INORGANIC CHEMISTRY
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2024
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IF 4.3
Jingyu Cai,Junjie Shi,Jian Zhang,Xiaoyu Miao,Sen Wang,Longqiang Xiao,Dan Liu,Linxi Hou
Electronic-grade isopropyl alcohol is widely utilized in the cleaning of semiconductors and microelectronic components. Removing ions like Pb2+ is crucial since the presence of impurities may cause degradation of electronics, increased failure rates, and short circuits. Membrane materials offer a number of advantages in the field of adsorption separation; however, the lack of adsorption sites results in limited adsorption capacity. In the current work, guanidino-grafted NH2-MIL-101(Fe) was incorporated into polyvinylidene fluoride (PVDF) to prepare MOF/PVDF mixed matrix membranes (NM/PVDF) for the removal of Pb2+ from isopropanol. Benefiting from the larger specific surface area and more lone electron pairs in the guanidine group, the Pb2+ adsorption capacity of the as-prepared NM/PVDF membrane was 29.4458 mg/g, which was higher than that of the NH2-MIL-101(Fe)/PVDF membrane (20.9306 mg/g) and the pure PVDF membrane (6.7324 mg/g). The NM/PVDF membrane was able to reduce the concentration of Pb2+ from 500 to 86.73 ppb. This work highlights the potential of guanidine-grafted Fe-based MOFs/PVDF membranes as adsorbents for acquisition of electronic-grade solvents.
研究领域:
材料科学
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环境工程
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化学工程
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2024
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IF 8.4
Tong Zhang,Qiaoying Wang,Bingbing Zhang,Zhichao Wu,Zhiwei Wang
Inspired by the simultaneous increase of permeability and selectivity by introducing nanobubbles by physical methods, this study firstly proposed a in situ chemical nanobubbles controlled guanidyl-incorporated double layer nanofiltration (NF) membrane for Mg/Li separation in salt-lake brine. As a bridge, 1,3-diaminoguanidine released nanobubbles rapidly and uniformly by pH control while polymerizing with trimesoyl chloride (TMC) during interfacial polymerization, followed by polyethyleneimine (PEI) secondary reaction, which effectively changed the solute transportation to obtain the shortest pathways in horizontal and normal directions. Compared with conventional PEI-TMC membrane, the water flux of guanidyl-incorporated PEI (G-PEI) membrane was obviously increased by 54.28% while separation factor of Li/Mg ( S Li/Mg ) enhanced by 63.27% in the initial 1 h, indicating chemical nanobubble interlayer effectively broke Trade-off effect by increasing the effective filtration area. In the long-term operation, G-PEI-NF membrane exhibited an excellent S Li/Mg of >60, low mass rate of Mg 2+ and Li + (MLR) of 0.31 and Li + purity of >75% with the stable flux of 19–20 L/(m 2 ·h). This study expected to provide a novel chemical nanobubble interlayer NF membrane with high filtration performance for Mg/Li separation in salt-lake brine.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Shuo Yang,Jianhao Liang,Nan Wang,Xiao-Kun Ouyang,Junhua Hu
Infected wounds are highly susceptible to bacterial contamination, which not only delays the healing process but also leads to a range of complications. NO is one of the most widely used gas molecules in wound treatment strategies due to its potent antibacterial and healing-promoting properties. However, excessive NO in infected wounds can damage cellular components and exacerbate inflammation. Therefore, precise control of NO dosage and targeted delivery to the wound site are crucial for effective treatment. Herein, a cationic hydrogel was constructed using modified guar gum and polyvinyl alcohol to enhance antibacterial effects, with guanidine-modified chitosan (Met-CS) and the photosensitizer sodium copper chlorophyllin (SCC) incorporated to create a light-triggered NO release system. Both in vitro and in vivo experiments confirmed that the proposed hydrogel exhibits excellent antibacterial performance, anti-inflammatory effects, and wound healing capabilities, demonstrating its potential for precise therapeutic applications.
