Hong Zhou,Bailin Cong,Yongqi Tian,Yu He,Huanghao Yang
Three new cyclic lipopeptides (compounds 1–3) were isolated from Bacillus sp. SY27F, which collected from the deep-sea hydrothermal vent in the Indian Ocean. The planar structures of compounds 1–3 were characterized by LC–MS, GC–MS and NMR, whereas their absolute configurations were determined by modified Marfey’s analysis and optical rotation contrast. They shared the same heptapeptide chain (N-L-Gln 1 -D-Leu 2 -L-Leu 3 -L-Val 4 -L-Asp 5 -D-Leu 6 -L-Ile 7 -C), differing only by the length of the fatty acid chain. Compounds 1–3 displayed significant cytotoxic activity against DU145, MCF-7 and HepG2 cancer cell lines with IC 50 values of 96.8–190.7 nM and moderate to weak cytotoxicity against A549, HeLa and HT1080, with IC 50 values of 9.3–43.2 μM, respectively. However, none of the three compounds showed any antibacterial activity against Escherichia coli, Staphylococcus aureus and Monilia albicans .
Yong Zeng,Di Sha,Liyuan Zhang,Yizhen Chen,Renhui Qiu,Wendi Liu
Photo-curing three-dimensional (3D) printing technology is normally used for the manufacture of covalently cross-linked thermosets due to its high efficiency and resolution. However, printed thermosets are mostly derived from petroleum resources and tend to be highly brittle and poorly deformable. Herein, renewable palm oil (PO) was used to fabricate highly robust and deformable bio-based thermosetting networks with an intrinsic soft phase assembled by long fatty acid chains via a liquid crystal display 3D printing technique. A PO-based methacrylate (MPOEA) with two C═C bonds and a fatty acid chain was synthesized via an amidation and esterification strategy. Isobornyl acrylate (IBOA) with a stiff alkyl ring was selected as a comonomer for MPOEA to form photosensitive MPOEA-IBOA inks. The printed MPOEA-IBOA networks possessed a satisfactory combination of the cross-linking density, the molecular distance between cross-linking points, and the soft phase distributed in the matrix. Therefore, the optimally designed thermosets exhibited a tensile strength of 52.1 MPa, a fracture elongation of 8.2%, a flexural strength of 57.3 MPa, a flexural deflection of 34.6 mm, a Tg of 105.1 °C, and excellent shape memory behavior. The formation mechanism of the fatty acid chain soft phase and its effects on the UV-initiated curing rate, gel content, dynamic mechanical property, thermal stability, and micromorphology of the MPOEA-IBOA polymer were fully investigated.
In order to obtain margarine free of trans-fatty acids, four interesterified basestocks were prepared by chemical interesterification (CIE) of oil blends. Different ratios of palm stearin, palm olein and soybean oil were mixed without and with 1) fully hydrogenated Acer truncatum oil (FHATO), 2) fully hydrogenated rapeseed oil or 3) palm kernel oil containing a similar amount of saturated, monounsaturated and polyunsaturated fatty acids, but different saturated fatty acid length for CIE. Compared to the physical blends, the CIE samples demonstrated lower slip melting points and decreased solid fat contents, especially at high temperatures, indicating that the CIE samples might have improved mouthfeel. In all CIE samples, the β crystal form disappeared and only the β’ crystal form was observed, except for sample 2, which contained a mixed β and β’ forms. Furthermore, in all CIE samples, except sample 1, the β' crystal forms began transforming to β form after only two cycles of higher temperature treatments indicating that the CIE sample with FHATO had the most resistance to temperature fluctuation during storage which may be attributed to its longer saturated chains. In conclusion, the CIE basestocks containing longer saturated fatty acids could be more suitable for margarine use.
危险品化学品经营许可证（带存储）