JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2018
·Vol. 56
·期 14
·1520-1527
·
IF 2.588
Chunying Wang,Yunhui Li,Yuqin Ma,Ying Gao,Dewen Dong,Jianyong Fang,Ning Zhang
Hydrogen bonding is widely present and plays a significant role in material science and supramolecular chemistry. This work reports a straightforward strategy for the preparation of polymeric nanoparticles from neutral poly(2-oxazoline)s (POx) and tannic acid (TA) driven by their intermolecular hydrogen bonding. Dynamic light scattering (DLS) and scanning electron microscope (SEM) measurements showed that POx bearing different substituents, that is, methyl, ethyl and n -propyl in the 2-position all could assemble with TA into stable nanoparticles in water or ethanol. The diameter of the assembled nanoparticles could be manipulated by varying parameters such as molecular weight of POx, concentration and ratio of POx, and TA. Interestingly, POx/TA nanoparticles exhibited upper critical solution temperature (UCST)-type thermoresponsive properties in ethanol or water depending on the molecular weight and substituent in the 2-position of POx. Increasing or decreasing the temperature at the transition point resulted in the reversible transformation between assembled nanoparticles and disassembled poly(2- n -propyl-2-oxazoline) (PnPrOx) and TA. In view of the tailored size of the stable nanoparticles and the biocompatibilities of POx and TA, the prepared thermoresponsive nanoparticles are promising candidates as carriers for medicine toward related biomedical applications. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 1520–1527
研究领域:
材料科学
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超分子化学
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生物医学
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 41
·6650-6657
·
IF 5.342
Shanshan Chen,Tingting Sun,Zhigang Xie,Dewen Dong,Ning Zhang
Mobile divalent zinc, Zn(II), is an essential cofactor involved in mammalian biological processes. To understand the intrinsic action mechanism of mobile zinc, the development of a Zn2+-selective fluorescent probe that can detect mobile zinc via biological imaging is of great significance. We present here a novel Zn2+-selective fluorescent sensor based on poly(2-oxazoline) (POx) cylindrical molecular brushes with good water solubility and biocompatibility. The POx molecular brushes were end-capped by a Zn2+-responsive functionality, which can give efficient blue emission upon coordination with zinc ions. Fluorescence investigation indicates that the POx molecular brushes exhibit superior selectivity toward Zn2+ in comparison with most competitive heavy and transition metal ions. Due to the ease of cellular uptake that results from their unique molecular contour, POx molecular brushes are capable of detecting intracellular Zn2+ ions as demonstrated by living cell fluorescence studies.
研究领域:
生物化学
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材料科学
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分析化学
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DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 25
·4164-4171
·
IF 5.342
Muhammad Waqas Ali,Zahir Muhammad,Qun Jia,Lianwei Li,Muhammad Saleem,Muhammad Siddiq,Yougen Chen
Cyclic poly(2-ethyl-2-oxazoline) (PEtOx) with a degradable disulfide bond has been synthesized by combining cationic ring opening polymerization (ROP) and reversible thiol/disulfide exchange chemistry. In greater detail, a living linear PEtOx with two cationic propagating terminals was initially synthesized using 1,3-bis(bromomethyl)benzene as a difunctional initiator. Both the living ends of PEtOx were then reacted with potassium ethyl xanthate to afford α,ω-xanthate end-functionalized PEtOx (xanthate-PEtOx-xanthate). The xanthate groups were then in situ cleaved using n-butylamine as a cleaving agent as well as a base in the same reaction media, which produced α,ω-thiol end-functionalized PEtOx (HS-PEtOx-SH). The cyclic polymer was eventually obtained by the successive intramolecular oxidation coupling of the thiol terminals of HS-PEtOx-SH to form a disulfide bond as a ring-closure link. For the polymeric information, 1H NMR spectroscopy, SEC spectroscopy, MALDI-TOF-MS, and UV-visible spectroscopy were combined to characterize the linear and cyclic polymers. Ellman's assay was used to determine the thiol content in the cyclic and thiol terminated polymers. Clean cyclic PEtOxs with number-average molar masses around 2000 (2 K) and 4000 (4 K) g mol−1 were obtained at an unreported high polymer concentration of 5 g L−1 (ca. 2.5 × 10−3 M for the 2 K polymer and ca. 1.25 × 10−3 M for the 4 K polymer) in THF. In addition, the synthetic route was compared with the intramolecular copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction and proven to be more advantageous in terms of reactant concentration, yield, purification, and bonding reversibility.
