FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Suchen Liu,Liuming Xie,Mingyue Shen,Yuehuan Xiao,Qiang Yu,Yi Chen,Jianhua Xie
The effects of dual modifications on the gelatinization, textural, and morphology properties of pea starch by Na 2 CO 3 and Mesona chinensis polysaccharide (MCP) were investigated. Results showed that Na 2 CO 3 promoted granular swelling and disruption but decreased the rearrangement tendency of disordered starch fraction of PS during gelatinization. The addition of 0.05%–0.1% MCP slightly affected granular swelling and protected the integrity of starch granules of Na 2 CO 3 –PS. 0.2% MCP enhanced the retrogradation and recrystallization of gelatinized starch in the presence of Na 2 CO 3 . Near-UV circular dichroism spectra showed that adding Na 2 CO 3 and MCP in PS resulted in a strong peak at 285 nm and a small trough at 310 nm in the spectra of MCP and PS. The peak intensity orders of samples were consistent with the reaggregation tendency, suggesting that the characteristic peak at 285 nm was closely related to the retrogradation degree of starch.
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 17
·1900450
·
IF 15.621
Xin Liu,Qin Zhang,Lijie Duan,Guanghui Gao
Adhesive gels have attracted increasing attention in biological medicine and industrial fields. However, it remains a huge challenge to achieve robust adhesion in various nonpolar and polar solvents. Herein, a tough nucleobase-tackified adhesive gel is successfully fabricated and exhibits strong adhesion to various materials in diverse solvents, including hexane, chloroform, dimethyl sulfoxide, ethanol, and water (seawater, high salt, acid, and alkali aqueous solutions). The adhesive gels possess high toughness and excellent resist fatigue as well as impressive nonswelling behavior in water or oil. This tough gel-based adhesive holds great promise for various applications, such as battery adhesives, soft robots, wound dressing, wearable devices, and 3D printing in various environments. It is anticipated that this strategy will provide a novel route for fabricating the next generation of adhesive soft materials.
研究领域:
生物医学
·
材料科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Mingming Hao,Yongfeng Wang,Lianhui Li,Yinhang Liu,Yuanyuan Bai,Weifan Zhou,Qifeng Lu,Fuqin Sun,Lili Li,Simin Feng,Wei Wei,Ting Zhang
Articular cartilage, which exhibits toughness and ultralow friction even under high squeezing pressures, plays an important role in the daily movement of joints. However, joint soft tissue lesions or injuries caused by diseases, trauma, or human functional decline are inevitable. Poly(vinyl alcohol) (PVA) hydrogels, which have a water content and compressive strength similar to those of many tissues and organs, have the potential to replace tough connective tissues, including cartilage. However, currently, PVA hydrogels are not suitable for complex dynamic environments and lack rebound resilience, especially under long-term or multicycle mechanical loads. Inspired by biological tissues that exhibit increased mechanical strength after swelling, we report a tough engineered hydrogel (TEHy) fabricated by swelling and freeze–thaw methods with a high compressive strength (31 MPa), high toughness (1.17 MJ m–3), a low friction coefficient (0.01), and a low energy loss factor (0.22). Notably, the TEHy remained remarkably resilient after 100 000 cycles of contact extrusion and remains intact after being compressed by an automobile with a weight of approximately 1600 kg. The TEHy also exhibited excellent water swelling resistance (volume and weight changes less than 5%). Moreover, skeletal muscle cells were able to readily attach and proliferate on the surface of TEHy-6, suggesting its outstanding biocompatibility. Overall, this swelling and freeze–thaw strategy solves the antifatigue and stability problems of PVA hydrogels under large static loads (>10 000 N) and provides an avenue to fabricate engineering hydrogels with strong antifatigue and antiswelling properties and ultralow friction for potential use as biomaterials in tissue engineering.
