CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yan Zhao,Yan Zhang,Zhe Liu,Song Zhang,Dekui Song,Yu Zhai,Chunming Lu,Hongping Yan,Nan Liu
In brain science, neural activity inevitably leads to the fluctuation of cerebral blood flow. Toward comprehensively understanding brain, it is necessary to develop an epidermal electrode that can concurrently monitor the brain’s electrical activity and hemodynamic activity. Here, we report an ultra-conductive and transparent epidermal electrode for simultaneous dual-mode assessment of brain function. The electrode can accurately and imperceivably detect electrophysiological signals and functional near-infrared spectroscopy (fNIRS) optical signals. It is fabricated by two monolayer graphene with confined poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) in between, namely GPG. Its extremely low sheet resistance (20.8 Ω/sq, 3727 S/cm, 129 nm) and high transmittance (∼80%) can be attributed to the more ordered alignment and dense packing of PEDOT due to the nano-confinement effect of bi-layer graphene. The strong π-π interaction between graphene and PEDOT:PSS results in the decreased stacking distance between PEDOT. Leveraging the excellent electrical property and ultrathin nature, this epidermal electrode is able to achieve low skin-electrode impedance and monitor various electrophysiological signals accurately and stably, even if the participant is in motion. Beneficial from the appropriate transparency, it can simultaneously record very weak EEG electrical signals and fNIRS optical signals, enabling dual-model brain activity analysis with high temporal and spatial resolution.
研究领域:
生物医学工程
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神经科学
✓ 已验证
DOI
高影响因子
Frontiers in Neurology
·
2025
·
IF 2.8
Jili Xu,Xing Tang,Xiaotong Liu,Yi Wang,Jie Wu
Acupuncture, as an effective external treatment method, has been widely used in various clinical diseases, but the research on its mechanism still needs to be further deepened. Functional near-infrared spectroscopy (fNIRS) technology, as an emerging non-invasive neuroimaging technique, has the advantages of high timeliness, wide application scenarios, good portability and low cost. Currently, it is widely used in the mechanism research of acupuncture. This paper reviewed all the studies on the application of fNIRS in acupuncture, analyzed and summarized the current application status of fNIRS technology in acupuncture research. Firstly, we elaborated on the working principle of fNIRS and highlighted its advantages in acupuncture research and application. Secondly, we detailed the specific applications of fNIRS in acupuncture research. Finally, we discussed the existing problems of fNIRS in acupuncture research at present and the improvement directions for future research.
研究领域:
神经科学
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生物医学工程
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针灸学
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转化医学
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脑功能成像
✓ 已验证
DOI
PubMed
高影响因子
Translational Psychiatry
·
2021
·Vol. 11
·期 1
·1-27
·
IF 6.222
Guo Yinrui,Zhu Xiangxiang,Zeng Miao,Qi Longkai,Tang Xiaocui,Wang Dongdong,Zhang Mei,Xie Yizhen,Li Hongye,Yang Xin,Chen Diling
Gut microbiota (GM) metabolites can modulate the physiology of the host brain through the gut–brain axis. We wished to discover connections between the GM, neurotransmitters, and brain function using direct and indirect methods. A diet with increased amounts of sugar and fat (high-sugar and high-fat (HSHF) diet) was employed to disturb the host GM. Then, we monitored the effect on pathology, neurotransmitter metabolism, transcription, and brain circularRNAs (circRNAs) profiles in mice. Administration of a HSHF diet-induced dysbacteriosis, damaged the intestinal tract, changed the neurotransmitter metabolism in the intestine and brain, and then caused changes in brain function and circRNA profiles. The GM byproduct trimethylamine-n-oxide could degrade some circRNAs. The basal level of the GM decided the conversion rate of choline to trimethylamine-n-oxide. A change in the abundance of a single bacterial strain could influence neurotransmitter secretion. These findings suggest that a new link between metabolism, brain circRNAs, and GM. Our data could enlarge the “microbiome–transcriptome” linkage library and provide more information on the gut–brain axis. Hence, our findings could provide more information on the interplay between the gut and brain to aid the identification of potential therapeutic markers and mechanistic solutions to complex problems encountered in studies of pathology, toxicology, diet, and nutrition development.
研究领域:
神经科学
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微生物学
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分子生物学
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营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Huan Wei,Fei Wu,Lijuan Li,Xiaoti Yang,Cong Xu,Ping Yu,Furong Ma,Lanqun Mao
Probing chemical information in the central nervous system is essential for understanding the molecular mechanism of brain function. Electrochemistry with tissue-implantable carbon fiber electrodes (CFEs) provides a powerful tool for monitoring the dynamics of neurochemicals in a subsecond time scale; however, the implantation of CFEs into brain tissue immediately causes the nonspecific adsorption of proteins on electrode surfaces. This process can dramatically impact the performance of the electrochemical method in terms of reduced sensitivity and accuracy. Herein, we report a strategy to minimize the electrode biofouling by masking CFEs with leukocyte membranes (LMs). We find that the LM masking endows CFEs with a highly hydrophilic surface that gains a high resistance to nonspecific protein adsorption. The electrode reactivity to target molecules decreases by a small degree due to the membrane coating, but the sensitivity loss of the LM-masked CFEs is greatly lessened even after in vivo implantation for 8 h. This study offers a new method of microelectrode modification by natural cell membranes for sustained sensing performance during long-term in vivo analysis.
