Polymers
·
2018
·Vol. 10
·期 2
·190
·
IF 2.935
Sa Liu,Chunting Zhong,Weiwei Wang,Yongguang Jia,Lin Wang,Li Ren
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties againstEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus).Keywords:polyrotaxane;silver sulfadiazine;mechanism;antibacterial
研究领域:
药学
·
材料科学
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PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1607-1618
·
IF 1.282
Liu Huijun,Qi Caixia,Feng Zhiyuan,Lei Lanlin,Deng Shanxia
The adsorption of thorium(IV) was studied using a novel supramolecular polyrotaxane based on β-cyclodextrin derivatives. The effects of pH, contact time, Th(IV) initial concentration and adsorbents dosage on the adsorption of thorium(IV) by polyrotaxane were optimized using Box–Behnken design of response surface methodology. Analysis of variance and correlation coefficients showed that the predicted model was consistent with the experimental data well. The adsorption best fitted to the Langmuir model indicated that the adsorption process happened on homogeneous surface. The thermodynamic parameters (∆ G
0 < 0, ∆ H
0 > 0, ∆ S
0 > 0) demonstrated that the adsorption of Th(IV) ions onto polyrotaxane was spontaneous and endothermic.
研究领域:
环境科学
·
化学工程
·
材料科学
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DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 11
·2098-2107
·
IF 5.52
Yang Kang,Xiao-Mei Zhang,Sheng Zhang,Li-Sheng Ding,Bang-Jing Li
Self-assembly of stimuli-responsive polymeric nanoparticles have attracted great attention in recent years due to their prospective biological applications. This paper developed a novel pH-sensitive amphiphilic dendritic polyrotaxane drug-polymer conjugate by covalently linking doxorubicin (DOX) and dendritic polyrotaxane via a pH-responsible hydrazone bond with 1.84 wt% (weight percent) of DOX. The drug-polymer conjugate was amphiphilic and could be self-assembled to micelles (PR-g-DOX micelles) in an aqueous solution. The globular morphology and compact micelles with a diameter of around 110 nm were observed by SEM and TEM. Moreover, the micelles showed a significantly faster DOX release at mildly acidic pH of 6.0 and 5.0 and almost no burst release at the physiological pH of 7.4. Notably, it was confirmed that this micelle could efficiently deliver DOX to the nuclei of the tumor cells, which led to a much greater cytotoxic effects in the A549 cancer cells than the parent DOX. In vivo results revealed better drug tolerability of PR-g-DOX micelles and a higher in vivo efficacy without any increase in the toxicity of the PR-g-DOX micelles. Furthermore, the maximum tolerated dose (MTD) results showed that PR-g-DOX micelles showed an excellent safety profile with a two-fold higher MTD (10 mg kg−1 DOX) than that of free DOX (5 mg kg−1 DOX). We are convinced that the PR-g-DOX micelle has tremendous potentials for targeted cancer therapy.
研究领域:
药学
·
生物医学工程
·
肿瘤学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Sisi Ma,Ligang Lin,Qi Wang,Yuhui Zhang,Honglei Zhang,Yixin Gao,Lin Xu,Fusheng Pan,Yuzhong Zhang
A simple and effective strategy to simultaneously enhance the permeability and antifouling properties of ethylene vinyl alcohol (EVAL) membrane was developed based on the bioinspired natural cleaner, cilia. Taking clue from the self-cleaning effect of cilia, supramolecular polyrotaxanes (PRs) with sliding and rotating cyclic molecules along linear chains were synthesized using azide-alkyne click chemistry. Cilia-like PRs were incorporated into EVAL matrix in the fabrication of modified EVAL membranes. Cilia-like structures protruding from the membrane surface have been observed by SEM, TEM and AFM. By imitating natural ciliary movements, these structures provided a proactive self-cleaning system to remove the foulants. The introduction of cilia-like PRs enhanced the surface roughness and hydrophilicity, and significantly enhanced permeability by 55.3% compared to raw EVAL membrane. Moreover, the membrane modified with cilia-like PRs showed an excellent antifouling property with a lower water flux decline (12.6%) and higher water flux recovery (94%) in dynamic fouling tests. Furthermore, this modified membrane develops the scope of bioinspired membranes, inspiring more attractive potential applications in self-cleaning materials, dynamic membranes and supramolecular machines.