研究领域:
高分子化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2012
·Vol. 291
·期 4
·919-925
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IF 2.331
Ambreen Jaweria,Yang Jinxian,Ye Xiaodong,Siddiq Mohammad
The temperature-induced phase transition of poly(2-ethyl-2-oxazoline) (PEtOx) aqueous solution under mixing with a series of small carboxylic acids has been studied by turbidity measurements and laser light scattering. It has been found that cloud point temperature ( T
cp ) of the PEtOx was changed to varying degrees depending upon the pH, ionic strength, molar ratio of acids to 2-ethyl-2-oxazoline unit, and carbon chain length of small carboxylic acids. Significant change in T
cp was observed in the case of hexanoic acid. At acidic pH, an increase in the molar ratio of hexanoic acid to the 2-ethyl-2-oxazoline unit gradually decreased the phase transition temperature of the polymer as compared to the T
cp of pure PEtOx. At original pH 6 (pH > p K
a ), T
cp shifts to higher value than that of pure PEtOx for lower molar ratios and decreased later on with increasing the molar ratio. The shift in the T
cp is described based on the differences in the driving force of phase transition, including hydrogen bonding between small carboxylic acids and PEtOx polymer and hydrophobic interaction.
研究领域:
高分子化学
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物理化学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2016
·Vol. 27
·期 11
·11142-11150
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IF 1.798
Xiong Shanxin,Kong Zhenzhen,Lan Jinpeng,Yi Siyuan,Wang Yuyun,Zhang Runlan,Gong Ming,Wu Bohua,Chu Jia,Wang Xiaoqin
This paper demonstrates a simple and effective approach to fabricate highly crystalline poly(2,5-dimethoxyaniline) (PDMA) nanoplates using various organic sulfonic acids including Dodecyl benzenesulfonic acid (DBSA), Camphorsulfonic acid (CSA) and p -Toluenesulfonic Acid ( p -TSA) as the dopant agents. The structures and morphologies of PDMA nanoplates were characterized using Fourier transform infrared spectrometer, Raman spectrometer, X-ray diffraction, Atom force microscope and Electron microscope. The results show that the PDMA nanoplates possess high crystallinity and layered nanoplate aggregation structure. The estimated degree of crystallinity is higher than 95 %. With different organic sulfonic acids used, the aggregation structures of PDMA nanoplates vary from triclinic hexahedron to cuboid and rod shape. Through adjusting the dopant agent/monomer molar ratio, the yield of PDMA nanoplates can be as high as 53 %.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
Shihui Qiu,Gang Liu,Wei Li,Haichao Zhao,Liping Wang
Impermeable and rigid graphene nanosheet is regarded as the thinnest corrosion protection layer and superior solid lubricant up to now, and has been largely reported and used for metal anticorrosion and wear reduction in both academic and industrial field. Here, we obtain few-layers graphene functionalized by poly (2-aminothiazole) (PAT) with free basal plane defects in organic solvent on the basis of π−π interaction between them. The barrier performance of composite coating with PAT-G hybrids is evaluated by water uptake and electrochemical measurement in 3.5 wt % NaCl solution compared to neat epoxy coating and PAT-based coating. The wear reduction of PAT-functionalized graphene-based coating is investigated via friction test. Composite coating with PAT-G hybrids exhibited excellent anticorrosion performance and wear reduction thanks to the multifunctional graphene and passive effect of PAT. The optimized specimen PAT-G 0.5% shows a superior barrier property during 80 days' immersion and exhibits the lowest wear rate, which is reduced by 69.48% relative to neat epoxy.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2020
·
IF 2.69
Ye Han Yan,Muhammad Atif,Ren Yong Liu,Hai Kun Zhu,Li Juan Chen
In this work, the comb-like poly(2-methyl-2-oxazoline) copolymer, poly(2-aminoethyl methacrylate-random-poly(2-methyl-2-oxazoline) (PMOXA-r-AEMA, PMA) is synthesized, and the CuSO4/H2O2-triggered dopamine/PMA co-deposition process is investigated. Ellipsometry, water contact angle (WCA), and X-ray photoelectron spectroscopy (XPS) are used to characterize the thickness, hydrophilicity, and surface composition of PMA-based coatings. PMA is facilely anchored to substrates within 60 min with the assistance of dopamine/polydopamine triggered by CuSO4/H2O2, and the coating thickness can achieve about 13 nm. Anti-protein adsorption and anti-blood platelet adhesion measurements are also studied to verify their antifouling properties. The adsorption capacity of FITC-BSA can be reduced to 5% of the original surface, and PMA-based coatings present excellent protein-resistant properties (∼95% reduction relative to gold surface) according to surface plasmon resonance (SPR) measurement, and it can resist adhesion of almost all blood platelets. Moreover, it is applied to a capillary inner wall for surface modification. An alkaline protein mixture and egg white proteins are successfully separated, and present excellent stability. The relative standard deviation (RSD) of migration time is lower than 0.71%. The practicability of this promising PMA-based coatings with this preparation strategy can be used for further proteomics analysis.
