SEPARATION SCIENCE AND TECHNOLOGY
·
2015
·
IF 1.171
Yuanchao Pei,Jianzhou Zhang,Xinxin Song,Ming Zhao,Jianji Wang
In this paper, a series of ionic liquids (ILs) contains cholinium as cations were prepared. These ILs were used as extractants to separate some model drug molecules. The partition coefficients of these drug molecules between ILs and aqueous solutions were determined. Furthermore, the influence of different extraction parameters was investigated: volume ratio, equilibrium time, pH values, temperature, and ILs structure. It is shown that these ILs are highly effective materials for the extraction of drug molecules. The results imply that these ILs may have potential in drug extraction or separation as a new type of media.
研究领域:
药学
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化学
✓ 已验证
DOI
高影响因子
CATALYSIS LETTERS
·
2013
·Vol. 143
·期 5
·463-468
·
IF 2.244
Zhu Anlian,Li Qianqian,Li Lingjun,Wang Jianji
Abstract A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO 4 ] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO 4 ] > [Choline] [HSO 4 ] > [DMEA][H 2 PO 4 ] > [Choline] [H 2 PO 4 ] .
研究领域:
有机化学
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催化化学
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药物合成
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2014
·
IF 2.423
Yuanchao Pei,Yanjie Huang,Lin Li,Jianji Wang
In this paper, micro-emulsions composed of cholinium-based ionic liquids (ILs), octylphenol ethoxylate (Triton X-100) and water were prepared. These ternary systems were found to be stable over 12 months at room temperature. Their phase behaviour was investigated by using cloud titrations, and their microstructures were characterised by means of cyclic voltammetry and electrical conductance measurements at T = 298.15 K. It was shown that the micro-emulsions exhibited IL-in-water, bi-continuous and water-in-IL microstructures. Dynamic light scattering data suggest that Triton X-100 forms micelles in water, which were swelled by the ILs added. Droplets with the size about 20 nm were formed in these IL-based micro-emulsions, and the droplet size increased with the increase of the IL concentrations. These IL-based micro-emulsions may have potential in drug delivery, chemical reactions and nanomaterial preparation as a new type of nanoreactors.
研究领域:
化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2017
·
IF 3.648
Li-rong Nie,Shun Yao,Bing Dong,Xin-lu Li,Hang Song
In this paper, five novel cholinium-based organic magnetic ionic liquids (MILs) were synthesized. The carbon chain links to the nitrogen atom from cationic nucleus. The MILs were comprehensively identified by FT-IR, HPLC, UV–Vis, 1 H NMR and ESI-MS. The MILs have interesting performance to form aqueous two-phase system and can respond to the external magnetic field after the formation of aqueous two-phase system, which can assists magnetically phase separation. The magnetic susceptibility of the MILs was measured at 298 K. Other physical properties such as conductivities, acidity and density were measured in range of 278.15 K to 323.15 K for further application investigation. Satisfactory results were obtained after the data of physical properties were correlated. Based on the measurements and correlations above, some discussions were carried out, including the ion association and ion diffusion , the influences of MILs carbon chain and temperature on the molar conductivity , the influences of the cation size on the molar volume , acidity variation of the MILs.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 4
·504
·
IF 4.034
Zisheng Zhang,Ning Kang,Jingjing Zhou,Xingang Li,Lin He,Hong Sui
In this study, a series of choline-based amino acid ionic liquids have been synthesized in an economic method and are used to assist solvents with extracting asphalt from carbonate rocks. All of the ionic liquids perform well in extracting asphalt, especially choline histidine, by which the single-step recovery of asphalt is up to 91%. Furthermore, oil product with higher quality (fewer solids entrained) is also obtained. Molecular dynamics simulation and thermodynamic equilibrium method are applied to investigate the role of amino acid ionic liquids via interaction energy calculation and surface free energy calculations. The simulation results suggest that the ionic liquid phase is beneficial for the transfer of oil fraction from the carbonate surface to the organic solvent phase. Moreover, the results of simulated calculation show that the introduction of a functional group with conjugated structures into ionic liquid, such as an imidazole ring and a benzene ring, is beneficial for enhancing oil recovery, which are in accordance with the results of experimental tests.Keywords:amino acid ionic liquid;carbonate asphalt rock;COSMOtherm;molecular dynamics simulation
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2013
·
IF 2.004
Duan-Jian Tao,Zheng Cheng,Feng-Feng Chen,Zhang-Min Li,Na Hu,Xiang-Shu Chen
