Polymers
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2020
·Vol. 12
·期 11
·2592
·
IF 3.426
Mingcong Hao,Tongtong Wu,Qunzhi Chen,Xueyan Lian,Haigang Wu,Bingyang Shi
Owing to the wide spectrum of excitation wavelengths of up-conversion nanoparticles (UCNPs) by precisely regulating the percentage of doping elements, UCNPs have been emerging as bioimaging agents. The key drawback of UCNPs is their poor dispersibility in aqueous solution and it is hard to introduce the chemical versatility of function groups. In our study, we present a robust and feasible UCNP modification approach by introducing hyperbranched polyglycerols (hbPGs) as a coating layer. When grafted by hbPGs, the solubility and biocompatibility of UCNPs are significantly improved. Moreover, we also systematically investigated and optimized the chemical modification approach of amino acids or green fluorescence protein (GFP), respectively, grafting onto hbPGs and hbPGs-g-UCNP by oxidizing the vicinal diol to be an aldehyde group, which reacts more feasibly with amino-containing functional molecules. Then, we investigated the drug-encapsulating properties of hbPGs-Arg with DOX and cell imaging of GFP-grafted hbPGs-g-UCNP, respectively. The excellent cell imaging in tumor cells indicated that hbPG-modification of UCNPs displayed potential for applications in drug delivery and disease diagnosis.Keywords:hyperbranched polyglycerols;up-conversion nanoparticle;bioimaging
研究领域:
材料科学
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生物医学工程
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Zejun Xu,Yi Zhang,Qian Hu,Qiao Tang,Jiake Xu,Jianping Wu,Thomas Brett Kirk,Dong Ma,Wei Xue
The development of biocompatible vector for hydrophobic drug delivery remains a longstanding issue in cancer therapy. We design and synthesis a drug delivery system based on HPG modified β -CD ( β -CD-HPG) by conjugating HPG branches onto β -CD core and its structure was confirmed by NMR, FTIR, GPC and solubility. In vitro biocompatibility tests showed that HPG modification significantly improved red blood cells morphology alteration and hemolysis cause by β -CD and β -CD-HPG displayed cell safety apparently in a wide range of 0.01–1 mg/mL. An anti-cancer drug, docetaxel, was effectively encapsulated into β -CD-HPG which was confirmed by DSC analysis. This copolymer could form nanoparticles with small size (< 200 nm) and exhibited better DTX loading capacity and controlled release kinetics without initial burst release behavior compared with β -CD. Furthermore, antitumor assay in vitro show that β -CD-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. Therefore, β -CD-HPG/DTX exhibit great potential for cancer chemotherapy.
研究领域:
药学
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生物材料
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 133
·期 5
·
IF 1.768
Hao Ying,Guijin He,Lifeng Zhang,Qunfang Lei,Yongsheng Guo,Wenjun Fang
Hydrogels were synthesized from hyperbranched polyglycerol (HPG) and acrylic acid through free-radical polymerization with HPG as the crosslinker. The HPG/poly(acrylic acid) (PAA) hydrogel could absorb cationic dyes in aqueous solutions because of the existence of a porous structure and the large numbers of hydroxyl and carboxylic groups. With methyl violet chosen as a model compound, the HPG/PAA hydrogel reached a maximum adsorption of 394.12 mg/g at a feed concentration of 1 g/L. The highest removal ratio of 98.33% was observed at a feed concentration of 50 mg/L. The effects of the pH, contact time, and feed concentration on the dye adsorption were investigated. The dye adsorption data fit well with the pseudo-second-order and Langmuir models. We believe that the HPG/PAA hydrogels could perform well in appropriate applications in the removal of cationic dyes from aqueous solutions because of their high adsorption capacity and environmental friendliness. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 42951.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Functional Materials Letters