研究领域:
材料科学
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生物医学工程
·
表面化学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 44
·7785-7794
·
IF 0
Longchao Bai,Lin Tan,Lijuan Chen,Songtao Liu,Yanmei Wang
Poly(2-methyl-2-oxazoline) (PMOXA) has been proved to be a kind of potential antifouling coating material. In this work, a series of comb copolymers, poly[(2-methyl-2-oxazoline)-random-glycidyl methacrylate] (PMOXA-r-GMA), with a variety of compositions were synthesized by free radical polymerization of the oligo(2-methyl-2-oxazoline) methacrylate macromonomer and glycidyl methacrylate, and then characterized and used to coat silicon/glass surfaces. A one-step coating procedure by a simple annealing protocol was used to yield covalent and cross-linked PMOXA-based antifouling coatings. The coatings were rigorously characterized in terms of the surface chemical composition, hydrophilicity, thickness and morphology using X-ray photoelectron spectroscopy (XPS), the water contact angle (WCA) test, ellipsometry and atomic force microscopy. The results demonstrated that the PMOXA-r-GMA brushes could successfully be bonded onto silicon/glass surfaces. Finally, the fouling resistance ability of the modified surface was evaluated by analyzing the adsorption of bovine serum albumin protein, bacterial cell attachment and platelet adhesion, which indicated that the modified silicon/glass surfaces had a superior resistance to protein, bacterial cell and platelet adsorption, and the performance of fouling resistance was enhanced with the content of PMOXA segments in the copolymers.
研究领域:
材料科学
·
生物医学工程
·
表面化学
✓ 已验证
DOI
PubMed
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2019
·Vol. 304
·期 4
·1800685
·
IF 3.038
Haikun Zhu,Lijuan Chen,Chong Zhang,Muhammad Atif,Kai Gong,Chaoshi Chen,Yanmei Wang
A series of the copolymer, poly(styrene-random-glycidyl methacrylate) (P(St-r-GMA)), is synthesized by free radical polymerization, and characterized by 1 H NMR spectroscopy and gel permeation chromatography. The various substrates are then modified by P(St-r-GMA) under ultraviolet (UV) irradiation. Subsequently, the poly(2-methyl-2-oxazoline) (PMOXA) based coatings are prepared by anchoring amino-terminated PMOXA onto the P(St-r-GMA) modified surfaces through the reaction between the amino group of PMOXA and epoxy group of P(St-r-GMA). The results of ellipsometry, X-ray photoelectron spectroscopy, atomic force microscopy, and water contact angle reveal that PMOXA-based coatings can be prepared successfully on the substrates through UV-crosslinked P(St-r-GMA) as anchoring coatings. Besides, the PMOXA-based coatings display not only a superior antifouling property but long-term stability as well. Furthermore, the location of the coating formed on the substrate can be well controlled through selecting the site of UV irradiation, which can be utilized for the selectivity of protein adsorption (or resistance) on special devices.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2022
·
IF 2.042
Abdullah Akhdhar,Amr A. Yakout
Heavy metals sequestration from industrial discharges has aroused increasing attention worldwide to cleaner and sustainable water production by developing fast, effective eco-friendly nanosorbents. This study aimed to design a robust and fast nanocomposite to remove heavy metal ions, mainly Pb(II) and Cd(II). To this end, poly-(2-aminothiophenol); PATP was incorporated into graphene oxide; GO to fabricate PATP@GO nanocomposite. The structure and morphology of the novel nanocomposite were evaluated by FTIR, TEM, XRD, Raman, EDX, and TGA. Integrating PATP improved the adsorption efficiency of the GO from 61.3% to 98.6% for Pb(II) and 34.6% to 87.3% for Cd(II). Furthermore, the impact of pH, the mass of nanocomposite, metal ions concentrations, and coexisting