FirePhysChem
·
2023
·
IF 0
Weijun He,Yaning Li,Peng Bao,Yuanlin Fan,Mingshuai Xue,Boliang Wang
To reduce the mechanical sensitivity of CL-20, this study is based on the surface modification of CL-20, and explores the effects of two preparation processes, the water solution-suspension method and the phase separation method, on the coating process of CL-20. Based on the structural characteristics of surfactants, a formulation was devised, using 2-cyanoethyltriethoxysilane (SCA2) as the surfactant and microcrystalline wax as the desensitizer. The samples underwent comprehensive characterization employing SEM, XPS, DSC, XRD, friction sensitivity testing, and impact sensitivity testing to evaluate both their structural composition and inherent properties. The results showed that the composite particles prepared using the phase separation method displayed a compact coating layer on CL-20 surfaces. Specifically, the composite particle CL-20@SCA2/Wax-P, which contained the surfactant, exhibited a thin and dense film on its surface. The proportion of -NO 2 groups on the surface of the composite particles experienced a reduction of 13.12% compared with CL-20. The crystal form of CL-20 remained unchanged in four composite particles. The decomposition peak temperatures and activation energy of all four composite particles were decreased, resulting in reduced thermal stability. The critical friction sensitivity load for composite particles produced via the aqueous suspension method is 252N, whereas for those prepared using the phase separation method, it elevates to 360N. The characteristic drop height (H 50 ) of composite particles prepared by the phase separation method increased significantly, 34cm for CL-20/W-P composite particles and 55cm for CL-20@SCA2/W-P composite particles, compared with the raw CL-20. These results suggest that the utilization of SCA2 effectively modified the surface of CL-20, and the composite particles prepared using the phase separation method demonstrated a considerable reduction in mechanical sensitivity.
研究领域:
材料科学
·
化学工程
·
安全工程
✓ 已验证
DOI
Materials Horizons
·
2025
·
IF 10.7
KuangDi Xin,Wanshan Gao,Yulu Xie,Xioahua Dong,Lingshan Ran,Tianyi Xia,Jing Xie,Jiaojiao Yang,Tao Hu,Jianshu Li,Xiaoyu Huang,Rongming Qiu,Jun Luo
Dentin hypersensitivity (DH) causes sharp pain due to external stimuli transmitted through narrow dentinal tubules (DTs) in exposed dentin. Current desensitizers struggle to provide sufficient DT occlusion depth and density, limiting long-term effectiveness under daily erosion and friction. Inspired by fish schooling behavior, we introduce an adaptive hydrogel desensitizer (STU) composed of “sardines” (tannic acid and silk fibroin) and “predators” (urea). The “sardines” form a tightly packed hydrogel "shoal" through hydrogen bonds, while the “predators” disrupt these bonds, transforming STU into a fluid form that quickly infiltrates DTs upon application. As urea diffuses in saliva, hydrogen bonds rapidly re-form, reassembling the hydrogel “shoal” to securely bond DT walls and achieve stable, dense occlusion up to 660 μm deep -- approximately 3 times greater than the current best. This occlusion remains effective under extended in vitro and in vivo erosion and friction, restoring dentin hardness to healthy levels without noticeable mucosal damage in the rat cavity. Deep occlusion and biocompatibility were further validated in a rabbit model with significantly smaller DTs. Along with its long shelf life (> 10 m in dehydrated form) and ease of application, this natural desensitizer offers a promising clinical solution for instant, permanent relief from DH.
研究领域:
口腔医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Ying Li,Bindong Li
Titanium dioxide (TiO 2 ) had the potential to be a desensitizing material, but its inherent characteristics presented challenges for coating on energetic materials. To enhance the interfacial interactions of energetic materials and TiO 2 , the surface of TiO 2 was modified with biomass tannic acid (TA) to prepare the core-shell (hexanitrohexaazaisowurtzitane) CL-20@TA-TiO 2 energetic composites. Various characterization techniques were used to investigate the thermal performance, impact sensitivity, structure, and surface morphology of CL-20@TA-TiO 2 . The protective layer formed by the TA-TiO 2 coating on the surface of CL-20, thus protecting the material from external stimulation. The results indicated that the organic-inorganic core-shell energetic composites prepared with biomass TA as the interface layer exhibited outstanding performance.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROPELLANTS EXPLOSIVES PYROTECHNICS
·
2022
·Vol. 48
·期 2
·e202200192
·
IF 2.134
Qi Huang,Yulan Song,Zhicheng Guo,Jinhao Zhang,Bo Jin,Ya Guo,Rufang Peng
Interface interaction has always been considered a major challenge in the field of desensitization. Co-crystal explosives can balance the properties of energetic materials, but their limited desensitization effect limits their further practical applications. Based on this, we proposed the desensitization of CL-20/HMX co-crystal by three functionalized graphene oxide (NH 2 -GO, Am-GO and M550-GO). The sensitivity results indicate that the M550-GO has the best desensitization. To further explore the reasons for the better desensitization effect of M550, molecular dynamics was used to simulate the binding energy and mechanical properties of different systems. The results showed that the electrostatic interaction between functionalized graphene oxide and CL-20/HMX co-crystal can enhance the interfacial interaction more than van der Waals force. In a word, this work provides new ideas and insights for enhancing the interface interaction of coating materials and popularizing the practical application of co-crystal explosives.