·
2015
·
IF 1.606
Ning Cai,Dajun Hou,Liang Shen,Xiaogang Luo,Yanan Xue,Faquan Yu
The application of graphene for some particular fields including biomedical engineering was hindered by its poor aqueous dispersivity and hydrophobic property. In this study, the strategy of the functionalization of graphene with hyperbranched polyglycerol (HPG) by a facile procedure was proposed. By the epoxy ring-opening hyperbranched polymerization of glycidol, graphene surface was grafted with HPG layer with rich hydroxyl groups. The content of polyglycerol on HPG functionalized graphene (HPG-G) was determined to be 55%. The results of fourier transform infrared (FTIR), X-ray diffraction (XRD), Raman, X-ray photoelectron spectroscopy (XPS) and UV–Vis demonstrated that HPG was successfully grafted onto graphene sheets (GSs), and the aromatic and crystalline structure of graphene was maintained after HPG functionalization. The obtained HPG-G composites possess high hydrophilicity and can be dispersed well in water. Furthermore, no discernable precipitation was found in HPG-G aqueous solution even after three months of storage.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
·
IF 3.8
Han Zhang,Hanshu Sun,Yiping Zhao,Yang He,Li Chen
Grafting hyperbranched polymers on polymer membrane surfaces offers a promising route to desalination and boron removal. However, the functional modulation of hyperbranched polymers is still not fully realized, and the specific selective synthesis of terminal hydroxyl groups still needs further exploration. Here, we report a method to prepare high-performance adsorption membranes using hyperbranched polyglycerol (HPG) that can optimize the dendritic distribution of the terminal hydroxyl groups. Poly(caffeic acid) (PCA) was rapidly deposited on the surface of the poly(ether sulfone) (PES) membrane assisted by copper sulfate (CuSO4) and hydrogen peroxide (H2O2), and subsequently, HPG was grafted onto PCA coatings via a covalent bond. The prepared functional modified membrane exhibited excellent performance on salt and boron removal; especially, the maximum boron uptake was 1.661 mmol g–1 at an initial boron concentration of 5.0 mmol L–1, better than most of the traditional adsorption membranes reported. The boron adsorption on the membranes was fitted well with the pseudo-first-order adsorption kinetic model and Langmuir isothermal model. Strikingly, the regeneration efficiency could be recovered to 97% after 10 cycles of acid rinsing and desorption. The functional membrane had good application potential and research value in seawater desalination and boron removal.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2017
·Vol. 12
·期 1
·1-9
·
IF 2.833
Shen Yanyu,He Guijin,Guo Yongsheng,Xie Hujun,Fang Wenjun
Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the “thiol−ene” click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent. The size of Au NPs can be tuned by changing the molecular weight of HPG. It is observed that the HPG molecular weights of 1123, 3826, and 55,075 lead to the NP diameters of 4.1 nm for Au@DSHPG-1, 9.7 nm for Au@DSHPG-2, and 15.1 nm for Au@DSHPG-3, respectively. The morphology and size of Au NPs are characterized by TEM and DLS. Especially, the dispersion abilities of Au NPs in different pure solvents and co-solvent mixtures are investigated. The long alkyl chains on DSHPG give the ability of Au NPs to be well dispersed in nonpolar solvents. Hydrocarbon-based nanofluids can be obtained from the hydrophobic Au NPs dispersed into a series of hydrocarbons. The dispersion stability for Au NPs in hydrocarbons is monitored by UV-Vis spectroscopy, and the relative concentration of Au NPs is observed to still maintain over 80% after 3600 h.