研究领域:
材料科学
·
环境工程
·
生物启发设计
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DOI
PubMed
高影响因子
Journal of Functional Biomaterials
·
2023
·Vol. 14
·期 7
·360
·
IF 4.8
Lulu Wang,Yuehai Peng,Wenfang Liu,Li Ren
Corneal disease has become the second leading cause of blindness in the world. Corneal transplantation is currently considered to be one of the common treatments for vision loss. This paper presents a novel approach utilizing dual-crosslinked membranes composed of polyrotaxane multiple aldehydes (PRAs), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS) in the development process. Collagen was crosslinked, respectively, by EDC/NHS and PRAs to form stable amide bonds and imine groups. Through the formation of a double interpenetrating network, dual-crosslinked (Col-EDC-PRA) membranes exhibited enhanced resistance to collagenase degradation and superior mechanical properties compared to membranes crosslinked with a single crosslinker. Furthermore, Col-EDC-PRA membranes display favorable light transmittance and water content characteristics. Cell experiments showed that Col-EDC-PRA membranes were noncytotoxic and were not significantly different from other membranes. In a rabbit keratoplasty model, corneal stromal repair occurred at 5 months, evidenced by the presence of stromal cells and neo-stroma, as depicted in hematoxylin–eosin-stained histologic sections and optical coherence tomography images of the anterior segment. Moreover, there was no inflammation and corneal neovascularization, as well as no corneal rejection reaction in the surgical area. Overall, the results demonstrated that the dual-crosslinked membranes served effectively for corneal tissue regeneration after corneal defect.Keywords:collagen membrane;corneal repair;corneal regeneration
研究领域:
生物医学工程
·
眼科研究
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 26
·5277-5283
·
IF 4.726
Shuling Yu,Jintao Yuan,Jiahua Shi,Xiaojiao Ruan,Yali Wang,Shufang Gao,Yu Du
A small, nano-sized, water-soluble polyrotaxane (PR) was synthesized using a highly efficient one-pot synthesis strategy in a homogeneous water system, formed from β-cyclodextrin-(COOH)2, poly(propylene glycol)bis(2-aminopropyl ether) (PPG, 2 kDa) and a mono-(6-azido-6-desoxy)-β-cyclodextrin stopper via room temperature click chemistry. β-cyclodextrin-(COOH)2 and PR were characterized by one- and two-dimensional NMR as well as by high resolution transmission electron microscopy (HR-TEM). The number of carboxyl groups in one PR was determined by 1H NMR. Two-dimensional diffusion-ordered NMR spectroscopy (2D DOSY) and nuclear Overhauser enhancement spectroscopy (2D NOESY) show that β-cyclodextrin-(COOH)2 and PPG successfully formed an inclusion complex. HR-TEM revealed the morphology of water-soluble PR as a spherical nanoparticle with a size of approximately 3.5 nm ± 1.5 nm. PR was labeled with rhodamine to assess its biocompatibility and cell membrane penetrability in vitro. The in vivo real-time fluorescent imaging biodistribution experiments indicated that water-soluble PR can actively target tumor sites using an enhanced permeability and retention (EPR) effect, with a significantly prolonged blood circulation time in tumor-bearing mice.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 41
·期 1
·95-107
·
IF 3.815
Xie Zhen-Hua,Huang Zi-Xin,Zhang Ze-Ping,Rong Min-Zhi,Zhang Ming-Qiu
To construct structurally stable sulfur cathode of Li-S battery with improved cycling performance, poly(acrylic acid) (PAA) crosslinked by cationic hydroxypropyl polyrotaxane (HPRN + ) via dynamically reversible boronic ester bonds is synthesized and serves as the cathode binder. The smart polymer networks offer multifunction including buffering the volume change of the cathode during charge/discharge through the pulley effect of polyrotaxanes (PR), suppressing the shuttle effect by adsorption of polysulfide using the plentiful carboxyl, hydroxyl and quaternary ammonium cationic groups, and self-healing the micro-damages to ensure stable conduction pathways of the electrode. As a result, the Li-S batteries based on this novel multifunctional binder and simple commercial sulfur/carbon composites cathode exhibit excellent specific capacity and cycling stability. In particular, the specific capacity decay per cycle of the cell is only 0.064% along with high Coulombic efficiency after 550 cycles at 1.0 C, which is superior to most of the reported binders. Even under high sulfur loading, moreover, the cathode can deliver superior areal capacity and cycling stability. This proposed binder provides a new way for the design of high-stability sulfur cathodes.