Nowadays the knowledge of thermodynamic properties for amino acid ionic liquids (AAILs) has been paramount for the design of many chemical processes. In this present work, a series of cholinium-based AAILs ([Ch][AA]) were synthesized by neutralization of choline hydroxide solution with five amino acids and then were characterized by 1H NMR, Fourier transform infrared (FT-IR), elemental analysis, thermogravimetry, and differential scanning calorimetry (DSC) analysis. Physico-chemical properties such as density, viscosity, refractive index, and conductivity were measured and correlated with the empirical equations in a wide temperature range. The thermal expansion coefficient values were also calculated from the acquired experimental density values. From the experimental data, it was found that the density, viscosity, and refractive index decreased while conductivity increased with the increase of temperature. The correlation results were proposed to be in good agreement with the experimental data, and optimal fitting parameters were presented. In addition, the coefficient of thermal expansion was considered to be independent of temperature in the range of (298.15 to 353.15) K.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2020
·
IF 2.213
Ming Duan,Mengjuan Luo,Ziyi Yang,Yan Xiong,Peng Shi,Shenwen Fang,Shan Qin
Choline-based deep eutectic solvents (DESs) have many outstanding features as they are easy to prepare, inexpensive, low-toxic, low volatile, and biodegradable, which make them increasingly attractive in industrial chemistry and green chemistry. In this paper, the abilities of three different kinds of DESs for crude oil removal from contaminated soils were compared and it was found the DES formed by phenylpropionic acid and choline chloride (mole ratio = 2:1) had the best performance. The effects of extraction time, temperature and the solvent–soil ratio on phenylpropionic acid/choline chloride DES performance were evaluated. The rational extraction conditions were recommended as follows: mass ratio of DES to soil was 10:1 and 60 min extraction time at 80°C. The extraction (desorption) process could be described by Freundlich desorption isotherm mode. In addition, the phenylpropionic acid/choline chloride DES could be recycled and the oil removal efficiency was about 90% after 10 cycles. This finding suggested that choline-based DES extraction was a promising technology for crude oil removal from contaminated soil.
研究领域:
环境科学
·
绿色化学
✓ 已验证
DOI
高影响因子
Drug Delivery and Translational Research
·
2024
·
IF 5.7
Li Yang,Yu Qin,Lu Yi,Ma Yanyun,Qi Jianping,Chen Zhongjian,Zhu Quangang,Wu Wei
Psoriasis is a prevalent chronic disease affecting 2–3% of the global population. Cyclosporine A (CyA) has been widely used with great promise in the treatment of moderate to severe psoriasis despite various side effects associated with its systemic administration. Topical administration of CyA circumvents systemic side effects; however, the poor water solubility and large molecular weight of CyA pose challenges for dermal delivery. In this study, choline-based ionic liquids (ILs) were used to enhance the dermal delivery of CyA for the potential treatment of psoriasis. All four ILs tested significantly improved the solubility of CyA, which was greater than that of the control group with dimethyl sulfoxide (DMSO) as a solubilizer (20%, w/w). The saturated solubility of CyA in two of the ILs, choline geranate ([Ch][Ge]) and choline ricinoleate ([Ch][Ra]), reached more than 90 mg/mL, and the solubilization capability of the ILs except [Ch][Ci] was resistant to water dilution. The negligible change in CyA content determined by high-performance liquid chromatography and the secondary structure detected by circular dichroism spectroscopy confirmed the stability of CyA in the ILs. At 4 h in the in vitro penetration test, the amount of CyA retained in the skin in the IL groups was slightly greater than that in the control group (20% DMSO). The water content of the ILs significantly affected their penetration ability. When the water content increased from 10 to 70%, the dermal delivery of CyA first increased, peaked at a water content of 30%, and then decreased. The dermal delivery ability of [Ch][Ge] and [Ch][Ra] with a water content of 70% was still comparable to that of 20% DMSO. Moreover, CyA-loaded ILs (0.5%, w/w) significantly relieved the symptoms of psoriasis in an imiquimod (IMQ)-induced mouse model, and the levels of inflammatory factors, including tumor necrosis factor α, interleukin 22 and interleukin 17, in the affected area were reduced by 71.7%, 75.6%, and 89.3%, respectively. The IL tested, choline sorbate ([Ch][So]), showed low cytotoxicity to human immortalized epidermal cells (HaCaT). After 7 days of consecutive application, [Ch][So] did not cause significant irritation. In conclusion, ILs demonstrate promising potential for the dermal delivery of CyA for the treatment of psoriasis. Graphical Abstract
研究领域:
药学
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皮肤科
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Wenxin Xu,Manyue Zhang,Wenzhen Du,Guixia Ling,Yue Yuan,Peng Zhang
