JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2014
·Vol. 29
·期 5
·1071-1077
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IF 0.422
Qiu Bingsong,Mai Weizhong,Zeng Rong,Tu Mei,Zhao Jianhao,Zha Zhengang
Heparin was covalently immobilized onto polyurethane surface via a PEG spacer by a microwave-assisted approach to improve blood compatibility. Firstly, amino-terminated poly(ethylene glycol) (APEG) was rapidly grafted onto PU surface within 20 min by a two-step method involving microwave-assisted MDI-functionalization and subsequent microwave-assisted APEG coupling. Then, heparin was covalently immobilized through an amide linkage by the direct coupling of the carboxylic acid of heparin with the amino group of APEG on PU surface using carbodiimide coupling reaction. The surface structure and properties were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and water contact angle measurements. The results revealed that heparin-immobilized PU surface had slightly increased roughness and significantly improved hydrophilicity in comparison to the original PU surface. The anticoagulant activity of films was evaluated by whole blood clotting time (CT) and prothrombin time (PT). Complement activation was assessed by detecting complement fragment 3a concentrations of serum exposed to the films. The results revealed that the microwave-assisted heparin-immobilized PU films had excellent antithrombogenicity and suppressed complement activation, indicating improved blood compatibility.
研究领域:
生物医学工程
·
材料科学
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DOI
高影响因子
Polymer Chemistry
·
2013
·Vol. 4
·期 22
·5597-5602
·
IF 5.231
Zengchao Tang,Xiaoli Liu,Yafei Luan,Wei Liu,Zhaoqiang Wu,Dan Li,Hong Chen
A new strategy to regulate the attachment of plasminogen and its activator, t-PA, to a polyurethane surface is reported. The method is based on the one-step graft copolymerization of a lysine-containing methacrylic monomer and hydroxyethyl methacrylate (HEMA). The copolymer-modified PU surfaces showed high capacity for plasminogen and t-PA binding. The release of pre-adsorbed t-PA from the lysine-containing PU surfaces in contact with plasma was also investigated. It was shown that the interactions of plasminogen and t-PA on this type of surface can be controlled simply by changing the monomer feed ratio, and thus the relative quantities of HEMA and lysine in the grafts. This approach may be useful for the development of fibrinolytic, blood-contacting materials and, more generally, for controlling protein-surface interactions for biocompatibility.
研究领域:
生物材料学
·
医学工程
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DOI
高影响因子
Canadian Journal of Chemistry
·
2018
·Vol. 96
·期 10
·
IF 1.084
Lingdong Li,Fengxiang Zhang,Fangyuan Gai,Hao Zhou,Xiaofang Chi,Hande Wang,Zongbao Zhao (Kent)
To control the pathogen cross contaminations on medical material surface, there is a pressing need to develop antimicrobial materials with highly efficacious surface biocidal activity. In this work, N-chloramine precursors containing a quaternary ammonium unit and perfluorophenyl azide unit were synthesized and covalently immobilized on inert polyurethane (PU) film upon UV light irradiation. The surface modification was confirmed by contact angle, Fourier transform infrared (ATR FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) analyses. After bleaching treatment, satisfactory biocidal activity was achieved for the surface-modified PU films. It was found that the introduced surface QA center contributed an even faster surface contact killing behavior and that precursors with a longer structural linker caused higher surface chlorine content and higher antimicrobial efficacy. This approach provides a novel and facile method that enables the covalent immobilization of N-chloramine precursors on inert polymeric surface to produce durable antimicrobial materials.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2016
·Vol. 105
·期 2
·531-538
·
IF 3.263
Deqiu Xu,Yuling Su,Lili Zhao,Fancui Meng,Chang Liu,Yayuan Guan,Jiya Zhang,Jianbin Luo
Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO 3 was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag + ions were reduced in situ into metallic silver nanoparticles by the “bridge” of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1 H , 1 H , 2 H , 2 H -perfluorodecanethiol (CF 3 (CF 2 ) 7 CH 2 CH 2 SH, F-SH) was attached on the PDA coating via the Michael addition reaction . The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531–538, 2017.
研究领域:
生物材料学
·
医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2017
·
IF 5.715
Xiaopeng Sun,Yong Jin,Shuangquan Lai,Jiezhou Pan,Weining Du,Liangjie Shi
The aim of the present work is to provide a new retanning system for aldehyde-tanned leather, which can improve the physical-mechanical property of resultant leather and reduce the formaldehyde content in the resultant leather. This new retanning system consists of polyacrylic acid and gemini polyurethane surfactant, which are not harmful to human. The physical-mechanical property of leathers treated with different retanning system was analyzed, and the fiber structure of leather treated with the new complex retanning system was observed; the effects of some factors on the physical-mechanical property and formaldehyde content of leathers were studied, which were the hydrophobic chain length of gemini polyurethane surfactant, the offer percentage of retanning agent and the pH condition of retanning process. The results showed that the complex retanning system had better retanning effect, and the physical-mechanical property and formaldehyde content of leathers would be affected by above factors. When the hydrophobic chain length was eight and the offer percentage was 6%, the retanning effect was the best, and the thickening rate was 8.5%, the elongation and tear strength increased by 14.5% and 18.4%, respectively. At the same time, the reduction rate of formaldehyde content was 30.0%. Notably, when the value of pH decreased to 2.7 in the retanning stage, the reduction rate of formaldehyde content could increase to 39.3%. This retanning system had better retanning effect, which indicated that it would be helpful to the clean production of leather and the development of environmental protection. In addition, the work provided a good alternative to solve the other formaldehyde problems in our life.
研究领域:
皮革化学与工程
·
环境科学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Heng Quan,Xueqing Lin,Jingyi Wu,Zhonghua Dong,Zengfeng Wei,Lijie Ni
Three cationic polyurethane surfactants (LC1–1, LC2–2, and LC2–3), each featuring different hydrophobic structures, were synthesized using isophorone diisocyanate, N-methyl diethanolamine, 1-bromohexadecane, and 1-bromobutane. The synthesized cationic polyurethane surfactants exhibited low surface tension, excellent foaming properties, and resistance to salt, attributed to steric hindrance among long-chain alkyl groups and their “multi-point anchoring” ability. The corrosion inhibition performance of polyurethane surfactants on carbon steel in 1 M HCl solution was evalutated, and LC2–2 showing a considerable corrosion inhibition efficiency of 97.0 %. This film effectively reduced/isolated contact between the corrosive solution and the steel interface. Furthermore, quantum chemical calculations corroborated the electrochemistry experiment results, affirming that the molecular structure of LC2–2 is particularly conducive to inhibiting the corrosion of carbon steel. This study explores the relationship between the molecular structure of surfactants and its impact on both surface activity and corrosion inhibition efficiency.
研究领域:
材料科学
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腐蚀与防护
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）