ACS Nano
·
2024
·
IF 15.8
Yanzhi Dong,Gang Shu,Yibo Wei,Jinbin Pan,Dong Li,Shao-Kai Sun
Tantalum (Ta) emerges as a promising element for advanced computed tomography (CT) imaging probes owing to its high X-ray attenuation coefficient and excellent biocompatibility. Nevertheless, the synthesis of renally clear Ta-based imaging probes through simple methods remains a significant challenge. Herein, we introduce a simple and gram-scale approach for the synthesis of renal-clearable Ta nanodots with high water solubility for CT imaging in vivo. The Ta nanodots, coordination polymers, are fabricated via coordination reactions involving Ta(OH)5, citric acid (CA), and hydrogen peroxide. The Ta nanodots exhibit an ultrasmall hydrodynamic diameter (2.8 nm), high water solubility (1.88 g/mL, 688 mg Ta/mL), superior X-ray absorption capacity, gram-scale production capability (>10 g in lab synthesis), renal-clearable ability, and good biocompatibility. The Ta nanodots possess superior CT imaging efficacy across diverse tube voltages, enabling highly sensitive gastrointestinal CT imaging, renal CT imaging, and CT angiography (CTA). Moreover, Ta nanodots maintain robust CT imaging capabilities even at high X-ray energies, and Ta nanodots-based spectral CT achieves metallic artifacts-minimized CTA. The proposed Ta nanodots present substantial potential as a potent CT imaging probe for diagnosing various diseases.
研究领域:
医学影像学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Small
·
2015
·Vol. 11
·期 30
·3676-3685
·
IF 8.368
Fuyao Liu,Xiuxia He,Junping Zhang,Huimao Zhang,Zhenxin Wang
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic diameter (HD) to be less than 8 nm for efficient renal clearance. To address this problem, tryptone is employed as the novel ligand to fabricate a simple, versatile, and inexpensive strategy for transferring hydrophobic NaGdF 4 nanodots (3 nm in diameter) from organic phase into aqueous phase without any complicated organic synthesis. The paramagnetic properties of NaGdF 4 nanodots are well retained after the phase transfer process. In particular, the tryptone–NaGdF 4 nanodots have ultrasmall HD (ca., 7.5 nm), which greatly improves their tumor accumulation and facilitates renal clearance within 24 h postinjection. The as-prepared tryptone–NaGdF 4 nanodots can also be further functionalized with other molecules for extensively biomedical and bioanalytical applications. Furthermore, the proposed strategy can easily be extended to transfer other types of inorganic nanoparticles from hydrophobic to hydrophilic for facilitating biomedical applications.
研究领域:
材料科学
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生物医学工程
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纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2020
·
IF 0
Hao Li,Jiamei Han,Guohai Liang
The renal-clearing feature of inorganic nanoparticles is highly desired for their transition to the clinic. Although high-quality ultrasmall inorganic nanoparticles can be routinely synthesized via the thermal decomposition method, rendering them suitable for in vivo application without enlarging their hydrodynamic size is still challenging. In this study, we report a facile and general method for phase transfer of hydrophobic inorganic nanoparticles from the organic phase to the aqueous phase using a zwitterionic silylation agent. The phase transfer process can be accomplished in one pot within minutes and was found to be suitable for a wide variety of inorganic nanoparticles. Interestingly, the resulting nanoparticles showed excellent colloidal stability, minimal effective hydrodynamic size, and low nonspecific affinities toward serum proteins. Thus, nanoparticles with the desired renal-clearing property were obtained. These features rendered the phase transfer method reported here considerably advantageous over previous polymer-based strategies and will be useful for preparing biocompatible nanomaterials for biomedical applications.
