5
Jiaxin Liu,Canying Li,Chenyang Zhang,Rui Huang,Linhong Qu,Yonghong Ge
Black spot rot caused by Alternaria alternata is one of the major postharvest disease of apple fruit during logistic. This study evaluated in vitro inhibitory effect of 2-hydroxy-3-phenylpropanoic acid (PLA) at various concentrations on A. alternata and the possible mechanisms involved in its action. Results showed that different concentrations of PLA inhibited conidia germination and mycelial growth of A. alternata in vitro, and 1.0 g L −1 was the lowest effective concentration to suppress A. alternata growth. Moreover, PLA significantly reduced relative conductivity and increased malondialdehyde and soluble protein contents. PLA also increased H 2 O 2 and dehydroascorbic acid contents, but reduced ascorbic acid content. Additionally, PLA treatment inhibited catalase , ascorbate peroxidase , monodehydroascorbate acid reductase, dehydroascorbic acid reductase and glutathione reductase activities, whereas promoted superoxide dismutase activity. All these findings suggest that the possible mechanisms involved in the inhibitory effect of PLA on A. alternata included damaging the cell membrane integrity to cause electrolyte leakage and destroying reactive oxygen species balance.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Hui Liang,Xihua Du,Jing Li,Limei Sun,Ming Song,Wenjiang Li
The active sites in porous carbon nanotube (CNT) would determine hydrogen storage performance of CNT. Here, we reported an effective, simple and controllable strategy to improve the hydrogen storage property of function group grafted CNT (fg-CNT). N -CNT-M (La 2 O 3 , Ni) would be obtained by the mixture of fg- N -CNT and metallic precursor at calcination of 600 °C. N -CNT-La 2 O 3 has the highest H 2 storage capacity of 7.4 wt%, displaying stable hydrogen adsorption/ desorption cycles for more than 20 times at 100 °C and 18 bar. fg-Ni-CNT-PLLA were formed by electrostatic interactions between C N bond of amide and carbonyl of l -polylactic acid (PLLA). fg- Ni-CNT-PLLA also has H 2 storage capacity of 6.2 wt% at 100 °C and 18 bar. The experiment found that metal ions or PLLA might be dispersed uniformly in CNT by adjusting the ratio of grafted hydroxyl (OH) to acylamino (–CONH 2 ). N -CNT-La 2 O 3 has better hydrogen storage performance than fg-CNT-PLLA because the aggregation of CNT would be caused by the molecular movement of PLLA during hydrogenation and dehydrogenation. This work provides guidance for the development of efficient hydrogen storage materials.
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