研究领域:
材料科学
·
爆炸物化学
·
界面工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2019
·Vol. 140
·期 5
·2111-2122
·
IF 2.471
Cheng Jian,Yan Jingchun,Wang Lei,Zhang Rongxian,Liu Zuliang,Wang Rui,Li Zhenming
Abstract A new family of metal-free and energetic graphene oxide (GO)-based burning rate catalysts (FGO 1–6 ) with excellent catalytic and desensitization performances for ammonium perchlorate (AP) were synthesized by nucleophilic substitution reaction of energetic functional groups with acylated GO. The chemical structures, thermal stabilities, catalytic properties and desensitization performances of the functionalized GO were determined. It was shown that the functional groups on the nanosheets of GO imparted its energetic performance and thermal stability, and the catalytic properties and desensitization performances were also enhanced. The reduced mass loss rate along with enhanced residues formation indicated significant improvement in thermal stabilities for FGO 1–6 compared with GO. Besides, not only did FGO 1–6 lower the decomposition temperature, but also enhanced the overall heat for the thermal decomposition of AP. The FGO 1–6 decreased the exothermic peak of the high-temperature decomposition process of AP by 88.1, 93.4, 98.3, 85.8, 90.7 and 79.8 °C, corresponding to the decomposition heat of AP increased significantly from 655 to 2707, 2915, 3529, 3002, 3642 and 2718 J g −1 , which exhibited better catalytic activity than that of GO. In addition, the mechanical sensitivities of AP/GO and AP/FGO 1–6 mixtures decreased obviously in comparison with pure AP were also obtained. Graphic abstract A new family of metal-free and energetic GO-based burning rate catalysts with excellent catalytic properties and desensitization performances for ammonium perchlorate were developed.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2022
·Vol. 15
·期 1
·127-143
·
IF 8.307
Luyao Yi,Hongling Wu,Yue Xu,Jian Yu,Yaning Zhao,Hongye Yang,Cui Huang
Dentin hypersensitivity (DH) treatment is far from being unequivocal in providing a superior strategy that combines immediate and long-term efficiency of dentinal tubule (DT) occlusion and clinical applicability. In order to achieve this aim, a type of multifunctional yolk–shell nanocomposite with acid resistance, mechanical resistance and biomineralization properties was developed in this study, which consists of a silica/mesoporous titanium–zirconium nanocarrier (STZ) and poly(allylamine hydrochloride) (PAH)-stabilized amorphous calcium phosphate (ACP) liquid precursor. First, the nanocomposite, named as PSTZ, immediately occluded DTs and demonstrated outstanding acid and mechanical resistance. Second, the PSTZ nanocomposite induced intrafibrillar mineralization of single-layer collagen fibrils and remineralization of demineralized dentin matrix. Finally, PSTZ promoted the odontogenic differentiation of dental pulp stem cells by releasing ACP and silicon ions. The reconstruction of the dentin-mimicking hierarchical structure and the introduction of newly formed minerals in the upper, middle and lower segments of DTs, defined as sandwich-like structures, markedly reduced the permeability and achieved superior long-term sealing effects. The nanocomposite material based on mesoporous yolk–shell carriers and liquid-phase mineralized precursors developed in this study represents a versatile biomimetic sandwich desensitization strategy and offers fresh insight into the clinical management of DH.
研究领域:
牙科材料
·
生物材料科学
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Cell Communication and Signaling
·
2024
·Vol. 22
·期 1
·1-21
·
IF 8.2
Wu Chengyan,Hu Li,Liu Bing,Zeng Xingyue,Ma Haixiang,Cao Yongkai,Li Huijun,Zhang Xiaohan
Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists. The binding of β-arrestin to the cytoplasmic cavity of the phosphorylated receptor, which competes with the G protein, has been widely accepted as an extensive model for explaining GPCRs desensitization. However, studies on various GPCRs, including dopamine D 2 -like receptors (D 2 R, D 3 R, D 4 R), have suggested the existence of other desensitization mechanisms. The present study employed D 2 R/D 3 R variants with different desensitization properties and utilized loss-of-function approaches to uncover the mechanisms underlying GPCRs homologous desensitization, focusing on the signaling cascade that regulates the ubiquitination of AKT. Results AKT undergoes K8/14 ubiquitination by TRAF6, which occurs in the nucleus and promotes its membrane recruitment, phosphorylation and activation under receptor desensitization conditions. The nuclear entry of TRAF6 relies on the presence of the importin complex. Src regulates the nuclear entry of TRAF6 by mediating the interaction between TRAF6 and importin β1. Ubiquitinated AKT translocates to the plasma membrane where it associates with Mdm2 to phosphorylate it at the S166 and S186 residues. Thereafter, phosphorylated Mdm2 is recruited to the nucleus, resulting in the deubiquitination of β-Arr2. The deubiquitinated β-Arr2 then forms a complex with Gβγ, which serves as a biomarker for GPCRs desensitization. Like in D 3 R, ubiquitination of AKT is also involved in the desensitization of β 2 adrenoceptors. Conclusion Our study proposed that the property of a receptor that causes a change in the subcellular localization of TRAF6 from the cytoplasm to the nucleus to mediate AKT ubiquitination could initiate the desensitization of GPCRs.