研究领域:
材料科学
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生物医学工程
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纳米医学
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DOI
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2017
·Vol. 34
·期 6
·1700035
·
IF 4.474
Haixia Liu,Junying Wang,Yaqi Jing,Jiang Yang,Xueting Bai,Xiaoyu Mu,Fujuan Xu,Xuhui Xue,Lingfang Liu,Yuan-Ming Sun,Qiang Liu,Haitao Dai,Changlong Liu,Xiao-Dong Zhang
High-energy ionizing radiation is widely used in medical diagnosis and cancer radiation therapy. However, high-energy radiation can also impose significant damages in healthy tissues during medical treatments via direct DNA damages and indirect damages from production of reactive oxygen species (ROS). Therefore, it is urgent to develop highly effective radioprotectants with low toxicities that can meet the increasing needs for alleviating the adverse effects from cancer radiation therapy and nuclear emergency. In this work, strongly catalytic ultrasmall (sub-5 nm) cysteine-protected WSe 2 dots are employed to protect healthy tissues against radiation via diminishing radiation-induced free radicals. The WSe 2 dots with high surface activities can recover radiation-induced DNA damages and eliminate the excessive ROS generated from radiation. In vivo experiments confirm that the survival rate of mice treated with WSe 2 dots is significantly elevated with radiation damages postponed under exposure to high-dose ionizing radiation. Furthermore, the free radicals in major organs and hematological system can be appreciably omitted, suggesting their unique role as free radical scavengers. These WSe 2 dots in ultrasmall size show rapid renal clearance of ≈74% injection dose via urine excretion in 24 h and do not cause any apparent toxicity in vivo for up to 30 d.
研究领域:
生物医学工程
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纳米医学
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放射生物学
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DOI
高影响因子
BIOMATERIALS
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2020
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IF 10.317
Ya Su,Shi Liu,Yuyao Guan,Zhigang Xie,Min Zheng,Xiabin Jing
Carbon dots (CDs) are emerging as powerful nanoprobes for multiple-model bioimaging. Nowadays, orthotopic xenograft models attract increasing attention because of their superiorities of duplicating the tumor microenvironment . However, compared with the extensive study of subcutaneous xenograft tumors , less attention has been paid to CDs for in vivo orthotopic tumor imaging . Furthermore, it is very desirable for a nanoprobe to achieve preferential accumulation at the tumor site and efficient renal clearance . In this work, a novel kind of Hafnium-doped CDs (HfCDs) were successfully prepared via a simple one-pot pyrolysis method. The significant advantages including robust stability, good biocompatibility , excellent water solubility, remarkable computed tomography (CT) contrast performance and preferential tumor accumulation capability endow HfCDs with particular functions of CT/fluorescence imaging of orthotopic liver cancer initially. More importantly, HfCDs could locate at the tumor site and achieve the rapid imaging within 1 min. The findings of the current study represent a facile and universal approach to fabricate outstanding renal clearable multimodal imaging nanoprobes with great potential for clinical diagnosis.
研究领域:
医学影像学
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纳米医学
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肿瘤学
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DOI
高影响因子
Theranostics
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2016
·
IF 8.854
Yuan Ma,Quanbing Mou,Mo Sun,Chunyang Yu,Jianqi Li,Xiaohua Huang,Xinyuan Zhu,Deyue Yan,Jian Shen
Nano drug delivery systems have emerged as promising candidates for cancer therapy, whereas their uncertainly complete elimination from the body within specific timescales restricts their clinical translation. Compared with hepatic clearance of nanoparticles, renal excretion of small molecules is preferred to minimize the agent-induced toxicity. Herein, we construct in vivo renal-clearable nanoparticles, which are self-assembled from amphiphilic small molecules holding the capabilities of magnetic resonance imaging (MRI) and chemotherapy. The assembled nanoparticles can accumulate in tumor tissues for their nano-characteristics, while the small molecules dismantled from the nanoparticles can be efficiently cleared by kidneys. The renal-clearable nanoparticles exhibit excellent tumor-inhibition performance as well as low side effects and negligible chronic toxicity. These results demonstrate a potential strategy for small molecular nano drug delivery systems with obvious anticancer effect and low-toxic metabolism pathway for clinical applications.
研究领域:
药学
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纳米医学
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肿瘤学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Haiying Wang,Lifeng Hang,Hong Qu,Peiru Wu,Kelei Hua,Rongjian Jiang,Yanzhao Diao,LaiPing Fang,Sulian Su,Guihua Jiang
Sonodynamic therapy (SDT) is a noninvasive approach to tumor treatment, with ongoing efforts being focused on developing highly effective sonosensitizers with low toxicity. Herein, a liquid-phase stripping technique was introduced as a simple reflux method for synthesizing ultrasmall Mn-PCN-224 nanodots (MM NDs). Compared with PCN-224 nanodots, the synthesized MM NDs, which function as renal-clearable nanoagents, produced 2.42 times more reactive oxygen species (ROS) under identical ultrasound (US) irradiation conditions. In vivo and in vitro experiments revealed that A549 lung cancer cells treated with MM NDs under US irradiation and H2O2 exhibited a relative cell viability of ∼9% and a tumor inhibition rate of ∼91%. This result demonstrates that MM NDs can efficiently increase the effectiveness of SDT by leveraging their catalase-like activity and ultrasmall size (4 nm) to prevent ROS quenching. Furthermore, these nanoagents could be effectively utilized for photoacoustic (PA) imaging to track their accumulation in tumors and monitor the alleviation of the hypoxic tumor microenvironment. Notably, MM ND-mediated SDT demonstrated superior penetration depth compared to PDT, making it more effective in inhibiting contralateral tumors while facilitating deep-tissue treatment. Thus, this study introduces renal-clearable nanoagents with promising potential for PA-guided SDT, thereby paving the way for more effective tumor treatment strategies.
