JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 17
·
IF 1.866
Ruiqing Hu,Yuping Pi,Na Wang,Qian Zhang,Jinqi Feng,Weilin Xu,Xia Dong,Dujin Wang,Hongjun Yang
Biodegradable polymers have received increased attention due to their potential application in the medicine and food industries; in particular, poly(lactic acid) (PLA) is a primary biopolymer because of its excellent biocompatibility and absorbability features. In this study, a porous PLA membrane was fabricated by phase separation using water microdroplets produced by an ultrasonic atomizer as a coagulation bath. The formation of S-type clusters was attributed to the slow exchange rate between solvent and coagulant, which provided time for the movement of polymer molecules. The effect of preparation conditions on the structure of S-type clusters, including polymer concentration in solution and ambient temperature was investigated. The PLA porous membrane prepared from water micro-droplets with different morphology compared with the sample fabricated from distilled water has potential application in fields of tissue engineering and artificial organ generation. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43355.
研究领域:
生物材料学
·
高分子科学
·
组织工程
·
再生医学
·
纳米结构制备
·
相变动力学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2013
·Vol. 101
·期 8
·1359-1366
·
IF 2.308
Yu-fei Wang,Hong-feng Guo,Da-jun Ying
Dural closure after the neurosurgery can prevent postoperative complications. Although many types of dural substitute have been developed, most of them lack functional and structural characteristics compared with the natural dura mater. In this study, we used electrospinning method to fabricate a multilayer scaffold to promote dural repair. The inner layer of the scaffold that faces the brain tissue is composed of poly-lactic acid (PLA) to reduce tissue adhesion. The middle layer of the scaffold is composed of poly-ɛ-caprolactone and PLA, which provides a watertight seal. The outer layer of the scaffold contains a large amount of collagen to promote cell attachment and proliferation. The results from in vitro study and an animal model have shown that this multilayer fibrous scaffold has sufficient mechanic strength and biochemical properties to enhance dural repair. Therefore, fabrication of scaffold with multiple functional and structural layers may provide a novel approach for tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1359–1366, 2013.
研究领域:
生物材料
·
神经外科
·
组织工程
·
再生医学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 139
·期 25
·e52390
·
IF 3.057
Xinyi Dong,Zhenggui Wu,Yang Wang,Ting Li,Hao Yuan,Xuhui Zhang,Piming Ma,Mingqing Chen,Jing Huang,Weifu Dong
Despite polylactide (PLA) representing one of the most promising biodegradable materials, its applications lag far behind owing to the disadvantages of inherent brittleness and flammability, which is challengeable to simultaneously overcome. In this work, a phosphorus-containing core-shell starch nanoparticle (FR-CSS) was synthesized via soap-free emulsion polymerization for concurrent improvement of toughness and flame retardancy of PLA. The results revealed that with the incorporation of 10 wt% FR-CSS, the elongation at break of PLA/10FR-CSS was prominently improved to 308% while the tensile strength was about 40.0 MPa. Particularly, the toughness of PLA/FR-CSS was as high as 108.2 MJ/m 3 , which was 48 times higher than that of neat PLA. Besides, the PLA/10FR-CSS exhibited improved flame retardancy with a UL-94 V-2 rating and a LOI value of 24.5%. These results established an integrated design strategy of incorporating phosphorus-containing core-shell nanoparticles to prepare PLA composites combined excellent toughness with enhanced flame retardancy, therefore broadening the application gallery of PLAs.