研究领域:
生物材料学
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医学工程
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药剂学
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DOI
PubMed
高影响因子
DRUG DELIVERY
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2023
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IF 6
Ce Yi,Fei Xie,Xin Xu,Dian Xiao,Xinbo Zhou,Maosheng Cheng
Aiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve efficacy for the first time. A series of modified albumin drug conjugates were designed and synthesized with different structures, including guanidine (GA), biguanides (BGA) and phenyl (BA), and different quantities of modifications. Then, the endocytosis ability and in vitro/vivo potency of albumin drug conjugates were systematically studied. Finally, a preferred conjugate A4 was screened, which contained 15 BGA modifications. Conjugate A4 maintains spatial stability similar to that of the unmodified conjugate AVM and could significantly enhance endocytosis ability (p*** = 0.0009) compared with the unmodified conjugate AVM. Additionally, the in vitro potency of conjugate A4 (EC50 = 71.78 nmol in SKOV3 cells) was greatly enhanced (approximately 4 times) compared with that of the unmodified conjugate AVM (EC50 = 286.00 nmol in SKOV3 cells). The in vivo efficacy of conjugate A4 completely eliminated 50% of tumors at 33 mg/kg, which was significantly better than the efficacy of conjugate AVM at the same dose (P** = 0.0026). In addition, theranostic albumin drug conjugate A8 was designed to intuitively realize drug release and maintain antitumor activity similar to conjugate A4. In summary, the guanidine modification strategy could provide new ideas for the development of new generational albumin drug conjugates.
研究领域:
药学
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生物医学工程
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癌症研究
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DOI
PubMed
高影响因子
Theranostics
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2019
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IF 8.063
Huijuan Yu,Wen-Chao Geng,Zhe Zheng,Jie Gao,Dong-Sheng Guo,Yuefei Wang
Detection and quantification of trimethylamine N -oxide (TMAO), a metabolite from gut microbial, is important for the disease diagnosis such as atherosclerosis, thrombosis and colorectal cancer. In this study, a novel method was established for the sensing and quantitative detection of TMAO via molecular recognition of guanidinium-modified calixarene from complex matrix. Methods : Various macrocycles were tested for their abilities to serve as an artificial TMAO receptor. Using the optimized receptor, we developed an indicator displacement assay (IDA) for the facile fluorescence detection of TMAO. The quantification of TMAO was accomplished by the established calibration line after excluding the interference from the various interfering substances in artificial urine. Results : Among various macrocycles, water-soluble guanidinium-modified calix[5]arene (GC5A), which binds TMAO in submicromolar-level, was identified as the optimal artificial receptor for TMAO. With the aid of the GC5A•Fl (fluorescein) reporter pair, TMAO fluorescence “switch-on” sensing was achieved by IDA. The fluorescence intensity increased linearly with the elevated TMAO concentration. The detection was not significantly interfered by the various interfering substances. TMAO concentration in artificial urine was quantified using a calibration line with a detection limit of 28.88 ± 1.59 µM, within the biologically relevant low µM range. Furthermore, the GC5A•Fl reporter pair was successfully applied in analyzing human urine samples, by which a significant difference in fluorescence response was observed between the [normal + TMAO] and normal group. Conclusion: The proposed supramolecular approach provides a facile, low-cost and sensitive method for TMAO detection, which shows promise for tracking TMAO excretion in urine and studying chronic disease progression in humans.
研究领域:
分析化学
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生物医学工程
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分子生物学
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临床化学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Jianxin Wen,Xiaomei Liu,Zhuoyue Han,Zhijuan Wang,Hidetoshi Saitoh,Hua Li
Biofouling has been persisting as a global problem due to the difficulties in finding efficient and environmentally friendly antifouling coatings for long-term applications. Initial attachment of bacteria on material surface and subsequent formation of biofilm are the predominate phenomena accounting for subsequent occurrence of biofouling. Among the various factors influencing the bacterial attachment, conditioning layer formed by organic macromolecules usually plays the key role in mediating bacterial attachment through altering physicochemical properties of substrate surface. In this study, a guanidine-modified polysaccharide conditioning layer with the capability of tuning the bacterial attachment is constructed and characterized. Dextran, a polysaccharide widespread in bacteria extracellular polymeric substances (EPS), is oxidized by sodium periodate, and cationic polymer polyhexamethylene guanidine hydrochloride (PHMG) is anchored to oxidized dextran (ODEX) by Schiff base reaction. AFM characterization reveals morphological changes of the polysaccharide conditioning layer from tangled chain to island conformation after the PHMG modification. The guanidine-based dextran conditioning layer promotes attachment of both P. aeruginosa and S. aureus and disrupted bacterial cytomembranes are seen for the attached bacteria due to electrostatic interaction of the electropositive guanidine group with the electronegative bacteria. The guanidine-based dextran conditioning layer shows a low survival ratio of 22 %-34 % and 1 %-4 % for P. aeruginosa and S. aureus respectively after incubation in the bacterial suspension for 72 hours. The results would give insight into further exploring the potential applications of the newly designed polysaccharides conditioning layer for combating occurrence of biofouling.
研究领域:
材料科学
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生物技术
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微生物学
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表面化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
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