研究领域:
肿瘤学
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生物医学工程
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影像医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Manman Xie,Ziyang Wang,Qian Lu,Shuming Nie,Christopher J. Butch,Yiqing Wang,Bo Dai
Herein, we present a new magnetic iron oxide nanoparticle (MION) with a succinylated heparin monolayer coating, which exhibits the highest T1 relaxivity at 7 T and the lowest r2/r1 reported for any MION at these high-field conditions. While the recent proliferation of 7 T MRI instruments in hospitals worldwide has enabled widespread access to higher quality, more finely detailed, diagnostic imaging, clinically available contrast agents have not kept pace due to the general phenomenon of reduced efficacy of T1 relaxation as magnetic field strength is increased. Development of new MION agents is one strategy to address this need, and to this end, we demonstrate the in vitro magnetic properties of the MIONs reported here to extend to in vivo applications, providing greatly increased contrast in tumor imaging in a murine xenograft subject at 7 T. While MION-based contrast agents can have side effects in clinical application, these are generally thought to be less than those of gadolinium-based agents and here are further reduced by the small size allowing direct glomerular filtration from the blood followed by renal-excretion. Finally, we show the succinylated heparin monolayer coating to provide class leading magnetic properties over a homologous series of particles with core size ranging from 2 to 18 nm and show the properties to be strongly related to the surface area. We suggest the increased porosity and hydrophilicity of the coating to increase water accessibility to the surface resulting in the increased magnetic properties.
研究领域:
医学影像学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
·
IF 19
Fangzheng Tian,Siyu Li,Xue Yang,Kai Fan,Mei Zhou,Duyang Gao,Dehong Hu,Shenghong Ju
Glutathione-capped gold nanoclusters (GSH-Au NCs) with second near-infrared (NIR-II, 1000–1700 nm) fluorescence have received increasing interest in biomedical applications. However, conventional aqueous synthesis of GSH-Au NCs results in low NIR-II absolute fluorescence quantum yield (≈0.27%) and limited renal clearance efficiency (≈70%), which restricts its clinical applications. This study reports a GSH-etching post-synthesis method to selectively convert nonfluorescent GSH-Au n NCs ( n > 25) into fluorescent GSH-Au 25 NCs (eGSH-Au NCs). This molecular etching process decreases the size of the NCs from 3.3 to 2.0 nm and afforded 37% increase in NIR-II absolute fluorescence quantum yield and 11.9% enhancement in renal clearance efficiency. The optimized eGSH-Au NCs facilitates whole cerebrovascular imaging through the scalp and skull, tumor vasculature imaging with a resolution of 40.8 µm, dynamic tumor perfusion imaging with a signal-to-background ratio of 10.5, and enhanced lymphatic vessel and lymph node imaging. Additionally, eGSH-Au NCs exhibit superior photothermal properties, achieving almost 100% tumor growth inhibition in Hepa1-6 tumor-bearing mice. This study presents a novel strategy to improve the bioimaging and therapeutic performance of NIR-II Au NCs, thus advancing their clinical translation.
