JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Hui Shao,Bingqiao Yang,Huihua Luo,Ruiqi Ge,Jie Wu
In this study, N-OSS combined with DDA was examined as an novel collector. The collecting performances and their synergetic interaction mechanisms were investigated comprehensively. The micro-flotation results illustrated N-OSS/DDA exhibited excellent selectivity on separation without pre-activation. Contact angle tests revealed N-OSS/DDA could selectively enhance the hydrophobicity of spodumene, whereas, they barely affected that of albite. FTIR, SEM-EDS and Zeta potential revealed N-OSS/DDA might co-adsorb on spodumene surface rather than that of albite. XPS analysis and DFT calculations inferred the O 1 2p orbitals of -COO- within N-OSS could bond with Al 3s orbitals and the -NH 3 + groups of DDA adsorbed onto spodumene surface via hydrogen bonding and electrostatic attraction. Meanwhile, the hydrogen bonding between N-OSS and DDA promoted the co-adsorption on spodumene surface. While N-OSS/DDA weakly adsorbed on albite surface through physical adsorption. N-OSS/DDA exhibited outstanding floatability, which maybe a good substitute for conventional collectors in future.
研究领域:
矿物加工工程
·
表面化学
✓ 已验证
DOI
高影响因子
TALANTA
·
2017
·
IF 4.162
Zhonghua Xue,Hui Wang,Honghong Rao,Nan He,Xiaofen Wang,Xiuhui Liu,Xiaoquan Lu
Indicator displacement assay plays a fundamental role in the development of chemosensors . We explored here an ingenious yet effective strategy for amperometric assay of electrochemically inactive sarcosine based on an indicator displacement principle, in which 1,2-naphthoquinone-4-sulphonic acid sodium salt (NQS) was proposed as the receptor and the electroactive Ru(NH 3 ) 6 3+ cations used as an indicator. Due to the stronger binding affinity of the NQS toward sarcosine than toward Ru(NH 3 ) 6 3+ , the developed amperometric indicator displacement assay (A-IDA) exhibits high selectivity and excellent sensitivity toward sarcosine determination as well as with a lower detection limit (30.00 nM, S/N =3).
研究领域:
分析化学
·
生物医学工程
·
电化学传感器
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yubin Sun,Shuming Wen,Qicheng Feng,Yanyu Tang,Yongchao Miao,Xu Wang,Zhihao Shen
This work explored the application of sodium lauroyl sarcosinate (SLAS) as a green surfactant in rutile flotation systems. A detailed examination of the flotation behavior and adsorption characteristics of rutile was conducted, particularly under Pb 2+ ion-modified conditions. The experimental methodology incorporated multiple analytical techniques: micro-flotation experiments, surface potential analysis, adsorption quantification, FTIR spectroscopy, SEM-EDS characterization, XPS surface analysis, and computational DFT simulations. Micro-flotation experiments demonstrated that under the optimal conditions (SLAS concentration of 2.8 × 10 −4 mol/L, pH 3), a rutile recovery of 81.49 % was obtained. Notably, as the pH increased, the recovery of rutile exhibited a decreasing trend. Following Pb 2+ modification (8.0 × 10 −5 mol/L) combined with SLAS treatment (2.8 × 10 −4 mol/L), the rutile demonstrated consistent flotation recovery exceeding 90.02 % across a broad pH range (3 ∼ 7). The adsorption capacity experiments and SEM-EDS results indicated that multiple SLAS layers were adsorbed on the rutile. Moreover, Pb 2+ modification improved the favorability of SLAS adsorption. A combination of surface potential measurements and infrared spectroscopy confirmed the chemical adsorption mechanism of SLAS on positively charged rutile surface atoms. XPS characterization confirmed that the SLAS oxygen atoms chemically bonded with the rutile surface Ti/Pb atoms. DFT simulations demonstrated that the adsorption processes were spontaneous, with Pb 2+ and SLAS respectively, forming O − Pb and Ti − O bonds on the (110) surface. This mechanism explains how Pb 2+ enhances the SLAS adsorption capacity and subsequent flotation efficiency of the rutile. These studies proved the industrial potential of environmentally friendly collector SLAs in rutile flotation.