研究领域:
高分子材料
·
生物材料
·
阻燃材料
·
纳米复合材料
·
可降解聚合物
✓ 已验证
DOI
高影响因子
POLYMER BULLETIN
·
2024
·Vol. 81
·期 11
·10175-10185
·
IF 3.1
Hu Jing,Wang Guoqiang
Polylactic acid (PLA) is a kind of polyester from biomass. To increase the ductility of PLA, melt blending was used to prepare the polylactic acid/poly(butylene diglycolate) blends in this study. The effect of poly(butylene diglycolate) (PBD) on the thermal, crystallization, tensile, and dynamic mechanical properties of PLA was investigated. The blend containing 30 wt% PBD has a substantially improved elongation at break (79%) due to the lower glass transition temperature of PBD compared to PLA. The results indicated that PLA and PBD exhibited partial compatibility, which was confirmed by dynamic mechanical analysis (DMA) and scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) analysis showed there is the interaction between PLA and PBD. In summary, the incorporation of PBD resulted in improved mechanical properties, indicating potential for applications requiring enhanced ductility.
研究领域:
高分子材料科学
·
生物医用材料
·
聚合物共混
·
材料力学性能
·
可降解高分子
✓ 已验证
DOI
高影响因子
Journal of Coatings Technology and Research
·
2017
·Vol. 15
·期 3
·505-514
·
IF 1.557
Zhao Yuan,Huang Chongxing,Bei Ronghua,Su Hongxia,Wang Shuangfei
Silicon oxide (SiO
x
) films are widely used as barrier layers in different types of commodity packaging and have caught the interest of manufacturers and researchers alike owing to their high barrier functionality, good acid and alkali resistance, ability to withstand high-temperature and microwave treatments, and good transparency. In this study, we first synthesized polylactic acid (PLA) films by extrusion calendaring and then deposited a SiO
x
layer on the PLA films by plasma-enhanced chemical vapor deposition to prepare SiO
x
/PLA composite films. We then evaluated the barrier functionality of the SiO
x
layer and elucidated its underlying mechanism. We also analyzed its effect on the mechanical properties of the composite films by comparing the oxygen and water vapor transmission rates, soil degradation performances, and surface morphologies of the two types of synthesized films (uncoated and coated with SiO
x
). The results showed that, because of the SiO
x
layer, the barrier properties and mechanical properties of the SiO
x
/PLA composite films were better than those of the uncoated films. In particular, the oxygen and water vapor transmission rates of the composite films were approximately 8–10 and 6–8 times lower, respectively, than those of the uncoated PLA films. In addition, the SiO
x
layer lowered the rate of soil degradation of the composite films, owing to which the weight-loss rates of the composite films were also lower than those of the uncoated films. Further, the tensile strengths and elongations at break of the composite films were higher because of the SiO
x
layer. Graphical
研究领域:
材料科学
·
高分子材料
·
包装工程
·
表面改性
·
生物降解材料
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2015
·
IF 3.005
Hongwei Zhang,Qijian Niu,Ning Wang,Jun Nie,Guiping Ma
In this research a thermo-sensitive drug loaded core–shell fibers were prepared by UV photo-polymerization combined with electrospinning technology. The biodegradable polymer polylactic acid (PLA) was used as the core with electrospinning and the N-isopropylacrylamide (NIPAM) was selected to be shell of the fibers via UV photo-polymerization, respectively. Combretastatin A4 (CA4) was used as the model drug loaded in PLA (core structure) to test the thermo-sensitivity of the core–shell fibers. SEM was performed to observe the morphology of the fibers. TEM was carried out to confirm the core–shell structure of the fibers. Furthermore, XPS and FTIR results demonstrated that the core–shell structure had been fabricated as designed. Water contact angle (WCA) test indicated that the fibers show different wettability when the temperature was below or above the lower critical solution temperature (LCST). Moreover, in vitro drug release test was conducted to explore the difference of the drug release when the temperature was at 25 °C and 40 °C. The cell culture studies showed that the prepared core–shell structure nanofibers have a potential application in the biomedical fields as tissue engineering.