研究领域:
生物医学工程
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材料科学
·
组织工程
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2017
·
IF 2.896
Han-bin Chen,Chao-dan Luo,Jia-li Liang,Zhen-biao Zhang,Guo-sheng Lin,Jia-zhen Wu,Cai-lan Li,Li-hua Tan,Xiao-bo Yang,Zi-ren Su,Jian-hui Xie,Hui-fang Zeng
Coptisine is one of the main constituents of Coptis chinensis which has been widely used for the remedy of inflammatory disorders. Although the biological activities of coptisine have been well known, the pharmacological properties of its free base have seldomly been elucidated thus far. The aim of this study was to investigate the potential anti-inflammatory properties of coptisine free base (CFB, 8-hydroxy-7,8-dihydrocoptisine) on three animal models, namely xylene-induced ear edema, acetic acid-induced vascular permeability and carrageenan-induced paw edema . The results exhibited that CFB exerted a dose-dependent suppression on ear edema induced by xylene, significantly mitigated the aggravation of vascular permeability caused by acetic acid and paw edema induced by carrageenan . Additionally, CFB significantly suppressed the productions of interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandinE2 (PGE 2 ) and tumor necrosis factor (TNF-α) in the drug-treated groups as compared with the vehicle group after treatment with carrageenan. Signaling events of nuclear factor-κB (NF-κB) translocation, such as p-IKKα, p-IKKβ, p-IκBα and p65 (nucleus) were significantly inactivated, while inhibitor of nuclear factor κBα (IκBα) and p65 (cytosolic) were markedly up-regulated by CFB. Furthermore, CFB also significantly suppressed the mitogen-activated protein kinase (MAPK) pathway by blocking the phosphorylation of p-p38 (phospho-p38 mitogen-activated protein kinases) and p-JNK (phospho-c-jun N-terminal kinase) but not p-ERK (phospho-extracellular signal-regulated kinase). Hence, CFB efficiently prevented inflammation, at least partially, via inhibition of NF-κB and MAPK pathways. These findings provided a pioneering pharmacological basis for the anti-inflammatory effect of CFB and suggested CFB might be a potential candidate for the therapy of inflammatory disorders.
研究领域:
药理学
·
免疫学
·
炎症研究
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yuefei Ding,Zixuan Lian,Hangyang Liu,Hengyi Cheng,Dan Yu,Wei Wang
The application of electrocardiogram (ECG) monitoring in complex environments—such as underwater or under heavy perspiration—remains challenging due to interfacial instability and signal degradation in conventional electrodes. Developing flexible, environment-adaptive materials with cross-media compatibility is crucial for advancing wearable and subaquatic medical devices. Here, we report a novel strategy using aqueous PEDOT dispersion-induced phase separation to fabricate conductive hydrogels with robust underwater functionality. The resulting biphasic structure exhibits exceptional stretchability (up to 2500 % tensile strain), strong adhesion (40 kPa underwater), and intrinsic conductivity (16.7 S/m), without post-processing. These hydrogels maintain stable performance across air–water interfaces, enabling high-fidelity biopotential recording even in liquid environments. Demonstrated as ECG electrodes, they deliver clinical-grade signal quality underwater and resist interference from sweat during physical activity. This one-step fabrication method supports scalable, cost-effective production, facilitating integration into diving gear and marine protective suits. The material’s dual adaptability to both wet and dry conditions opens new pathways for reliable biosignal monitoring in extreme environments. These findings represent a significant step toward industrial deployment of hydrogel-based soft electronics in aquatic healthcare and sports physiology applications.
研究领域:
生物医学工程
·
材料科学
·
电子皮肤
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Yulian Wang,Xiaobo Wang,Yueran Zhao,Lizhong Dong,Tao Zhou,Zhenzhong Yong,Jiangtao Di
Coiled artificial muscle yarns outperform their straight counterparts in contractile strokes. However, challenges persist in the fabrication complexity and the susceptibility of the coiled yarns to becoming stuck by surrounding objects during contraction and recovery. Additionally, torsional stability remains a concern. In this study, it is reported that straight carbon nanotube (CNT) yarns when driven by a low-voltage electrochemical approach, can achieve a contractile stroke that surpasses even NiTi shape memory alloy fibers. The key lies in the suitable match between a yarn consisting of randomly aligned CNTs and the reversible and substantial electrochemical swelling induced by solvated ions. Wrinkled structures are formed on the surface of the CNT yarn to adapt to the swelling process. This not only assures torsional stability but also enhances the surface area for improved electrode–electrolyte interaction during electrochemical actuation. Remarkably, the CNT artificial muscle yarn generates a contractile stroke of 8.8% and an isometric stress of 7.5 MPa under 2.5 V actuation voltages, demonstrating its potential for applications requiring low energy consumption while maintaining high operational efficiency. This study highlights the crucial impact of CNT orientation on the effectiveness of electrochemically-driven artificial muscles, signaling new possibilities in smart material and biomechanical system development.