研究领域:
神经科学
·
生物工程
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Heliyon
·
2023
·
IF 4
Yanfeng Huang,Qing Lin,Xue Tan,Liangliang Jia,Hui Li,Zaishi Zhu,Changlong Fu,Lili Wang,Linlong Liu,Min Mao,Zhouping Yi,Dezun Ma,Xihai Li
Osteoarthritis (OA) is a common joint disease characterized by chronic pain, and the perception of pain is closely associated with brain function and neuropeptide regulation. Rehmannia is common plant herb with anti-inflammatory and analgesic properties that is used to treat OA. However, it is unclear whether Rehmannia alleviates OA-related pain via regulation of neuropeptides and brain function. We examined the pain relief regulatory pathway in OA after treatment with Rehmannia by verifying the therapeutic effect of Rehmannia alcohol extract in vivo and vitro and exploring of the potential mechanism underlying the analgesic effect of Rahmanian using functional magnetic resonance imaging and measuring neuropeptide secretion. Our results showed that Rehmanni a alcohol extract and the related active ingredient, Rehmannioside D , can delay cartilage degradation and alleviate inflammation in OA rats. The Rehmanni a alcohol extract can also relieve OA pain, reduce the secretion of calcitonin gene-related peptide (CGRP) and substance P (SP), and reverse the pathological changes in the cerebral cortex and hippocampus. Our research results demonstrate that Rehmannia alleviates OA pain by protecting cartilage, preventing the stimulation of inflammatory factors on neuropeptide secretion, and influencing the relevant functional areas of the brain.
研究领域:
药理学
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神经科学
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风湿病学
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中医
✓ 已验证
DOI
PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2022
·
IF 5.572
Shanshan Hu,Zhiyuan Lin,Sibo Zhao,Bowen Zhang,Liyong Luo,Liang Zeng
Brain inflammation develops with increased colitis . Pu-erh tea is considered a potential dietary intervention to improve colitis. However, it's unclear whether Pu-erh tea helps alleviate colitis-mediated brain dysfunction . Here, we found that colitis triggered brain dysfunction and increased the risk of depression. Pu-erh tea improved gut-brain barrier function (increased ZO-1 and Occludin) and restored short-chain fatty acids (SCFAs) as well as neurotransmitter release (γ-GABA, 5-HT, and dopamine), which stemmed from the production of butyric acid (BA). Pu-erh tea and BA promoted the production of SCFAs by reshaping the gut microbes (increased Lactobacillus , Akkermansia , Faecalibaculum ), thereby downregulating gut inflammatory protein expression (PI3K/AKT/NF-κB). SCFAs, especially BA, intervened directly in the blood-brain barrier via the gut-brain axis to restore neurotransmitter release. Collectively, our results highlighted that increasing BA through Pu-erh tea consumption may be a key mechanism for improving colitis-mediated brain dysfunction by lowering gut inflammation and balancing gut microbe-gut-brain axis homeostasis . These results provide a promising step that might encourage further investigations of Pu-erh tea as a protective agent for brain function in colitis patients.
研究领域:
胃肠病学
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神经科学
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微生物学
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营养科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 32
·2002644
·
IF 16.836
Wei Ling,Jingxian Yu,Ning Ma,Ya Li,Ziyue Wu,Rong Liang,Yafeng Hao,Huizhuo Pan,Wentao Liu,Bo Fu,Kun Wang,Hanjie Wang,Lizhu Li,Xing Sheng,Hui Peng,Baoan Ning,Jiajia Yang,Xian Huang
Simultaneous neuron stimulation and biophysiological sensing in multi-encephalic regions can lead to profound understanding of neural pathways, neurotransmitter transportation, and nutrient metabolism. Here, a flexible electronic device with tentacle-like channels radiating from a central wireless circuit is presented. The device is constructed by different organic and inorganic materials that have been made into thin-film or nanoparticle formats. All channels have been equipped with flexible components for distributed and synchronized opto-electrical stimulation, biopotential sensing, and ion concentration monitoring. They can be implanted into different brain regions through adaptive bending and individually addressed to follow programmable working sequences. Experimental results conducted in vitro and in vivo have demonstrated the capability in generating optical or electrical stimulation, while sensing 16-channels biopotential and concentration of Ca 2+ , Na + , and K + ions in distributed regions. Behavior and immunohistochemistry studies suggest potential applications in regulating brain functions for freely moving animals. In combination with various functional materials, the device can serve as a comprehensive research platform that can be modularized to accommodate different needs for brain studies, offering numerous possibilities and combinations to yield sophisticated neuromodulation and behavior regulation.
研究领域:
神经科学
·
材料科学
·
生物医学工程
·
电子学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
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