CELLULAR AND MOLECULAR BIOLOGY
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2019
·Vol. 65
·期 7
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IF 1.463
Lijuan Wang,Liji Huang,Nan Li,Junjun Miao,Wei Liu,Jiangyi Yu
To investigate the effect of polydatin on glucose transporter, blood glucose homeostasis and renal injury in streptozotocin (STZ)-induced diabetic rats. The in vitro inhibitory effect of polydatin on sodium-glucose cotransporter-1 (SGLT1) and 2 (SGLT2) was determined using HEK293 cells. The inhibitory effect of polydatin on GLUT1 and GLUT4 was evaluated using 3T3-L1 adipocytes. Streptozotocin-induced diabetic rats were used for this study. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), urea nitrogen, serum creatinine and urinary protein were determined using biochemical analyzer. Histopathological examination was performed on renal tissue. Serum levels of interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), monocyte chemoattractant protein 1 (MCP-1) and C-reactive protein (CRP) were also determined. Polydatin significantly inhibited SGLT1/2 and exhibited high selectivity for both GLUT1 and GLUT4. It significantly and dose-dependently decreased hyperglycemia, enhanced urine glucose excretion in the diabetic rats. The polydatin treatment significantly ameliorated symptoms of DN such as polyuria, polydipsia and hyperphagia. The hypoglycemic effect of polydatin was maintained throughout the treatment period. In addition,the levels of IL-1β, TNF-α, MCP-1 and CRP were significantly reduced in treated group. Treatment with polydatin significantly ameliorated most of the structural and morphological changes induced by STZ. Moreover, the levels of urinary protein, serum creatinine and urea nitrogen were significantly reduced after treatment with polydatin. As a potential dual inhibitor of SGLT1/2, polydatin has high selectivity for GLUT1 and GLUT4. Its long-term administration delays the development of DN, protects renal function and ameliorates renal tissue injury.
研究领域:
药理学
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内分泌学
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分子生物学
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DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Qianlan Huang,Jialing Li,Zhiyuan Peng
An active hydroxymethyl group was introduced to the phenolic ring structure of tannin, and then the polyphenol network from hydroxymethyl tannin was immobilized on the surface of the filter paper (FP) by the reaction between hydroxymethyl tannin and cellulose of FP. Due to the introduction of the polyphenol structure on the surface of the FP, the ultraviolet absorption of the FP was broadened, the thermal stability of the FP was increased, and the FP was endowed with the antibacterial properties. The inhibition efficiency for Escherichia coli and Staphylococcus aureus was 82.3 and 80.1%, respectively. The FP-immobilized polyphenol network of tannin had good adsorption performance for methyl violet (MV), and the maximum adsorption capacity for MV was 131.5 mg·g–1. The adsorption efficiency could reach more than 98% when the initial mass concentration of MV was lower than 50 mg·L–1. The adsorption process conformed to the Langmuir isothermal adsorption model and quasi-secondary adsorption kinetic model. The FP-immobilized polyphenol network of tannin has good adsorption repeatability, and the preparation method is facile, green, and ecofriendly, which can be considered as a new potential adsorbent for dye wastewater.
研究领域:
材料科学
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环境科学
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生物学
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产品关联
DOI
高影响因子
Food Bioscience
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2025
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IF 5.9
Yahong Cheng,Yi Ding,Ziyan Tang,Xiaoyi Lei,Yufang Ma,Mengxin Xia,Jiaying Li,Gaoge Hu,Jiahui Zhang,Jing Rao
This study investigated the antiepileptic effects of polydatin (PD) and its potential mechanisms. Racine scoring and EEG were used to assess seizure severity in a PTZ-induced mouse epilepsy model. The results demonstrated that PD significantly reduced the intensity of seizures. Behavioral tests revealed that PD improved learning, memory, and motor coordination. Histological analysis using HE and Nissl staining showed that PD alleviated hippocampal neuronal damage. TUNEL staining further confirmed that PD effectively prevented neuronal apoptosis. Network pharmacology predicted SIRT1 as a potential target of PD, and GO and KEGG pathway enrichment analyses indicated that PD regulated mitochondrial function. Therefore, PD may reduce neuronal damage by protecting mitochondrial function through SIRT1. This process was tested both in vitro and in vivo . In a Mg 2+ -free neuronal excitability model, CCK-8, LDH, and Hoechst staining results demonstrated that PD significantly increased cell survival and reduced apoptosis. Reduced mitosox staining, along with increased activity of Complexes IV and V and ATP production, indicated that PD mitigated mitochondrial function. Gene expression studies revealed that PD activated the SIRT1-PGC-1α signaling pathway via AMPK. In conclusion, PD exerted neuroprotective effects by regulating mitochondrial function, suggesting a potential therapeutic target for epilepsy.