研究领域:
细胞生物学
·
分子生物学
·
药理学
·
信号转导
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2019
·Vol. 10
·期 7
·3934-3941
·
IF 3.241
Ziye Zhang,Hang Xiao,Xiaofeng Zhang,Peng Zhou
Shrimp tropomyosin (TM) is a glycoprotein allergen with high lysine content, however, there is little data on how deglycosylation and glycation modify the allergenicity of TM. In this work, the effects of deglycosylation (enzymatic and chemical) and glycation of TM by glucose on in vivo allergenicity and mast cell function were investigated using BALB/c mouse and RBL-2H3 mast cells. Compared with TM, after deglycosylation, the deglycosylated TMs (DGTMs) exacerbated the in vivo allergenicity and mast cell allergy response. As for the TM glycated by glucose (TM-G), glycation led to weaker allergy responses on mouse and mast cells, which might be due to glucose destroying the epitopes with glycation sites. Moreover, the glucose residues on TM-G functioned as both a resistance to prevent the accessibility of TM-G to the IgE on mast cell and masking epitopes. Therefore, deglycosylation of TM was not suitable for desensitizing TM-induced food allergy, while glycation of TM might be applied to desensitize TM allergenicity, which could provide new insight into food allergy desensitization for larger cohorts of shrimp-allergic patients.
研究领域:
免疫学
·
食品科学
·
过敏研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Yang Yuan,Luo Ruizeng,Chao Shengyu,Xue Jiangtao,Jiang Dongjie,Feng Yun Hao,Guo Xin Dong,Luo Dan,Zhang Jiaping,Li Zhou,Wang Zhong Lin
Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization. Here, we develop a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS) by integrating a sliding free-standing triboelectric nanogenerator with a microneedle patch to achieve improved epidermal growth factor pharmacodynamics. We show that the mn-STESS facilitates drug penetration and utilization by using microneedles to pierce the stratum corneum. More importantly, we find that it converts the mechanical energy of finger sliding into electricity and mediates transcutaneous electrical stimulation through microneedles. We demonstrate that the electrical stimulation applied by mn-STESS acts as an “adjuvant” that suppresses the reduction of epidermal growth factor by glutathione and upregulates its receptor expression in keratinocyte cells, successfully compensating for receptor desensitization. Collectively, this work highlights the promise of self-powered electrical adjuvants in improving drug pharmacodynamics, creating combinatorial therapeutic strategies for traditional drugs.
研究领域:
药学
·
生物医学工程
·
材料科学
·
药物递送系统
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Xiaoning Zhang,Haiyan Cong,Yu Sun,Haohui Li,Baoer Zuo,Meifeng Li,Sining Li,Mingyi Wang
The covalent conjugation of chitosan to β-lactoglobulin (βLg) via Maillard reaction alters its structure and characteristics, providing a method to reduce allergenicity. The molecular weight (Mw) of chitosan plays a crucial role in the conjugation process, which in turn affects the desensitization effectiveness to βLg. The degree of conjugation decreased from 46.4 % ± 2.6 % (βC-1 ) to 27.6 % ± 2.9 % (βC-100) as the Mw increased from 1 kDa to 100 kDa. Notably, βC-1 showed a significant reduction in β-sheet content, resulting in a greater increase in surface hydrophobicity and improved thermostability compared to βC-10 and βC-100. Consequently, βC-1 demonstrated the most effective desensitization, with the highest inhibition of immunoglobulin E (IgE) combining capacity and the best suppression of cytokine overproduction in KU812 cells. Additionally, the overexpression of IgE and inflammatory factors in mice was significantly suppressed after βLg was conjugated with chitosan, alleviating dysbiosis of gut microbiota at both phyla and family levels and lessening anaphylactic response to βLg. The desensitization effects were observed in the order of βC-1 > βC-10 > βC-100.
研究领域:
食品科学
·
过敏学
·
糖化学
·
免疫学
·
分子营养学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）