研究领域:
生物医学工程
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纳米医学
·
影像学
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肿瘤学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2018
·
IF 0
Guohai Liang,Jiamei Han,Qiubo Hao
Extremely small-sized iron oxide nanoparticles (ESIONs) have been accepted as a potential alternative to gadolinium-based contrast agents for enhanced T1-weighted MR imaging. Recently developed zwitterion-coated ESIONs showed a high T1 contrast power and efficient renal clearing ability, but the tedious preparation steps that required high-cost, unfriendly experimental conditions and a sophisticated phase transition process would likely hinder their clinical translation. Herein, we present a one-pot gram-scale synthesis of zwitterion-capped ultrasmall iron oxide nanoparticles (ZUIONs). The nanoparticles have a core size as small as 3.7 nm and display high colloidal stability in various buffers. The r1 relaxivity of 2.4 mM–1 s–1 and r2/r1 ratio as low as 2.2 at 1.0 T guarantee their application as effective T1 MRI contrast agents. In vivo studies showed that ZUIONs could induce a significant contrast enhancement in blood pool and be eliminated from the body mainly through the renal excretion pathway. The combined advantageous features including facile preparation, excellent biocompatibility, strong T1 MRI contrast effect, appropriate circulation time, and renal clearable property would render ZUIONs attractive for practical applications.
研究领域:
医学影像学
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纳米医学
·
生物材料
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产品关联
DOI
PubMed
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Lile Dong,Peng Zhang,Xiangjian Liu,Ruiping Deng,Kaimin Du,Jing Feng,Hongjie Zhang
Recent development of precise nanomedicine has aroused an overwhelming interest in integration of diagnosis and treatment for cancers. Designing renal-clearable and targeting nanoparticles (NPs) has specific cancer theranostic implications and remains a challenging task. In this work, the ultrasmall folic acid (FA) and bovine serum albumin-modified Bi–Bi2S3 heterostructure nanoparticles NPs (Bi–Bi2S3/BSA&FA NPs) with excellent computed tomography (CT) and photoacoustic imaging abilities and outstanding photothermal performances were synthesized in an aqueous phase route via a simple method. Bi–Bi2S3/BSA&FA NPs have the following criteria: (i) Bi–Bi2S3/BSA&FA NPs with heterostructure possess better stability than Bi NPs and higher Bi content than Bi2S3 NPs, which are conducive to the enhancement of CT imaging effect; (ii) Bi–Bi2S3/BSA&FA NPs with FA molecules on the surface could target the tumor site effectively; (iii) Bi–Bi2S3/BSA&FA NPs could inhibit tumor growth effectively under 808 nm laser irradiation; (iv) ultrasmall Bi–Bi2S3/BSA&FA NPs could be cleared through kidney and liver within a reasonable time, avoiding a long-term retention/toxicity. Therefore, the renal clearable Bi–Bi2S3/BSA&FA NPs are a promising agent for targeting cancer theranostics.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-15
·
IF 10.6
Chen Can,Huang Baoxing,Zhang Ruru,Sun Chaoping,Chen Lei,Ge Jianxian,Zhou Dandan,Li Yueping,Wu Shuwang,Qian Zhiyuan,Zeng Jianfeng,Gao Mingyuan
Background The general sluggish clearance kinetics of functional inorganic nanoparticles tend to raise potential biosafety concerns for in vivo applications. Renal clearance is a possible elimination pathway for functional inorganic nanoparticles delivered through intravenous injection, but largely depending on the surface physical chemical properties of a given particle apart from its size and shape. Results In this study, three small-molecule ligands that bear a diphosphonate (DP) group, but different terminal groups on the other side, i.e. , anionic, cationic, and zwitterionic groups, were synthesized and used to modify ultrasmall Fe 3 O 4 nanoparticles for evaluating the surface structure-dependent renal clearance behaviors. Systematic studies suggested that the variation of the surface ligands did not significantly increase the hydrodynamic diameter of ultrasmall Fe 3 O 4 nanoparticles, nor influence their magnetic resonance imaging (MRI) contrast enhancement effects. Among the three particle samples, Fe 3 O 4 nanoparticle coated with zwitterionic ligands, i.e. , Fe 3 O 4 @DMSA, exhibited optimal renal clearance efficiency and reduced reticuloendothelial uptake. Therefore, this sample was further labeled with 99m Tc through the DP moieties to achieve a renal-clearable MRI/single-photon emission computed tomography (SPECT) dual-modality imaging nanoprobe. The resulting nanoprobe showed satisfactory imaging capacities in a 4T1 xenograft tumor mouse model. Furthermore, the biocompatibility of Fe 3 O 4 @DMSA was evaluated both in vitro and in vivo through safety assessment experiments. Conclusions We believe that the current investigations offer a simple and effective strategy for constructing renal-clearable nanoparticles for precise disease diagnosis. Graphical Abstract
研究领域:
医学影像学
·
纳米医学
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生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）