研究领域:
药理学
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神经科学
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生物信息学
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
·
IF 24.319
Yizhou Wu,Yu Chen,Donglin Li,Dania Sajjad,Yixuan Chen,Yiying Sun,Shusong Liu,Jiafu Shi,Zhongyi Jiang
Heterostructure materials are increasingly utilized in solar energy conversion to pursue high efficiency and long-term stability. The charge transfer across interfaces gives rise to major energy loss arising from non-ideal interfacial effects, i.e., high interfacial energy barrier and low interfacial contacting area. Herein, we demonstrate a facile interface engineering strategy to eliminate non-ideal interfacial effects. A heterojunction of CN@C-P25 is constructed via polyphenol-assisted assembly of titania (P25) and carbon nitride (CN). The uniform dispersion of P25 on CN enlarges the interfacial contacting area of 3.2-fold compared with random dispersion, while the transformation of polyphenols into conjugated carbon facilitates the interfacial charge transfer by switching a 0.4 eV Schottky contact to a 0.1 eV Ohmic contact between CN and P25. A 2.5-fold enhancement of charge transfer flux is obtained with an initial reaction rate of 5185 μmol h −1 g −1 for photocatalytic nicotinamide regeneration.
研究领域:
材料科学
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能源转换
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界面化学
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DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
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2023
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IF 5.4
Jiao Li,Jian Zhang,Hongyu Zhang,Xuwen Wang,Taojie Lu,Jiayan Liang,Yulin Yang,Kaifeng Lin,Debin Xia
Interface modification of aluminum particles plays a crucial part in reducing the agglomeration during the combustion of solid propellants . In this study, the aluminum (Al) particles are pretreated with gallic acid (GA) to get Al@GA with an adhesion-favorable surface, which facilitates the further coating procedure. One new fluorine-containing organic substance is prepared, namely p-HFBA. The p-HFBA further coats the Al@GA to produce Al@GA/p-HFBA. The interface between Al@GA and the coating layer p-HFBA forms Al F bonds and induces a pre-ignition reaction with an aluminum oxide shell. Hence, the agglomerate size of propellants containing Al@GA/p-HFBA significantly decreases from 176.30 μm to 84.72 μm. The agglomerates volume is reduced by approximately 97 %. Additionally, more gaseous products investigated by TG-MS provide the Al particles with greater impetus (aerodynamic forces, F ae ), enabling them to leave the burning surface and reduce the residence time. The rise in F ae and drop in adhesion force ( F ad ) effectively reduce the agglomeration intensity according to the skeleton layer model. This work proves that interface modification can effectively enhance the combustion performance of aluminized solid propellants .
研究领域:
材料科学
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燃烧学
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化学工程
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
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2025
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IF 6.7
Xinyi Wang,Zezhen Zhang,Weishan Deng,Haolan Xiao,Liming Xia,Lili Wu
Carbon nanotube (CNT) is a promising raw material for membrane fabrication due to its good electrical conductivity, great specific surface area, and special piping structure. In this report, tannin (TA), CNT, and D-aspartic acid (DAS) were co -deposited on the surface of polyethersulfone (PES) ultrafiltration membrane to construct an electrically responsive coating. The membrane can maintain the high electrical conductivity while avoiding the membrane defects due to the accumulation of CNTs and the different lengths of chain segments in the process of CNT co-blending to form the membrane. The results show that the average pore size of the membrane is reduced from 19.55 nm to 8.165 nm, and the retention capacity is greatly improved, showing good separation efficiency (99.5 %) and hydrophilicity (water contact angle of 13°). Through adsorption and electric field deflection, CNT endows the membrane with the ability to selectively separate dyestuffs with different electrically charged properties. Long-term stability tests show that the modified membrane still maintains a high level of pure water flux and conductivity after seven days of operation. This paper is of exploratory significance in the field of electrically responsive smart membranes for dye separation. The membrane developed in this study exhibits unique selective separation performance and can dynamically adjust its separation efficiency by externally controlling the electric field strength. This demonstrates its excellent intelligence, making it highly promising for applications in electrically responsive intelligent separation membranes. Additionally, it offers a novel approach for treating dye-containing wastewater using electrically charged functional membranes.
