AAPS PHARMSCITECH
·
2017
·Vol. 18
·期 8
·2889-2897
·
IF 2.451
Xiong Hui,Fu Jinping,Sun Hanjing,Wang Enfu,Ding Yunhui,Ren Guobin,Jing Qiufang,Ren Fuzheng
Micro-particles of 17β-estradiol (ED) were prepared with polyvinylpyrrolidone (PVP) by in situ pH-dependent solubility technique. Products were characterized using multiple instruments, and molecular interactions between ED and PVP were explored. Powder X-ray diffraction and thermal analysis revealed crystalline ED in the micro-particles is hemihydrated. PVP was also present in the micro-particles. Laser particle size analysis and scanning electron microscopy revealed thin slice morphology, which might have resulted from the influence of PVP. Moreover, the results of contact angle, specific surface area, and dynamic vapor sorption showed that the surface properties of products were improved. These physicochemical properties of the micro-particles resulted in an obvious improvement in dissolution rate. Fourier transform infrared spectroscopy and 1 H nuclear magnetic resonance revealed hydrogen bonding between ED and PVP. A method was established for the preparation of micro-particles through the addition of PVP during the reaction process.
研究领域:
药剂学
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2019
·
IF 2.121
Libing Huang,Kuan Cao,Ping Hu,Yong Liu
How to improve the bioavailability of the Sanguis Draconis (SD) is an important problem in the potential clinical applications. The aim of this study was to develop a drug delivery system to achieve high bioavailability of SD, a drug with poor water solubility. It will promote the research about new formulations of the SD and the other insoluble drugs. In this study, a highly biocompatible hydrophilic polymer, polyvinylpyrrolidone (PVP), was selected as a carrier, mixed with different proportions of SD to produce SD-PVP microfibers by solution electrospinning. By orthogonal experiments, the optimal spinning conditions of the preparation of SD-PVP fibers were investigated. The morphology of different proportions of SD-PVP microfibers was observed by scanning electron microscopy, and the phase characteristics were characterized by Fourier transform infrared spectrometry, X-ray diffraction, and differential scanning calorimetry. The hydrophilic properties of SD-PVP fiber membranes with different SD content were analyzed by the water contact angle assay. In vitro dissolution experiments were carried out to observe the dissolution of drugs in SD-PVP fiber membranes. The results showed that the diameter of SD-PVP fibers increased with the enlargement of SD content. A eutectic mixture was formed after blending PVP and SD, and the hydrogen bonds were formed between the SD and PVP with no chemical reaction occurred. The dispersion of SD in the fiber decreased with the increase of SD content. The higher the content of SD in the fiber, the more hydrophobic the fiber membrane. In vitro dissolution studies revealed that the dissolution content of SD from SD-PVP microfibers was significantly higher than that of the pure or original drug SD. However, as the SD content increased from 15% to 30%, the dissolution of the drug in the SD-PVP fibers decreased. The SD-PVP fiber prepared in this study showed much higher solubility than the original drug in vitro, which has great significance for the development of new dosage forms for the clinical application of SD, and it has a useful reference for the study of similar bioavailability of poorly soluble drugs.