研究领域:
材料科学
·
能源化学
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 8
·2000461
·
IF 2.527
Yushi Wang,Jiyu Dong,Jiahong Jin,Yong-Guang Jia
As an effective alternative to suture in wound closure, tissue adhesives often need to have excellent biocompatibility and suitable bioadhesion. To achieve long-term adhesion on moist tissue, polyrotaxane (PR) crosslinked self-healing hydrogels have been prepared by the introduction of dynamic borate bonds between PR bearing phenylboronic acid moieties (PR-PBA) and dopamine grafted poly(vinyl alcohol) (PVA-DOP). Synthesis of these precursor polymers PR-PBA and PVA-DOP is quite simple and the hydrogels combine dynamic borate bonds with the sliding motion of the phenylboronic acid moieties on PR. The sliding nature of the crosslinking points along the axle in the PR is thought to enhance the mechanical properties and adhesion ability of the resultant hydrogels. Meanwhile, catechol groups on dopamine units have been protected by borate bonds under alkaline conditions to avoid oxidation, and they then are released to react with various functional groups on tissue surface to ensure the switchable tissue adhesion. The self-healing test and adhesion of hydrogels on pigskin demonstrate the ability to restore the original performance after repeated strain cycles and maintain strong tissue adhesion. The components of these hydrogels have satisfying biocompatibility. These results indicate that these self-healing hydrogels have great potentials in tissue adhesion.
研究领域:
材料科学
·
生物医学工程
·
组织工程
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DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Qi Qin,Xue Ma,Xiali Liao,Bo Yang
As a prerequisite of gene delivery in living cells, DNA condensation has attracted more and more attention. In order to improve the efficiencies of polyamine-β-cyclodextrin-based cationic polyrotaxanes (PR-EDA and PR-DETA) as DNA condensation materials, we have designed and prepared two novel scutellarin-grafted cationic polyrotaxanes (PR-EDA-SCU and PR-DETA-SCU), in which scutellarins (SCU), the planar molecules, were conjugated on the cyclodextrin molecules of PR-EDA and PR-DETA. These materials were characterized by 1D and 2D NMR, XRD, TG and DSC. The electrophoresis assays showed that pDNA condensation efficiencies of PR-EDA and PR-DETA were better than that of PR-EDA and PR-DETA. The complexes of PR-EDA, PR-DETA, PR-EDA-SCU and PR-DETA-SCU with pDNA were further investigated by zeta potential and atomic force microscopy analysis. The results indicated that the planar structure of SCU played an important role in improvement of pDNA condensation efficiencies of PR-EDA-SCU and PR-DETA-SCU. The satisfactory pDNA condensation abilities of PR-EDA-SCU and PR-DETA-SCU could be helpful in designing non-viral gene delivery vectors to control gene expression and delivery.