研究领域:
材料科学
·
生物力学
·
智能材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Junqing Qian,Yan Chen,Haiyan Yang,Changyan Zhao,Xiaohua Zhao,Hui Guo
In order to develop starch hemostatic materials with excellent hemostatic properties, the preparation of crosslinked porous starch (SPS) with sodium trimetaphosphate (STMP) as cross-linking agent was studied in this paper. When the solid-liquid ratio of porous starch (PS) was 30%, the mass ratio of cross-linking agent to starch was 0.04–1, and the SPS was crosslinked at pH 10.0, 55 °C for 50–60 min, the water absorption ratio and swelling ratio of SPS reach up to 160.5% and 239.1%, respectively. The characterization by infrared spectra, scanning electron microscopy and X-Ray diffraction spectra confirmed that the structure of SPS is similar to that of PS. The degradation experiment in vitro indicated that the degradation effect of PS was better than that of SPS. The whole blood coagulation kinetics experiment showed that SPS could promote the formation of blood clot, and the adsorption experiment of red blood cells in vitro showed that SPS could adsorb red blood cells. The average hemostasis time of SPS in tail amputation 1 cm and liver laceration were 181.03 s and 179.30 s.
研究领域:
生物材料学
·
医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 26
·5682-5693
·
IF 5.344
Xinchen Du,Yujie Hou,Le Wu,Shilin Li,Ao Yu,Deling Kong,Lianyong Wang,Guiling Niu
A non-swelling hydrogel adhesive is urgently needed in clinical application for wound closure; however, preparing a non-swelling hydrogel adhesive with superior mechanical and tissue adhesion properties remains a challenge. In this study, we developed a new family of non-swelling hydrogel adhesives composed of Pluronic F127 diacrylate, poly(ethylene glycol) diacrylate, modified sodium alginate, and tannic acid. Physical and biological properties of the hydrogels were systematically evaluated in vitro/vivo. The results indicated that the hydrogels exhibited non-swelling features, robust mechanical properties and good adhesion abilities toward various tissues. The hydrogels also exhibited good cytocompatibility and strong antibacterial activities against S. aureus and E. coli. Additionally, the hydrogel could be used for sutureless wound closure and displayed better advantages compared to sutures and commercial adhesive pads. The above results demonstrated that our non-swelling hydrogel adhesive with robust mechanical properties holds great promise for applications in clinical surgery.
研究领域:
生物材料学
·
医学工程
·
临床医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Tarig Elshaarani,Haojie Yu,Li Wang,Jingyi Feng,Chengjiang Li,Weibin Zhou,Amin Khan,Muhammad Usman,Bilal Ul Amin,Rizwan Khan
Different hydrogels of poly(acrylamide- co -3-acrylamido phenylboronic acid- co -chitosan grafted maleic acid) (P(AM- co -AAPBA- co -CSMA)s) were synthesized using poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker to serve for glucose sensing and insulin delivery. The structure and morphology of the hydrogels, named as CSPBA were studied by FTIR and SEM, while the mechanical properties were tested using dynamic mechanical analysis (DMA) and universal testing machine. The prepared hydrogels shrinked at low glucose concentration due to the 2:1 boronate-glucose binding, and swelled at high glucose concentration because of 1:1 boronate-glucose complexation. Both binding mechanisms are useful for glucose sensing and insulin delivery. The integration of CSMA into hydrogels network not only enhanced the response to glucose at physiological pH, but also improved the mechanical properties and increased the encapsulation efficiency of the prepared hydrogels. These CSPBA may find potential as implantable hydrogels in applications were continuous glucose monitoring and controlled release is beneficial.
