AIP Advances
·
2024
·Vol. 14
·期 3
·
IF 1.4
Li Zhengqiu,Chen Yueling,Yang Wenchao,Ye Jingbiao,Song Xiangqian,Jin Ying,Liu Xiaoqing
This paper investigated the static in vitro degradation behavior of poly(L-lactic acid) (PLLA)-oriented microcellular materials. The study compared the influence of different molecular chains and internal morphological structures on water penetration into the material. Also, the relationship between thse self-accelerated degradation caused by ester bond breakage and reduced material molecular weight and mechanical properties was explored. Furthermore, the mechanism behind the static in vitro degradation of oriented microcellular PLLA materials in simulated human body fluid was explored, laying the foundation for regulating the mechanical performance decline of oriented microcellular biomimetic bone repair materials to match specific bone healing periods.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2012
·
IF 2.686
Shen Liu,Jingwen Zhao,Hongjiang Ruan,Wei Wang,Tianyi Wu,Wenguo Cui,Cunyi Fan
The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly( l -lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa . Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury.
研究领域:
生物材料学
·
组织工程学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Liang Chaoan,Jiang Qiming,Yu Yi,Xu Tao,Sun Hanyu,Deng Feilong,Yu Xiaolin
Lithium (Li) reportedly has anti-bacterial properties. Thus, it is an ideal option to modify barrier membranes used for guided bone regeneration to inhibit the bacterial adhesion. The aims of this study were to fabricate and characterize nanofibrous poly(L-lactic acid) (PLLA) membranes containing Li, and investigate their antibacterial effects on Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in vitro. Li (5%Li, 10%Li, and 15%Li)-loaded nanofibrous PLLA membranes were fabricated using an electrospinning technique, and characterized via scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, a contact angle measuring device, and a universal testing machine. Sustained release of Li ions was measured over a 14-day period and biocompatibility of the Li-PLLA membranes was investigated. Evaluation of bacterial adhesion and antibacterial activity were conducted by bacterial colony counting, LIVE/DEAD staining and inhibition zone method using P.gingivalis and A.actinomycetemcomitans. Of the three Li-loaded membranes assessed, the 10%Li-PLLA membrane had the best mechanical properties and biocompatibility. Adhesion of both P.gingivalis and A.actinomycetemcomitans on Li-PLLA membranes was significantly lower than adhesion on pure PLLA membranes, particularly with regard to the 10%Li and 15%Li membranes. Significant antibacterial activity of Li-PLLA were also observed against according to the inhibition zone test. Given their better mechanical properties, biocompatibility, and antibacterial activity, PLLAs with 10%Li are a better choice for future clinical utilization. The pronounced antibacterial effects of Li-loaded PLLA membranes sets the stage for further application in guided bone regeneration.
研究领域:
生物材料学
·
口腔医学
✓ 已验证
DOI
高影响因子
Nano Energy
·
2025
·
IF 17.1
Xiuzi Che,Huiqing Fan,Jiahao Cao,Yongbo Fan,Yuxin Jia,Yidi Duan,Qinghua Guo,Yafei Feng,Weijia Wang
Piezoelectric biomaterials can convert mechanical energy into electricity, which make them attractive for implant applications, such as sensing, energy harvesting, and medical devices. The β-glycine has excellent piezoelectric performance, but their practical use is hindered by instable crystal phase and water solubility. Here, we present a simple method for preparing poly L-lactide (PLLA) composite fibers encapsulating β-glycine nano crystals via coaxial electrospinning. The formation of β-glycine crystals is the synergistic outcome of the ionization of glycine solution under the electric field and the confinement of external PLLA solution, which enhances the piezoelectric performance of the film. The V oc , I sc , and power density of composite film reach 14 V, 0.94 μA, and 0.92 mW/cm 2 , respectively. In addition, PLLA shell stabilizes β-glycine, leading to a stable piezoelectric performance for device applications. The composite film can be ultrasonically driven to generate electric signals, and therefore functions well in promoting cell proliferation and bone tissue repairing in vivo . Moreover, the film can be naturally degraded after long-term implantation. This study provides a strategy to deal with the instability of β-glycine-based biodegradable piezoelectric films, and promotes the implant applications.
