JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Nianqi Meng,Peijing Xu,Changchun Wen,Huihui Liu,Cunji Gao,Xing-Can Shen,Hong Liang
Bismuth sulfide is widely used as an n -type semiconductor material in photocatalytic reactions. However, bismuth sulfide has poor absorption in the near-infrared region and low charge separation efficiency, limiting its application in phototherapy and sonodynamic therapy (SDT). In this study, we successfully synthesized an “all-in-one” phototheranostic nanoplatform, namely Bi 2 S 3-x [email protected] , based on a single second near-infrared (NIR-II) light-responsive Schottky-type Bi 2 S 3-x -Au heterostructure for photoacoustic (PA) imaging-guided SDT-enhanced photodynamic therapy (PDT)/photothermal therapy (PTT). Bi 2 S 3-x [email protected] exhibits excellent NIR-II plasmonic and photothermal properties, rendering it with NIR-II PA imaging capabilities for accurate diagnosis. Additionally, the high-density sulfur vacancies constructed on the Bi 2 S 3 surface cause it to possess a reduced band gap (1.21 eV) that can act as an electron trap. Using the density functional theory, we confirmed that the light and ultrasound-induced electrons are more likely to aggregate on the Au nanoparticle surface through interfacial self-assembly, which promotes electron-hole separation and enhances photocatalytic activity with increased reactive oxygen species (ROS) generation. With a further modification of hyaluronic acid (HA), Bi 2 S 3-x [email protected] can selectively target cancer cells through HA and CD44 protein interactions. Both in vitro and in vivo experiments demonstrated that Bi 2 S 3-x [email protected] effectively suppressed tumor growth through SDT-enhanced PTT/PDT under a single NIR-II laser and ultrasound irradiation with negligible toxicity. Our findings provide a framework for fabricating Schottky-type heterostructures as single NIR-II light-responsive nanotheranostic agents for PA imaging-guided cancer phototherapy.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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材料科学
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医学成像
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Wenxue Zhao,Aihua Yan,Zigao Su,Fei Huang,Jixu Zhang,Ye Gao,Huaqi Yuan
Enabling highly-efficient multiplex-optimization photocatalysts is critical to overcome the bottlenecks of hydrogen evolution reaction efficiency and photostability. Herein, novel CoS/S v -ZnIn 2 S 4 /MoS 2 composites are successfully synthesized through an in situ technique. Taking advantage of the synergistic effect of sulfur vacancy, Schottky-type MoS 2 /S v -ZnIn 2 S 4 junction and Ohmic-type CoS/S v -ZnIn 2 S 4 junction, the light absorption, electron/hole separation efficiency, charge transfer rate and hydrogen reduction reaction dynamic can be significantly enhanced. As a result, an impressive photocatalytic hydrogen evolution rate of 18.43 mmol g −1 h −1 is achieved under the visible-light irradiation. Furthermore, apparent quantum efficiencies of 72.14 % and 9.91 % are also achieved under 350 and 420 nm monochromatic light irradiation. This work presents an in situ perspective to design multiplex-optimization photocatalytic system for highly-efficient hydrogen production.
研究领域:
材料科学
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光化学
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能源材料
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产品关联
DOI
PubMed
高影响因子
Small Structures
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2024
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IF 13.9
Wenxue Zhao,Aihua Yan,Zigao Su,Fei Huang,Quande Wang,Shihang Li,Shijian Lu,Chuanjian Wang,Tongyang Zhang,Jixu Zhang,Ye Gao,Huaqi Yuan
Photocatalytic water splitting into hydrogen production provides a new avenue to produce clean chemical fuels. However, developing high-efficiency photocatalytic materials still remains a challenge till now. Herein, multiobjective-optimization MoS 2 /Cd-ZnIn 2 S 4 /CdS (MS/CZIS/CS) composites are successfully constructed by an in situ structure-tailored technique. Benefiting from the synergistic feature integrating sulfur vacancy, II-type CZIS/CS heterojunction and Schottky-type MS/CS heterojunction, such composites not only effectively steer photogenerated carrier transfer but also markedly expedite surface reaction kinetics for hydrogen reduction reaction. As a result, an optimal hydrogen evolution rate of 11.49 mmol g −1 h −1 is achieved over the MS/CZIS/CS catalysts, which is approximately 4.79 times higher than that of pristine ZIS (2.40 mmol g −1 h −1 ). This work provides some new inspirations for the steering of carrier transfer and the design of multiobjective-optimization photocatalysts with high efficiency.
研究领域:
材料科学
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化学工程
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环境科学
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产品关联
DOI
高影响因子
ADVANCED MATERIALS
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2024
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IF 27.4
Hongli Yang,Peihua Lin,Bo Zhang,Fangyuan Li,Daishun Ling
During fractionated radiotherapy, DNA damage repair intensifies in tumor cells, culminating in cancer radioresistance and subsequent radiotherapy failure. Despite the recent development of nanoradiosensitizers targeting specific DNA damage repair pathways, the persistence of repair mechanisms involving multiple pathways remains inevitable. To address this challenge, a nucleophilicity-engineered DNA ligation blockade nanoradiosensitizer (DLBN) comprising Au/CeO 2 heteronanostructure modified with trans-acting activator of transcription peptides is reported, which targets and inhibits the DNA ligation inside cancer cell nuclei via heterointerface-mediated dephosphorylation of DNA, a crucial step in overcoming cancer radioresistance. First, the Schottky-type heteronanostructure of cancer cell nucleus-targeting DLBN effectively intensifies radiation-induced DNA damage via catalase-mimetic activity and radiation-triggered catalytic reactions. Notably, by leveraging Au/CeO 2 heterointerface, DLBN spontaneously dissociates H 2 O to hydroxide, a nucleophile with higher nucleophilicity, thereby exhibiting remarkable dephosphorylation capability at DNA nicks through facilitated nucleophilic attack. This enables the blockade of DNA ligation, a pivotal step in all DNA damage repair pathways, effectively interrupting the repair process. Consequently, DLBN resensitizes radioresistant cells by overcoming therapy-induced radioresistance, leading to a substantial accumulation of unrepaired DNA damage. These findings offer insight into the dephosphorylation of DNA within nuclei, and underscore the potential of heteronanostructure-based nanoradiosensitizer to block DNA ligation against therapy-induced radioresistance.
研究领域:
癌症治疗
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纳米技术
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放射生物学
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分子生物学
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材料科学
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产品关联
DOI
PubMed
高影响因子
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