研究领域:
材料科学
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纳米技术
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化学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
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2023
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IF 3.7
Pengfei Jiang,Ji Mi,Chongkun Shao,Yitong Dai,Shu Yan,Yongsheng Guo,Wenjun Fang
In this study, palmitoyl and hindered phenolic hyperbranched polyglycerol (CBHPG), with hyperbranched polyglycerol (HPG) as the structural core and hindered phenol or alkyl chain as the decorated shell, has been strategically designed and synthesized as an efficient integrated additive to enhance the energy efficiency and inhibit the oxidation coking of hydrocarbon fuels. The superior thermal stability and solubility of CBHPG were confirmed by thermal gravimetric analysis and dynamic light scattering. In the presence of CBHPG with high antioxidant activity, the oxidation induction time of n-undecane increased more than 2-fold at 170 °C. In deposition tests, the amphiphilic macromolecule CBHPG showed excellent performance with 58% oxidation coking inhibition rate of Chinese Jet Fuel (RP-3). The Jet Fuel Thermal Oxidation Stability test at 355 °C also exhibited that CBHPG could greatly reduce the deposit of RP-3 by decreasing the deposit rating from >4 to <1. In cracking experiments, the addition of 0.1 wt % CBHPG with sufficient polymerization could increase the conversion of n-undecane by 17.6%, with the corresponding heat sink by 6.1% at 675 °C. The above results indicated that CBHPG could efficiently enhance the performance of hydrocarbon fuels due to multipurposes in antioxidation, coking inhibition, and cracking promotion. CBHPG with a strategically designed structure as an integrated additive shows great promise in improving the energy efficiency and safety in future advanced aircraft.
研究领域:
材料科学
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能源化学
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航空工程
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产品关联
DOI
高影响因子
RSC Advances
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2015
·Vol. 5
·期 105
·86730-86739
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IF 3.84
Jing Li,Huimin Li,Xiaoyuan Yang,Pingyan Luo,Zhongming Wu,Xinge Zhang
Hydrogels are good candidates to satisfy many needs for functional and tunable biomaterials. How to precisely control the gel structure and functions is crucial for the construction of sophisticated soft biomaterials comprising supramolecular hydrogels, which not only facilitate the impact of the surrounding environment on a unique biological function occurring, but also manipulate various biological phenomena. Here, we designed and synthesized a new supramolecular hydrogel (AD-g-HPG/CD-g-Dex) based on hyperbranched polyglycerol and dextran using the association of β-cyclodextran with adamantine. AD-g-HPG/CD-g-Dex hydrogel with the typical porous structure and ideal three-dimensional network showed a rapid increase in equilibrium of swelling, which was up to 185% after 2 min incubation. The hydrogel could encapsulate the protein drug and controlled drug release by modifying the compositions. Importantly, the viability of NIH 3T3 cells was more than 80% after treatment with AD-g-HPG/CD-g-Dex hydrogel, displaying good cytocompatibility. Taken together, we confirmed the feasibility of cytocompatible AD-g-HPG/CD-g-Dex hydrogel as a platform scaffold with controlled drug delivery and other various tissue engineering applications.
研究领域:
生物材料学
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组织工程学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
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2012
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IF 2.103
Zhengji Chen,Li Zhou,Faai Zhang,Chuanbai Yu,Zhibo Wei
The aim of the present work was to investigate the potential of multicarboxylic hyperbranched polyglycerol (HPG) modified mesoporous SBA-15 (SBA/HPG-COOH) as adsorbent for the removal of cationic dyes or/and heavy metal ions from aqueous media. The SBA/HPG-COOH adsorbents can be facilely synthesized through two steps: in situ anionic ring-opening polymerization of glycidol and further modification of hydroxyl groups by succinic anhydride. The resulting SBA/HPG-COOH was characterized by means of FTIR, TGA, XRD, SEM and nitrogen adsorption–desorption isotherms. The results demonstrate that the SBA/HPG-COOH was successfully synthesized and the density of carboxylic groups on the SBA/HPG-COOH is calculated to be as high as 1.5 mmol/g, posing a powerful base for adsorbing cationic adsorbates. Four kinds of dyes and copper ions were chosen as representatives to investigate the adsorption ability of SBA/HPG-COOH. The SBA/HPG-COOH adsorbent showed quick adsorption rate, high adsorption capacity (e.g., its saturated adsorption capacity for methylene blue (MB) can reach 0.50 mmol/g, while for unmodified SBA-15 is lower than 0.05 mmol/g), and high selectivity for cationic adsorbates. The fitness of Langmuir adsorption model and pseudo second-order kinetics on describing the adsorption isotherm and kinetics of SBA/HPG-COOH for MB dye was examined, respectively. It is believed that this robust SBA/HPG-COOH adsorbent will find important application in removal of cationic adsorbates from aqueous solution.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2011
