Gong Zhang,Jiaxing Zhang,Yuefei Wang,Yifei Wu,Qing Li,Yaoyu Liang,Wei Qi,Hengjun Rao,Rongxin Su,Zhimin He
In this work, we report a strategy to self-assemble multifunctional hydrogels composed of highly ordered polyoxometalates (POMs) helical arrays using a liquid crystalline tripeptide as the template. The cationic peptide can self-assemble into long-range ordered nanofilaments with a diameter of ~4.1 nm in aqueous media. Through the incorporation of various multivalent polyoxometalates (POMs), the POMs clusters can spontaneously organize into periodic nanowire arrays by the colloidal co-assembly with the as-prepared nematic peptide nanofilaments. This leads to the formation of hybrid gels with tunable mechanical strength by simply changing the charge number of the POMs. The H 3 PW 12 O 40 (noted as PW) clusters@peptide hybrid hydrogels show excellent adsorption performance of dyes. Moreover, the long-range aligned PW clusters within the co-assembled fiber bundles exhibit great improvement in the efficiency of photodegradation of dyes, which shows 8.7 times higher than that of the pristine PW clusters in the homogeneous phase. The synergistic effect between the adsorption and catalytic process within the hybrid gels is considered to be responsible for its highly catalytic activity. This work highlights a general pathway upon the well-defined organization of the various components into hybrid materials with superior properties using simple peptide liquid crystals as templates.
Gong Zhang,Qing Li,Jieai Li,Menghan Pan,Yuefei Wang,Rongxin Su,Wei Qi,Wei Zhang
The development of stable multifunctional enzyme mimics with tandem catalytic effects provides a great opportunity to construct economical and convenient bioassays. Inspired by biomineralization, in this work self-assembled N-(9-fluorenylmethoxycarbonyl)-protected tripeptide (Fmoc-FWK-NH2) liquid crystals were used as templates to in situ mineralize Au nanoparticles (AuNPs), and then a dual-functional enzyme-mimicking membrane reactor based on AuNPs and peptide-based hybrids was constructed. AuNPs with a uniform particle size and good dispersion were in situ reduced on the surface of the peptide liquid crystal due to the reduction of the indole group on the tryptophan residue, which exhibited excellent peroxidase-like and glucose oxidase-like activities simultaneously. Meanwhile, the oriented nanofibers aggregated into a three-dimensional network, which was further immobilized on the mixed cellulose membrane to form a membrane reactor. A biosensor was made to realize fast, low-cost, and automatic detection for glucose. This work represents a promising platform for the design and construction of novel multifunctional materials based on the biomineralization strategy.
Rong Huang,Chuang Cai,Wei-Wei Cheng,Yin-Jia Cheng,Wen-Long Liu,Yi-Han Ma,Ai-Qing Zhang,Si-Yong Qin
A highly hierarchical microstructure with aligned myofibers is a hallmark of native skeletal muscle. To treat volumetric muscle loss (VML), the development of tissue scaffolds that replicate the hierarchically aligned microstructures of the native muscle environment is both promising and challenging. Moreover, effective scaffolds should possess tunable components that enable specific functional modulations. This study proposes an injectable, self-assembling peptide liquid crystal (LC) hydrogel with hierarchical fiber alignment to support skeletal muscle regeneration. To emulate the physicochemical functions of skeletal muscle, Ti 3 C 2 T x MXene is incorporated as an exogenous component to enhance the mechanical strength, anti-inflammatory activity, and electrical conductivity of the LC hydrogel. The resulting Ti 3 C 2 T x /LC peptide hydrogel effectively guides myoblast alignment and promotes myogenic differentiation and angiogenesis. Compared to its unaligned non-liquid crystal (NLC) hydrogel counterpart, the aligned Ti 3 C 2 T x /LC hydrogel with a hierarchical microstructure significantly enhances new muscle tissue formation and functional recovery in a Sprague–Dawley (SD) rat model of VML. This study offers a robust and practical strategy for fabricating aligned hydrogel scaffolds with substantial potential in muscle tissue engineering and regenerative medicine.
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