ACS Omega
·
2018
·
IF 0
Guorong Gao,Liufang Wang,Yang Cong,Zhenwu Wang,Yang Zhou,Rong Wang,Jing Chen,Jun Fu
Hydrogel actuators that deform in response to external stimuli have promising applications in diverse fields. It is desirable to develop robust hydrogels with multiple and synergistic stimuli responsiveness. This work reports on robust poly(NIPAM-co-DMAPMA)/clay hydrogel bilayers that undergo reversible and repeatable curling/uncurling in response to pH and/or temperature changes. The bilayers are fabricated by sequential synthesis of thermoresponsive N-isopropylacrylamide (NIPAM) and N-[3-(dimethylamino)propyl] methacrylamide (DMAPMA) monomers, which produces robust interface bonding between the layers. Different NIPAM/DMAPMA ratios were used between two gel layers to manipulate the asymmetric responsiveness, thus leading to curling/uncurling of bilayers upon exposure to stimuli. The hydrogel bilayers are fabricated into soft manipulators to grasp and release target objects by pH and temperature changes, and as artificial muscle to lift and move a hanging weight by synergistic pH and temperature stimuli. This work provides a new type of asymmetric responsive hydrogel bilayer with potential applications in biomimetic actuators.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
TALANTA
·
2021
·
IF 6.057
Huiting Wang,Li Dong,Ling Zhang,Xiangxiang Chen,Qian Zhang,Lixin Xia
A thermally responsive hybrid poly(NIPAm- b -BVIm[FcCOO])-rGO composed of block co-polymer poly(NIPAm- b -BVImBr), reduced graphene oxide (rGO) and electroactive anions was designed and synthesized to achieve electroactive functionality. It is the polymeric ionic liquids (PILs) segment in the block co-polymer that integrated the three different components into a whole hybrid. Such segment of PILs could not only promote the modification of polar PNIPAm onto the non-polar rGO by cation-π interaction, but also realize the immobilization of ferrocenecarboxylate anion (FcCOO − ) via anion-exchange reaction. The PNIPAm moiety endowed the poly(NIPAm- b -BVIm[FcCOO])-rGO with thermal responsiveness, while the anion moiety provided additional electroactive function. It is noteworthy that the conformational change of PNIPAm segment upon different temperature could reveal or seal the redox probe of FcCOO − , thereby leading to a controllable expression of electroactivity switching by thermal stimuli. Owing to such regulation on surface property and conformation of PNIPAm segment, the modified electrode exhibited excellent thermally responsive electrocatalysis with reversible ‘ON-OFF’ effect toward the detection of ascorbic acid (AA), which led to two different catalytic states at the same electrode. The reversible electrocatalytic performance with switching capability of the poly(NIPAm- b -BVIm[FcCOO])-rGO/GCE is expected to have a broad application in the field of intelligent electrochemical sensors and devices.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 100
·98147-98152
·
IF 3.289
Yuting Cai,Gaolai Du,Guorong Gao,Jing Chen,Jun Fu
Monodisperse poly(NIPAM-co-AAc) microgels doped with either a monocolour photoluminescent quantum dot (QD) or multiple colour QDs have been fabricated by the charge-driven introduction of cysteamine-capped CdTe QDs and the collapse of the polymer network by adjusting the pH of the solution. The photoluminescence intensity and colour of the resulting microgels can be easily adjusted by changing the content of the CA–CdTe QDs in the hybrid microgels and using single or a mixture of different-sized QDs, respectively. In addition, the microgel-encapsulated QDs showed blue shifts, owing to surface coordination by the carboxylic acid. The combined effect of electrostatic interactions and surface chelating resulted in a reduction in microgel size. By tuning the ratio of QDs with different sizes, the photoluminescence of the hybrid hydrogels could be conveniently controlled. This work provides a facile and versatile method to fabricate colour-tunable or multifunctional hybrid hydrogels with broad potential applications.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2019
·Vol. 30
·期 35
·355604
·
IF 3.399
Keju Zhang,Dong Zhou,Zhiguo Wang,Yuhong Zhang,Peixin He
The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m2 g−1, 3.7 nm, 0.58 cm3 g−1, respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA–MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA–MSNs demonstrated high drug encapsulation efficiency (70.4% ± 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 111
·91308-91314
·
IF 3.84
Chunning Heng,Meiying Liu,Ke Wang,Xiaoyan Zheng,Hongye Huang,Fengjie Deng,Junfeng Hui,Xiaoyong Zhang,Yen Wei
A highly benign, simple and effective strategy was successfully developed for the first time for the fabrication of hydrophilic thermo-responsive polymer modified silica nanoparticles (SiO2-PDA-poly(NIPAM)) at low temperature and under mild reaction conditions via a combination of mussel inspired chemistry and SET-LRP. The SiO2 NPs were first modified with polydopamine (PDA), which was formed by the self-polymerization of dopamine under rather mild conditions. 2-Bromo-2-methylpropionyl bromide was covalently attached on the surface of the PDA modified SiO2 NPs. Afterward, the poly(NIPAM) was grown in situ on the surface of the Br-containing SiO2 NPs by the SET-LRP method. Consequently, the surface of the SiO2-PDA nanoparticles is intrinsically covered by a layer of free poly(NIPAM) chains, which enables the poly(NIPAM) to be colloidally stable not only at room temperature, but also upon incubation in the presence of proteins under physiological conditions. After modifying with PNIPAM, the functional SiO2 NPs retain their pristine structure, however their dispersibility was significantly improved in polar and nonpolar solutions. As compared with previous methods, the strategy developed in this work is rather simple and effective. More importantly, due to the universality of mussel inspired chemistry, this novel strategy could also be used for the surface modification of many other materials.