研究领域:
材料科学
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环境工程
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化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2019
·
IF 8.456
Ziyi Cai,Jiafu Shi,Weiran Li,Yizhou Wu,Yishan Zhang,Shaohua Zhang,Zhongyi Jiang
Enclosed films, also called capsules, bearing an ultrathin and robust nanoshell have sparked much interest for use in many applications, for which facile preparation methods are urgently pursued. Inspired by the pH-programmed adhesion/cohesion of mussel-secreted foot proteins, polyphenol/polyamine capsules with an ultrathin and robust nanoshell are fabricated through a pH-switched assembly on sacrificial calcium carbonate (CaCO3) templates. Polyphenols adhere to the templates at pH 6.0 and rapidly cohere with polyamines at pH 8.0. The pH-switched assembly process is accomplished in only a few minutes where multiple instances of electrostatic interactions and chemical conjugation between polyphenols and polyamines occur. As a result, the capsules exhibit a nanoshell thickness of ∼10 nm and a superior mechanical strength of ∼1.575 GPa (elasticity modulus). Cell mimics are prepared through encasing enzymes in the lumen and present an activity recovery of ∼70% along with little activity decline during reuse. Amine or phenolic groups on the nanoshell of capsules are then applied to induce the generation of titania or silver nanoparticles, which may expand the applications of the capsules to the photo- and biorelated realms. Our study not only deepens the understanding of the adhering process of mussels but also offers a generic method toward functional materials for diverse applications.
研究领域:
材料科学
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生物化学
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仿生学
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DOI
高影响因子
BIOMACROMOLECULES
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2021
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IF 6.988
Zhiqing Liu,Wei Yu,Wenbo Sheng,Rui Li,Helin Guo,Xiantao Feng,Qian Li,Rongjie Wang,Wei Li,Xin Jia
A facile and general strategy for preparing uniform and multifunctional polyphenol-based colloidal particles through amine-catalyzed polymerization-induced self-assembly is described. The size and interfacial adhesion of polyphenol spheres can be easily controlled over a wide range via adjusting the concentration of the cosolvent and monomer. Moreover, the polyphenol spheres showed excellent thermal and chemical stability and highly active properties and could efficiently deplete the reactive oxygen species (ROS), which are helpful for in vivo ROS regulation for inflammatory therapeutic. The accessible and versatile method provides a feasible way for the rational engineering of multifunctional polyphenol spheres, which have great potential in many fields.
研究领域:
材料科学
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生物医学
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化学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Xiao Chen,Meizhou Sun,Lujiao Zhang,Yang Hu,Zhiwei Yang,Shun Duan,Fu-Jian Xu,Juehua Jing
Infected bone defect is a critical problem in clinical practice of orthopedics. To solve this problem, implants with dual-functional surfaces which possess both antibacterial and osteogenic properties have extensive applications. However, there remains a pressing need to develop a convenient strategy for preparing such surfaces facilely. In this study, we reported a novel one-step polyphenol-based surface functionalization strategy for preparing two fibrous membranes with antibacterial and osteogenic capabilities. The formation of RGD-HHC36 (RH) or RGD-polyhexamethylene guanidine (RP) coating was fabricated by Michael reaction with poly (tannic acid) (PTA) to produce dual-functional fibrous membranes (PLA-RH and PLA-RP, respectively). The surfaces of PLA-RH and PLA-RP exhibited increased roughness and hydrophilicity. In vitro tests revealed that PLA-RH and PLA-RP could eradicate over 99% of clinically common pathogenic bacteria while exhibiting significant improvements in the adhesion, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Moreover, RNA-Seq analysis revealed that the up-regulation of Chrdl1 played a key role in promoting ossification through activation of the CHRDL1 - BMP4 pathway. The favourable in vivo anti-infection and osteogenesis-promoting performances were demonstrated in an infected bone defect model. PLA-RH and PLA-RP inhibited bacterial infection in the early stage, and enhanced osteogenesis in the late stage. This study provides a facile and universal strategy for designing and fabricating dual-functional surfaces for antibacterial application and tissue regeneration simultaneously.