研究领域:
矿物加工工程
·
表面化学
·
计算化学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Ronglu Cui,Kai Hao,Yunyun Xue,Chuyao Wang,Shuyang Shen,Zihao Zhao,Yu Zhao,Jun Ling,Baoku Zhu,Lifeng Fang
Polysarcosine (PSar), a polypeptoid with a chemical structure resembling natural amino acids, stands out as a prominent non-ionic polypeptoid due to its outstanding water solubility and biocompatibility. These extraordinary properties make PSar a highly appealing material for a wide range of biomedical applications, especially in biocompatible membranes. However, due to its high-water solubility, PSar is inherently not stable enough for membranes. It is an effective way to apply PSar in membrane field by improving its stability while ensuring the hydrophilicity. Here, a novel copolymer, consisting of PSar and polysulfone (PSF) blocks (PSF- b -PSar, denoted as PSbS), is presented and synthesized by ring-opening polymerization (ROP) of N -phenyloxycarbonyl-sarcosine (Sar-NPC), which is used as a functional skin layer on PSF substrates. The results demonstrated that the PSbS performed a highly hydrated layer on the membrane surface, thus mitigating interactions between biomolecules and biological entities. Notably, the PSbS/PSF membrane showed improved antifouling, biocompatibility, hemocompatibility and stability. Moreover, the hemolysis rate of the composite membrane was reduced to 0.56%, and the activated partial thromboplastin time (APTT) was effectively prolonged. In summary, this work proposed a strategy for solidifying PSar on the membrane surface as the non-water-soluble amphiphilic polymer, which is promising in the biomedical applications, especially in biocompatible membranes.
研究领域:
材料科学
·
生物医学工程
·
聚合物化学
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Hui Shao,Bingqiao Yang,Huihua Luo,Huanyu Zhu,Ruiqi Ge,Jie Wu
In this study, N-OSS was explored as an efficient collector in the flotation of spodumene from albite. The flotation behaviors were examined by micro-flotation tests and the interaction mechanisms were comprehensively uncovered from atomical scale. It indicated N-OSS could effectively collect spodumene from albite at low temperature and N-OSS was more inclined to adsorb on spodumene surface than that on albite surface, thus significantly expanding the hydrophobicity difference. X-ray photoelectron spectroscopy (XPS) analysis suggested that N-OSS chemically interacted with both Ca and Al active sites on Ca-activated spodumene surface. Whereas, it weakly adsorbed on Ca-activated albite. Density functional theory (DFT) calculations reconfirmed that the adsorption of N-OSS on Ca-activated spodumene surface was more favorable than that on albite surface. The strong adsorption on spodumene was due to the hybridization reaction between the O 2p orbitals of C-O and C=O groups of N-OSS with Ca 4s orbitals as well as Al 3s orbitals on spodumene surface. Nevertheless, N-OSS weakly interacted with Ca atoms on Ca-activated albite due to steric hindrance. N-OSS exhibited selective collecting ability at low temperature in the flotation of spodumene from albite compared with conventional collector, which has promising prospects in the low-temperature flotation of spodumene from albite.
研究领域:
矿物加工工程
·
材料科学与工程
·
计算化学
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Muhammad Ibrar,Tao Wang,Yanqing Luo,Yajun Ruan,Shiqinq Zhu,Yue Wu,Shuangfei Li,Ming Ying,Xuewei Yang
Multicomponent heteronanostructures offering catalytic and optical properties have applications across various fields. Photonic crystals (diatom frustules) coated with Au and copper chalcogenide domains represent a unique nanosystem that integrates multiple plasmon resonances from guided-mode resonance, conduction electrons, and valence holes in a single nanoscale system. In this work, we fabricate an enzyme-assisted photonic crystal-enhanced plasmonic nanosystem using a live diatom (Thalassiosira pseudonana) for surface-enhanced Raman scattering (SERS) quantification of sarcosine, an early stage prostate cancer (PCa) biomarker. The biosynthesized heteronanostructure was constructed by coating bimetallic nanoparticles (Au/CuX) on the diatom frustule via a two-stage cultivation process. A silaffin peptide-tagged sarcosine oxidase (SoX) was designed for specific substrate recognition and oriented conjunction. The components were coupled into a single entity (SoX-immobilized Au/CuX-coated frustule, BioNPS) to overcome the interenzyme distance and analyte trade-offs between mass transport. The sarcosine detection by BioNPS outperforms suspended bimetallic nanoparticles and single NP-coated diatom frustules. The improvement is attributed to the coupling of photonic frustule guided-mode resonance to the localized surface plasmonic resonance of bimetallic NPs via both electromagnetic and CT mechanisms. The cascade reaction in close proximity greatly enhances the catalytic efficiency by 5.47-fold compared to the solution-phase assay. The biochem nanosystem precisely detects tiny sarcosine concentration changes in the urine samples of PCa patients and healthy individuals. As a proof of concept, the in vivo fabrication of photonic/plasmonic heterostructures with tunable properties holds great promise for noninvasive biomarker screening.