研究领域:
药剂学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 21
·9984-9996
·
IF 9.931
Shunlong Zhang,Xiaojian Tan,Zhen Meng,Huajun Tian,Fangfang Xu,Wei-Qiang Han
Rechargeable multivalent ion (Al3+, Mg2+ and Zn2+) batteries provide a viable alternative to lithium ion batteries because of the supply risk of lithium resources and safety concern. In this study, rechargeable metal–iodine batteries, particularly aluminum/iodine batteries, were fabricated with novel active carbon cloth/polyvinylpyrrolidone (ACC/PVPI) composite cathodes prepared via a facile solution-adsorption method combined with freeze-drying. The use of active carbon cloth (ACC) endows the composites superior electronic conductivity, and significantly decreases the weight of the electrode due to its function as a current collector. Hydrogen bonding interaction between PVP and iodine in PVPI guarantees the depression of the shuttle effect of polyiodide, thus lengthening the cycle life. The density functional theory (DFT) analysis shows that such shuttle depression occurs due to the hydrogen-bonded iodine species, and the relatively large formation energy hints at higher conversion reaction efficiency of Al ion batteries. These characteristics make the composites an ideal electrode in various metal ion batteries. To be specific, the Al/I2 battery with a distinct working potential window achieves a high capacity of 180.1 mA h g−1 at 0.2C and can remain stable after 500 cycles with a stable capacity of 127 mA h g−1 at 0.6C. Moreover, at higher current density of 1C, the battery delivers a capacity of 102.7 mA h g−1 for up to 1050 cycles. These above-mentioned characteristics of metal–iodine (Li, Mg and Al/I2) batteries, related electrochemical performance measurements and theoretical modeling analysis show that the rechargeable iodine-based batteries provide a promising direction in designing high-performance energy storage/transfer systems.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Shicun Jin,Jinfeng Cao,Kuang Li,Jianzhang Li,Huining Xiao,Ping Wu
Hydrogels can simulate the physiological environment of soft tissues, showing great promise in spinal cord injury (SCI) repair. Nevertheless, hydrogels for effective SCI repair have limitations such as their inability to effectively contact with irregular cavities and structural damage caused by long-term physical movement. In this study, a unique and facile hydrogel with injectable, electroconductive, self-healing, and adhesive properties was synthesized by introducing tannic acid (TA) and polyvinylpyrrolidone (PVP)-stabilized polypyrrole (PPy) nanoparticles. Fe(III) ion-triggered in situ polymerization of pyrrole, and the dispersibility of PPy was significantly improved utilizing the stabilizing effect of PVP. The P@Py/TA had excellent injectable, self-healing, and cytocompatibility properties. Meanwhile, the hydrogel coating exhibited robust self-adhesion to different substrates. The P@Py/TA provided a suitable microenvironment for axon regeneration, effective angiogenesis, and immune-regulated function. This facilitated functional recovery from traumatic SCI. The multifunctional conductive P@Py/TA hydrogel scaffold provides a new strategy for SCI repair and has potential applications in other fields of bionic skin and multi-functional coatings.
研究领域:
生物材料学
·
组织工程学
·
神经科学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Mu Li,Lili Wu,Chaocan Zhang,Wanyu Chen,Cong Liu
Membrane technology has received wide attention as it plays an important role in water treatment process. However, membrane fouling results in a decrease in water permeation flux and separation effect, which lead to degraded membrane lifespan. A facile and novel strategy to form a multifunctional modified coating on the membrane surface by using the one-step assembly coating on the basis of tannin acid had been reported in this work. Tannin acid is a plant-derived polyphenolic substance that is hydrophilic and bactericidal. As a common nonionic polymer, polyvinylpyrrolidone (PVP) has a hydrophobic interaction and hydrogen bonding with TA and is beneficial to improve the hydrophilicity and antifouling performance of the substrate. However, the benefits of coating on the membrane have been limited due to the strong complexing ability of TA and PVP in aqueous solution. Herein, 50% N , N -dimethylformamide (DMF) aqueous solution were found that promoted the co-deposition of TA and PVP on the surface of the membrane. The catechol-rich polyphenol coating provides versatile properties on the membrane surface, including ultra-high pure water flux, high antifouling properties, recyclability, and a certain degree of antimicrobial performance. Moreover, the TA-PVP coating imparts a binding site for binding metal ions that allows it to capture metal ions through complexation and immobilization on the coating. The modified membranes showed more significant antifouling performance after iron ions have been complexed, and showed stronger bactericidal activity after silver ions have been complexed.