ions were thoroughly investigated and optimized. The potential efficiency and adsorption capacity of PATP@GO nanocomposite toward Pb(II) was 98.6.00%, 142.9 mg.g-1 for Pb(II) at pH 5 and 87.3%, 125.0 mg.g-1 for Cd(II) at pH 7 within 25 minutes, respectively. This behavior was explained in terms of strong complex formation with the thiol groups of PATP, as well as the hydroxyl and carboxyl groups in GO. Kinetic studies were based on pseudo-second order (R2 > 0.99) and the adsorption data are best fitted with the Langmuir model. The excellent stability of PATP@GO nanocomposite enabled effective extractions for seven successive runs (98.6%-95.3% for Pb(II) and 87.3–85.1% for Cd(II)). The developed PATP@GO nanocomposite is believed to show fast and high potential in detoxifying of heavy metal ions from different environmental samples in aquatic life.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Xin Bai,Jian Nie,Siyao Cheng,Daohu Sheng,Jijun Xiao,Wei Dong
The development of non-viral gene delivery systems often requires balancing transfection efficiency and cytotoxicity, particularly when using cationic polymers. Poly(2-hydroxypropenimine) (PHP), with its hydroxyl groups, presents a more biocompatible alternative to traditional polymers such as polyethyleneimine (PEI). In this study, we explored the potential to enhance PHP’s transfection capabilities and reduce its cytotoxicity through a targeted fluorination strategy. Specifically, fluorinated alkyl groups were grafted onto PHP via an ethylene oxide ring-opening reaction, with the reaction conditions optimized for temperature, solvent, and time to ensure efficiency. Transfection experiments using HEK 293 cells demonstrated that fluorinated PHP variants, especially PHP-FH8 16 , significantly improved transfection efficiency, achieving a 75.1 % gene expression rate at an N/P ratio of 2, compared to 44.0 % for unmodified PHP. The transfection experiments in Hela cells also showed substantial transfection efficiency. The gene expression rate was 53.2 % at an N/P ratio of 2 compared to 31.6 % for unmodified PHP. Notably, the fluorinated polymers exhibited lower cytotoxicity and increased serum stability, which suggests their potential as safer gene delivery systems. This study carefully evaluates the feasibility of using fluorinated cationic polymers as next-generation gene delivery vectors, balancing efficacy and safety. It underscores the strategic application of fluorination technology in developing modified polymer vectors that could lead to more efficient and safer non-viral gene therapy solutions.
研究领域:
生物材料学
·
基因治疗
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS RESEARCH INNOVATIONS
·
2025
·
IF 0
Pingli Dai,Di Zhu,Li Jiang,Qimin Jiang,Hongjun Yang,Wenyan Huang,Xiaoqiang Xue,Bibiao Jiang
This paper takes poly2-hydroxyethyl methacrylate (PHEMA) as an example, the effects of linear and branched structures on the microrheological properties of polymers are studied to further supplement and further understand the importance of microrheological properties for optimising material properties and expanding the scope of application. The experimental results show that the higher the molecular weight of linear PHEMA, the higher the storage modulus and the higher the complex viscosity; the higher the degree of branching of branched PHEMA, the lower the storage modulus and the lower the complex viscosity. The mean square displacement of tracer particles in isopropanol solutions of linear and branched PHEMA has a good linear relationship with the lag time, and the slope of the curve of linear PHEMA(0.74 ~ 0.86) is smaller than that of branched PHEMA(0.91 ~ 0.95). The loss factor of linear PHEMA is lower than that of branched PHEMA.
研究领域:
材料科学
·
高分子化学
·
流变学
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）