研究领域:
纳米技术
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生物医学工程
·
癌症研究
·
材料科学
·
分析化学
·
生物物理学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Kai Hao,Ronglu Cui,Lifeng Fang,Jun Ling,Baoku Zhu
Polysarcosine (PSar) is an electrically neutral and excellently hydrophilic polypeptoid showing limited interaction with proteins and cells, which possesses better biocompatibility compared with polyethylene glycol. However, the immobilization of PSar is difficult due to the high water solubility. Herein, lysine-sarcosine PiPo, which was the random copolymer of lysine and sarcosine (PLS), was synthesized via a phosgene-free and water-tolerable polymerization of N-phenyloxycarbonyl-amino acids for the first time. PLS was immobilized by tannic acid (TA) on the polysulfone (PSf) membrane for a short time to obtain a neutral surface. The modified membrane showed improved hydrophilicity, decreased protein adsorption, and low cytotoxicity. Moreover, barely any hemolysis, no platelet adhesion, prolonged clotting time, and low complement activation further suggested good hemocompatibility. In order to improve the antifouling ability of the membrane under pressure, the neutral surface was oxidized by sodium periodate, which accelerated the chemical reaction between amino groups in PLS and phenolic hydroxyl groups in TA. Meanwhile, carboxyl groups generated due to the decomposition of TA and a negatively charged surface were obtained. While maintaining the good properties of the unoxidized one, the hydrophilicity of the oxidized membrane was improved and the clotting time was further prolonged. Besides, the filtration recovery of the oxidized membrane was improved remarkably. This approach of rapid immobilization of PSar has great potential for applications in the biomedical area, especially for blood-contacting materials.
研究领域:
生物医学工程
·
材料科学
·
生物材料
·
血液相容性
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2018
·Vol. 41
·期 15
·3121-3128
·
IF 2.415
Yuan Huang,Xiaobing Huang,Liping Huang,Qicai Liu,Yun Lei,Lijuan Yang,Liying Huang
Sarcosine is a potential prostate cancer marker. In this study, we developed a method of three-phase solvent bar liquid-phase microextraction combined with high-performance liquid chromatography to determine sarcosine after derivatization with 4-dimethylarminoazobenzene-4-sulfonyl chloride from human urine. The effects of different extraction conditions on extraction efficiency were investigated and optimized. Under optimum experimental conditions, a calibration graph exhibited linearity over the range of 0.05–25 μmol/L with a correlation coefficient ( r 2 ) of 0.9990. The enrichment factor was 168, and the detection limit was 0.02 μmol/L. The method was successfully used to analyze sarcosine in human urine and non-invasive detection, and good spiked recoveries ranging from 90.5 to 93.6% were obtained. The proposed method exhibited high sensitivity, high enrichment factor, good precision, and a simple setup. It may contribute to the early accurate diagnosis and the progression monitoring of prostatic carcinoma.
研究领域:
分析化学
·
医学诊断
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2021
·
IF 5.161
Mengle Huang,Yanjun Tang,Peng Zhu
The dispersibility of the carbon black (CB) in aqueous phase is rather critical for its application in paper coatings . In the present work, sodium N-lauroylsarcosinate/hypromellose (HPMC) was developed/prepared via hydrated reaction, which was subsequently used as a dispersant for improving the dispersibility of CB dispersion. The effects of the as-prepared dispersant on the dispersibility and rheological behavior of the CB dispersion were systematically studied, and the microstructure and properties of the CB dispersion were comprehensively characterized. The results showed that the presence of dispersant could reduce the viscosity and enhance the zeta potential of the CB dispersion. Compared with the CB dispersion without dispersant, the viscosity of CB dispersion with 4.0 wt% dispersant was decreased by 7.3%, and the zeta potential was increased by 167%. The average particle size and adsorption capacity of CB dispersion with 4.0 wt% dispersant retained 190 nm and 3351 mg/g, respectively. With the increase of dispersant amount, the dynamic viscoelasticity was gradually increased. It was further inferred that sodium N-lauroylsarcosinate part increased the electrostatic repulsion between CB particles, and the HPMC part particularly enhanced the steric hindrance. These two parts could produce a positive synergistic dispersion effect and made the CB dispersion more stable.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Jingyu Hou,Jun Wang,Jiawen Han,Juan Wang,Daiyong Chao,Qing Dong,Daoqing Fan,Shaojun Dong
As the well-known test-indicator for early prostate cancer (PCa), sarcosine (SA) is closely related to the differential pathological process, which makes its accurate determination increasingly significant. Herein, we for the first time expanded the peroxidase (POD)-like property of facile-synthesized Zn-TCPP(Fe) MOF to fluorescent substrates and exploited it to ratiometric fluorescent (RF) sensing. By harnessing the effective catalytic oxidation of MOF nanozyme toward two fluorescent substrates (Scopoletin, SC; Amplex Red, AR) with contrary changes, and target-responsive (SA + SOx)/MOF/(SC + AR) tandem catalytic reaction, we constructed the first MOF nanozyme-based RF sensor for the quantitative determination of SA. Superior to previous works, the operation of this RF sensor is under the guidance of AND-(ANDˆNAND) contrary logic circuit. The dual-channel binary output changes (from 1/0 to 0/1) not only enable the intelligent logical recognition of SA, bringing strengthened reliability and accuracy, but also manifest the proof-of-concept discrimination of PCa individuals and healthy ones. Through recording the fluorescence alterations of SC (F 465 ) and AR (F 585 ), two segments of linear relationships between ratiometric values (F 585 /F 465 ) and varied contents of SA are realized successfully. The LOD for SA could reach to as low as 39.98 nM, which outperforms all nanozyme-originated SA sensors reported till now. Moreover, this sensor also demonstrates high selectivity and satisfactory performance in human serum samples. Furthermore, the portable sensing of SA is realized under the assistance of smartphone-based RGB analysis, demonstrating the potential of point-of-care diagnostics of PCa in the future.