Immediate hemostatic control and anti-infection are critical for wounds and have received much attention in the pharmacological fields. Whereas the development of effective wound dressings has faced the challenge with the desired combination of properties, including antimicrobial agent selection, adhesion to tissue, hemostatic performance, biocompatibility, ease of use, etc. It is known that hyaluronic acid (HA) derivatives are beneficial to promoting coagulation and wound healing, and have many functional groups in the structure, which are easy to be chemically modified. ε-Poly-(L-lysine) (ε-PL) has long-acting and broad-spectrum antibacterial properties and can bind to the aldehyde group by Schiff base reaction. Choline-based bio-ionic liquids (Bio-ILs) are structural precursors of phospholipid bilayers in cell membranes, and the adhesive strength of the polymers could be improved by conjugated with them. In addition, the humid environment also facilitates wound healing. Herein, we developed a novel wound dressing, which was a multifunctional hydrogel interwoven with two networks, one network was constructed from conjugation of Bio-ILs with methacrylated hyaluronic acid (MeHA) and self-coupling of MeHA, and the other network was formed by oxidized hyaluronic acid (OHA) and ε-PL via Schiff base reaction. In vitro studies indicated that hydrogels exhibited a three-dimensional porous structure with good swelling, antibacterial and biocompatibility properties. In addition, the rat tail amputation and wound healing experiments expressed that hydrogels had the ability of rapid hemostasis and promoting wound healing. In conclusion, Bio-IL/MeHA/OHA/ε-PL hydrogel is a naturally-derived, biocompatible and promising wound dressing.
研究领域:
药理学
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材料科学
·
生物材料
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Yang Li,Qin Yu,Yi Lu,Haisheng He,Jianping Qi,Zongguang Tai,Zhongjian Chen,Quangang Zhu,Wei Wu
Ionic liquids (ILs) show promises as chemical penetration enhancers (CPEs) for transdermal delivery of macromolecular drugs. However, their high viscosity and strong drug-IL affinity may limit drug diffusion and release from the drug-loaded IL (one-step strategy). Herein, a two-step strategy was used by applying choline-based ILs as pretreatment agents followed by insulin solution to improve penetration. Insulin remained stable in the ILs and are released slowly from the IL matrices. In vitro and in vivo studies showed that two-step treatment enhanced insulin penetration compared to one-step treatment, with choline citrate ([Ch][Ci]) and choline geranate ([Ch][Ge]) performing the best. In a diabetic rat model, two-step treatment with [Ch][Ge] reduced blood glucose levels to below 80% within 8 h, while one-step treatment only maintained for 12 h. Trans-epidermal water loss and molecular dynamics simulations suggested that variations in release rates and skin condition accounted for the differences between the two strategies. Physical characterization confirmed that ILs enhanced transdermal delivery of insulin by permeabilizing stratum corneum and opening tight junctions. Preliminary safety assessment indicated mild irritation by [Ch][Ge], whereas [Ch][Ci] showed good biocompatibility. It is concluded that ILs hold potential in enhancing transdermal delivery of insulin.
研究领域:
药学
·
药物递送系统
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生物物理学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Sizhe Liu,Qian Zhang,Ying Han,Yulong Sun,Yifei Zhang,Hongyu Zhang
In clinics it is extremely important for implanted devices to achieve the property of enhanced lubrication and bacterial resistance; however, such a strategy has rarely been reported in previous literature. In the present study, a surface functionalization method, motivated by articular cartilage-inspired superlubrication and mussel-inspired adhesion, was proposed to modify titanium alloy (Ti6Al4V) using the copolymer (DMA–MPC) synthesized via free radical copolymerization. The copolymer-coated Ti6Al4V (Ti6Al4V@DMA–MPC) was evaluated by X-ray photoelectron spectroscopy, water contact angle, and Raman spectra to confirm that the DMA–MPC copolymer was successfully coated onto the Ti6Al4V substrate. In addition, the tribological test, with the polystyrene microsphere and Ti6Al4V or Ti6Al4V@DMA–MPC as the tribopair, indicated that the friction coefficient was greatly reduced for Ti6Al4V@DMA–MPC. Furthermore, the bacterial resistance test showed that bacterial attachment was significantly inhibited for Ti6Al4V@DMA–MPC for the three types of bacteria tested. The enhanced lubrication and bacterial resistance of Ti6Al4V@DMA–MPC was due to the tenacious hydration shell formed surrounding the zwitterionic charges in the phosphorylcholine group of the DMA–MPC copolymer. In summary, a bioinspired surface functionalization strategy is developed in this study, which can act as a universal and promising method to achieve enhanced lubrication and bacterial resistance for biomedical implants.
研究领域:
材料科学
·
生物医学工程
·
表面化学
·
摩擦学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）