研究领域:
生物化学
·
分子生物学
·
材料科学
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DOI
PubMed
高影响因子
Small
·
2016
·Vol. 12
·期 45
·6223-6232
·
IF 8.315
Hongxin Tong,Yangjun Chen,Zuhong Li,Huan Li,Tingting Chen,Qiao Jin,Jian Ji
Photodynamic theranostics has recently been extensively explored as a promising approach for precise localization and therapy. Herein, glutathione (GSH) activatable photosensitizer (PS)-conjugated pseudopolyrotaxane nanocarriers (α-CD-ss-Ce6 NPs) are reported for enhanced photodynamic theranostics by taking advantage of the noncovalent interactions between α-cyclodextrin (α-CD) and poly(ethylene glycol). The designed α-CD-ss-Ce6 NPs are nonactivated and stable during circulation but exhibited strong photodynamic theranostics through GSH activating after arriving at tumor site. More importantly, compared to free chlorin e6 (Ce6), such kind of pseudopolyrotaxane nanocarrier can dramatically enhance Ce6 accumulation in tumor and prolong its tumor retention time, demonstrating excellent therapeutic effects after light irradiation. Overall, the designed GSH activatable PS-conjugated pseudopolyrotaxane nanocarrier possessing high-performance photodynamic therapeutic efficacy together with reduced side effects offers a promising alternative for photodynamic theranostics.
研究领域:
生物医学工程
·
纳米医学
·
药物递送
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DOI
PubMed
高影响因子
Acta Biomaterialia
·
2022
·
IF 10.633
Guowei Li,Kai Lv,Xiangjun Pan,Siting Zhou,Hui Xing,Jun Xu,Dong Ma,Yunfeng Hu,Hao Xu
The low permeability of antifungal agents to fungal biofilms , which allows the continued survival of the fungus inside, is a key issue that makes fungal infections difficult to cure. Inspired by the unique dynamic molecule motion properties of the polyrotaxane (PR) nanomedicine , herein, a dynamic delivery system [email protected] /NONOate was fabricated by co-loading nitric oxide (NO) and the antifungal drug clotrimazole (Clo) onto the α-cyclodextrin (α-CD) PR modified mesoporous polydopamine (mPDA) nanoparticles , in which pentaethylenehexamine (PEHA) was grafted to α-CDs. The cationic α-CDs endowed this dynamic NO/Clo codelivery system with the ability to effectively attach to fungal biofilms through electrostatic interaction , while the introduction of PRs with flexible molecule motion (slide and rotation of CDs) enhanced the permeability of nanoparticles to biofilms. Meanwhile, NO could effectively inhibit the formation of fungal hyphae, showing an dissipating effect on mature biofilms, and could be further combined with Clo to completely eradicate fungi inside the biofilms. In addition, the dynamic system [email protected] /NONOate could efficiently and synergistically eliminate planktonic Candida albicans ( C. albicans ) in a safe and no toxic side effect manner, and effectively cured C. albicans -induced vaginal infection in mice. Therefore, this dynamic NO/Clo codelivery system provided an effective solution to the clinical treatment of C. albicans -induced vaginal infection, and the application prospect could even be extended to other microbial infectious diseases. Statement of significance A dynamic codelivery system based on cationized cyclodextrin polyrotaxane combining nitric oxide and antifungal drugs clotrimazole was prepared to deal with the issue of clinical fungal biofilm infection. This dynamic codelivery system could be attached to the Candida albicans biofilms and penetrate into biofilm via flexible molecular mobility to effectively eradicate the fungi. This dynamic codelivery system could synergistically and efficiently eliminate planktonic-state Candida albicans , but did not show significant cytotoxicity to normal somatic cells .
研究领域:
药学
·
微生物学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Rui-Dong Wang,Yi-Fei Zhang,Xiao-Long Han,Yu-Kun Gao,Ting-Ting You,Peng-Gang Yin
This work explores the design and optimization of polyrotaxane-based solid polymer electrolytes (SPEs) by adjusting crosslinker, composition, and polyrotaxane coverage ratio. By incorporating poly (ethylene glycol) (PEG) crosslinkers and refining their molecular weight and loading, we developed SPEs exhibiting high ionic conductivity (7.05 × 10 −5 S/cm at 30 °C), excellent flexibility (elongation at break over 270 %) and thermal resistance above 150 °C. Investigations into polyrotaxane with reduced coverage ratios revealed limitations in mechanical properties and ionic conductivity, emphasizing the importance of PEG crosslinker and the need of a robust cross-linked network. This study underscores the potential of polyrotaxane cross-linked networks for advanced SPE applications and provides insights for future design strategies in the field.
研究领域:
材料科学
·
能源存储
·
高分子化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）