研究领域:
材料科学
·
环境工程
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2020
·
IF 2.87
Xiaofei Lv,Sifang Li
Microspheres of the graphene oxide and crospolyvinylpyrrolidone composite (GO–PVPP) were prepared via suspension polymerization and investigated for the adsorption of 2,4,6-trichlorophenol (2,4,6-TCP) from wastewater. The microspheres were thoroughly characterized using scanning electron microscopy, infrared spectroscopy, N2 physisorption, elemental analysis, X-ray diffraction, and thermogravimetric analysis. The GO–PVPP microspheres comprised GO sheets on the surface and demonstrated good thermal stability, good swelling rate, and excellent adsorption capacity of 2,4,6-TCP (up to 466.77 mg/g). The adsorptions were determined as a function of pH, temperature, adsorbent loading, adsorption time, and initial content of 2,4,6-TCP in the solutions. The sorption kinetics was satisfactorily modeled using the pseudo-second-order rate equation, and the sorption equilibrium can be described using the Freundlich model. The 2,4,6-TCP adsorption by GO–PVPP was shown to be endothermic and spontaneous. The reusability of GO–PVPP was also demonstrated by the adsorption and desorption cycles.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2017
·
IF 2.536
Jin Zhang,Ran Guo,Anqi He,Shifu Weng,Xiuxiang Gao,Yizhuang Xu,Isao Noda,Jinguang Wu
In this work, we investigated the influence of polyvinylpyrrolidone (PVP) on the solubility of artemisinin in aqueous solution by using quantitative 1 H NMR. Experimental results demonstrate that about 4 times of incremental increase occurs on the solubility of artemisinin upon introducing PVP. In addition, dipole-dipole interaction between the ester group of artemisinin and the amide group of N -methylpyrrolidone (NMP), a model compound of PVP, is characterized by two-dimensional (2D) correlation FTIR spectroscopy with the DAOSD (Double Asynchronous Orthogonal Sample Design) approach developed in our previous work. The observation of cross peaks in a pair of 2D asynchronous spectra suggests that dipole-dipole interaction indeed occurs between the ester group of artemisinin and amide group of NMP. Moreover, the pattern of cross peaks indicates that the carbonyl band of artemisinin undergoes blue-shift while the bandwidth and absorptivity increases via interaction with NMP, and the amide band of NMP undergoes blue-shift while the absorptivity increases via interaction with artemisinin. Dipole-dipole interaction, as one of the strongest intermolecular interaction between artemisinin and excipient , may play an important role in the enhancement of the solubility of artemisinin in aqueous solution.
研究领域:
药剂学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Jingshan Rao,Chaoyi Shen,Zhichao Yang,Olaniyi Amos Fawole,Jiangkuo Li,Di Wu,Kunsong Chen
Much attention and endeavor have been paid to developing biocompatible food packaging films. Here, ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) were fabricated into films through a facile method, microfluidic spinning. Morphology observations showed that the fibers were neatly arranged with an average diameter of 1–4 μm. FTIR and X-ray diffraction analysis suggested the existence of good compatibility and interaction between EC and PVP. Thermogravimetric analysis demonstrated that PVP ameliorates the thermal properties; moreover, the tensile properties were improved, with tensile strength (TS) and Young's modulus up to 11.10 ± 1.04 MPa and 350.16 ± 45.46 MPa, respectively. The optimal formula was EC/PVP (2:3), of which the film displayed an enhanced TS of 4.61 ± 1.15 MPa and a modified water contact angle of 61.8 ± 4.4°, showing fine tensile and hydrophilic performance. This study provides a facile and green film fabrication method promising to be used for food wrapping.
研究领域:
食品科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PROSTHETIC DENTISTRY
·
2024
·
IF 4.3
Yaoxin Wang,Ning Ding,Zutai Zhang
Statement of problem Phosphoric acid is commonly used in dentistry as an etchant but can result in excessive demineralization of dentin, a major contributor to the instability of dentin-bonded restorations. Nevertheless, research on the development of etchants that can reduce acid damage is sparse. Purpose The purpose of this in vitro study was to investigate the effects of polyvinylpyrrolidone-modified phosphoric acid on the dentin bonding of an etch-and-rinse adhesive. Material and methods Protective etchants were prepared by adding polyvinylpyrrolidone to 35% phosphoric acid aqueous solutions: the 3 concentrations were 0.5% (P0.5% group), 1% (P1% group), and 2% (P2% group) w/v. The treatment agent of the control group (C) was 35% phosphoric acid gel. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), microhardness, microtensile bonding strength (µTBS), nanoleakage, and in situ zymography were used to evaluate the appearance of the protective etchant on dentin bonding. The results were analyzed with a 1-way ANOVA test (α=.05). Results SEM showed no obviously exposed collagen fiber in the P1% and P2% groups. FTIR showed less demineralization of the dentin surface, and microhardness was higher after treatment with the protective etchant ( P <.05). The µTBS of P1% (70 ±9.2 MPa) was the highest, and group C (44 ±5.8 MPa) was the lowest in all groups ( P <.05). Moreover, there was weaker MMP activity in the P1% and P2% groups ( P <.05). Conclusions This study demonstrated that the protective etchant effectively reduced demineralization, enhanced bond strength, and reduced nanoleakage and enzyme activity within the hybrid layer.