研究领域:
生物材料
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组织工程
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yongxian Wen,Menghan Xu,Yang Hu,Jiangkai Bao,Quanling Yang,Chuanxi Xiong,Zhuqun Shi
Poly(L-lactic acid) (PLLA), a piezoelectric material with excellent biocompatibility, has garnered significant attention due to its wide applications in wearable biosensors. Enhancing its piezoelectric performance has thus become a key research focus. In this study, we fabricated a composite electrospun membrane composed of Poly (L-lactic acid) (PLLA) and tetragonal barium titanate (T-BTO). By the strong stretching of the collector and incorporating the piezoelectric phase of T-BTO, the PLLA/submicron- sized T-BTO composite membranes generated an open-circuit voltage of 1.03 V and a short-circuit current of 33.5 nA. The submicron-sized T-BTO demonstrated significantly better dispersion and performance enhancement compared to the micron-sized T-BTO. Furthermore, flexible devices based on these membranes demonstrated sensitivity to joint movement, producing corresponding electrical signals. These findings suggest that PLLA/T-BTO electrospun fiber membranes hold great potential as flexible, sensitive piezoelectric materials for bio-sensing applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Cijun Shuai,Jun Zan,Youwen Yang,Shuping Peng,Wenjing Yang,Fangwei Qi,Lida Shen,Zongjun Tian
The poor interfacial bonding and resultant agglomeration of nanoparticles in polymer-based composite severely deteriorated their reinforcement effect. In this work, MgO nanoparticles (MgO-NPs) were surface modified with Poly (L-lactic acid- co -malic acid) (PLMA) to improve the interfacial compatibility in Poly-l-lactic acid (PLLA) scaffold manufactured by selective laser sintering. PLMA possess a hydrophilic end with carboxyl group (comes from the malic acid) and an l-lactic acid chain. On one hand, the carboxyl group was able to form hydrogen bonding with the hydroxyl groups of MgO-NPs. On the other hand, the l-lactic acid chain containing the hydroxyl groups could react with the carboxyl group of PLLA. Results revealed that the scaffold exhibited significantly enhanced compressive strength and modulus by 47.1% and 237.7%, respectively, which could be ascribed to the enhanced interfacial bonding between PLLA and MgO-NPs, as well as the rigid particle reinforcement. In addition, the scaffold was favorable for cell adhesion, proliferation and differentiation, owing to the improved hydrophilic and suitable pH environment. It was suggested the scaffold was a promising material for bone repair application.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2018
·Vol. 19
·期 3
·477-488
·
IF 1.353
Peng Qingyan,Xu Pengjun,Xiao Shili
Fabrication of porous polymer membrane with controlled drug release and efficient antibacterial performances is of great interest in biomedical fields. In this study, Laponite (LAP) nanodisks were first used to encapsulate a model antibiotic drug, tetracycline hydrochloride (TCH). Then, drug-loaded LAP nanodisks with an optimized loading efficiency (85.3 %) were mixed with poly(L-lactic acid) (PLLA) polymer to form drug-loaded composite porous membrane via solvent coasting. The structure, morphology and swelling property of the porous membranes formed with varied solvent ratio of methylene dichloride (DCM) and dimethyl formamide (DMF) in the mixture solvent were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy and swelling test. In vitro drug release behavior, the cytotoxicity and the antibacterial activity of drug-loaded composite membranes were evaluated. Results showed that the TCH release was dependent on the physical structure of PLLA membrane and the presence of LAP nanodisks effectively weakened the initial burst release of TCH, and improved the sustained release property of porous PLLA membrane. The released TCH of TCH/LAP/PLLA 3:1 and TCH/LAP/PLLA 4:1 was 10.0 % and 5.3 % within initial 1 h, respectively. More importantly, the porous TCH/LAP/PLLA membrane was cytocompatible and displayed considerable antibacterial activity, solely associated with the loaded TCH drug, confirming its potential utility in wound dressings and tissue engineering.