研究领域:
材料科学
·
聚合物化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Huali Li,Liuqin Zhang,Xiaohu Zhang,Shuwen Luo,Baoshan Yang,Min Wu,Wei-Hua Li,Fa-Qian Liu
The antifouling of marine facilities placed below the waterline is a key constraint to the development of the marine economy. Currently, commercial Cu 2 O-based antifouling coatings still have defects such as agglomeration, oxidation, short duration and high dosage. For this reason, we developed for the first time a triple antifouling system consisting of Cu 2 O@poly(NIPAM-co-DAm) (Cu 2 O@PND) dynamic redox microgels triggered by copper ions and polydimethylsiloxane (PDMS). The catechol groups of PND nanogels can chelate Cu 2+ and reduce it in situ to obtain Cu 2 O@PND microgels, which guarantees the stable release of Cu + . Furthermore, Cu 2 O remains stable and free from oxidation because of the electron transfer between PND and Cu 2+ . Finally, superior antifouling performance was achieved by combining the stable Cu + released from Cu 2 O, in situ conversion of PND to hydrogel, and its oxidation to produce active substances and H 2 O 2 , and PDMS coating with low surface energy.
研究领域:
材料科学
·
化学
·
海洋工程
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 22
·2201155
·
IF 17.521
Xiaocheng Wang,Yunru Yu,Chaoyu Yang,Luoran Shang,Yuanjin Zhao,Xian Shen
Biological scaffolds hold promising perspectives for random skin flap regeneration, while the practical application is greatly limited by their insufficient vascularization ability and the lack of responsiveness during the dynamical healing process. Herein, a novel MXene-incorporated hollow fibrous (MX-HF) scaffold with dynamically responsive channels is presented for promoting vascularization and skin flap regeneration by using a microfluidic-assisted 3D printing strategy. Benefiting from the photothermal conversion capacity of the MXene nanosheets and temperature-responsive ability of poly(NIPAM) hydrogels in the MX-HF scaffolds, they display a near-infrared (NIR)-responsive shrinkage/swelling behavior, which facilitates the cell penetration into the scaffold channels from the surrounding environment. Moreover, by incorporating vascular endothelial growth factor (VEGF) into the hydrogel matrix for controllable delivery, the MX-HF scaffolds can achieve promoted proliferation, migration, and proangiogenic effects of endothelial cells under NIR irradiation. It is further demonstrated in vivo that the NIR-responsive VEGF@MX-HF scaffolds can effectively improve skin flap survival by promoting angiogenesis, decreasing inflammation, and attenuating apoptosis in skin flaps. Thus, it is believed that such responsive MX-HF scaffolds are promising candidates for clinical random skin flap regeneration as well as other diverse tissue engineering applications.
研究领域:
组织工程
·
生物医学工程
·
再生医学
·
材料科学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Matter
·
2020
·Vol. 16
·期 46
·10558-10566
·
IF 3.14
Qiaofeng Gao,Jing Hu,Jianmin Shi,Wenwei Wu,Dereje Kebebew Debeli,Pengju Pan,Guorong Shan
A graphene oxide/poly(N-isopropylacrylamide-co-β-cyclodextrin) (GO/poly(NIPAM-co-β-CD)) hydrogel has been synthesized through host–guest interaction between β-cyclodextrin (β-CD) and the isopropyl group of N-isopropylacrylamide (NIPAM). The product exhibits rapid responses to the stimuli of temperature and near-infrared (NIR) irradiation, self-healing properties, and excellent mechanical properties. The host–guest interaction serves as the main physical cross-linker, while a hydrogen bond between the hydroxyl group of β-CD, GO sheets and amide group of NIPAM acts as a secondary cross-linker. The volume phase transition temperature and NIR response rate of such a hydrogel are controlled by its contents of β-CD and GO. The obtained hydrogels showing excellent properties might be applied in remote contactless control devices in advanced smart technologies. Based on the excellent characteristics of the hydrogels, remote light-controlled switches have been designed, and more applications will be explored, such as intelligent light-controlled drivers and soft robots.
研究领域:
材料科学
·
聚合物化学
·
纳米技术
·
智能材料
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）