研究领域:
生物材料
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMPHYSCHEM
·
2018
·Vol. 19
·期 11
·1404-1413
·
IF 2.947
Ran Kou,Jian Zhang,Zhen Chen,Guangming Liu
Graphical The counterion specificity of polyelectrolyte brushes is determined by specific ion-pairing interactions, modulating the osmotic pressure and hydrophobicity of the brushes. We demonstrate here that the properties of poly (2-(methacryloyloxy) ethyl trimethylammonium chloride) brushes can be tuned by counterion species. When the brushes are exposed to external chloride (Cl − ) counterions, obvious dehydration and collapse are only observed at high salt concentrations. In the presence of very strongly chaotropic perchlorate (ClO 4 − ), the brushes strongly dehydrate and collapse at a very low salt concentration. For the strongly chaotropic thiocyanate ion (SCN − ), the changes in hydration and conformation of the brushes are similar to those observed for ClO 4 − but at a smaller extent at very low salt concentrations. With the addition of kosmotropic acetate (Ac − ), hydration of the brushes increases, accompanied by a swelling of the brushes in the low-salt-concentration regime. In contrast, the brushes dehydrate and collapse with increasing concentration of Ac − in the high-salt-concentration regime. The counterion specificity of the brushes demonstrated here is determined by specific ion-pairing interactions through modulating the osmotic pressure within the brushes and the hydrophobicity of the ion pairs.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuanming Ye,Jun Guo,An Wang,Chengxiang Zheng,Tao Wu,Zhipeng Chen,Xuanqi Wang,Yichen Chu,Ruiyu Bai,Zekai Liang,Honglong Chang,Kai Tao,Tengjiao Wang,Bowen Ji
Underwater surface electromyography (UW-sEMG) acquisition with long-term high quality is crucial to underwater activities, including rehabilitation, fatigue measurement, and sports monitoring. However, most UW-sEMG electrodes suffer significant performance decline, especially for hydrogel electrodes, due to the swelling-induced mechanical, electrical, and adhesive degradation. Maintaining high performance underwater over extended periods is challenging. The controlled underwater adhesion-detachment behavior of starfish is inspirative. Here, a starfish tube feet-inspired hydrogel (STFH) electrode is developed for UW-sEMG recording, including a micro-swelling hydrogel pillar, a biomimetic silicone sucker, and an Ag/AgCl disc electrode. By soaking freeze-dried hydrophilic hydrogel in tannic acid (TA) solution, the hydrogel exhibits skin-like modulus of 22.4 kPa, low skin impedance of 18.3 kΩ (10 Hz) and low equilibrium swelling ratio. Unlike traditional strategies for improving anti-swelling properties, this work leverages the interaction between the sucker and the swollen hydrogel to promote conformal contact. Consequently, the sEMG signal exhibits SNR of 26.7 dB and baseline noise of 12.8 μV even after 60 min of underwater working. The STFH electrode also shows anti-noise capability to resist skin vibration and wave oscillation. This STFH electrode enables durable UW-sEMG acquisition, which could further extend from the arm to the wrist to adapt wearing habits.
研究领域:
生物医学工程
·
材料科学
·
神经工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2018
·Vol. 58
·期 12
·2304-2310
·
IF 1.551
Jianrong Xia,Baoling Chen,Qinhui Chen
Urushiol, the main component of the natural product of raw lacquer, can react with ester easily owing to its two adjacent phenolic hydroxyls, and urushiol-ester compounds can polymerize further attributing to its unsaturated side chain. In this work, poly(urushiol borate) (PUB) was coated on the surface of polystyrene (PS) microspheres by transesterification between urushiol and tributyl borate. Then, the core–shell composite microspheres of polystyrene@poly(urushiol borate) (PS@PUB) were obtained. Finally, we used a general method to synthesize anisotropic grenade-like Janus composite particles of PUB/PS, that is, the core–shell composite microspheres of PS@PUB were swelled assisted protrusion in the emulsion of organic monomer and water. The morphologies of PUB/PS Janus composite particles could be tuned by changing the swelling time and the dosage of organic monomer. POLYM. ENG. SCI., 58:2304–2310, 2018. © 2018 Society of Plastics Engineers
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）