研究领域:
牙科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Yu Han,Xiao Qiaohong,Qi Guilin,Chen Feixiang,Tu Biyue,Zhang Suo,Li Yinping,Chen Yun,Yu Hui,Duan Peng
Hydrogels with adhesive properties have the potential for rapid haemostasis and wound healing in uncontrolled non-pressurized surface bleeding. Herein, a typical hydrogen bond-crosslinked hydrogel with the above functions was constructed by directly mixing solutions of humic acid (HA) and polyvinylpyrrolidone (PVP), in which the HA worked as a crosslinking agent to form hydrogen bonds with the PVP. By altering the concentration of HA, a cluster of stable and uniform hydrogels were prepared within 10 s. The dynamic and reversible nature of the hydrogen bonds gave the HA/PVP complex (HPC) hydrogels injectability and good flexibility, as well as a self-healing ability. Moreover, the numerous functional groups in the hydrogels enhanced the cohesion strength and interaction on the interface between the hydrogel and the substrate, endowing them with good adhesion properties. The unique chemical composition and cross-linking mechanism gave the HPC hydrogel good biocompatibility. Taking advantage of all these features, the HPC hydrogels obtained in this work were broadly applied as haemostatic agents and showed a good therapeutic effect. This work might lead to an improvement in the development of multifunctional non-covalent hydrogels for application to biomaterials.
研究领域:
生物材料学
·
医学工程
✓ 已验证
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2020
·Vol. 413
·期 2
·649-659
·
IF 3.637
Halawa Mohamed Ibrahim,Wu GuoXing,Li Bing Shi
In this work, we fabricated gold nanoparticles (AuNPs) capped with both polyvinyl pyrrolidone (PVP) and iodine (I 2 ) to act as efficient chemiluminescent coreactants for luminol. AuNPs synthesis was based on the direct chemical reduction of Au 3+ with NaBH 4 in the presence of PVP-I 2 complex. The successful synthesis of PVP-I 2 @AuNPs was confirmed with scanning electron microscopy (SEM) and UV-vis spectrophotometry. Chemiluminescence (CL) intensity of luminol was greatly enhanced, upon its chemical reaction with chemisorbed I 2 on AuNPs surfaces owing to the excellent catalytic activity of AuNPs. The PVP-I 2 @AuNPs/luminol CL sensing system was successfully applied for determination of Hg 2+ ions and the results displayed linearity in a wide range from 0.5 to 2000 nM and an ultrasensitive response to 1.0 nM Hg 2+ . The detection limit of Hg 2+ ions was 0.1 nM, which was 100 times lower than the limit value (10 nM) defined by the U.S. Environmental Protection Agency in drinkable water. This ultrasensitive luminogenic system for Hg 2+ detection also exhibited excellent selectivity among 13 types of metals, suggesting that the luminol/PVP-I 2 @AuNPs system is a promising sensor for real-time detection of Hg 2+ .
Graphical abstract
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FISH BIOLOGY
·
2025
·
IF 2
Zhilong Chen,Lixin Ma,Sien Chen,Yao Huang,Zhendong Qin,Li Lin,Fei Shi
Gut microbiota stability is crucial for maintaining fish health. In aquaculture, antibiotics and disinfectants are frequently used to manipulate the host gut microbiota, but the combined effects on asymptomatic fish remain unclear. We investigated the effects of single and combined treatments with antibiotics and disinfectants on grass carp ( Ctenopharyngodon idella ) gut health, immune response, microbiome dynamics and transcriptome profile. In a 2-week trial, grass carp were exposed to enrofloxacin (10 mg/kg) in the basal diet or povidone-iodine (0.05 mg/L) in fresh water. A 14-day treatment led to significant oxidative stress, as indicated by reduced catalase and total superoxide dismutase activities. Digestive enzyme activities, including amylase and lipase, were also significantly suppressed. Gut microbiota diversity decreased, with notable shifts in dominant bacterial phyla, including reduced abundances of Firmicutes and Bacteroidetes and increased Proteobacteria and Fusobacteria. Transcriptomic analysis revealed downregulation of immune-related pathways, including those linked to IgA production, and suppression of key immune-related genes, such as major histocompatibility complex 2 ( MHC2 ) and tumour necrosis factor alpha ( TNF-α ). Histopathological analysis showed damaged intestinal villi, increased goblet cell numbers and significant apoptosis in intestinal epithelial cells, as confirmed by terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) staining and upregulation of caspase -3, caspase -8 and caspase -9. These findings demonstrate that enrofloxacin and povidone-iodine disrupt gut microbiota balance, impair mucosal immunity and induce apoptosis in grass carp.
研究领域:
水产养殖学
·
微生物学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）