研究领域:
生物医学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2022
·
IF 4.432
Manman Yu,Youpei Du,Pengwu Xu,Weijun Yang,Pingxia Zhang,Tianxi Liu,Pieter Jan Lemstra,Piming Ma
The role of hydrogen bonding (H-bonding) in polymer nucleation and crystallization is not yet so clear. To understand this physical issue, a series of poly (L-lactide) (PLLA) with different amount of terminal oxamide segments (OXA, -NHCOCONH-) were tailor-made as model H-bonding polymers (PLLA nOXA , n is the number of –NHCO–), and then the influence of H-bonding on the polymer nucleation and crystallization were investigated by a combination of experiments and molecular dynamics (MD) simulations. Compared with PLLA, much more types of H-bonds are created between the OXA segments and either the PLLA chains or the other OXA segments in the PLLA nOXA systems. A segment can be immobilized in the melt by H-bonding induced topological constraint and/or steric hindrance leading to a certain extent of reduction in entropy. Thus, the pair of H-bonded segments acting as a precursor of the “first stems” is expected to inducing local ordered structures (LOS) at elevated temperatures, which further facilitates the formation of both primary and secondary nuclei. As a consequence, the nOXA segments induced H-bonds not only significantly enhanced the crystallization temperature ( T c , from 100 °C to 112 °C) and the crystallinity ( X c , from 10% to 52%) of PLLA, but also increases the crystal growth rate ( G ) by nearly 10 times (from 0.25 to 2.66 μm min −1 at 150 °C). Moreover, a HI-MS (H-bond induced multi-stage) nucleation phenomenon in the melt of the PLLA nOXA was revealed by in-situ small-angle X-ray scattering (SAXS) under both non-isothermal (1 °C/min) and isothermal (135 °C) conditions. The HI-MS nucleation mechanism is well correlated to the nOXA induced multi-types of H-bonds which possess different thermodynamical stability at a certain high temperature. Therefore, this work not only provides a new route to make rapid crystallizing PLLA via hybridizing H-bonding segments, but also provides a molecular-level insight in the H-bonding assisted nucleation of semi-crystalline polymers in general.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2025
·
IF 3.3
Beibei Zhou,Yulong Zou,Hongyang You,Bing Zhang,Xili Lu
The integration of water-induced shape memory polymers into 4D printing provides novel opportunities to create innovative intelligent medical devices. Herein, poly(L-lactic) acid (PLLA)/silk fibroin (SF) scaffolds with water-induced shape memory capabilities and enhanced mechanical properties are developed using direct-write 4D printing technology. By analyzing the influence of the content of SF on the rheological properties, apparent viscosity and volatile properties of the ink, and the direct writing process of PLLA/SF scaffolds is systematically investigated. Results reveal that the PLLA/SF-30 wt% scaffold with a 50% filling ratio achieves the optimal mechanical properties, a compressive strength of 12.27 MPa, and a compressive modulus of 2.01 MPa, which is 1.42 and 2.83 times that of pure PLLA scaffolds, respectively. Furthermore, the PLLA/SF-30 wt% scaffold exhibits good shape memory behavior in water at 40 °C, with a shape fixation ratio ( R f ) of 94.6% and a shape recovery ratio ( R r ) of 67.0%. A 4D-printed grabber made from PLLA/SF-30 wt% can successfully grasp objects weighing 10 times its own weight. These results provide important insights into the potential applications in healthcare, enhancing their promise for personalized medical devices.