研究领域:
生物医学工程
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组织工程
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材料科学
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DOI
高影响因子
OPTICAL MATERIALS
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2024
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IF 3.8
Zhenyu Zeng,Hongxing Xie,Yun Ye,Xingke Zheng,Qizhong Lin,Enguo Chen,Sheng Xu,Tailiang Guo
Alloyed quantum dots (QDs) show great potential for photoluminescence (PL) applications. However, the oxidative decay of QDs during photoexcitation has been a major hurdle to the application of QDs. Blocking water-oxygen erosion by coating oxides on the surface of QDs is a common technique. Even though, this approach often leads to alterations in the optical properties of QDs and reduced compatibility with polymers. In this paper, hindered phenol was utilized to treat QDs to form QD/Hindered phenol complexes. Using the reduction of phenolic hydroxyl group in the hindered phenol, the hindered phenol was used as an exhausted substance to protect QDs from oxidation . After 450 h of aging, the obtained QD/Hindered phenol complex kept the photoluminescence quantum yield (PLQY) at 48 %. The luminance of the QD diffusion plate prepared by the QD/Hindered phenol complexes maintained above 98 % of the initial value after aging 1032 h. The introduction of phosphite ester further improved the photostability of QD/Hindered phenol complex under blue-light excitation. This technique promotes the application of QDs in polymers and offers a new reference for improving the stability of QDs under photoexcitation.
研究领域:
材料科学
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光学工程
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
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IF 2.986
Huan Zhou,Mengmeng Yang,Saisai Hou,Xinye Ni,Yaping Bi,Wenjie Wang,Muralithran Govindan Kutty,Lei Yang
Hydroxyapatite (HA) is a well-known material for biomedical applications and its performance depends greatly on its morphological features. Therefore, preparation of mesoporous HA with high surface area and adsorption capacity is highly deserved. In this research, a hydrothermal approach to synthesize mesoporous HA without post-processing calcination step is presented. The possibility using different polyphenols to generate mesoporous HA as well as using different phosphate sources to tailor the morphological features of HA is investigated. The as-prepared mesoporous HA particles are characterized by XRD , FTIR, SEM, TEM , BET, and zeta potential . Besides, the impacts of HA morphological features on model drug Dox are also studied. It is expected the strong interaction between –OH of polyphenols and Ca 2+ makes polyphenols molecules occupy the inner sites of growing HA particles. After the removal of polyphenols by hydrothermal treatment and ethanol extraction, the occupied sites are transformed into mesopores. The typical mesoporous HA generated in present work has a rod-like morphology with BET specific surface area of 106.6 m 2 /g and an average pore size of 14.4 nm.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shengqiu Zhao,Yucong Liao,Rui Wang,Guoliang Liu,Haining Zhang,Haolin Tang
The chemical degradation of proton exchange membranes (PEMs) suffering from radical attack is a crucial issue in the development of proton exchange membrane fuel cells (PEMFCs), while incorporating cerium oxide (CeO 2 ) nanoparticles (NPs) with regenerative redox properties to eliminate radicals could effectively alleviate degradation. However, the low stability and restricted activity of CeO 2 in the PEMFC operating condition and the poor compatibility with PEM due to CeO 2 agglomeration stimulate the urgency for structural modulation of CeO 2 . Achieving a balance of membrane performance and oxidation resistance through a rational surface modification strategy of CeO 2 is important for expanding PEMFC applications. Herein, polyphenols surface functionalized CeO 2 core-shell structure (CeO 2 @TP) were constructed via assembling oxidation-induced coupling tea polyphenols (TP) on CeO 2 NPs. The TP oligomeric shell as a protective layer enhances the stability of CeO 2 , mitigating radical scavenging activity degradation and improving compatibility with PEMs. Physicochemical characterisation shows that the overall performance of the nanocomposite membrane is improved due to the interaction of CeO 2 @TP nanoparticles with the polymer matrix. Gratifyingly, the phenolic hydroxyl-rich reductive TP oligomeric shell accelerates the regeneration of Ce(IV) to Ce(III), increasing the proportion of Ce(III) and oxygen vacancies on the CeO 2 surface, thus boosting antioxidation efficiency. As a result, the CeO 2 @TP-based PEMs exhibited an OCV decay rate of 0.22 mV h −1 , a maximum power density of 1.06 W cm −2 , an H 2 crossover value of 2.18 mA cm −2 , thickness retention (91.1%), and negligible Ce migration after 404 h of accelerated degradation testing. It is proven that the desired consequences of doping antioxidants in PFSA matrix can be intensified by surface modulation of the physicochemical properties of CeO 2 .
研究领域:
材料科学
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能源工程
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化学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）