·Vol. 124
·期 5
·3633-3640
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IF 1.24
Shixin Liu,Man Jiang,Sai Ye,Xiaohong Xu,Ping Lu,Jian Dong
This study reports properties of a class of biodegradable polyesters based on citric acid and glycerin, both of which are safe ingredients in food, and their usefulness for drug control release applications. Transparent thin films of poly(glycerin citrate) (PGC) prepared by condensation polymerization were characterized by dynamic mechanical analysis, tensile testing, and FTIR spectroscopy. Depending on the acid-to-glycerin molar ratios, the crosslinked films could have glass transition temperatures varying from 30 to 81°C as shown by dynamic mechanical analysis. The ductile PGC films were more prone to hydrolytic degradation than poly(lactic acid). The controlled release properties of the PGC films were evaluated by a permeation study of an exemplary drug theophylline. The diffusion of theophylline in PGC film follows a Super Case II mechanism, but in PGC film modified with PEG4000, the diffusion follows approximately a Case II mechanism (near zero-order release mechanism). © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
研究领域:
材料科学
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药学
·
生物医学工程
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 23
·3913-3921
·
IF 5.342
Bowen Xiang,Yudong Xue,Zhiyong Liu,Jia Tian,Holger Frey,Yun Gao,Weian Zhang
Porphyrin and its derivatives as promising photosensitizers have been widely utilized in photodynamic therapy (PDT). However, the water-solubility and biocompatibility of porphyrins are the typical bottlenecks in clinical PDT processes. Herein, we successfully fabricated a new type of water-soluble, hyperbranched polyglycerol photosensitizer through one-step esterification between water-soluble hyperbranched polyglycerol (hbPG) and fluorophenylporphyrin (FP). Compared with the linear control polymer, i.e., FP covalently connected with linear polyethylene glycol (LPEG), the hyperbranched structures bearing multiple porphyrin units generated more singlet oxygen and exhibited higher cytotoxicity under laser irradiation. As an additional benefit of the hyperbranched structure, the aggregation of porphyrins could be significantly reduced, and greatly enhanced the drug-loading ratio of the single polymers. Base on a series of in vitro and in vivo experiments, we found that hbPG was capable of improving the water-solubility of porphyrin and enhancing the PDT effect. These results demonstrate that hbPG will have the opportunity to become an ideal substitute for traditional linear polymers in PDT.
研究领域:
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Jianxiao Wang,Shuang Hao,Pengfei Qi,Wenliang Wang,Yunxia Hu
Polyamide reverse osmosis (RO) membranes with high separation performance and excellent chlorine-resistant properties are highly desirable. Many strategies have been developed to fabricate chlorine-resistant RO membranes but often at the expense of a trade-off between separation performance, chemical stability and chlorine-resistance. Herein, in this study, we grafted unique three-dimensional hyperbranched polyglycerol (hPG) onto the polyamide RO membrane to simultaneously improve the chlorine-resistance of the polyamide RO membranes without compromising separation performance. The effects of hPG grafting on the surface morphology , surface properties, as well as the perm-selectivity and the chlorine-resistance of the modified RO membrane were systematically investigated. Results show that the hPG grafted polyamide RO membranes reached a high water permeance of 3.27 ± 0.17 L m −2 h −1 bar −1 while maintaining an excellent NaCl rejection (99.30 ± 0.15%). Importantly, the hPG grafted PA RO membranes exhibit the impressive chlorine-resistance with the maximum exposure of 20,000 ppm·h where the NaCl rejection of the membrane was still 98.69 ± 0.39%, surpassing most of the reported chlorine-resistant polyamide RO membrane with the maximum exposure of 2000–16,000 ppm·h. Both simulation and XPS results suggest that the chlorine-resistant mechanism of the hPG grafted RO membrane is because of the reactivity inertness and steric hindrance of hPG, repelling chlorine away from the membrane surface and thus preventing the PA from chlorine attacking with the suppressed Orton rearrangement of the PA. Our findings demonstrate that the hPG grafted RO membrane possesses exceptional chlorine-resistance and high separation performance, which has a great potential for the practical applications.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
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