研究领域:
生物材料
·
药物递送
·
组织工程
·
高分子科学
·
纳米医学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Le Li,Rui-Ying Bao,Tao Gao,Zheng-Ying Liu,Bang-Hu Xie,Ming-Bo Yang,Wei Yang
Improving the physical properties of biobased polymers using bionanofillers is essential to preserve its biodegradability. This work presents a dopamine-induced functionalization of cellulose nanocrystals (CNCs) with polyethylene glycol (PEG), to enhance the crystallization, mechanical and barrier properties of poly( L -lactic acid) (PLLA) bionanocomposites. The effect of molecular weight of grafted PEG on the properties of PLLA is also studied. PEGylation of CNCs significantly enhance the crystallization of PLLA, especially for CNCs functionalized with PEG of lower molecular weight, which lead to balanced strength and ductility, and 66.4% reduction in the oxygen permeability coefficient at a low content of 0.5 wt %. Moreover, 168% improvement of ductility for PLLA can be obtained by CNCs functionalized with longer PEG chains. The surface functionalization of CNCs proposed here opens up a green avenue towards designing and fabricating fully bio-based, high-barrier and low-cost polymer nanocomposites for packaging applications.
研究领域:
高分子材料
·
纳米复合材料
·
生物基包装
·
材料科学
·
聚合物改性
·
结晶动力学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 12
·51827
·
IF 3.125
Yuan Li,Lu Zhang,Fayong Li,Ke Wang,Xiaoru Wu,Hailu Liu,Bibo Long,Yang Zhao,Dong Xie,Junjia Chen
The hydrophobic modification of cellulose nanofibers (CNF) was carried out via free radical polymerization using methyl methacrylate (MMA) as the monomer to improve the compatibility between CNF and poly lactic acid (PLA). Followed by the preparation of the novel nanocomposites in combination of the organic montmorillonite and the substrate. The resulting nanocomposites were then coated on paper surface using a cast-coating process in an attempt to improve the barrier properties towards water vapor and oxygen. In addition, the composite films are prepared via a solution casting method. The water vapor transmission rate (WVTR), water vapor permeability (WVP), oxygen transmission rate (OTR), and tensile strength of the as-prepared films were systematically measured. The corresponding results demonstrated that the WVTR, WVP and OTR decreased with the addition of a certain content of MCNF in coatings. 0.2 wt% MCNF is the optimum content, showing the best gas resistance and tensile performance. The lowest value of WVTR and WVP are 10.30 g/(m 2 ⋯24 h) and 3306.58 g⋯μm/(m 2 ⋯24 h) for films with 0.2 wt% MCNF added, which is 88.23% and 26.05% lower than that of PLA composite film without NFC.
研究领域:
高分子材料
·
纳米复合材料
·
包装材料
·
表面涂层
·
生物基材料
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 17
·7456-7468
·
IF 4.5
Zhang Ning,Wang Zongliang,Zeng Yuqi,Guo Yueming,Wang Liqiang,Liu Jianguo,Wang Yu,Zhang Peibiao
Preformed three-dimensional scaffolds with insufficient mechanical properties, poor surgical performance, and morphological mismatch to defects with irregular shape have shown drawbacks in animal evaluations and clinical applications. This motivates the development of novel injectable systems to ideally fill bone defects, allowing in situ solidification within the host tissues while retaining high initial mechanical strength and appropriate porosity. In this study, an in situ forming scaffold with time-dependent pore formation inspired by the metamorphosis of a butterfly was fabricated by incorporating gelatin microspheres (GMs) into a poly(lactic-co-glycolic acid) (PLGA)-based injectable implant. After optimizing solvent, molecular weight and solution concentration of PLGA matrix, the injectable mixture could be easily injected into both aqueous solution and random-shaped grooves while in situ solidified instantaneously. The injectability enabled an in situ morphological match within an irregular bone defect, providing high initial strength in the early period. The toughness of the injectable implant also allowed them to be easily bent into a ring without breaking. Time-dependent pore formation was accomplished by gradual degradation of GMs, generating appropriate space for tissue ingrowth in the scaffold. It is expected that the injectable in situ forming implant would aid the bone healing process by maintaining initial mechanical support and creating a spatiotemporally evolutionary microstructure during bone tissue regeneration.
研究领域:
生物材料学
·
组织工程
·
骨科学
·
再生医学
·
高分子科学
·
药物递送系统
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）