研究领域:
生物材料学
·
医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Shanshan Zhou,Yubin Yang,Zhe Zhu,Zhanghua Xie,Xaioyu Sun,Chunfeng Jia,Fude Liu,Junsheng Wang,Jinjun Yang
A novel flame retardant (POCODA) was synthesized using the POC and ODA. The POCODA/APP as a synergistic flame retardant (FR) was incorporated into the poly(L-lactic acid) (PLA) to investigate effects of this synergistic FR on the thermal stability , combustion behavior and flame retardancy on the PLA. The limited oxygen index (LOI) value of the PLA-based composites gradually increased with an enhancement in the amount of the POCODA/APP. Except the PLA/5%APP, the V-0 level achieved for other composites. Both the POCODA and POCODA/APP exhibited the self-extinguishing effect on the PLA in the UL-94 test. The pHRR , THR, TSP and other combustion performance parameters of the composites reduced, compared to neat PLA, and the PLA/2%POCODA/10%APP composite exhibited the dense and continuous carbon residue after the CONE measurement and showed most excellent flame retardance. With combination of the results of the SEM , TG-IR and PY-GC/MS measurement, the flame retardant mechanism of the PLA/2%POCODA/10%APP composite was also proposed and discussed in detail.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 129
·期 6
·3459-3465
·
IF 1.395
Shen Liu,Shenghe Liu,Xudong Liu,Jingwen Zhao,Wenguo Cui,Cunyi Fan
Electrospun fibrous membranes have been used frequently in biomedical applications, but their simultaneous use as antibacterial agents and in the prevention of cell adhesion on repaired tendons after injury has not been investigated. In this study, silver-nanoparticle (SN)-loaded poly( L -lactide) (PLLA) fibrous membranes were prepared by the electrospinning of SNs into PLLA fibers. Micrograph results showed that these membranes were composed of electrospun fibers and that the fibers were incorporated with SNs. From the results of X-ray diffraction and thermogravimetry, we concluded that the SNs were physically mixed into the fibers at the desired content. The mechanical properties were not significantly changed. The preliminary antibacterial effects on Staphylococcus epidermidis and Staphylococcus aureus and the synergistic antiproliferative effects of the SN-loaded PLLA fibrous membranes were observed. Taken together, these results demonstrate that SNs can be directly loaded onto a biodegradable PLLA fibrous membrane via electrospinning to achieve proper material properties with preliminary potential as antibacterial antiadhesion barriers for tendon injury. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Xiaoyu Liu,Jiayi Jiang,Hailei Liu,Fei Liu,Huarong Shao,Shaojuan Chen,Shaohua Wu
An integrated strategy that combines innovative electrospinning technique with traditional hot-stretching post-treatment is designed and implemented to generate high-molecular-weight poly(l-lactic-acid) (hmwPLLA, Mw = 2 80 000 Da) electrospun nanofiber-constructed yarns (ENCYs). The internal fiber diameter within the hmwPLLA ENCYs is found to increase gradually with the increase of hmwPLLA solution concentration. The hmwPLLA ENCY generated from a concentration of 10% (w v −1 ) is demonstrated with uniform morphology with an average fiber diameter of 737.7 ± 72.2 nm and an average yarn diameter of 454.9 ± 3.5 µm. Compared with the unstretched hmwPLLA ENCY, increasing the hot-stretching temperature can significantly enhance the fiber orientation and crystallinity. Moreover, the mechanical properties of stretched ENCYs are obviously enhanced compared with the unstretched control. The fiber orientation and crystallinity of stretched ENCYs are also found to be significantly improved with the increase of hot stretching rate, further resulting in the obvious increase of breaking strength and Young's modulus. Importantly, the braided textiles made from stretched hmwPLLA ENCYs exhibited great biocompatibility by effectively guiding the cell alignment and supporting the cell adhesion and proliferation. In summary, the high performance hmwPLLA ENCYs show great potential for the future design and development of advanced biomedical textiles.
研究领域:
材料科学
·
生物医学工程
·
纺织科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）