研究领域:
生物技术
·
分析化学
·
癌症诊断
·
纳米技术
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 3.9
Runcheng Tan,Guangqi Huang,Cong Wei,Zepeng He,Tianyu Zhao,Yi Shi,Zhijia Liu,Yongming Chen
Lipid nanoparticles (LNPs) have been demonstrated to be potent and well-tolerated vehicles for delivering mRNA in vaccination and therapeutics. However, the presence of anti-poly(ethylene glycol) (PEG) antibodies in the body resulted in the problems of hypersensitivity reaction, accelerated blood clearance and high systemic reactogenicity after repeated dosing of PEG lipid-contained LNPs, thus limiting the utility for in vivo messenger RNA (mRNA) delivery. Here, we synthesized well-defined polysarcosine functionalized lipids (pSar-lipids) with various hydrophobic tail lengths and molecular weights by the accelerated ring-opening polymerization of sarcosine N -carboxyanhydride (NCA). The obtained pSar-lipids were utilized as PEG lipid alternatives to explore structure–activity relationships of pSar-lipid-based LNPs. The results demonstrated that pSar-lipid-based LNPs by intravenous administration represented higher mRNA delivery efficiency in the liver and spleen with the increased hydrophobic tail length of pSar-lipids. Importantly, more significant preference for mRNA delivery into the liver was identified by increasing the molecular weight of pSar segments. As a result, this work elucidated the effect of structural variations in pSar-lipids on LNP-mediated in vivo mRNA delivery, providing clues to optimize pSar-lipids as potential alternatives to PEG lipids for developing next-generation of LNP delivery systems. Graphical
研究领域:
生物技术
·
医学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2025
·
IF 3.3
Yiwen Sun,Ying Xie,Zixuan Yuan,Yujiao Mao,Huiru Liu,Yiting Zhu,Jinyu Dong,Xiaojun Chen
As a significant biomarker for the early development of prostate cancer (PCa), the sensitive detection of sarcosine (SA) in urine can serve as an effective non-invasive early warning method. Herein, we developed novel a hollow double shell NiMn PBA (NiMn-PBA-DSNB) with outstanding peroxidase-like activity through a facile cation exchange reaction according to the distinct solubility product constants (Ksp) of different Prussian blue analogues (PBAs). Moreover, we have innovatively proposed a “enzyme - nanozyme” cascade strategy to realize ultrasensitive SA sensing. This system utilized the enzymatic reaction between SA and sarcosine oxidase (SOX) to generate H2O2 in situ. In the presence of the generated H2O2, the NiMn-PBA-DSNB nanozyme can efficiently catalyze the oxidation of 3, 3’, 5, 5’-tetramethylbenzidine (TMB) to produce the blue oxTMB. Consequently, the concentration of SA directly correlated with the absorbance value of oxTMB, providing a quantitative detection. Based on this dual-enzyme cascade mechanism, a highly sensitive colorimetric assay was developed for the precise analysis of SA. The assay achieved a wide linear range from 8 to 500 μM, with a low detection limit of 1.75 μM, fully fulfilling the requirements for SA sensing in the urine of PCa patients. The method was also successfully applied to the analysis of real human urine samples, achieving recoveries ranging from 102.15% to 104.35% with relative standard deviations ≤ 5.03%, which demonstrates its strong potential for clinical application.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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