Regulating the immune microenvironment around the central neurons is a difficult problem. To address this critical matter, drug-loading scaffolds are promising ways of releasing drugs directly to the surrounding cells and ignoring the influence of blood–brain barrier and blood–medullary barrier. Microglia are fundamental innate immune sentinels in the central nervous system, usually activated during neuroinflammation. Citicoline (CDPC), a neuroprotective agent on secondary injuries, is used in clinical treatment of central nervous system diseases. To overcome low efficiency of CDPC uptake and improve immune microenvironment of CDPC in central nervous system (CNS), in this work, double local drug delivery systems, hybrid CDPC–liposome and CDPC blending directly waterborne polyurethane scaffolds, were prepared. It shows that CDPC–liposome composite scaffolds are more conducive to inhibit the inflammatory response of microglia and promote axon elongation, which presents a certain prospect in the field of nerve repair. Graphical abstract
An original molecularly imprinted polymer (MIP) sensor was constructed by fabricating a membrane on the surface of electrochemically reduced graphene oxide (ERGO)-modified electrode, for selective and sensitive probing of thiabendazole (TBZ). The membrane was prepared by means of electropolymerization, with o-phenylenediamine (oPD) and resorcinol (REC) as the monomers while TBZ as the template. The sensor features were characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The results suggested that the prepared sensor displayed good selectivity toward TBZ compared with three analogues. Under the optimal conditions, the current response of the imprinted sensor was linear to thiabendazole concentration in the ranges of 5.0 × 10−7−1.0 × 10−5 M and 1.0 × 10−5 − 1.2 × 10−4 M, with a limit of detection (LOD) of 1.25 × 10−7 M (S/N = 3). Finally, the imprinted electrochemical sensor was applied in the specific detection of TBZ in real samples with spiked recoveries of 96.3–104.9%.
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